99520-82-8

Basic information

• Product Name: (S)-1,4-DITOSYL-2-BUTANOL
• Synonyms: (S)-1,4-DITOSYL-2-BUTANOL;(S)-1,4-DITOSYLOXY-2-BUTANOL;1,2,4-BUTANETRIOL, 1,4-BIS(4-METHYLBENZENESULFONATE), (S);(S)-1,4-Di-O-(p-tosyl)-1,2,4-butanetriol
• CAS NO: 99520-82-8
• Molecular Formula: C18H22O5S2
• Molecular Weight: 382.49
• Mol File: 99520-82-8.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (S)-1,4-DITOSYL-2-BUTANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-1,4-DITOSYL-2-BUTANOL(99520-82-8)
• EPA Substance Registry System: (S)-1,4-DITOSYL-2-BUTANOL(99520-82-8)

Safety Data

• Hazardous Substances Data: 99520-82-8(Hazardous Substances Data)

Usage

General Description

(S)-1,4-DITOSYL-2-BUTANOL, also known as (S)-(+)-1,4-Ditosyl-2-butanol, is a chiral chemical compound commonly used in organic synthesis. It is a stereochemically pure derivative of 2-butanol and is often utilized as a versatile building block in the preparation of various pharmaceuticals and fine chemicals. The compound contains two tosyl (p-toluenesulfonyl) groups, making it a useful protecting group for alcohols and amines in synthetic reactions. (S)-1,4-DITOSYL-2-BUTANOL is also an important intermediate in the production of other complex organic molecules and is widely utilized in the pharmaceutical and chemical industries.

Upstream product

• 76494-96-7 (2S,1'RS)-2-(1'-ethoxyethyloxy)-1,4-butanediyl bis(p-toluenesulfonate) 
• 70005-88-8 (R)-1,2,4-butanetriol 
• 98-59-9 p-toluenesulfonyl chloride 

Relevant articles and documents

β-Alkoxy- and β-Hydroxyalkylphosphanes as Ligands in the Stereoselective Hydrogenation - A Comparison

Optically pure 1,4-bis(diphenylphosphanyl)-2-hydroxy-butane (2) and its methyl ether 1 can be conveniently prepared by starting from chiral pool substances such as malic or L-ascorbic acid.Different pathways to these compounds were elucidated.In one case an interesting migration of an acetalic OH-protective group was observed.The reaction of the bisphosphenes with Rh(I) or Pd(II) gave uniform metal complexes.On the basis of X-ray structural analysis, NMR and IR data it was concluded that in the investigated precatalysts of the type BF4 a coordination of the alkoxy or hydroxy oxygen to the metal does not take place .Nevertheless, significant differences in enantioselectivity and activity could be observed when several prochiral substrates were hydrogenated. - Keywords: Ether phosphanes / Hydroxyalkylphosphanes / Rhodium / Asymmetric hydrogenation