98753-19-6 Usage
Description
Cefpirome sulfate is a fourth-generation cephalosporin antibiotic, characterized as a white crystalline powder. It is a new injectable cephalosporin indicated for the treatment of severe urinary and respiratory tract infections, including septicemia and nosocomial infections. Cefpirome sulfate is recognized as the first true fourth-generation cephalosporin due to its similar activities to third-generation antibiotics against Gram-positive bacteria and to first-generation antibiotics against Gram-negative bacteria. Its efficacy against P.aeruginosa is comparable to ceftazidime, and it exhibits a broad spectrum of activity against various bacteria, including Klebsiella, methicillin-sensitive staphylococci, penicillin-resistant pneumococci, E.coli which generates extended-spectrum beta-lactamases, and multi-resistant organisms such as Citrobacter, Enterobacter, and Serratia.
Uses
Used in Pharmaceutical Industry:
Cefpirome sulfate is used as an antibiotic for the treatment of severe urinary and respiratory tract infections, septicemia, and nosocomial infections. Its broad-spectrum activity and effectiveness against both Gram-positive and Gram-negative bacteria make it a valuable asset in combating multi-resistant organisms and providing effective treatment options for patients.
Used in Hospital Settings:
Cefpirome sulfate is used as an injectable antibiotic in hospital settings to treat patients with severe infections, particularly those that are resistant to other antibiotics. Its ability to target a wide range of bacteria, including multi-resistant strains, makes it an essential tool in the management of serious infections and the prevention of the spread of antibiotic resistance.
Used in Research and Development:
Cefpirome sulfate is also used in research and development for the study of antibiotic resistance, the development of new antibiotics, and the investigation of novel drug delivery systems to improve the efficacy and safety of antibiotic treatments. Its unique properties as a fourth-generation cephalosporin make it an important subject for scientific inquiry and potential innovation in the field of infectious disease management.
Check Digit Verification of cas no
The CAS Registry Mumber 98753-19-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,8,7,5 and 3 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 98753-19:
(7*9)+(6*8)+(5*7)+(4*5)+(3*3)+(2*1)+(1*9)=186
186 % 10 = 6
So 98753-19-6 is a valid CAS Registry Number.
InChI:InChI=1/C22H22N6O5S2.H2O4S/c1-33-26-15(13-10-35-22(23)24-13)18(29)25-16-19(30)28-17(21(31)32)12(9-34-20(16)28)8-27-7-3-5-11-4-2-6-14(11)27;1-5(2,3)4/h3,5,7,10,16,20H,2,4,6,8-9H2,1H3,(H3-,23,24,25,29,31,32);(H2,1,2,3,4)/b26-15-;/t16-,20-;/m1./s1
98753-19-6Relevant articles and documents
Synthesis method of cefpirome sulfate
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Paragraph 0022-0031, (2021/11/10)
The invention discloses a synthesis method of cefpirome sulfate, and relates to the technical field of biological medicine synthesis. 7-ACA with protected amino and carboxyl is obtained through the action of 7-ACA with hexamethyldisilazane and trimethyliodosilane, then 7-ACA with protected amino and carboxyl reacts with trimethyliodosilane and 2,3-cyclopentenopyridine, a 7-ACP intermediate is synthesized through a one-pot method, the 7-ACP intermediate product reacts with AE active ester, the cefpirome sulfate is obtained through acylation and salt forming reaction, then dissolution, crystallization and crystal growing are conducted, and finally the cefpirome sulfate crystal is obtained. By means of the arrangement, the cefpirome sulfate crystal can be prepared through the scheme, and the cefpirome sulfate crystal is good in crystallization performance, high in purity and free of mixed color; and the microwave method is adopted in the process of synthesizing the 7-ACP intermediate product by the one-pot method and the acylation reaction process, the organic synthesis reaction rate can be greatly accelerated by using microwaves, the yield and the purity of the product are improved, many tedious steps are saved, and the reaction time is greatly shortened.
Method using microwave method to synthesize cefpirome sulfate
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Paragraph 0027; 0040; 0041; 0042; 0043; 0044; 0045, (2017/01/02)
The invention discloses a method using a microwave method to synthesize cefpirome sulfate. The method is characterized by including the steps of firstly, weighing 7-aminocephalosporanic acid and AE-active ester, mixing, evenly grinding, and adding 2, 3-cyclopentenopyridine and concentrated sulfuric acid; secondly, performing 300W microwave reaction for 1-2 minutes, performing 450W microwave reaction for 1-2 minutes, and performing 750W microwave reaction for 2-3 minutes; thirdly, adding reaction residues into deionized water after the reactions, well mixing through stirring, filtering to obtain filtrate, and removing solvent to obtain white solid, namely the cefpirome sulfate. The method has the advantages that the microwave method is used, synthesizing is performed through a one-pot method, the method is simple in synthesizing step, and the high-purity cefpirome sulfate can be obtain at high yield without reaction solvents and expensive catalysts.
CRYSTALLINE SULFATE SALT OF CEPHALOSPORIN ANTIBIOTIC
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Page/Page column 6, (2008/12/05)
The present invention relates to novel crystalline form of cephalosporin sulfate of the following formula and provides a process for preparing the same.
