98474-78-3

Basic information

• Product Name: Pseudoginsenoside RT5
• Synonyms: Pseudoginsenoside RT5;(3beta,6alpha,12beta,24R)-20,24-Epoxy-3,12,25-trihydroxydammaran-6-yl beta-D-glucopyranoside;24(R)-Pseudoginsenoside rt(5);b-D-Glucopyranoside, (3b,6a,12b,24R)-20,24-epoxy-3,12,25-trihydroxydammaran-6-yl (9CI)
• CAS NO: 98474-78-3
• Molecular Formula: C₃₆H₆₂O₁₀
• Molecular Weight: 654.876
• Product Categories: Ginsenoside series;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract
• Mol File: 98474-78-3.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 759.532 °C at 760 mmHg
• Flash Point: 413.15 °C
• Appearance: /
• Density: 1.27
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.588
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Pseudoginsenoside RT5(CAS DataBase Reference)
• NIST Chemistry Reference: Pseudoginsenoside RT5(98474-78-3)
• EPA Substance Registry System: Pseudoginsenoside RT5(98474-78-3)

Safety Data

• Hazardous Substances Data: 98474-78-3(Hazardous Substances Data)

Usage

Description

Pseudoginsenoside RT5, a novel active ginsenoside derived from Ginseng, is known for its protective effects against cisplatin-induced nephrotoxicity in vivo. It is a metabolite of pseudoginsenoside F11 and has gained attention for its potential therapeutic applications.

Uses

Used in Pharmaceutical Industry:
Pseudoginsenoside RT5 is used as a nephroprotective agent for mitigating the harmful effects of cisplatin, a widely used chemotherapeutic drug. Its protective properties help reduce the incidence of nephrotoxicity, a common side effect associated with cisplatin treatment, thereby improving patient outcomes and quality of life.
Additionally, Pseudoginsenoside RT5 can be used as a research compound for further exploration of its potential benefits and applications in various therapeutic areas. Its unique properties and origin from Ginseng, a well-known medicinal plant, make it a promising candidate for the development of novel pharmaceutical agents and treatments.

InChI:InChI=1/C36H62O10/c1-31(2)23(39)10-12-33(5)22-15-19(38)25-18(36(8)14-11-24(46-36)32(3,4)43)9-13-34(25,6)35(22,7)16-20(29(31)33)44-30-28(42)27(41)26(40)21(17-37)45-30/h18-30,37-43H,9-17H2,1-8H3/t18-,19+,20-,21+,22+,23-,24+,25-,26+,27-,28+,29-,30+,33+,34+,35+,36-/m0/s1

Upstream product

• 80952-71-2 ginsenoside Rh₁ 

Downstream Products

• 50-99-7 D-glucose 

Relevant articles and documents

Synthesis of Ocotillol-Type Ginsenosides

A total of 14 ocotillol-type ginsenosides were conveniently synthesized employing glycosylation of ocotillol sapogenin derivatives with glucosyl ortho-alkynylbenzoate donors under the promotion of a gold(I) catalyst as the key step. Relying on a rational protecting group strategy and the unexpected regioselectivity of the glycosylation of the 3,25-diol sapogenins (2a/2b, 5a/5b) for the tertiary 25-OH, mono 3-O-glucosyl ocotillol-PPD, 6-O-glucosyl ocotillol-PPT, 25-O-glucosyl ocotillol-PPD/PPT and 3,25-di-O-glucosyl ocotillol-PPD/PPT ginsenosides were prepared in which the configuration at the C-24 is either R or S.