2(1H)-Pyridinone,5,6-dihydro- supplier

Name
5,6-dihydro-1H-pyridin-2-one
EINECS
CAS No. 6052-73-9
Article Data24
CAS DataBase
Density 1.052 g/cm³
Solubility
Melting Point 187-188℃
Formula C₅H₇NO
Boiling Point 287 °C at 760 mmHg
Molecular Weight 97.1167
Flash Point 158 °C
Transport Information
Appearance
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms 2(1H)-Pyridone,5,6-dihydro- (7CI,8CI);2-Pentenoic acid, 5-amino-, lactam;3,4-Dehydro-2-piperidone;5,6-Dihydro-1H-pyridin-2-one;5,6-Dihydro-2(1H)-pyridone;
PSA 29.10000
LogP 0.39130

Synthetic route

: 128372-89-4
6-oxo-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

: 6052-73-9
5,6-dihydro-2(1H)-pyridinone

Conditions

Conditions	Yield
With hydrogenchloride In methanol; water at 0℃; for 1h; Inert atmosphere;	98%
With trifluoroacetic acid In dichloromethane at 0 - 20℃; for 2h;	72%
With trifluoroacetic acid In dichloromethane at 20℃; Inert atmosphere;

: 3-(phenylselanyl)-1-(trimethylsilyl)piperidin-2-one

: 6052-73-9
5,6-dihydro-2(1H)-pyridinone

Conditions

Conditions	Yield
With dihydrogen peroxide In tetrahydrofuran at 0 - 20℃; for 2h;	97.7%
In tetrahydrofuran at 0 - 20℃; for 2h;	0.55 g

: (E)-N-(but-3-en-1-yl)but-2-enamide

: 6052-73-9
5,6-dihydro-2(1H)-pyridinone

Conditions

Conditions	Yield
With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride In dichloromethane for 2h; Reflux;	94%
With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride In dichloromethane at 40℃; for 2h;	56%

: 104261-03-2
3-(phenylthio)piperidin-2-one

: 6052-73-9
5,6-dihydro-2(1H)-pyridinone

Conditions

Conditions	Yield
Stage #1: 3-(phenylthio)piperidin-2-one With sodium hydrogencarbonate In dichloromethane for 0.166667h; Stage #2: With 3-chloro-benzenecarboperoxoic acid for 1h; Further stages.;	90%
Stage #1: 3-(phenylthio)piperidin-2-one With 3-chloro-benzenecarboperoxoic acid In dichloromethane at 0 - 20℃; for 2h; Stage #2: In toluene for 1h; Reflux;	80%
Multi-step reaction with 2 steps 1: m-CPBA, aq.NaHCO3 / CH2Cl2 / 1 h / 0 °C 2: 1.17 g / benzene / 1 h / Heating View Scheme

: 1415686-28-0
N-(but-3-en-1-yl)prop-2-enamide

: 6052-73-9
5,6-dihydro-2(1H)-pyridinone

Conditions

Conditions	Yield
With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride In toluene at 85 - 90℃; for 7h;	75%
With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride In dichloromethane for 6h; Grubbs Olefin Metathesis; Reflux;	70%
With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride In dichloromethane for 6h; Reflux;	70%

: 2-oxopiperidin-3-yl dimethyldithiocarbamate

: 6052-73-9
5,6-dihydro-2(1H)-pyridinone

Conditions

Conditions	Yield
at 260℃; under 1 Torr;	68%

: 1-(perfluorobenzoyl)-5,6-dihydropyridin-2(1H)-one

: 6052-73-9
5,6-dihydro-2(1H)-pyridinone

Conditions

Conditions	Yield
With lithium hydroxide monohydrate In tetrahydrofuran at 50℃; for 4h;	68%

