99855-42-2Relevant articles and documents
Exploring the Conformation of Mixed Cis- Trans α,β-Oligopeptoids: A Joint Experimental and Computational Study
Dumonteil, Geoffrey,Bhattacharjee, Nicholus,Angelici, Gaetano,Roy, Olivier,Faure, Sophie,Jouffret, Laurent,Jolibois, Franck,Perrin, Lionel,Taillefumier, Claude
, p. 6382 - 6396 (2018/06/26)
The synthesis and conformational preferences of a set of new synthetic foldamers that combine both the α,β-peptoid backbone and side chains that alternately promote cis- and trans-amide bond geometries have been achieved and addressed jointly by experiment and molecular modeling. Four sequence patterns were thus designed and referred to as cis-β-trans-α, cis-α-trans-β, trans-β-cis-α, and trans-α-cis-β. α- and βNtBu monomers were used to enforce cis-amide bond geometries and α- and βNPh monomers to promote trans-amides. NOESY and molecular modeling reveal that the trans-α-cis-β and cis-β-trans-α tetramers show a similar pattern of intramolecular weak interactions. The same holds for the cis-α-trans-β and trans-β-cis-α tetramers, but the interactions are different in nature than those identified in the trans-α-cis-β-based oligomers. Interestingly, the trans-α-cis-β peptoid architecture allows establishment of a larger amount of structure-stabilizing intramolecular interactions.
Syntheses d'amidoesters par reaction de Kolbe
Abderrahman, Ben Moufida,Laurent, Eliane,Marquet, Bernard
, p. 571 - 578 (2007/10/02)
The synthesis of amidoesters has been investigated by anodic cooxidation of diacid hemiesters CO2H-CH2-Z-CO2CH3 -CH2-> and amidoacids R1-N(Y)-(CH2)2-CO2H .The scope of this reaction was examined in detail.This synthetic pathway provided very a simple access to a wide range of amidoesters R1-N(Y)-(CH2)3-Z-CO2CH3 by varying Z and R1 as well as n value.
