99767-31-4

Basic information

• Product Name: 1-(2-hydroxyprop-2-yl)cyclobutanol
• Synonyms: 1-(2-hydroxyprop-2-yl)cyclobutanol
• CAS NO: 99767-31-4
• Molecular Weight: 130.187
• Mol File: 99767-31-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(2-hydroxyprop-2-yl)cyclobutanol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-hydroxyprop-2-yl)cyclobutanol(99767-31-4)
• EPA Substance Registry System: 1-(2-hydroxyprop-2-yl)cyclobutanol(99767-31-4)

Safety Data

• Hazardous Substances Data: 99767-31-4(Hazardous Substances Data)

Upstream product

• 917-64-6 methyl magnesium iodide 
• 89489-58-7 methyl 1-hydroxycyclobutanecarboxylate 

Downstream Products

• 4541-32-6 2,2-dimethylcyclopentanone 

Relevant articles and documents

Regioselective synthesis of α,α-dialkylcyclopentanones from 1-hydroxycyclobutanecarboxylic acid or from O-protected cyclobutanone cyanohydrin

1-(1-Hydroxyalkyl)cyclobutanols 4a-f, readily available either from 1-hydroxycyclobutane carboxylic acid or from O-protected cyclobutanone cyanohydrin, appeared the most suitable precursors for a regioselective synthesis of cyclopentanones α,α- disubstituted with various similar or different alkyl, alkenyl, aryl or cycloalkyl groups. The key steps consist of acid or Grignard reagent induced C4→C5 ring expansions.