99914-14-4

Basic information

• Product Name: 2-CHLORO-5-AMINO-ACETOPHENONE
• Synonyms: 2-CHLORO-5-AMINO-ACETOPHENONE;1-(5-AMINO-2-CHLOROPHENYL)ETHANONE;5-AMINO-2-CHLOROACETOPHENONE;5'-amino-2'-chloroacetophenone,1-(5-amino-2-chlorophenyl)ethanone
• CAS NO: 99914-14-4
• Molecular Formula: C₈H₈ClNO
• Molecular Weight: 169.61
• Product Categories: pharmacetical
• Mol File: 99914-14-4.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 297°C at 760 mmHg
• Flash Point: 133.4°C
• Appearance: /
• Density: 1.254g/cm³
• Vapor Pressure: 0.00139mmHg at 25°C
• Refractive Index: 1.586
• CAS DataBase Reference: 2-CHLORO-5-AMINO-ACETOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-5-AMINO-ACETOPHENONE(99914-14-4)
• EPA Substance Registry System: 2-CHLORO-5-AMINO-ACETOPHENONE(99914-14-4)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 99914-14-4(Hazardous Substances Data)

Usage

General Description

2-Chloro-5-amino-acetophenone is a chemical compound with the molecular formula C8H8ClNO. It is an aromatic ketone derivative with a chlorine atom attached to the 2 position and an amino group attached to the 5 position of the acetophenone molecule. 2-CHLORO-5-AMINO-ACETOPHENONE is used as an intermediate in the synthesis of pharmaceuticals and organic compounds. It may also be used in the production of dyes, pigments, and other fine chemicals. 2-Chloro-5-amino-acetophenone is a versatile building block in organic chemistry and has potential applications in various industries.

InChI:InChI=1/C8H8ClNO/c1-5(11)7-4-6(10)2-3-8(7)9/h2-4H,10H2,1H3

Upstream product

• 23082-50-0 2'-chloro-5'-nitroacetophenone 

Downstream Products

• 112290-95-6 2-chloro-5-(trifluoro)acetylaminoacetophenone 
• 86308-71-6 [5-Amino-2-(2-chloro-4-methyl-phenoxy)-phenyl]-acetic acid 
• 112290-89-8 1-(4-Amino-2-chloro-5-methylamino-phenyl)-ethanone 
• 112290-90-1 2-chloro-6-nitro-5-(N-methylamino)acetophenone 
• 112290-91-2 2-chloro-4-nitro-5-(N-methylamino)acetophenone 
• 112290-94-5 2-chloro-5-(N-methyl-N-trifluoro)acetylaminoacetophenone 
• 112290-92-3 N-(3-Acetyl-4-chloro-2-nitro-phenyl)-2,2,2-trifluoro-N-methyl-acetamide 
• 112290-93-4 N-(5-Acetyl-4-chloro-2-nitro-phenyl)-2,2,2-trifluoro-N-methyl-acetamide 
• 372093-06-6 N-(3-acetyl-4-chlorophenyl)methanesulfonamide 
• 1182843-44-2 1-(5-azido-2-chlorophenyl)ethanone 
• 1202021-81-5 C₁₆H₁₁ClF₃NO₂ 
• 1232688-51-5 1-(5-amino-4-bromo-2-chloro-phenyl)-ethanone 

Relevant articles and documents

Highly selective hydrogenation of halogenated nitroarenes over Ru/CN nanocomposites by: In situ pyrolysis

A highly chemoselective and recyclable ruthenium catalyst for the hydrogenation of halogenated nitroarenes has been prepared via the simple in situ calcination of a mixture of melamine, glucose and ruthenium trichloride. Superfine Ru particles (2.3 ± 0.3 nm) were obtained and highly dispersed in the nitrogen-doped carbon matrix. The Ru/CN catalyst smoothly transforms a variety of halogenated nitroarenes to the corresponding haloanilines with high intrinsic activity (e.g. TOF = 1333 h-1 for p-chloronitrobenzene) and selectivity of more than 99.6percent. Furthermore, through an analysis of the products in the reaction process, it was concluded that there are two parallel reaction pathways (a direct pathway and an indirect pathway) for the hydrogenation of aromatic nitro compounds over the Ru/CN catalyst, and the direct pathway was proved to be dominant in catalyzing the intermediates. This journal is

Microwave-assisted benzyne-click chemistry: preparation of 1H-benzo[d][1,2,3]triazoles

The benzotriazoles were prepared by three-component and two-component microwave-assisted [3+2] cycloadditions of various azides to benzyne, 3-methoxybenzyne, and 4,5-difluorobenzyne. In the three-component reaction, the aryne is generated, in the presence of an azide prepared in situ, by the reaction of an o-(trimethylsilylaryl) triflate with either CsF or KF/18-Crown-6. However, in the two-component reactions, a freshly prepared azide is added to the reaction vessel prior to aryne generation. Good to excellent yields of benzotriazoles were obtained in 15-20 min when the microwave-assisted reactions were carried out at 125 °C. These reaction times are significantly faster than similar reactions carried out using conventional heating.

QUINOXALINE INHIBITORS OF THE HEDGEHOG SIGNALLING PATHWAY

The invention provides novel inhibitors of hedgehog signaling that are useful as a therapeutic agents for treating malignancies where the compounds have the general formula I wherein A is a carbocycle or heterocycle; X is alkylene, NR4C(O), NR