• Name

  1,6-Hexanediol diglycidyl ether

• EINECS 240-260-4
• CAS No. 16096-31-4
• Article Data7
• CAS DataBase
• Density 1.076 g/cm³
• Solubility
• Melting Point
• Formula C₁₂H₂₂O₄
• Boiling Point 328.7 °C at 760 mmHg
• Molecular Weight 230.304
• Flash Point 120 °C
• Transport Information
• Appearance Clear liquid
• Safety
• Risk Codes
• Molecular Structure
• Hazard Symbols
• Synonyms Hexane,1,6-bis(2,3-epoxypropoxy)- (6CI,8CI);1,6-Bis(glycidyloxy)hexane;1,6-Hexamethylenediol diglycidyl ether;Hexamethylene diglycidyl ether;Hexamethylene glycol diglycidyl ether;Hexanediol diglycidyl ether;NPEK 051;ZH 16;
• PSA 43.52000
• LogP 1.37760

Synthetic route

629-11-8

1,6-hexanediol

106-89-8

epichlorohydrin

16096-31-4

1,6 hexanediol diglycidyl ether

Conditions

Conditions	Yield
With tetrabutyl-ammonium chloride; sodium hydroxide In water at 40℃; for 2h;	68.2%
With tetrabutylammomium bromide; sodium hydroxide In water at 40℃; for 2h;
Etherification;
tin(IV) chloride Etherification;

81866-56-0

1,6-bis(allyloxy)hexane

A

16096-31-4

1,6 hexanediol diglycidyl ether

B

1246463-46-6

C12H22O3

Conditions

Conditions	Yield
With dihydrogen peroxide; benzonitrile; triethylamine In water at 60℃; for 25h; Conversion of starting material;	A 29% B 44%

629-11-8

1,6-hexanediol

106-89-8

epichlorohydrin

A

16096-31-4

1,6 hexanediol diglycidyl ether

B

6-hydroxy hexyl glycidyl ether

Conditions

Conditions	Yield
With potassium hydroxide In tetrahydrofuran for 5h; Heating;	A 14 g B 50 g

...Expand

629-11-8

1,6-hexanediol

3132-64-7

1,2-Epoxy-3-bromopropane

A

16096-31-4

1,6 hexanediol diglycidyl ether

B

6-hydroxy hexyl glycidyl ether

Conditions

Conditions	Yield
With potassium hydroxide In tetrahydrofuran for 7h; Heating;	A 35 g B 35 g

...Expand

20387-39-7

1-chloro-3-[6-(3-chloro-2-hydroxy-propoxy)-hexyloxy]-propan-2-ol

16096-31-4

1,6 hexanediol diglycidyl ether

Conditions

Conditions	Yield
With sodium hydride In hexane; toluene at 20℃; for 0.0833333h; Cyclization;	228 mg

629-11-8

1,6-hexanediol

16096-31-4

1,6 hexanediol diglycidyl ether

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: SnCl4 / toluene; heptane / 3 h / 90 °C 2: 228 mg / NaH / toluene; hexane / 0.08 h / 20 °C View Scheme

16096-31-4

1,6 hexanediol diglycidyl ether

871835-30-2

2-oxo-1,3-dioxolane-4-carboxylic acid

C20H30O14

Conditions

Conditions	Yield
With chromium(III) acetylacetonate; triethylamine In tetrahydrofuran at 80℃; for 16h;	100%

16096-31-4

1,6 hexanediol diglycidyl ether

(2-dimethylamino-1-(4-morpholinophenyl)-2-(4-carboxyphenylmethyl)butan-1-one)

C60H82N4O12

Conditions

Conditions	Yield
With tetrabutylammomium bromide In acetonitrile for 10h; Reflux;	88%

16096-31-4

1,6 hexanediol diglycidyl ether

3-{[6-(2,3-dihydroxypropoxy)hexyl]oxy}-1,2-propanediol

Conditions

Conditions	Yield
With water; trifluoroacetic acid Hydrolysis; ring cleavage;	63%

16096-31-4

1,6 hexanediol diglycidyl ether

111-86-4

n-Octylamine

189192-11-8

di[(2-hydroxy-3-octylamino)propyloxy]hexamethylene

Conditions

Conditions	Yield
In ethanol for 4h;	105 g

16096-31-4

1,6 hexanediol diglycidyl ether

108-24-7

acetic anhydride

64-19-7

acetic acid

acetic acid 2-acetoxy-1-[6-(2,3-diacetoxy-propoxy)-hexyloxymethyl]-ethyl ester

Conditions

Conditions	Yield
Acetoxylation; acetylation; ring cleavage;

