96304-42-6 Usage
Description
Trypanothione is a unique thiol compound found in trypanosomatid parasites, such as Trypanosoma brucei, which causes African trypanosomiasis (sleeping sickness) and Chagas disease. It plays a crucial role in the defense against oxidative stress and maintaining cellular redox balance in these organisms. Trypanothione disulfide is the oxidized form of N1,N8-bis(glutathionyl)-spermidine from the insect-parasitic trypanosomatid Crithidia fasciculata.
Uses
Used in Pharmaceutical Industry:
Trypanothione is used as a target for drug development for treating trypanosomiasis and Chagas disease. Its involvement in the defense against oxidative stress and its presence in trypanosomatid parasites make it an attractive target for the design of new therapeutic agents. Inhibiting trypanothione metabolism or function can lead to the death of the parasites and provide a potential treatment for these diseases.
Used in Research Applications:
Trypanothione is used as a research tool to study the biology and pathogenesis of trypanosomatid parasites. Understanding the role of trypanothione in these organisms can help researchers develop new strategies for combating these diseases and provide insights into the unique metabolic pathways of these parasites.
Used in Drug Discovery:
Trypanothione is used as a starting point for the development of new drugs targeting trypanosomiasis and Chagas disease. By studying the structure and function of trypanothione and its associated enzymes, researchers can identify potential drug candidates that can disrupt the redox balance in trypanosomatid parasites, leading to their death and providing a potential cure for the diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 96304-42-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,6,3,0 and 4 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 96304-42:
(7*9)+(6*6)+(5*3)+(4*0)+(3*4)+(2*4)+(1*2)=136
136 % 10 = 6
So 96304-42-6 is a valid CAS Registry Number.
96304-42-6Relevant articles and documents
Solid phase applications of Dde and the analogue Nde: Synthesis of trypanothione disulphide
Kellam, Barrie,Bycroft, Barrie W.,Chhabra, Siri Ram
, p. 4849 - 4852 (1997)
Bis - Dde and Nde spermidine derivatives selectively protected on the primary amines were readily prepared and attached via the secondary amine group to a p-nitrophenyl-1-chloroformate pre-activated HMPA resin. Deprotection for Nde was monitored by colour
Solid phase synthesis of polyamine conjugates for the study of trypanothione reductase
Marsh, Ian R.,Bradley, Mark
, p. 17317 - 17334 (2007/10/03)
A number of polyamine scaffolds were synthesised, enabling the facile preparation of a variety of polyamine conjugates using both Boc and Fmoc protecting group strategies. Products were released from the solid support by treatment with either triflic acid/trifluoroacetic acid or trifluoroacetic acid. The trypanosomal metabolite N1, N6-bis(glurathionyl)spermidine [trypanothione], and a range of related analogues were prepared for biological evaluation as previously communicated.
Synthesis of the Trypanosomatid Metabolites Trypanothione, and N1-Mono- and N8-Mono-glutathionylspermidine
Henderson, Graeme B.,Ulrich, Peter,Fairlamb, Alan H.,Cerami, Anthony
, p. 593 - 594 (2007/10/02)
The trypanosomatid metabolite trypanothione 1,N8-bis(glutathionyl)spermidine> and its biosynthetic co-metabolites the isomeric N1- and N8-mono-glutathionylspermidines have been synthesised by a mild route whic