99010-64-7 Usage
Description
4-Chloro-1-(2-methylpropyl)-1H-imidazo[4,5-c]quinoline, also known as Desamino Chloroimiquimod (Imiquimod USP Related Compound C), is a pharmacologically active compound related to Imiquimod (I475000), an immune response modifier. It is characterized by the presence of a chlorine atom at the 4-position and a 2-methylpropyl group at the 1-position, attached to an imidazo[4,5-c]quinoline core structure.
Uses
Used in Pharmaceutical Industry:
4-Chloro-1-(2-methylpropyl)-1H-imidazo[4,5-c]quinoline is used as an immune response modifier for stimulating the production of Interferon-a. This makes it a potential candidate for the development of therapeutic agents targeting various diseases and conditions, particularly those involving the immune system.
Used in Immunotherapy:
4-Chloro-1-(2-methylpropyl)-1H-imidazo[4,5-c]quinoline is used as an immunotherapeutic agent for enhancing the body's immune response against infections, tumors, and other pathological conditions. Its ability to stimulate Interferon-a production can contribute to the modulation of immune responses and the promotion of overall health.
Used in Research and Development:
4-Chloro-1-(2-methylpropyl)-1H-imidazo[4,5-c]quinoline is used as a research compound for studying the mechanisms of immune response modulation and the development of novel therapeutic agents. Its structural and functional properties make it a valuable tool for understanding the complex interactions between immune cells and their environment.
Check Digit Verification of cas no
The CAS Registry Mumber 99010-64-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,9,0,1 and 0 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 99010-64:
(7*9)+(6*9)+(5*0)+(4*1)+(3*0)+(2*6)+(1*4)=137
137 % 10 = 7
So 99010-64-7 is a valid CAS Registry Number.
InChI:InChI=1/C10H7N3/c1-2-4-8-7(3-1)10-9(5-11-8)12-6-13-10/h1-6H,(H,12,13)
99010-64-7Relevant articles and documents
Synthesis and structure - Activity-relationships of 1H-imidazo[4,5-c] quinolines that induce interferon production
Gerster, John F.,Lindstrom, Kyle J.,Miller, Richard L.,Tomai, Mark A.,Birmachu, Woubalem,Bomersine, Shannon N.,Gibson, Shiela J.,Imbertson, Linda M.,Jacobson, Joel R.,Knafla, Roy T.,Maye, Peter V.,Nikolaides, Nickolas,Oneyemi, Folakemi Y.,Parkhurst, Gwen J.,Pecore, Sharon E.,Reiter, Michael J.,Scribner, Lisa S.,Testerman, Tracy L.,Thompson, Natalie J.,Wagner, Tammy L.,Weeks, Charles E.,Andre, Jean-Denis,Lagain, Daniel,Bastard, Yvon,Lupu, Michel
, p. 3481 - 3491 (2007/10/03)
1H-Imidazo-[4,5-c]quinolines were prepared while investigating novel nucleoside analogues as potential antiviral agents. While these compounds showed no direct antiviral activity when tested in a number of cell culture systems, some demonstrated potent inhibition of virus lesion development in an intravaginal guinea pig herpes simplex virus-2 assay. We have determined that the in vivo antiviral activity can be attributed to the ability of these molecules to induce the production of cytokines, especially interferon (IFN), in this model. Subsequently, we found that the compounds also induce in vitro production of IFN in human peripheral blood mononuclear cells (hPBMCs). The in vitro results reported herein and the in vivo results reported previously led to the discovery of imiquimod, 26, which was developed as a topical agent and has been approved for the treatment of genital warts, actinic keratosis, and superficial basal cell carcinoma.