...Expand

16096-31-4

1,6 hexanediol diglycidyl ether

148102-19-6

reduced [3H]glutathione

A

oxidized glutathione

B

(S)-2-Amino-4-[2-[3-(6-{3-[2-((S)-4-amino-4-carboxy-butyrylamino)-2-(carboxymethyl-carbamoyl)-ethylsulfanyl]-2-hydroxy-propoxy}-hexyloxy)-2-hydroxy-propylsulfanyl]-1-(carboxymethyl-carbamoyl)-ethylcarbamoyl]-butyric acid

Conditions

Conditions	Yield
In phosphate buffer; dimethyl sulfoxide at 20℃; for 18h; pH=7.4; Enzyme kinetics; Kinetics; Further Variations:; Reaction partners; Condensation;

...Expand

16096-31-4

1,6 hexanediol diglycidyl ether

886463-09-8

2-methyl-2-morpholin-4-yl-1-(4-piperazinylphenyl)propan-1-one

C48H76N6O8

Conditions

Conditions	Yield
1,8-diazabicyclo[5.4.0]undec-7-ene In toluene for 10h; Heating / reflux;

85-52-9

2-Benzoylbenzoic acid

16096-31-4

1,6 hexanediol diglycidyl ether

C40H42O10

Conditions

Conditions	Yield
With triphenylphosphine at 110℃; for 8h;

16096-31-4

1,6 hexanediol diglycidyl ether

108-59-8

malonic acid dimethyl ester

1,6-bis[(γ-butyrolactone-4-yl)methyloxy]hexane

Conditions

Conditions	Yield
Stage #1: 1,6-diglycidyloxy hexamethylene; malonic acid dimethyl ester With potassium tert-butylate In tert-butyl alcohol for 16h; Reflux; Stage #2: With sodium hydroxide In tert-butyl alcohol at 70℃; for 5h;	64 g

16096-31-4

1,6 hexanediol diglycidyl ether

629-11-8

1,6-hexanediol

107-51-7

Octamethyltrisiloxane

79-10-7

acrylic acid

C84H178O36Si6

Conditions

Conditions	Yield
Stage #1: octamethyltrisiloxabe; acrylic acid With dihydrogen hexachloroplatinate at 80℃; for 48h; Stage #2: 1,6-diglycidyloxy hexamethylene With tetrabutylammomium bromide; hydroquinone at 100℃; for 14h; Stage #3: 1,6-hexanediol With sulfuric acid at 140℃; for 6h;

...Expand

16096-31-4

1,6 hexanediol diglycidyl ether

4767-03-7

2,2-bis(hydroxymethyl)propionic acid

C22H42O12

Conditions

Conditions	Yield
With triphenylphosphine at 140℃; for 3h;

16096-31-4

1,6 hexanediol diglycidyl ether

124-38-9

carbon dioxide

C14H22O8

Conditions

Conditions	Yield
With [N,N'-bis(2-pyridinylmethyl)cyclohexane-1,2-diamine]iron(II) chloride; tetrabutylammomium bromide In neat (no solvent) at 100℃; under 22502.3 Torr; for 4h; Catalytic behavior; Time; Autoclave; Glovebox; Green chemistry;

16096-31-4

1,6 hexanediol diglycidyl ether

C12H18N2

C37H64N2O8

Conditions

Conditions	Yield
at 75℃; for 3h;

16096-31-4

1,6 hexanediol diglycidyl ether

95-54-5

1,2-diamino-benzene

C18H28N3O4(1+)

Conditions

Conditions	Yield
Stage #1: 1,6-diglycidyloxy hexamethylene; 1,2-diamino-benzene at 65℃; for 1.5h; Inert atmosphere; Stage #2: With sulfuric acid; sodium nitrite In water at -10℃; for 3.5h;

1,6-Hexanediol diglycidyl ether Chemical Properties