98187-13-4

Basic information

• Product Name: 4-Chloro-2-trifluoromethylbenzoyl chloride
• Synonyms: 4-Chloro-2-(trifluoromethyl)benzoyl chloride; 4-Chloro-alpha,alpha,alpha-trifluoro-o-toluoyl chloride; benzoyl chloride, 4-chloro-2-(trifluoromethyl)-; GVR DG BXFFF; GVR DG BXFFF [WLN]
• CAS NO: 98187-13-4
• Molecular Formula: C₈H₃Cl₂F₃O
• Molecular Weight: 243.01
• Product Categories: Fluorine series
• Mol File: 98187-13-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 231℃
• Flash Point: 94℃
• Appearance: /
• Density: 1.506
• Vapor Pressure: 0.0629mmHg at 25°C
• Refractive Index: 1.486
• CAS DataBase Reference: 4-Chloro-2-trifluoromethylbenzoyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloro-2-trifluoromethylbenzoyl chloride(98187-13-4)
• EPA Substance Registry System: 4-Chloro-2-trifluoromethylbenzoyl chloride(98187-13-4)

Safety Data

• Hazardous Substances Data: 98187-13-4(Hazardous Substances Data)

Usage

General Description

4-Chloro-2-trifluoromethylbenzoyl chloride is a colorless to pale yellow liquid chemical compound with the molecular formula C8H4ClF3O. It is a versatile building block used in the production of various pharmaceuticals and agrochemicals. 4-Chloro-2-trifluoromethylbenzoyl chloride is commonly utilized as a reagent in organic synthesis for the preparation of various compounds, including anti-inflammatory drugs and pesticides. It is also used as a key intermediate in the manufacturing of dyes, pigments, and perfumes. Additionally, 4-Chloro-2-trifluoromethylbenzoyl chloride is a highly reactive compound and should be handled with caution, as it can cause skin and eye irritation upon contact.

InChI:InChI=1/C8H3Cl2F3O/c9-4-1-2-5(7(10)14)6(3-4)8(11,12)13/h1-3H

Upstream product

• 142994-09-0 4-chloro-2-(trifluoromethyl)benzoic acid 
• 157229-44-2 o-trifluoromethyl-4-chloro-α,α-dichlorotoluene 
• 320-43-4 4-chloro-2-(trifluoromethyl)benzaldehyde 
• 615-60-1 4-chloro-1,2-dimethylbenzene 

Downstream Products

• 873846-14-1 4-chloro-N,N-diethyl-2-(trifluoromethyl)benzamide 
• 1254073-55-6 4-{[4-chloro-2-(trifluoromethyl)phenyl]carbonyl}-2-piperazinone 

Relevant articles and documents

Intermediate compound for preparing 4-chloro-2-trifluoromethyl-acetophenone as well as preparation method and application of intermediate compound

The invention relates to an intermediate compound for preparing 4-chloro-2-trifluoromethyl-acetophenone as well as a preparation method and application of the intermediate compound. The intermediate compound is 2-(4-chloro-2-(trifluoromethyl) benzoyl) malonate, 3, 4-dimethylchlorobenzene is taken as an initial raw material, and the intermediate compound is obtained by chlorination, fluorine-chlorine exchange reaction, hydrolysis, continuous chlorination and coupling with malonate. The intermediate compound 2-(4-chloro-2-(trifluoromethyl) benzoyl) malonate is subjected to hydrolysis decarboxylation to obtain 4-chloro-2-trifluoromethyl-acetophenone, the raw materials in the route are easy to obtain, dangerous reactions such as nitration and Grignard reaction are avoided, and the method is suitable for industrial production.

Pyrrolo(oxo)isoquinolines as 5HT ligands

The present application describes compounds according to Formula I, pharmaceutical compositions, comprising at least one compound according to Formula I and optionally at least one additional therapeutic agent and methods of treating various diseases, conditions and disorders associated with modulation of serotonin receptors such as, for example: metabolic diseases, which includes but is not limited to obesity, diabetes, diabetic complications, atherosclerosis, impared glucose tolerance and dyslipidemia; central nervous system diseases which includes but is not limited to, anxiety, depression, obsessive compulsive disorder, panic disorder, psychosis, schizophrenia, sleep disorder, sexual disorder and social phobias; cephalic pain; migraine; and gastrointestinal disorders using compounds according to Formula I or pharmaceutically acceptable salt forms thereof, wherein A, B, D, E, m, n, R3, R7, R8, R9, R10, R11 and X are described herein.