981-15-7 Usage
Description
Ailanthone is a quassinoid compound found in Ailanthus with diverse biological activities. It exhibits potent antineoplastic properties and has demonstrated effectiveness against various cancer types, including hepatocellular carcinoma and prostate cancer.
Uses
Used in Pharmaceutical Industry:
Ailanthone is used as an antineoplastic agent for its potent activity against hepatocellular carcinoma (HCC) and prostate cancer. It inhibits Huh7 cancer cell growth through cell cycle arrest and apoptosis in vitro and in vivo, as well as reducing tumor volume in castration-resistant prostate cancer (CRPC) mouse xenograft models.
Used in Antimalarial Applications:
Ailanthone is used as an antimalarial agent, showing activity against the P. falciparum strains HB-3 and Dd-2 in vitro with IC50s of 0.003 and 0.037 μg/ml, respectively.
Used in Agricultural Industry:
Ailanthone is used as a phytotoxic agent, inhibiting radish seed germination by 88% when used at a concentration of 1 mM.
Used in Hormonal Regulation:
Ailanthone is used to inhibit dihydrotestosterone-induced androgen receptor transcriptional activity (IC50 = 69 nM in a reporter assay), as well as the growth and colony formation of androgen receptor-expressing cells LNCaP and 22RV1, but not androgen receptor-negative PC3 and DU145 cells, when used at a concentration of 0.1 μM.
Check Digit Verification of cas no
The CAS Registry Mumber 981-15-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 9,8 and 1 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 981-15:
(5*9)+(4*8)+(3*1)+(2*1)+(1*5)=87
87 % 10 = 7
So 981-15-7 is a valid CAS Registry Number.
InChI:InChI=1/C20H24O7/c1-8-4-12(21)16(24)18(3)10(8)5-13-19-7-26-20(25,17(18)19)15(23)9(2)11(19)6-14(22)27-13/h4,10-11,13,15-17,23-25H,2,5-7H2,1,3H3/t10-,11-,13+,15+,16+,17+,18+,19+,20-/m0/s1
981-15-7Relevant articles and documents
Structure Determination of Bitter Principles in Ailanthus altissima. Structure of Shinjulactone A and Revised Structure of Ailanthone
Naora, Hirokazu,Ishibashi, Masami,Furuno, Tetsuo,Tsuyuki, Takahiko,Murae, Tatsushi,et al.
, p. 3694 - 3698 (1983)
The structure of a new bitter principle, shinjulactone A, isolated from Ailanthus altissima SWINGLE was determined to be 11β,20-epoxy-1β,2α,11α,12α-tetrahydroxypicrasa-3,13(21)-dien-16-one and the configuration of a hydroxyl group at C-12 of ailanthone was revised to α-orientation by X-ray analysis.