: 21651-12-7
(E)-2,4-pentadienoic acid

A: 6052-73-9
5,6-dihydro-2(1H)-pyridinone

B: 61892-77-1
1,6-dihydropyridin-2(3H)-one

Conditions

Conditions	Yield
With ammonia Yield given. Yields of byproduct given;

: 3-Benzenesulfonyl-piperidin-2-one

: 6052-73-9
5,6-dihydro-2(1H)-pyridinone

Conditions

Conditions	Yield
In benzene for 1h; Heating;	1.17 g

: 3-(Phenylselenenyl)-2-piperidinone

: 6052-73-9
5,6-dihydro-2(1H)-pyridinone

Conditions

Conditions	Yield
With dihydrogen peroxide In tetrahydrofuran 1.) 0 deg C, 30 min, 2.) 25 deg C, 1.5 h; Yield given;

: 3553-93-3
1-(trimethylsilyl)piperidin-2-one

: 6052-73-9
5,6-dihydro-2(1H)-pyridinone

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: LDA / tetrahydrofuran; hexane / 1.) -50 deg C, 45 min, 2.) -78 deg C, 7 h 2: 50percent H2O2 / tetrahydrofuran / 1.) 0 deg C, 30 min, 2.) 25 deg C, 1.5 h View Scheme
Multi-step reaction with 2 steps 1.1: n-butyllithium / tetrahydrofuran / 0.75 h / -50 °C / Inert atmosphere 1.2: 7 h / -78 °C / Inert atmosphere 2.1: dihydrogen peroxide / tetrahydrofuran / 2 h / 0 - 20 °C View Scheme

: 1026076-90-3
1-(methoxymethyl)-3-(phenylthio)piperidin-2-one

: 6052-73-9
5,6-dihydro-2(1H)-pyridinone

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 78 percent / conc.HCl / ethanol / 6 h / Heating 2: m-CPBA, aq.NaHCO3 / CH2Cl2 / 1 h / 0 °C 3: 1.17 g / benzene / 1 h / Heating View Scheme
Multi-step reaction with 2 steps 1.1: hydrogenchloride / ethanol; water / 6 h / Reflux 2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 0 - 20 °C 2.2: 1 h / Reflux View Scheme

: C2HF3O2*C11H8F5NO2

A: 6052-73-9
5,6-dihydro-2(1H)-pyridinone

B: (3E,9E,15E)-1,7,13-Triaza-cyclooctadeca-3,9,15-triene-2,8,14-trione

Conditions

Conditions	Yield
With 4-methyl-morpholine In 1,4-dioxane at 80℃; for 18h;	A 6 mg B 36 mg

: C8H13NO

: 6052-73-9
5,6-dihydro-2(1H)-pyridinone

Conditions

Conditions	Yield
With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride Grubbs Olefin Metathesis;

: 85908-96-9
2-oxopiperidine-1-carboxylic acid tert-butyl ester

: 6052-73-9
5,6-dihydro-2(1H)-pyridinone

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: n-butyllithium; diisopropylamine / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere 1.2: 1.5 h / Inert atmosphere 2.1: 3-chloro-benzenecarboperoxoic acid; sodium hydrogencarbonate / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere 2.2: 3 h / 80 °C / Inert atmosphere 3.1: hydrogenchloride / methanol; water / 1 h / 0 °C / Inert atmosphere View Scheme
Multi-step reaction with 4 steps 1.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere 1.2: 1.5 h / -78 °C / Inert atmosphere 2.1: 3-chloro-benzenecarboperoxoic acid; sodium hydrogencarbonate / dichloromethane / 2 h / 0 °C 3.1: toluene / 3 h / 80 °C 4.1: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C View Scheme

