965-31-1

Basic information

• Product Name: Benzenesulfonamide, N-[bis[(1-methylethyl)amino]methylene]-4-methyl-
• Synonyms: N1,N2-Diisopropyl-N3-(toluol-4-sulfonyl)-guanidin;N,N'-Diisopropyl-N''-(4-tolylsulfonyl)guanidin;N1,N2-Diisopropyl-N3--guanidin;
• CAS NO: 965-31-1
• Molecular Formula: C14H23N3O2S
• Molecular Weight: 297.41600
• Mol File: 965-31-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Benzenesulfonamide, N-[bis[(1-methylethyl)amino]methylene]-4-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenesulfonamide, N-[bis[(1-methylethyl)amino]methylene]-4-methyl-(965-31-1)
• EPA Substance Registry System: Benzenesulfonamide, N-[bis[(1-methylethyl)amino]methylene]-4-methyl-(965-31-1)

Safety Data

• Hazardous Substances Data: 965-31-1(Hazardous Substances Data)

Upstream product

• 70-55-3 toluene-4-sulfonamide 
• 693-13-0 diisopropyl-carbodiimide 
• 64-77-7 N-[(butylamino)carbonyl]-4-methyl-benzenesulfonamide 

Relevant articles and documents

Development of C-N coupling using mechanochemistry: Catalytic coupling of arylsulfonamides and carbodiimides

Reported herein is the mechanochemical synthesis of sulfonyl guanidines, a family of molecules which are relevant as pharmaceuticals and herbicides, by direct coupling of sulfonamides and aromatic or aliphatic carbodiimides. Attempts to conduct the coupling in solution have either failed or given very low conversions, thus demonstrating mechanochemistry as the necessary component for the discovery of this synthetic strategy. Milling around: Mechanochemistry is used to develop a method for the direct coupling of carbodiimides and arylsulfonamides using a copper catalyst. Attempts to reproduce this C-N coupling reaction under conventional solution-based conditions either failed or gave very poor conversions.