98203-08-8

Basic information

• Product Name: 8-BROMO-7-METHYLQUINOLINE
• Synonyms: 8-BROMO-7-METHYLQUINOLINE
• CAS NO: 98203-08-8
• Molecular Formula: C₁₀H₈BrN
• Molecular Weight: 222.09
• Mol File: 98203-08-8.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 8-BROMO-7-METHYLQUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 8-BROMO-7-METHYLQUINOLINE(98203-08-8)
• EPA Substance Registry System: 8-BROMO-7-METHYLQUINOLINE(98203-08-8)

Safety Data

• Hazardous Substances Data: 98203-08-8(Hazardous Substances Data)

Usage

Description

8-Bromo-7-methylquinoline, a derivative of quinoline with the molecular formula C10H8BrN, is a heterocyclic aromatic compound known for its unique chemical properties. It is characterized by the presence of a bromine atom at the 8th position and a methyl group at the 7th position, which contribute to its diverse applications across various industries.

Uses

Used in Pharmaceutical Industry:
8-Bromo-7-methylquinoline serves as a crucial building block for the synthesis of a wide range of pharmaceuticals and agrochemicals. Its unique structure allows for the development of new drugs with potential therapeutic benefits.
Used in Antimicrobial and Antifungal Applications:
Due to its antimicrobial and antifungal properties, 8-bromo-7-methylquinoline is a promising candidate for the development of new drugs to combat various infections and fungal diseases.
Used in Crop Protection Products:
The antimicrobial and antifungal properties of 8-bromo-7-methylquinoline also make it a valuable component in the development of crop protection products, helping to protect plants from diseases and pests.
Used in Scientific Research:
8-Bromo-7-methylquinoline is utilized as a fluorescent probe for the detection and analysis of nucleic acids and other biomolecules. Its fluorescent properties enable researchers to study the structure, function, and interactions of these biomolecules in various scientific applications.

Upstream product

• 54879-20-8 2-bromo-3-methylaniline 
• 56-81-5 glycerol 
• 612-60-2 7-methylquinoline 
• 5470-82-6 7-methyl-8-amino quinoline 
• 7471-63-8 8-nitro-7-methylquinoline 
• 7745-91-7 3-bromo-4-methylaniline 

Downstream Products

• 1315322-77-0 7-methyl-8-phenylquinoline 
• 612-60-2 7-methylquinoline 

Relevant articles and documents

COMPOUNDS AND METHODS FOR TREATING CANCER

Compounds useful as modulators of AhR, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds to treat, prevent or ameliorate AhR-mediated disorders such as cancers and inflammatory diseases are provided.

Axially Chiral Bifunctional 8,8′-Biquinolyl: Synthesis of 7,7′-Dihydroxymethyl-8,8′-biquinolyl via Pd-Catalyzed Double C-H Oxidation of 7,7′-Dimethyl-8,8′-biquinolyl

Bifunctional C2-symmetric 7,7′-dihydroxymethyl-8,8′-biquinolyl (2) was synthesized in short steps via (i) Cu/Pd-catalyzed homo coupling of 7-methyl-8-bromoquinoline and (ii) Pd(II)-catalyzed double C-H oxidation. Axial chirality of 2 and its synthetic precursor 7,7′-dimethyl-8,8′-biquinolyl (3) is stable. Optically active 2 was obtained through separation of racemic 2 by chiral column HPLC or Pd(II)-catalyzed double C-H oxidation of optically active 3. The absolute stereochemistry of enantiomers of 2 and 3 was determined using the exciton chirality method.

BROMINATION OF QUINOLINE DERIVATIVES WITH N-BROMOSUCCINIMIDE. ISOMERIC COMPOSITION OF THE BROMINATION PRODUCTS BY PMR AND GLC

The bromination of quinoline and substituted quinolines with N-bromosuccinimide in concentrated H2SO4 takes place exclusively in the homocyclic part.Bromo-substituted quinolines can be obtained by this method.The bromination products were identified by PMR spectroscopy.The differences among the mono-, di-, and trisubstituted (in the benzene ring) compounds were established on the basis of the type of spectrum of the protons of the homocyclic part of the molecule.The compositions of the reaction mixtures were studied by GLC.