: 358732-56-6
N-(tert-butyloxycarbonyl)-3-(phenylthio)piperidine-2-one

: 6052-73-9
5,6-dihydro-2(1H)-pyridinone

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: 3-chloro-benzenecarboperoxoic acid; sodium hydrogencarbonate / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere 1.2: 3 h / 80 °C / Inert atmosphere 2.1: hydrogenchloride / methanol; water / 1 h / 0 °C / Inert atmosphere View Scheme
Multi-step reaction with 3 steps 1: 3-chloro-benzenecarboperoxoic acid; sodium hydrogencarbonate / dichloromethane / 2 h / 0 °C 2: toluene / 3 h / 80 °C 3: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C View Scheme

: 675-20-7
piperidin-2-one

: 6052-73-9
5,6-dihydro-2(1H)-pyridinone

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere 1.2: 16 h / 20 °C / Inert atmosphere 2.1: n-butyllithium; diisopropylamine / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere 2.2: 1.5 h / Inert atmosphere 3.1: 3-chloro-benzenecarboperoxoic acid; sodium hydrogencarbonate / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere 3.2: 3 h / 80 °C / Inert atmosphere 4.1: hydrogenchloride / methanol; water / 1 h / 0 °C / Inert atmosphere View Scheme
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 13 h / 0 - 20 °C 2: 2,5-di-tert-butyl-p-benzoquinone; palladium(II) trifluoroacetate; racemic methyl phenyl sulfoxide; zinc(II) trifluoroacetate; di-n-butylboryl trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine / dichloromethane; 1,4-dioxane / 24 h / 20 °C / Inert atmosphere; Sealed tube 3: lithium hydroxide monohydrate / tetrahydrofuran / 4 h / 50 °C View Scheme
Multi-step reaction with 3 steps 1.1: triethylamine / toluene / 4 h / Inert atmosphere 2.1: tetrahydrofuran / 0.75 h / -50 °C / Alkaline conditions; Enzymatic reaction 2.2: 7 h 3.1: tetrahydrofuran / 2 h / 0 - 20 °C View Scheme
Multi-step reaction with 3 steps 1.1: triethylamine / toluene / 4 h / 50 °C / Inert atmosphere 2.1: n-butyllithium / tetrahydrofuran / 0.75 h / -50 °C / Inert atmosphere 2.2: 7 h / -78 °C / Inert atmosphere 3.1: dihydrogen peroxide / tetrahydrofuran / 2 h / 0 - 20 °C View Scheme
Multi-step reaction with 4 steps 1.1: n-butyllithium / dichloromethane; tetrahydrofuran / 0.5 h / 0 °C 1.2: 3 h 2.1: lithium diisopropyl amide / tetrahydrofuran / 0.75 h / -78 °C / Inert atmosphere 2.2: -78 - 20 °C 3.1: hydrogenchloride / ethanol; water / 6 h / Reflux 4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 0 - 20 °C 4.2: 1 h / Reflux View Scheme

: 1-(perfluorobenzoyl)piperidin-2-one

: 6052-73-9
5,6-dihydro-2(1H)-pyridinone

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 2,5-di-tert-butyl-p-benzoquinone; palladium(II) trifluoroacetate; racemic methyl phenyl sulfoxide; zinc(II) trifluoroacetate; di-n-butylboryl trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine / dichloromethane; 1,4-dioxane / 24 h / 20 °C / Inert atmosphere; Sealed tube 2: lithium hydroxide monohydrate / tetrahydrofuran / 4 h / 50 °C View Scheme

: 50902-27-7
1-(methoxymethyl)piperidin-2-one

: 6052-73-9
5,6-dihydro-2(1H)-pyridinone

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: lithium diisopropyl amide / tetrahydrofuran / 0.75 h / -78 °C / Inert atmosphere 1.2: -78 - 20 °C 2.1: hydrogenchloride / ethanol; water / 6 h / Reflux 3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 0 - 20 °C 3.2: 1 h / Reflux View Scheme

: 3-benzenesulfinyl-2-oxo-piperidine-1-carboxylic acid tert-butyl ester

: 6052-73-9
5,6-dihydro-2(1H)-pyridinone

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: toluene / 3 h / 80 °C 2: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C View Scheme

