97914-53-9

Basic information

• Product Name: 2-DIFLUOROMETHOXY-BENZOIC ACID METHYL ESTER
• Synonyms: ART-CHEM-BB B006858;AKOS B006858;2-DIFLUOROMETHOXY-BENZOIC ACID METHYL ESTER;RARECHEM AL BF 0278;Methyl 2-(difluoromethoxy)benzoate
• CAS NO: 97914-53-9
• Molecular Formula: C₉H₈F₂O₃
• Molecular Weight: 202.15
• Mol File: 97914-53-9.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-DIFLUOROMETHOXY-BENZOIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 2-DIFLUOROMETHOXY-BENZOIC ACID METHYL ESTER(97914-53-9)
• EPA Substance Registry System: 2-DIFLUOROMETHOXY-BENZOIC ACID METHYL ESTER(97914-53-9)

Safety Data

• Hazardous Substances Data: 97914-53-9(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 97914-59-5 2-(difluoromethoxy)benzoic acid 

Downstream Products

• 1016690-71-3 C₁₀H₇F₂NO₂ 
• 1608129-74-3 5-amino-3-(2-difluoromethoxyphenyl)pyrazole-1-carboxylic acid tert-butyl ester 
• 1608129-59-4 3-piperidin-1-yl-pyrrolidine-1-carboxylic acid [5-(2-difluoromethoxyphenyl)-2H-pyrazol-3-yl]amide 
• 1608129-78-7 C₁₉H₂₁F₂N₃O₅ 
• 1040724-27-3 5-(2-difluoromethoxyphenyl)-2H-pyrazol-3-ylamine 
• 1040721-25-2 N-[5-(2-difluoromethoxyphenyl)-2H-pyrazol-3-yl]-4-pyrrolidin-1-yl-butyramide formate salt 
• 1040721-31-0 N-[5-(2-difluoromethoxyphenyl)-2H-pyrazol-3-yl]-4-piperidin-1-yl-butyramide formate salt 

Relevant articles and documents

SYNTHESIS OF DIFLUOROMETHYL ETHERS AND SULFIDES

The synthesis of difluoromethyl ethers and sulfides with a simple, non-ozone- depleting reagent is described. The difluoromethylation of phenols with this reagent occurs at room temperature within minutes with exceptional functional group tolerance. The mild conditions makes possible tandem processes for the conversion of aryl boronic acids, aryl halides and arenes to difluoromethyl ethers. Mechanistic studies support a reaction pathway involving nucleophilic attack of the phenolate to difluorocarbene.

NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS

The present invention provides compounds of formula (I) and compositions thereof, methods of making them, and methods of using them to modulate alpha7 nicotinic acetylcholine receptors and/or to treat any of a variety of disorders, diseases, and conditions. Provided compounds can affect, among other things, neurological, psychiatric and/or inflammatory system.