98815-43-1

Basic information

• Product Name: 1-[(4-hydroxy)phenyl]-2-methyl-2-propanol
• Synonyms: 1-[(4-hydroxy)phenyl]-2-methyl-2-propanol
• CAS NO: 98815-43-1
• Molecular Weight: 166.22
• Mol File: 98815-43-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-[(4-hydroxy)phenyl]-2-methyl-2-propanol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[(4-hydroxy)phenyl]-2-methyl-2-propanol(98815-43-1)
• EPA Substance Registry System: 1-[(4-hydroxy)phenyl]-2-methyl-2-propanol(98815-43-1)

Safety Data

• Hazardous Substances Data: 98815-43-1(Hazardous Substances Data)

Upstream product

• 917-64-6 methyl magnesium iodide 
• 6305-04-0 p-hydroxyphenacyl chloride 
• 2491-38-5 2-bromo-1-(4'-hydroxyphenyl)-1-ethanone 
• 75-16-1 methylmagnesium bromide 

Relevant articles and documents

Simple deprotection of acetal type protecting groups under neutral conditions

Heating acetals with ethylene glycol causes the deprotection of acetal type protecting groups. When acetals such as MOM ethers, MEM ethers, and THP ethers were heated in ethylene glycol or propylene glycol, solvolysis proceeded smoothly to produce alcohols in excellent yield. This reaction is a very promising method for chemoselective deprotection of acetal type protecting groups.

Reactions of 4-Substituted-2'-Halogenoacetophenones with Grignard Reagents

The initial reaction of 4-substituted 2'-halogenoacetophenones with an excess of methyl Grignard reagent is shown to be an attack at the 1'-carbonyl to form a halohydrin salt.The various reactions which then follow are substituent dependent.In the 4-hydroxy case the only product is 1-(4-hydroxyphenyl)-2-methylpropan-2-ol (13) which arises via a -aryl shift with simultaneous elimination of magnesium halide.When the substituent is 4-methoxy, a second pathway becomes important involving epoxide formation and a subsequent -hydride migration to the benzylic position, or attack of the Grignard reagent at the benzylic carbon of the epoxide.When the substituent is 4-bromo, the reaction proceeds exclusively via the epoxide and, following a -hydride shift, leads to the isomeric butanols (33) and (34).The reasons underlying such diversity of reactivity are discussed.