: 6052-73-9
5,6-dihydro-2(1H)-pyridinone

: 139374-43-9
cis-3,4-dihydroxy-2-piperidinone

Conditions

Conditions	Yield
osmium(VIII) oxide; 4-methylmorpholine N-oxide In tert-butyl alcohol Ambient temperature;	100%
With osmium(VIII) oxide; 4-methylmorpholine N-oxide In tert-butyl alcohol for 27h; Ambient temperature;	64 mg

: 853955-70-1
[2-(hydroxymethyl)phenyl]dimethyl(4-fluorophenyl)silane

: 6052-73-9
5,6-dihydro-2(1H)-pyridinone

: (R)-4-(4-fluorophenyl)-2-piperidinone

Conditions

Conditions	Yield
With potassium hydroxide; (1R,4R)-2,5-diphenylbicyclo[2.2.2]octa-2,5-diene; bis(ethylene)rhodium(I) chloride dimer In tetrahydrofuran at 50℃; for 12h;	92%

: 6052-73-9
5,6-dihydro-2(1H)-pyridinone

: 7519-91-7
tris(4-chlorophenyl)boroxine

: (R)-4-(4-chlorophenyl)-2-piperidinone

Conditions

Conditions	Yield
With (R)-2,2'-bis(diarylphosphino)-1,1'-binaphthyl; water; bis(ethylene)rhodium acetylacetonate In 1,4-dioxane at 60℃; for 12h;	88%

: 6052-73-9
5,6-dihydro-2(1H)-pyridinone

: 448-59-9
tris(4-fluorophenyl)boroxine

: (R)-4-(4-fluorophenyl)-2-piperidinone

Conditions

Conditions	Yield
With (R)-2,2'-bis(diphenylphosphino)-octahydro-1,1'-binaphthyl; water; bis(ethylene)rhodium acetylacetonate In 1,4-dioxane at 40℃; for 12h;	84%

: 6052-73-9
5,6-dihydro-2(1H)-pyridinone

: C13H11ClN2O

: (E)-1-(3-(4-((1H-imidazol-1-yl)methyl)phenyl)acryloyl)-5,6-dihydropyridin-2(1H)-one

Conditions

Conditions	Yield
Stage #1: 5,6-dihydro-2(1H)-pyridinone With sodium hydride In tetrahydrofuran; mineral oil at -5 - 0℃; for 2h; Stage #2: C13H11ClN2O In tetrahydrofuran; mineral oil for 21h;	82%
With triethylamine In tetrahydrofuran at 0℃; for 3h;

: 6052-73-9
5,6-dihydro-2(1H)-pyridinone

: 109-94-4
formic acid ethyl ester

: N-formyl-5,6-dihydropyridine-2(1H)-one

Conditions

Conditions	Yield
With titanium tetrachloride; triethylamine In dichloromethane at 0℃; for 1h;	76%

: 6052-73-9
5,6-dihydro-2(1H)-pyridinone

: C23H24Cl2O7

: piperarborenine B

Conditions

Conditions	Yield
In toluene at 20 - 80℃; for 12h; Inert atmosphere; Molecular sieve;	75%

: 6052-73-9
5,6-dihydro-2(1H)-pyridinone

: C16H9ClO5

: C21H15NO6

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 10h;	75%

: 6052-73-9
5,6-dihydro-2(1H)-pyridinone

: 1215765-27-7
1-chloro-5,6-dihydropyridin-2(1H)-one

Conditions

Conditions	Yield
With N-chloro-succinimide; potassium tert-butylate In tetrahydrofuran at 20℃; for 0.666667h; Inert atmosphere;	74%

: 6052-73-9
5,6-dihydro-2(1H)-pyridinone

: 35288-49-4
p-phenylenediacrylic diacid dichloride

: C22H20N2O4

Conditions

Conditions	Yield
Stage #1: 5,6-dihydro-2(1H)-pyridinone With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.25h; Stage #2: p-phenylenediacrylic diacid dichloride In tetrahydrofuran; hexane at -78℃; for 3h;	72%

