98760-43-1

Basic information

• Product Name: T-2 Toxin Glucuronide
• Synonyms: T-2 Toxin Glucuronide;PGCYSYUZXXMCEY-FIZZWQSPSA-N
• CAS NO: 98760-43-1
• Molecular Formula: C30H42O15
• Molecular Weight: 642.64548
• Mol File: 98760-43-1.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: T-2 Toxin Glucuronide(CAS DataBase Reference)
• NIST Chemistry Reference: T-2 Toxin Glucuronide(98760-43-1)
• EPA Substance Registry System: T-2 Toxin Glucuronide(98760-43-1)

Safety Data

• Hazardous Substances Data: 98760-43-1(Hazardous Substances Data)

Usage

Description

T-2 Toxin Glucuronide is a metabolite of T-2 Toxin, a tricothecene mycotoxin produced by fungi of the genus Fusarium. It is known for its ability to induce DNA damage and cell death upon prolonged administration.

Uses

Used in Pharmaceutical Industry:
T-2 Toxin Glucuronide is used as a research compound for studying the effects of T-2 Toxin on DNA damage and cell death. Its role in understanding the mechanisms of action of tricothecene mycotoxins can contribute to the development of potential therapeutic agents or countermeasures against their toxic effects.
Used in Toxicological Research:
T-2 Toxin Glucuronide is utilized as a biomarker in toxicological studies, helping to assess the exposure to T-2 Toxin and monitor its metabolic pathways. This information is crucial for evaluating the risks associated with T-2 Toxin and developing strategies to mitigate its harmful effects on human and animal health.

Upstream product

• 21259-20-1 T-2 toxin 
• 1245697-26-0 UDP-glucuronic acid 

Relevant articles and documents

HT-2 toxin 4-glucuronide as new T-2 toxin metabolite: Enzymatic synthesis, analysis, and species specific formation of T-2 and HT-2 toxin glucuronides by rat, mouse, pig, and human liver microsomes

Glucuronides of the mycotoxin T-2 toxin and its phase I metabolite HT-2 toxin are important phase II metabolites under in vivo and in vitro conditions. Since standard substances are essential for the direct quantitation of these glucuronides, a method for the enzymatic synthesis of T-2 and HT-2 toxin glucuronides employing liver microsomes was optimized. Structure elucidation by nuclear magnetic resonance spectroscopy (NMR) and mass spectrometry revealed that besides T-2 toxin glucuronide and HT-2 toxin 3-glucuronide also the newly identified isomer HT-2 toxin 4-glucuronide was formed. Glucuronidation of T-2 and HT-2 toxin in liver microsomes of rat, mouse, pig, and human was compared and metabolites were analyzed directly by liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS). A distinct, species specific pattern of glucuronidation of T-2 and HT-2 toxin was observed with interesting interindividual differences. Until recently, glucuronides have frequently been analyzed indirectly by quantitation of the aglycone after enzymatic cleavage of the glucuronides by β-glucuronidase. Therefore, the hydrolysis efficiencies of T-2 and HT-2 toxin glucuronides using β-glucuronidases from Helix pomatia, bovine liver, and Escherichia coli were compared.