97358-50-4Relevant articles and documents
Catalytic Leuckart-Wallach-type reductive amination of ketones
Kitamura, Masato,Lee, Donghyun,Hayashi, Shinnosuke,Tanaka, Shinji,Yoshimura, Masahiro
, p. 8685 - 8687 (2007/10/03)
A Cp*Rh(III) complex catalyzes reductive amination of ketones using HCOONH4 at 50-70°C to give the corresponding primary amines in high yields. The reaction is clean and operationally simple and proceeds at a lower temperature and with higher chemoselectivity than the original Leuckart-Wallach reaction. The new method has been applied to the synthesis of α-amino acids directly from α-keto acids.