: 6052-73-9
5,6-dihydro-2(1H)-pyridinone

: 1694-92-4
2-Nitrobenzenesulfonyl chloride

: 1266568-91-5
1-nosyl-5,6-dihydropyridin-2(1H)-one

Conditions

Conditions	Yield
Stage #1: 5,6-dihydro-2(1H)-pyridinone With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.5h; Inert atmosphere; Stage #2: 2-Nitrobenzenesulfonyl chloride In tetrahydrofuran; hexane at -78℃; for 1.5h; Inert atmosphere;	71%

: 6052-73-9
5,6-dihydro-2(1H)-pyridinone

: 645-36-3
2,2-diethoxy-ethanamine

: 5,6-Dihydroimidazo<1,2-a>pyridine

Conditions

Conditions	Yield
titanium tetrachloride In 1,3,5-trimethyl-benzene for 74h; Heating;	68.9%

: 6052-73-9
5,6-dihydro-2(1H)-pyridinone

: C19H31NO5

: tert-butyl (E)-4-(2-methyl-3-oxo-3-(6-oxo-3,6-dihydropyridin-1(2H)-yl)prop-1-en-1-yl)piperidine-1-carboxylate

Conditions

Conditions	Yield
Stage #1: 5,6-dihydro-2(1H)-pyridinone With n-butyllithium In tetrahydrofuran at -78℃; for 0.5h; Stage #2: C19H31NO5 In tetrahydrofuran at -78 - 20℃; for 1h;	67.8%
Stage #1: 5,6-dihydro-2(1H)-pyridinone With n-butyllithium In tetrahydrofuran at -78℃; for 0.5h; Stage #2: C19H31NO5 In tetrahydrofuran at 20℃; for 1h;	67.8%

: 6052-73-9
5,6-dihydro-2(1H)-pyridinone

: 79-04-9
chloroacetyl chloride

: 1-(2-chloroacetyl)-5,6-dihydropyridin-2(1H)-one

Conditions

Conditions	Yield
Stage #1: 5,6-dihydro-2(1H)-pyridinone With sodium hydride In tetrahydrofuran at 0℃; for 1h; Inert atmosphere; Stage #2: chloroacetyl chloride In tetrahydrofuran at 0 - 20℃; Inert atmosphere;	65%

: 6052-73-9
5,6-dihydro-2(1H)-pyridinone

: C13H14Cl3NO

: C18H20Cl2N2O2

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 10h;	65%

: 6052-73-9
5,6-dihydro-2(1H)-pyridinone

: 2687-12-9
cinnamyl chloride

: 1057962-70-5
1-cinnamoyl-5,6-dihydropyridin-2(1H)-one

Conditions

Conditions	Yield
Stage #1: 5,6-dihydro-2(1H)-pyridinone With sodium hydride In tetrahydrofuran at 0℃; for 0.25h; Inert atmosphere; Stage #2: cinnamyl chloride In tetrahydrofuran at 20℃; for 0.5h; Inert atmosphere;	64%

: 6052-73-9
5,6-dihydro-2(1H)-pyridinone

: 2904-57-6
mesitylenecarbonitrile oxide

: 3-(2,4,6-trimethyl-phenyl)-5,6,7,7a-tetrahydro-3aH-isoxazolo[4,5-c]pyridin-4-one

Conditions

Conditions	Yield
In benzene at 20℃; for 504000h; Cycloaddition;	62%

: 6052-73-9
5,6-dihydro-2(1H)-pyridinone

: C10H11ClN2O

: (E)-1-{3-[(3,5,6-trimethylpyrazin-2-yl)]prop-2-enoyl}-5,6-dihydropyridin-2(1H)-one

