983-28-8

Basic information

• Product Name: (3beta,17E)-17-(2-carbamoylhydrazinylidene)androst-5-en-3-yl acetate
• CAS NO: 983-28-8
• Molecular Formula: C₂₂H₃₃N₃O₃
• Molecular Weight: 387.5157
• Mol File: 983-28-8.mol
• Article Data: 2

Chemical Properties

• Density: 1.346g/cm³
• Refractive Index: 1.653
• CAS DataBase Reference: (3beta,17E)-17-(2-carbamoylhydrazinylidene)androst-5-en-3-yl acetate(CAS DataBase Reference)
• NIST Chemistry Reference: (3beta,17E)-17-(2-carbamoylhydrazinylidene)androst-5-en-3-yl acetate(983-28-8)
• EPA Substance Registry System: (3beta,17E)-17-(2-carbamoylhydrazinylidene)androst-5-en-3-yl acetate(983-28-8)

Safety Data

• Hazardous Substances Data: 983-28-8(Hazardous Substances Data)

Usage

Description

(3beta,17E)-17-(2-carbamoylhydrazinylidene)androst-5-en-3-yl acetate is a complex steroidal compound with a unique molecular structure. It features a steroid backbone with a hydrazine group attached to the 17th carbon atom and an acetate group attached to the 3rd carbon atom. (3beta,17E)-17-(2-carbamoylhydrazinylidene)androst-5-en-3-yl acetate is a derivative of androst-5-en-3-ol, a key molecule in the biosynthesis of androgens and estrogens. The presence of the hydrazine group suggests its potential as an intermediate for the synthesis of various pharmaceuticals or research chemicals. Its specific arrangement of atoms and functional groups makes it a promising candidate for the development of new drugs or for studying steroid biology.

Uses

Used in Pharmaceutical Synthesis:
(3beta,17E)-17-(2-carbamoylhydrazinylidene)androst-5-en-3-yl acetate is used as an intermediate in the synthesis of pharmaceuticals for its potential role in creating new drugs or enhancing existing ones. Its unique molecular structure allows for the development of compounds with specific therapeutic properties.
Used in Research Chemicals:
In the field of research, (3beta,17E)-17-(2-carbamoylhydrazinylidene)androst-5-en-3-yl acetate is used as a research chemical to study the effects and interactions of steroidal compounds. Its hydrazine group and steroid backbone provide a foundation for investigating the biological activity and potential applications of related compounds.
Used in Steroid Biology Studies:
(3beta,17E)-17-(2-carbamoylhydrazinylidene)androst-5-en-3-yl acetate is utilized in the study of steroid biology to understand the role of androst-5-en-3-ol and its derivatives in hormone production and regulation. This knowledge can contribute to the development of treatments for hormonal imbalances and related conditions.
Used in Drug Development:
In the pharmaceutical industry, (3beta,17E)-17-(2-carbamoylhydrazinylidene)androst-5-en-3-yl acetate is used as a starting material for drug development. Its unique properties and potential as a precursor for various compounds make it valuable in creating novel therapeutic agents.
Used in Hormone Regulation Research:
(3beta,17E)-17-(2-carbamoylhydrazinylidene)androst-5-en-3-yl acetate is employed in research aimed at understanding hormone regulation and the role of androgens and estrogens in the body. This research can lead to the development of treatments for conditions related to hormonal imbalances, such as polycystic ovary syndrome (PCOS) and certain types of cancer.

Upstream product

• 853-23-6 prasterone acetate 
• 563-41-7 semicarbazide hydrochloride 
• 114134-51-9 3β-hydroxy-16.17-seco-androstene-(5)-dioic acid-(16.17)-17-methyl ester 
• 2099-39-0 3β-hydroxy-17.17a-seco-D-homo-androstene-(5)-dioic acid-(17.17a) 
• 33534-57-5 3β-hydroxy-16,17-seco-androst-5-ene-16,17-dioic acid dimethyl ester 
• 514-50-1 3β-acetoxy-5α,6β-dibromocholestane 
• 53-43-0 dehydroepiandrosterone 
• 1778-02-5 Pregnenolone acetate 
• 604-35-3 Cholesteryl acetate 
• 72654-92-3 3β-hydroxy-10.13-dimethyl-17-isopropylidene-gonene-(5) 
• 60446-55-1 3β-acetoxy-20-methyl-pregnadiene-(5,17(20)) 
• 20976-92-5 3β,20-dihydroxy-20-methylpregn-5-ene 

Downstream Products

• 1224-93-7 5α-androstan-3β-ol 
• 1224-92-6 5beta-Androstan-3alpha-ol 
• 1476-64-8 androst-5-en-3β-ol 
• 5062-43-1 4,4-Dimethylandrost-5-en-3-on 
• 7673-19-0 4,4-Dimethyl-3β-hydroxy-5α-androstan 
• 898-96-4 4.4-Dimethyl-5α-androstanon-(3) 
• 7673-17-8 4,4-Dimethyl-androst-5-en-3β-ol 

Relevant articles and documents

Synthesis and biological evaluation of D-ring fused 1,2,3-thiadiazole dehydroepiandrosterone derivatives as antitumor agents

A series of D-ring fused 1,2,3-thiadiazole DHEA derivatives were synthesized and investigated for their activity against the growth of various tumor cell lines using the sulforhodamine B (SRB) assay. It is amazing that for these compounds, T47D cell line was much more sensitive than other tumor cell lines. The most potent saturated N-heterocyclic derivatives showed similar antitumor effect with the positive control compound ADM (adriamycin) on T47D cells, that was 44–60 folds more potent than the lead compound DHEA. Most compounds with potent antitumor activity displayed low toxicity on normal human fibroblasts (HAF). Especially compound 25 (CH33) showed an IC50 of 0.058 μM on T47D cells and its selectivity index (SI) between HAF and T47D was 364, which was 214 folds better than ADM (SI = 1.7). The apoptosis, colony formation and transwell migration assays of 25 were performed on T47D cell line. The primary mechanism study showed that 25 caused a dose-dependent induction of apoptosis, and induced phosphorylation of EphA2 and EphB3 in T47D cells. The in vivo antitumor effect of 25 was also observed in T47D tumor-bearing mice without obvious toxicity.