99446-53-4 Usage
General Description
5-Methoxy-pyrazolo[1,5-a]pyridine-3-carboxylic acid ethyl ester is a chemical compound with a molecular formula C10H10N2O3. It is an ethyl ester derivative of the pyrazolo[1,5-a]pyridine carboxylic acid with a methoxy group at the 5 position. 5-METHOXY-PYRAZOLO[1,5-A]PYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER is commonly used in the field of medicinal chemistry as a building block for the synthesis of pharmaceuticals and biologically active molecules. It is also used as a research chemical in the development of new drugs and can act as a precursor in organic synthesis. The compound's structure and properties make it valuable for various scientific applications, particularly in the development of new pharmaceutical drugs.
Check Digit Verification of cas no
The CAS Registry Mumber 99446-53-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,9,4,4 and 6 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 99446-53:
(7*9)+(6*9)+(5*4)+(4*4)+(3*6)+(2*5)+(1*3)=184
184 % 10 = 4
So 99446-53-4 is a valid CAS Registry Number.
InChI:InChI=1/C11H12N2O3/c1-3-16-11(14)9-7-12-13-5-4-8(15-2)6-10(9)13/h4-7H,3H2,1-2H3
99446-53-4Relevant articles and documents
Discovery of pyrazolo[1,5-a]pyridines as p110α-selective PI3 kinase inhibitors
Kendall, Jackie D.,O'Connor, Patrick D.,Marshall, Andrew J.,Frédérick, Rapha?l,Marshall, Elaine S.,Lill, Claire L.,Lee, Woo-Jeong,Kolekar, Sharada,Chao, Mindy,Malik, Alisha,Yu, Shuqiao,Chaussade, Claire,Buchanan, Christina,Rewcastle, Gordon W.,Baguley, Bruce C.,Flanagan, Jack U.,Jamieson, Stephen M.F.,Denny, William A.,Shepherd, Peter R.
experimental part, p. 69 - 85 (2012/03/08)
We have made a novel series of pyrazolo[1,5-a]pyridines as PI3 kinase inhibitors, and demonstrated their selectivity for the p110α isoform over the other Class Ia PI3 kinases. We investigated the SAR around the pyrazolo[1,5-a]pyridine ring system, and found compound 5x to be a particularly potent example (p110α IC50 0.9 nM). This compound inhibits cell proliferation and phosphorylation of Akt/PKB, a downstream marker of PI3 kinase activity, and showed in vivo activity in an HCT-116 human xenograft model.
