99853-87-9

Basic information

• Product Name: (E)-2-benzylidenebutanoyl chloride
• Synonyms: (E)-2-benzylidenebutanoyl chloride
• CAS NO: 99853-87-9
• Molecular Weight: 194.661
• Mol File: 99853-87-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (E)-2-benzylidenebutanoyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-2-benzylidenebutanoyl chloride(99853-87-9)
• EPA Substance Registry System: (E)-2-benzylidenebutanoyl chloride(99853-87-9)

Safety Data

• Hazardous Substances Data: 99853-87-9(Hazardous Substances Data)

Upstream product

• 64262-65-3 methyl 2-ethyl-3-phenylpropenoate 
• 100-52-7 benzaldehyde 
• 620-78-0 ethyl 3-phenylpropenoic acid 
• 26197-64-8 (E)-2-benzylidenebutanoic acid 

Downstream Products

• 1431617-48-9 (E)-isopropyl 2-benzylidenebutanoate 
• 26197-71-7 2-ethyl-3t-phenyl-acrylic acid diethylamide 
• 57558-82-4 2-ethyl-1,3t-diphenyl-propenone 

Relevant articles and documents

Novel and practical asymmetric synthesis of β2,3-amino esters using asymmetric Michael addition of chiral amine

A practical method for the synthesis of chiral β2,3-amino esters having various substituents was developed, which is characterized by an asymmetric Michael addition reaction of a chiral lithium amide with trisubstituted (E)-α,β-unsaturated esters. We found that a highly face-selective protonation occurred by the quick addition of water to the enolate intermediate derived from the Michael addition reaction to afford N-protected β2,3-amino esters in moderate to excellent yields. This finding was made possible by the facile preparation of geometrically pure trisubstituted (E)-α,β-unsaturated esters, which was established recently by our group. The subsequent deprotection of the amino group in the Michael adduct by using N-iodosuccinimide (NIS) efficiently provided β2,3-amino esters having various substituents.

Asymmetric hydrogenation of α,β-unsaturated carboxylic esters with chiral iridium N,P ligand complexes

Enantioselective conjugate reduction of a wide range of α,β-unsaturated carboxylic esters was achieved using chiral Ir N,P complexes as hydrogenation catalysts. Depending on the substitution pattern of the substrate, different ligands perform best. α,β-Unsaturated carboxylic esters substituted at the α position are less problematic substrates than originally anticipated and in some cases α-substituted substrates actually reacted with higher enantioselectivity than their β-substituted analogues. The resulting saturated esters with a stereogenic center in the α or β position were obtained in high enantiomeric purity. Copyright