98674-81-8

Basic information

• Product Name: (S)-(+)-5,5-DIMETHYL-2-HYDROXY 4-PHENYL-1,3,2-DIOXAPHOS-PHORINANE-2-OXIDE
• Synonyms: (S)-(+)-5,5-DIMETHYL-2-HYDROXY 4-PHENYL-1,3,2-DIOXAPHOS-PHORINANE-2-OXIDE;(S)-(+)-2-HYDROXY-5 5-DIMETHYL-4-PHENYL&;(S)-(+)-2-Hydroxy-5,5-dimethyl-4-phenyl-1,3,2-dioxaphosphorinane 2-oxide;1,3,2-Dioxaphosphorinane,2-hydroxy-5,5-diMethyl-4-phenyl-, 2-oxide,(4S)
• CAS NO: 98674-81-8
• Molecular Formula: C₁₁H₁₅O₄P
• Molecular Weight: 242.21
• Mol File: 98674-81-8.mol
• Article Data: 2

Chemical Properties

• Melting Point: 223-227 °C(lit.)
• Boiling Point: 344.4°Cat760mmHg
• Flash Point: 162.1°C
• Appearance: /
• Density: 1.27g/cm³
• Vapor Pressure: 2.51E-05mmHg at 25°C
• Refractive Index: 1.538
• CAS DataBase Reference: (S)-(+)-5,5-DIMETHYL-2-HYDROXY 4-PHENYL-1,3,2-DIOXAPHOS-PHORINANE-2-OXIDE(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-(+)-5,5-DIMETHYL-2-HYDROXY 4-PHENYL-1,3,2-DIOXAPHOS-PHORINANE-2-OXIDE(98674-81-8)
• EPA Substance Registry System: (S)-(+)-5,5-DIMETHYL-2-HYDROXY 4-PHENYL-1,3,2-DIOXAPHOS-PHORINANE-2-OXIDE(98674-81-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• Hazardous Substances Data: 98674-81-8(Hazardous Substances Data)

Usage

General Description

(S)-(+)-5,5-DIMETHYL-2-HYDROXY 4-PHENYL-1,3,2-DIOXAPHOSPHORINANE-2-OXIDE is a chiral organophosphorus compound. It is known for its use as a chiral auxillary in asymmetric synthesis, particularly in the preparation of chiral drugs and pharmaceuticals. The compound has a unique molecular structure, containing a dioxaphosphorinane ring with a hydroxy and a phenyl group attached, as well as two methyl groups. It is a white crystalline solid at room temperature and is typically handled and stored under inert gas conditions to prevent oxidation and degradation. As a chiral reagent, it is widely used in the pharmaceutical and chemical industries for the production of enantiomerically pure compounds.

InChI:InChI=1/C11H15O4P/c1-11(2)8-14-16(12,13)15-10(11)9-6-4-3-5-7-9/h3-7,10H,8H2,1-2H3,(H,12,13)/t10-/m0/s1

Upstream product

• 98634-22-1 5,5-dimethyl-2-hydroxy-4-phenyl-1,3,2-dioxaphosphorinane 2-oxide 
• 33950-46-8 1-phenyl-2,2-dimethyl-1,3-propanediol 
• 100-52-7 benzaldehyde 
• 98675-02-6 2-chloro-5,5-dimethyl-4-phenyl-1,3,2-dioxaphosphorinane 2-oxide 
• 133271-06-4 (S)-(+)-3-phenyl-3-hydroxy-2,2-dimethylpropanal 
• 98674-79-4 (S)-(+)-1-phenyl-2,2-dimethyl-1,3-propanediol 

Downstream Products

• 884325-50-2 5,5-Dimethyl-2-oxo-4-phenyl-2λ⁵-[1,3,2]dioxaphosphinan-2-ol; compound with (1R,2S)-2-methylamino-1-phenyl-propan-1-ol 
• 1016234-82-4 (-)-(cis)-7-bromo-8-fluoro-1,3,4,14b-tetrahydro-2H-dibenzo[b,f]pyrido[1,2-d][1,4]oxazepin-1-amine (4S)-2-hydroxy-5,5-dimethyl-4-phenyl-1,3,2-dioxaphosphorinane 2-oxide (1:1) 
• 1016235-10-1 (-)-(cis)-7-bromo-8,12-difluoro-1,3,4,14b-tetrahydro-2H-dibenzo[b,f]pyrido[1,2-d][1,4]oxazepine-1-amine (4S)-2-hydroxy-5,5-dimethyl-4-phenyl-1,3,2-dioxaphosphorinane 2-oxide (1 : 1) 
• 1426540-40-0 (R)-3-(4,4-dimethylpyrrolidin-2-yl)pyridine (+)-phencyphos salt 
• 1431332-56-7 C₁₃H₁₇NO₂*C₁₁H₁₅O₄P 
• 1431332-58-9 C₁₃H₁₇NO₂*C₁₁H₁₅O₄P 
• 1431332-60-3 C₁₂H₁₆ClN*C₁₁H₁₅O₄P 
• 1431332-62-5 C₁₂H₁₆ClN*C₁₁H₁₅O₄P 
• 1431332-64-7 C₁₂H₁₆ClN*C₁₁H₁₅O₄P 
• 1431332-66-9 C₁₂H₁₅Cl₂N*C₁₁H₁₅O₄P 
• 1431332-68-1 C₁₂H₁₅Cl₂N*C₁₁H₁₅O₄P 
• 1431332-70-5 C₁₂H₁₅Cl₂N*C₁₁H₁₅O₄P 

Relevant articles and documents

A method for preparing chiral ring phosphoric acid (by machine translation)

The invention discloses a method for preparing chiral ring of phosphoric acid, the method comprises the following steps: a Isobutyraldehyde, aromatic aldehyde under the condition of chiral catalyst to catalyze the reaction generating chiral 3-aryl-3-hydroxy -2,2-dimethyl-propionaldehyde; chiral b 3-aryl-3-hydroxy -2,2-dimethyl propionic aldehyde reduction to obtain chiral 1-aryl -2,2-dimethyl -1,3-propylene glycol; c in methylene chloride under the conditions of reaction with phosphorus oxychloride to obtain chiral 4-aryl-2-chloro -5,5-dimethyl-2-oxo -1, 3, 2-dioxo-phosphorus heterocycle hexane chloride; in d hydrolysis under alkaline conditions, dyeworks generating chiral ring phosphoric acid. The high optical purity of the target product, the operation is simple, low cost, high yield, less pollution, belonging to the field of organic synthesis. (by machine translation)