Product Name

  • Name

    (R)-(-)-Modafinil acid

  • EINECS
  • CAS No. 112111-45-2
  • Article Data9
  • CAS DataBase
  • Density 1.327 g/cm3
  • Solubility
  • Melting Point 118-120 °C
  • Formula C15H14O3S
  • Boiling Point 539.2 °C at 760 mmHg
  • Molecular Weight 274.34
  • Flash Point 279.9 °C
  • Transport Information
  • Appearance off-white solid
  • Safety
  • Risk Codes
  • Molecular Structure Molecular Structure of 112111-45-2 ((R)-(-)-Modafinil acid)
  • Hazard Symbols
  • Synonyms Aceticacid, [(R)-(diphenylmethyl)sulfinyl]- (9CI);(R)-(-)-Modafinic acid;Armodafinic acid;
  • PSA 73.58000
  • LogP 3.47500

Synthetic route

(benzhydrylthio)acetic acid
63547-22-8

(benzhydrylthio)acetic acid

(R)-Modafinil acid
112111-45-2

(R)-Modafinil acid

Conditions
ConditionsYield
With NADP; sodium hydroxide In isopropyl alcohol at 35℃; pH=8.54; Catalytic behavior; Concentration; Solvent; Reagent/catalyst; Temperature; pH-value; Alkaline conditions; enantioselective reaction;100%
Multi-step reaction with 4 steps
1.1: 99 percent / H2SO4 / Heating
2.1: H2SO4; 2-propanol; aq. H2O2 / methanol / 20 °C
3.1: 62.1 g / NaOH; H2O / ethanol / 1 h / 20 °C
4.1: (R)-(+)-α-methylbenzylamine / H2O / Heating
4.2: aq. HCl / pH 2
View Scheme
2-((R)-Diphenyl-methanesulfinyl)-1-((R)-4-phenyl-2-thioxo-thiazolidin-3-yl)-ethanone
827603-84-9

2-((R)-Diphenyl-methanesulfinyl)-1-((R)-4-phenyl-2-thioxo-thiazolidin-3-yl)-ethanone

(R)-Modafinil acid
112111-45-2

(R)-Modafinil acid

Conditions
ConditionsYield
With lithium hydroxide In tetrahydrofuran; water at 0 - 20℃;96%
Λ-[Ru(2,2-bipyridine)2((diphenylmethanesulfinyl)acetic acid-H)](PF6)

Λ-[Ru(2,2-bipyridine)2((diphenylmethanesulfinyl)acetic acid-H)](PF6)

(R)-Modafinil acid
112111-45-2

(R)-Modafinil acid

Conditions
ConditionsYield
With trifluoroacetic acid In acetonitrile at 60℃; for 3h; Inert atmosphere; enantioselective reaction;84%
modafinil acid
63547-24-0

modafinil acid

A

(R)-Modafinil acid
112111-45-2

(R)-Modafinil acid

B

(+)-(S)-(diphenylmethanesulfinyl)acetic acid
112111-44-1

(+)-(S)-(diphenylmethanesulfinyl)acetic acid

Conditions
ConditionsYield
Stage #1: modafinil acid With (S)-1-phenyl-ethylamine In water Heating;
Stage #2: With hydrogenchloride pH=2;
A 12.6 g
B n/a
Stage #1: modafinil acid With (R)-1-phenyl-ethyl-amine In water Heating;
Stage #2: With hydrogenchloride pH=2;
A n/a
B 17.0 g
modafinil acid
63547-24-0

modafinil acid

(R)-Modafinil acid
112111-45-2

(R)-Modafinil acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 44.5 percent / 4-(dimethylamino)pyridine; 1,3-dicyclohexylcarbodiimide / CH2Cl2
2: 96 percent / lithium hydroxide / tetrahydrofuran; H2O / 0 - 20 °C
View Scheme
1,1-Diphenylmethanol
91-01-0

1,1-Diphenylmethanol

BF3(C2H5)2O

BF3(C2H5)2O

(R)-Modafinil acid
112111-45-2

(R)-Modafinil acid

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: 99 percent / trifluoroacetic acid / 3 h / 20 °C
2.1: 99 percent / H2SO4 / Heating
3.1: H2SO4; 2-propanol; aq. H2O2 / methanol / 20 °C
4.1: 62.1 g / NaOH; H2O / ethanol / 1 h / 20 °C
5.1: (R)-(+)-α-methylbenzylamine / H2O / Heating
5.2: aq. HCl / pH 2
View Scheme
(diphenylmethyl)(ethyl acetate)sulfide
63547-23-9

