99129-21-2 Usage
Physical and chemical properties
The original medicine is amber transparent liquid with relative density 1.14 (20 ℃) and vapor pressure <1 × 10-2mPa (20 ℃). It is soluble in most organic solvents, stable under ultraviolet light, but unstable at extreme pH.
Toxicity
The acute oral toxicity of original medicine LD50 in rats was 1360 mg / kg (female) , 1630 mg / kg (male). The acute dermal toxicity LD(50) in rabbits was more than 5g/kg. The acute inhalation LC50 in rats (4 hours) is more than 4.6mg/L . No effect dose during Feeding test: rat 16mg / kg ? d, mice 30mg / kg ? d. ADI by humans is 0.01 mg / kg. The acute oral toxicity LD50 in quails is more than 2g / kg. The acute inhalation LC50 (8 days) in wild ducks and quails is more than 6g / kg. The LC50 in daphnias is > 120mg / L. The LD50 in insects is 454 mg / kg. The LC50 in blue gill fish (96 hours)is > 120mg / L, The LC50 in rainbow trout is 5056mg / L. The LD50 in bees is > 100μg per bee.
Mode of action
It is a selective, systemic post-emergence herbicide which can be rapidly absorbed by plant leaves and conducted to roots and growing points to inhibit the biosynthesis of plant branched-chain fatty acids. The target weeds then grow slowly and lose competitiveness with seedling tissue early yellowing and followed by the remaining leaves wilting. Finally they will die.
Target plants
Suitable for broad-leaf plants. All tested plants of non-grass family were highly resistant to RE-45601 throughout the entire growth and development period, even applied with 2 kg ai / hm2 (8-20 times higher than herbicides) plus vegetable oil 2.341 / hm2, the situation still remains the same.
Soybeans and cotton can be sowed immediately after application of RE-45601. Other crops can be sowed 4 months after application of RE-45601 at a dose of 1.12 kg ai / hm2 or less.
Application
Applicable to annual and perennial grass weeds and many Field maize cereals withbroad-leaf. (1) annual species (84-140 g ai / hm2): Kusamiligus ostreatus, wild oats, wool millet, brachiopod, mangrove, black brome, ryegrass, gall grass, French foxtail, hemostatic horse, Golden Foxtail, Crabgrass, Setaria viridis, Echinochloa crus-galli, Dichromatic Sorghum, Barnyardgrass, Wheat, Lemna, Corn; Barley , (2) Arabian sorghum of perennial species (84-140 g ai / hm2); (3) Perennial species (140 ~ 280g ai / hm2) bermudagrass, creeping wild wheat.
It’s not or slightly active against broad-leaf weeds or Carex. The crops of grass family such as barley, corn, oats, rice, sorghum and wheat are all susceptible to RE-45601. Therefore the autogenesis plants in the filed where crops of non-grass family can be controlled with RE-45601.
How to use
RE-45601 gets the best control effect during the period when grass weeds grow vigorously. Drought, low temperature (below 15 ° C) and other unfavorable factors sometimes reduce the activity of RE-45601. For annual weeds of grass family, it should be applied during the 3 to 5 leaf stage. For perennial weeds of grass family, herbicide should be applied after weeds tillering; increase of the dose or number of applications is needed for non- appropriate period for spraying. If an even distribution of droplets can be applied, low spray volume (ie 50L / hm2)is more effective than the high spray volume (180 ~ 280L / hm2). The biological activity can be improved by adding vegetable oil 2.34L / hm2. The active ingredient in RE-45601 is absorbed by plants within 1 hour, so the rainfall after application will not reduce the effect.
Preparation Methods
5-alkylcyclohexanedione-3-carboxylate is produced by the condensation and cyclization of the corresponding ketene and diethyl malonatein the presence of sodium hydroxide, then compound(Ⅰ) is obtained by hydrolysis and decarboxylation, followed by its reaction with propionyl chloride to form 3-propionyloxy-5-alkylcyclohexenone which is soluble in methylene chloride . then has isomerization reaction in the presence of aluminum trichloride and finally reacts with H2NOCH2CH = CHCl to produce,clethodim. The response equation is as follows:
Uses
Systemic graminicide. Post-emergent herbicide.
Agricultural Uses
Herbicide: Not approved for use in EU countries. A selective post-emergence herbicide used to control annual and
perennial grasses to a range of crops including cotton, flax,
peanuts, soybeans, sugarbeets, potatoes, alfalfa, sunflowers and most vegetables.
Trade name
CLETODIME?; PRISM?; RE 45601;
SELECT?
Check Digit Verification of cas no
The CAS Registry Mumber 99129-21-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,9,1,2 and 9 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 99129-21:
(7*9)+(6*9)+(5*1)+(4*2)+(3*9)+(2*2)+(1*1)=162
162 % 10 = 2
So 99129-21-2 is a valid CAS Registry Number.
InChI:InChI=1/C17H26ClNO3S/c1-4-14(19-22-8-6-7-18)17-15(20)10-13(11-16(17)21)9-12(3)23-5-2/h6-7,12-13,19H,4-5,8-11H2,1-3H3/b7-6u,17-14-
99129-21-2Relevant articles and documents
Preparation method of clethodim and intermediate thereof
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, (2020/06/17)
The invention discloses a preparation method of clethodim and an intermediate thereof. The preparation method of the intermediate comprises the step of acidifying a compound A to obtain a compound B.According to the invention, the compound B is obtained by acidifying the compound A, and reacts to obtain a compound D, and the compound D reacts to obtain clethodim, so that the reaction condition are mild, the operation is simple, the preparation process of the compounds A-D does not require separation, water washing, layering, rearrangement and other operations, the clethodim preparation process flow is simplified, the reaction time is shortened, the production efficiency is improved, the post-treatment is simple, water washing, layering and other processes are not needed, separation and purification are facilitated, the wastewater treatment burden is not increased, three wastes are reduced, the production cost is reduced, the environmental protection requirement is met, and the methodis suitable for industrial production.
NOXIOUS ARTHROPOD CONTROL AGENT CONTAINING AMIDE COMPOUND
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, (2017/08/26)
An object of the present invention is to provide a compound having the controlling activity on a noxious arthropod, and a noxious arthropod controlling agent containing an amide compound of formula (I): wherein X represents a nitrogen atom or a CH group, p represents 0 or 1, A represents a tetrahydrofuranyl group or the like, R1, R2, R3, R4, R5, R6 and R7 represent a hydrogen atom or the like, n represents 1 or 2, Y represents an oxygen atom or the like, m represents any integer of 0 to 7, and Q represents a C1-8 chain hydrocarbon group optionally having a phenyl group or the like, has the excellent noxious arthropod controlling effect.
LIQUID FORMULATIONS
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, (2011/06/28)
The present invention relates to a liquid formulation comprising a) agrochemically active salts of 2-iodo-N-[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)carbamoyl]benzenesulfonamide, and b) one or more non-polar organic solvents selected from the group of the C6-C16-aromatics mixture the Solvesso series (Exxon) and/or the Caromax series (Carless), and also ?optionally further non-polar organic solvents. The liquid formulation is suitable for crop protection.
