98026-79-0Relevant articles and documents
Conjugation-induced fluorescence labelling of mesoporous silica nanoparticles for the sensitive and selective detection of copper ions in aqueous solution
Cui, Jingjing,Wang, Shangfeng,Huang, Kai,Li, Yongsheng,Zhao, Wenru,Shi, Jianlin,Gu, Jinlou
, p. 6017 - 6024 (2014)
Although the development of sensors for the detection of Cu2+ ions has significant importance, sensitive and selective recognition systems are still limited. Herein, the non-fluorescent small molecule of 2-bromomaleimide (BM) was firstly converted to 2-aminomaleimide (NM) by a simple nucleophilic addition-elimination reaction with pre-grafted amino groups in the meso-space of mesoporous silica nanoparticles (MSNs), and then was designed as fluorescent on-off probes for Cu2+ ion recognition. The strong green fluorescence emitted from the pendent NM was induced by the interaction between the lone electron pairs of the N atoms in amino groups and the conjugated maleimide rings. The fluorescence of MSNs labelled NM (MSNs-NM) could be selectively quenched by Cu2+ ions in aqueous solution and consequently exhibited sensitive fluorescence on-off switching effects for Cu2+ ions. The detection limit was as low as 0.28 μM Cu2+, which was far below the U.S. EPA limit of 20 μM. This prefigured the potential applications of the current chemosensor for the detection of Cu2+ ions in aqueous solution and in living cells. The small-angle XRD, TEM, BET, FT-IR, UV-vis absorption measurements all agreed on the fact that the sensitive probes of BM had been successfully labelled at the pore surface of MSNs.
Sequential Photocatalytic Reactions for the Diastereoselective Synthesis of Cyclobutane Scaffolds
Deeprose, Mark J.,Lowe, Martin,Noble, Adam,Booker-Milburn, Kevin I.,Aggarwal, Varinder K.
supporting information, p. 137 - 141 (2021/12/17)
The synthesis of densely functionalized cyclobutanes containing all-carbon quaternary stereocenters in high regio- and diastereoselectivity remains synthetically challenging. Herein, we show that this can be achieved by using a sequential photocatalysis strategy, wherein 3-chloromaleimides undergo triplet sensitized [2 + 2] photocycloadditions with alkynes or alkenes followed by photoredox-catalyzed dechlorinative C-C bond forming reactions to install quaternary stereocenters. This allows the rapid assembly of structurally complex and sterically congested 3-azabicyclo[3.2.0]heptane scaffolds from readily available starting materials.
Compound based on cascade sulfydryl/bromo maleimide Michael addition and application thereof
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Paragraph 0067; 0071-0072, (2020/11/02)
The invention relates to a compound based on cascade sulfydryl/bromo maleimide Michael addition and application of the compound. The structural formula of the digitally encoded macromolecule is shownas a formula (I) which is described in the specification, and the digitally encoded macromolecule has a single molecular weight and an accurate sequence structure and is synthesized through an iterative sequence exponential growth strategy. The compound can be simply and quickly sequenced by utilizing tandem mass spectrometry, and can be widely applied to the fields of information storage and anti-counterfeiting.
N/O-LINKED DEGRONS AND DEGRONIMERS FOR PROTEIN DEGRADATION
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Page/Page column 283, (2019/01/10)
This invention provides Degronimers that have E3 Ubiquitin Ligase targeting moieties (Degrons) that can be linked to a targeting ligand for a protein that has been selected for in vivo degradation, and methods of use and compositions thereof as well as methods for their preparation. The invention also provides Degrons that can be used to treat disorders mediated by cereblon or an Ikaros family protein, and methods of use and compositions thereof as well as methods for their preparation.