(diphenylmethyl)(ethyl acetate)sulfide

(R)-Modafinil acid
112111-45-2

(R)-Modafinil acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: H2SO4; 2-propanol; aq. H2O2 / methanol / 20 °C
2.1: 62.1 g / NaOH; H2O / ethanol / 1 h / 20 °C
3.1: (R)-(+)-α-methylbenzylamine / H2O / Heating
3.2: aq. HCl / pH 2
View Scheme
(diphenylmethyl)(ethyl acetate)sulfoxide
118286-19-4

(diphenylmethyl)(ethyl acetate)sulfoxide

(R)-Modafinil acid
112111-45-2

(R)-Modafinil acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: 62.1 g / NaOH; H2O / ethanol / 1 h / 20 °C
2.1: (R)-(+)-α-methylbenzylamine / H2O / Heating
2.2: aq. HCl / pH 2
View Scheme
(-)-α-methylbenzylamine
2627-86-3

(-)-α-methylbenzylamine

modafinil acid
63547-24-0

modafinil acid

A

(S)-modafinic acid*(S)-α-methylbenzylamine
949092-13-1

(S)-modafinic acid*(S)-α-methylbenzylamine

B

(R)-Modafinil acid
112111-45-2

(R)-Modafinil acid

Conditions
ConditionsYield
In isopropyl alcohol at 20℃; Product distribution / selectivity; Heating / reflux;
In ethyl acetate at 20℃; Product distribution / selectivity; Heating / reflux;
In N,N-dimethyl-formamide; acetone at 20℃; Product distribution / selectivity; Heating / reflux;
(benzhydrylthio)acetic acid
63547-22-8

(benzhydrylthio)acetic acid

A

(R)-Modafinil acid
112111-45-2

(R)-Modafinil acid

B

(+)-(S)-(diphenylmethanesulfinyl)acetic acid
112111-44-1

(+)-(S)-(diphenylmethanesulfinyl)acetic acid

Conditions
ConditionsYield
With 3-butyl-1-methyl-1H-imidazol-3-ium hexafluorophosphate In tetrachloromethane at 20℃; for 48h; Title compound not separated from byproducts.;
Stage #1: (benzhydrylthio)acetic acid With 1,8-diazabicyclo[5.4.0]undec-7-ene In toluene at 0 - 5℃; for 0.5h;
Stage #2: With (1S)-(+)-(10-camphorsulfonyl)-oxaziridine In toluene at 25 - 30℃;
(+)-(S)-(diphenylmethanesulfinyl)acetic acid
112111-44-1

(+)-(S)-(diphenylmethanesulfinyl)acetic acid

(R)-Modafinil acid
112111-45-2

(R)-Modafinil acid

Conditions
ConditionsYield
In dimethyl sulfoxide at 90℃; for 17h; Product distribution / selectivity;
In N,N-dimethyl-formamide at 90℃; for 17h; Product distribution / selectivity;
2-(benzhydrylsulfinyl)acetic acid (-)-α-methylbenzylamine
112245-25-7

2-(benzhydrylsulfinyl)acetic acid (-)-α-methylbenzylamine

(R)-Modafinil acid
112111-45-2

(R)-Modafinil acid

Conditions
ConditionsYield
With hydrogenchloride In water at 20℃;
methyl iodide
74-88-4

methyl iodide

(R)-Modafinil acid
112111-45-2

(R)-Modafinil acid

(R)-(-)-methyl (diphenylmethanesulfinyl)-acetate
713134-72-6

(R)-(-)-methyl (diphenylmethanesulfinyl)-acetate

Conditions
ConditionsYield
With potassium carbonate In acetone Reflux;70%
With potassium carbonate In acetone Heating;68%
With potassium carbonate In acetone for 4h; Reflux;
(R)-Modafinil acid
112111-45-2

