98547-26-3Relevant articles and documents
The conversion of aryl and heteroaryl methylketones to the corresponding secondary or tertiary amides
Ding, Jiaoyang,Cao, Liping,Wang, Jungang,Xue, Weijian,Zhu, Yanping,Wu, Anxin
experimental part, p. 298 - 301 (2011/10/02)
Secondary or tertiary amides have been prepared directly from aryl, heteroaryl methyl ketones using an iodineamine-NaOH system which afforded the expected products in good yields in an aqueous medium. The present method has the advantages of using inexpensive reagents, mild reaction condition and ease of manipulation.
IMPROVED METHOD FOR THE PRODUCTION OF N-SUBSTITUTED AMIDES FROM NITRILES
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Page/Page column 9, (2010/02/06)
An improved method for the production of N-substituted amides of formula RCONHR1 (I) wherein R represents an optionally monosubstituted or polysubstituted C1-C20-alkyl-, C5 -C20-aryl- or C5-C20--heterocyclic radical and R1 represents an optionally monosubstituted or polysubstituted C1-C20-alkyl- or C5-C20-aryl radical from corresponding nitriles of formula RCN (II) wherein R1 is defined as above, wherein a nitril of formula (II) is reacted in polyphosphoric acid with an alcohol of formula R10H (III) wherein R1 is as defined above, in the presence of a compound from the group consisting of phosphorpentoxide, phosphoroxychloride, sulfurylchloride, dialkylcarbonate and dialkylsulfate at a temperature of 80 -190 °C to form the corresponding N-substituted amide.
