99646-28-3 Usage
Description
(S)-(-)-2,2'-BIS(DI-P-TOLYLPHOSPHINO)-1,1'-BINAPHTHYL, also known as (S)-T-BINAP, is a chiral ligand based on a bis naphthalene backbone with different phosphine derivatives. It is a white to cream powder and is an enantiomer of (R)-T-BINAP. (S)-(-)-2,2'-BIS(DI-P-TOLYLPHOSPHINO)-1,1'-BINAPHTHYL plays a crucial role in asymmetric catalysis, particularly in the field of organic synthesis.
Uses
Used in Asymmetric Hydroformylation:
(S)-T-BINAP is used as a chiral catalyst ligand for the asymmetric hydroformylation of vinyl acetate. This process is essential for the production of various pharmaceuticals, agrochemicals, and fine chemicals.
Used in Reductive Amination of Ketones:
(S)-T-BINAP is employed as a chiral catalyst for the reductive amination of ketones, which is a crucial step in the synthesis of various biologically active compounds and pharmaceuticals.
Used in Cation Trapping:
(S)-T-BINAP can be used as a catalyst for cation trapping with Pt dications, which is an important process in the synthesis of certain complex organic molecules.
Used in Hydrogenation of Acetamidoacrylic Acid Derivatives:
(S)-T-BINAP serves as a Rh(I)-catalyst for the hydrogenation of acetamidoacrylic acid derivatives, which is a key step in the synthesis of certain pharmaceuticals and agrochemicals.
Used in Asymmetric Mukaiyama-type Aldol Reaction:
The (S)-T-BINAP·AgF complex catalyzes the asymmetric Mukaiyama-type aldol reaction, which is an essential process in the synthesis of various chiral compounds.
Used in Chiral Catalyst for Allylation of N-Tosyl α-Imino Esters:
(S)-T-BINAP may be employed as a chiral catalyst for the allylation of N-tosyl α-imino esters, which is a significant process in the synthesis of various chiral amines and pharmaceuticals.
Reaction
Useful ligand for palladium-catalyzed carbon-oxygen bond formation.
Ligand for palladium-catalyzed α-arylation of ketones.
Ligand for Cu-catalyzed asymmetric conjugate reduction.
Ligand for Cu-catalyzed asymmetric dienolate addition to aldehydes.
Enantioselective conjugate reduction of lactones and lactams.
Ligand used in the enantioselective cycloaddition of allenylsilanes with α-Imino esters.
Catalytic Aldol reaction to ketones.
Ligand with rhodium catalyses [2+2+2] cycloaddition reaction of alkenes and alkynes.
Ligand used in the copper-catalyzed asymmetric conjugate addition of alkyl Grignard reagents on α,β-unsaturated esters.
Ligand used in the copper-catalyzed asymmetric synthesis of cyclopropanes via tandem conjugate addition and intramolecular enolate trapping.
Check Digit Verification of cas no
The CAS Registry Mumber 99646-28-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,9,6,4 and 6 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 99646-28:
(7*9)+(6*9)+(5*6)+(4*4)+(3*6)+(2*2)+(1*8)=193
193 % 10 = 3
So 99646-28-3 is a valid CAS Registry Number.
99646-28-3Relevant articles and documents
NOVEL RUTHENIUM COMPLEX AND PROCESS FOR PRODUCING OPTICALLY ACTIVE ALCOHOL COMPOUND USING SAME AS CATALYST
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Paragraph 0064, (2014/03/21)
The present invention provides: a novel ruthenium complex which has excellent catalytic activity with respect to reactivity in the reduction of a multiple bond, in particular, in the asymmetric reduction of a carbonyl compound, enantioselectivity, etc.; a catalyst which comprises the ruthenium complex; and a process for producing optically active compound, in particular, an optically active alcohol compound, using the catalyst. The ruthenium complex has a ruthenacyclic structure. The catalyst is a catalyst for asymmetric reduction which comprises the ruthenium complex.
PROCESS FOR PREPARATION OF DIPHOSPHINE COMPOUNDS AND INTERMEDIATES FOR THE PROCESS
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Page 41, (2008/06/13)
A production method of a_compound represented by the formula wherein R1a, R1b, R1c, R1d, R1e, R1f, R2a, R2b, R2c R2d, R2e and R2f are the same or different and each is a hydrogen atom and the like, and R3, R4, R5, R6, R7, R8, R9 and R10 are the same or different and each is a hydrogen atom and the like, or a salt thereof, which comprises reacting a compound represented by the formula wherein X is a leaving group and other symbols are as defined above, or a salt thereof, with a phosphine-borane complex represented by the formula wherein the symbols are as defined above, or a salt thereof, in a solvent in the presence of an amine and a nickel catalyst, is provided.
Ruthenium-I0D0-optically active phosphine complex
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, (2008/06/13)
This invention is concerned with a ruthenium-iodo-optically active bidentate phosphine complex of the formula (I):[Ru-(I)q-(T1)n(SOL)r(L)]m(T2)p(I)s(I)wherein T1 represents a carboxylic acid anion, SOL represents a polar solvent, L represents an optically active bidentate phosphine ligand, T2 represents an anion different from halogen atom anions and carboxylic acid anions, n denotes 0 or 1, r denotes 0, 3 or 4, m denotes 1 or 2, q denotes 0 or 1, or where m is 2, q may represent 1 or 1.5, p denotes 0 or 1, and s denotes 0, 1 or 2 is prepared. Said phosphine complex is usefull as an efficient catalyst for asymmetrically hydrogenating 4-methylene-2-oxetanone into optically active 4-methyl-2-oxetanone.