(R)-Modafinil acid

Nuvigil
112111-43-0

Nuvigil

Conditions
ConditionsYield
With Bacillus subtilis var. niger IFO-3180 In N,N-dimethyl-formamide at 28℃; for 168h;60%
Multi-step reaction with 2 steps
1: 68 percent / K2CO3 / acetone / Heating
2: 55 percent / aq. NH4OH; NH4Cl / methanol / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: potassium carbonate / acetone / Reflux
2: ammonium hydroxide; ammonium chloride / methanol / 20 °C
View Scheme
Stage #1: (R)-Modafinil acid With methanol; thionyl chloride at 0 - 20℃; for 3h;
Stage #2: With ammonium hydroxide In methanol; water at 0℃; Reagent/catalyst; Temperature; Time;
methanol
67-56-1

methanol

(R)-Modafinil acid
112111-45-2

(R)-Modafinil acid

(R)-(-)-methyl (diphenylmethanesulfinyl)-acetate
713134-72-6

(R)-(-)-methyl (diphenylmethanesulfinyl)-acetate

Conditions
ConditionsYield
With hydrogenchloride In water at 20℃; for 1 - 24h; Product distribution / selectivity; Heating / reflux;
With thionyl chloride at 0 - 20℃; for 3 - 20h; Product distribution / selectivity;
(R)-Modafinil acid
112111-45-2

(R)-Modafinil acid

(+)-(S)-(diphenylmethanesulfinyl)acetic acid
112111-44-1

(+)-(S)-(diphenylmethanesulfinyl)acetic acid

Conditions
ConditionsYield
Stage #1: (R)-Modafinil acid With indium; pivaloyl chloride In isopropyl alcohol at 15 - 30℃; for 3h;
Stage #2: With hydrogenchloride In water; isopropyl alcohol at 20℃; for 0.5h; Product distribution / selectivity;
With perchloric acid; sodium bromide In water; ethyl acetate at 20℃; for 20h; Product distribution / selectivity;
With perchloric acid; sodium bromide In water; acetonitrile at 20℃; for 20h; Product distribution / selectivity;
isobutyl chloroformate
543-27-1

isobutyl chloroformate

(R)-Modafinil acid
112111-45-2

(R)-Modafinil acid

C20H22O5S

C20H22O5S

Conditions
ConditionsYield
Stage #1: (R)-Modafinil acid With triethylamine In dichloromethane at 5 - 30℃; for 0.5h;
Stage #2: isobutyl chloroformate In dichloromethane at 0 - 25℃; for 3.25h;

(R)-(-)-Modafinil acid Specification

The (R)-(-)-Modafinil acid, with the CAS registry number of 112111-45-2, is also known as (R)-Modafinil carboxylate. It belongs to the product categories of Aromatics; Chiral Reagents; Intermediates & Fine Chemicals; Pharmaceuticals. This chemical's molecular formula is C15H14O3S and molecular weight is 274.339. What's more, its systematic name is [(R)-(Diphenylmethyl)sulfinyl]acetic acid. Besides, it can be used for treatment of human or animal oligospermia and ovum-deficient disease.

Physical properties about (R)-(-)-Modafinil acid are: (1)ACD/LogP: 2.24; (2)# of Rule of 5 Violations: 0; (3)ACD/BCF (pH 5.5): 1; (4)ACD/BCF (pH 7.4): 1; (5)ACD/KOC (pH 5.5): 1; (6)ACD/KOC (pH 7.4): 1; (7)#H bond acceptors: 3; (8)#H bond donors: 1; (9)#Freely Rotating Bonds: 5; (10)Polar Surface Area: 62.58 Å2; (11)Index of Refraction: 1.648; (12)Molar Refractivity: 75.26 cm3; (13)Molar Volume: 206.7 cm3; (14)Surface Tension: 66 dyne/cm; (15)Density: 1.327 g/cm3; (16)Flash Point: 279.9 °C; (17)Enthalpy of Vaporization: 85.93 kJ/mol; (18)Boiling Point: 539.2 °C at 760 mmHg; (19)Vapour Pressure: 1.86E-12 mmHg at 25 °C.

You can still convert the following datas into molecular structure:
(1) SMILES: O=S(C(c1ccccc1)c2ccccc2)CC(=O)O
(2) InChI: InChI=1/C15H14O3S/c16-14(17)11-19(18)15(12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-10,15H,11H2,(H,16,17)/t19-/m1/s1
(3) InChIKey: QARQPIWTMBRJFX-LJQANCHMBC

Post buying leads

About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia

Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog

©2008 LookChem.com,License: ICP

NO.:Zhejiang16009103

complaints:service@lookchem.com Desktop View