99237-42-0Relevant articles and documents
Self-immolative prodrugs: Candidates for antibody-directed enzyme prodrug therapy in conjunction with a nitroreductase enzyme
Mauger,Burke,Somani,Friedlos,Knox
, p. 3452 - 3458 (1994)
The synthesis and properties of some prodrug candidates for antibody- directed enzyme prodrug therapy (ADEPT) are described. These compounds have been designed to generate the corresponding active drug upon interaction with a bacterial nitroreductase that
Leaving group effects in reductively triggered fragmentation of 4-nitrobenzyl carbamatesf
Sykes, Bridget M.,Hay, Michael P.,Bohinc-Herceg, Dubravka,Helsby, Nuala A.,O'Connor, Charmian J.,Denny, William A.
, p. 1601 - 1608 (2007/10/03)
The rates and extent of release of a series of substituted anilines from 4-nitrobenzyl carbamates, following nitro group reduction by radiolytic, enzymic and chemical methods, are reported. The yield of released anilines decreased over the pH range 4-7, b