96206-45-0Relevant articles and documents
Novel design and synthesis of a radioiodinated glycolipid analog as an acceptor substrate for N-acetylglucosaminyltransferase v
Arimitsu, Kenji,Kimura, Hiroyuki,Kajimoto, Tetsuya,Ono, Masahiro,Ohmomo, Yoshiro,Yamashita, Masayuki,Node, Manabu,Saji, Hideo
, p. 562 - 572 (2013)
Guided by the known molecular recognition interactions between N-acetylglucosaminyltransferase V (GnT-V) and certain synthetic substrates, we synthesized a radiolabeled double-stranded glycolipid composed of a long-chain alkyl unit and a radioiodinated phenylalkyl unit, [125I]-2-[N-(2- hydroxy-3-hexadecyloxy)propyl-15-(4-iodophenyl)pentadecanecarboxamido]ethyl 2-acetamido-2-deoxy-β-d-glucopyranosyl-(1→2)-α-d-mannopyranosyl- (1→6)-β-d-glucopyranoside ([125I]2), as a novel intravital glycolipid mimic substrate of GnT-V. The radioactive iodine (125I) was incorporated via iododestannylation of the phenyltributyltin derivative, 2-[N-(2-acetoxy-3-hexadecyloxy)propyl-15-(4-tributylstannylphenyl) pentadecanecarboxamido]ethyl 3,4,6-tri-O-acetyl-2-acetamido-2-deoxy-β-d- glucopyranosyl-(1→2)-3,4,6-O-acetyl-α-d-mannopyranosyl-(1→6)-2, 3,4-tri-O-acetyl-β-d-glucopyranoside (26). Subsequent deacetylation at the final step afforded [125I]2. Copyright
Synthesis and properties of photolabile (Caged) phosphotriester derivatives of dinucleoside phosphates
Abramova,Leonetti,Vlassov,Lebleu
, p. 174 - 182 (2007/10/03)
Dinucleoside phosphates that harbor phosphate groups transiently blocked (caged) by o-nitrobenzyl or o-nitroveratryl residues were synthesized. It was shown that the conditions of the UV-induced deprotection largely depend on the nature of the protective
