977-96-8 Usage
Description
1,1'-Diethyl-2,2'-cyanine iodide is a chemical compound that exhibits potent inhibitory properties against the extraneuronal monoamine transporter EMT. It is characterized by its ability to inhibit the toxic metabolite 1-methyl-4-phenylpyridinium (MPP+), which is associated with the induction of apoptosis in cerebellar granule neurons (CGNs). Additionally, it has been utilized as an absorber in fluorescence excitation-emission matrix (EEM) correction methods.
Uses
Used in Neuroprotection:
1,1'-Diethyl-2,2'-cyanine iodide is used as a neuroprotective agent for inhibiting the toxic effects of 1-methyl-4-phenylpyridinium (MPP+), a metabolite derived from 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. 1,1'-DIETHYL-2,2'-CYANINE IODIDE helps in reducing apoptosis in cerebellar granule neurons (CGNs), thereby offering potential therapeutic benefits in the context of neurodegenerative diseases.
Used in Fluorescence EEM Correction:
1,1'-Diethyl-2,2'-cyanine iodide is used as an absorber in a method designed to correct the fluorescence excitation-emission matrix (EEM). This application aids in enhancing the accuracy and reliability of fluorescence-based measurements, which are crucial in various analytical and research settings.
Purification Methods
It crystallises from EtOH and is dried in a vacuum oven at 80o for 4hours. [Beilstein 23 II 267.]
Check Digit Verification of cas no
The CAS Registry Mumber 977-96-8 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 9,7 and 7 respectively; the second part has 2 digits, 9 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 977-96:
(5*9)+(4*7)+(3*7)+(2*9)+(1*6)=118
118 % 10 = 8
So 977-96-8 is a valid CAS Registry Number.
InChI:InChI=1/C23H25N2.HI/c1-3-24-20(15-13-18-9-5-7-11-22(18)24)17-21-16-14-19-10-6-8-12-23(19)25(21)4-2;/h5-13,15,17H,3-4,14,16H2,1-2H3;1H/q+1;/p-1