Conditions

Conditions	Yield
Stage #1: C10H11ClN2O With pivaloyl chloride; triethylamine In tetrahydrofuran at -20℃; for 0.75h; Stage #2: 5,6-dihydro-2(1H)-pyridinone With n-butyllithium In tetrahydrofuran at -70℃; for 1.75h;	53%

: 6052-73-9
5,6-dihydro-2(1H)-pyridinone

: (2E)-3-(3,5,6-trimethylpyrazin-2-yl)prop-2-enoic acid

: (E)-1-{3-[(3,5,6-trimethylpyrazin-2-yl)]prop-2-enoyl}-5,6-dihydropyridin-2(1H)-one

Conditions

Conditions	Yield
Stage #1: (2E)-3-(3,5,6-trimethylpyrazin-2-yl)prop-2-enoic acid With pivaloyl chloride; triethylamine In tetrahydrofuran; dichloromethane at -20℃; Stage #2: 5,6-dihydro-2(1H)-pyridinone With n-butyllithium In tetrahydrofuran for 1h;	53%

: 6052-73-9
5,6-dihydro-2(1H)-pyridinone

: (E)-(E)-3-(5-methoxypyrimidin-2-yl)acrylic pivalic anhydride

: (E)-1-(3-(5-methoxypyrimidin-2-yl)acryloyl)-5,6-dihydropyridin-2(1H)-one

Conditions

Conditions	Yield
Stage #1: 5,6-dihydro-2(1H)-pyridinone With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.5h; Stage #2: (E)-(E)-3-(5-methoxypyrimidin-2-yl)acrylic pivalic anhydride In tetrahydrofuran; hexane at -78℃; for 1h;	52.23%
Stage #1: 5,6-dihydro-2(1H)-pyridinone With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.5h; Stage #2: (E)-(E)-3-(5-methoxypyrimidin-2-yl)acrylic pivalic anhydride In tetrahydrofuran; hexane at -78℃; for 1h;	52.23%

: 6052-73-9
5,6-dihydro-2(1H)-pyridinone

: 698-16-8
benzohydroximoyl chloride

: 3-phenyl-5,6,7,7a-tetrahydro-3aH-isoxazolo[4,5-c]pyridin-4-one

Conditions

Conditions	Yield
With triethylamine In benzene at 20℃; for 48h; Cycloaddition; dehydrochlorination;	51%

: 6052-73-9
5,6-dihydro-2(1H)-pyridinone

: C19H31NO5

: (Z)-tert-butyl 4-(2-methyl-3-oxo-3-(2-oxo-5,6-dihydropyridin-1(2H)-yl)prop-1-enyl)piperidine-1-carboxylate

Conditions

Conditions	Yield
Stage #1: 5,6-dihydro-2(1H)-pyridinone With n-butyllithium In tetrahydrofuran at -78℃; for 0.5h; Stage #2: C19H31NO5 In tetrahydrofuran at -78 - 20℃; for 1h;	49.6%
Stage #1: 5,6-dihydro-2(1H)-pyridinone With n-butyllithium In tetrahydrofuran at -78℃; for 0.5h; Stage #2: C19H31NO5 In tetrahydrofuran at 20℃; for 1h;	49.6%

: 6052-73-9
5,6-dihydro-2(1H)-pyridinone

: (E)-(E)-3-(3,5-dimethyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl)acrylic pivalic anhydride

: (E)-1-(3-(3,5-dimethyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl)acryloyl)-5,6-dihydropyridin-2(1H)-one

Conditions

Conditions	Yield
Stage #1: 5,6-dihydro-2(1H)-pyridinone With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.5h; Stage #2: (E)-(E)-3-(3,5-dimethyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl)acrylic pivalic anhydride In tetrahydrofuran; hexane at -78℃; for 1.5h;	48.92%
Stage #1: 5,6-dihydro-2(1H)-pyridinone With n-butyllithium In tetrahydrofuran at -78℃; for 0.5h; Stage #2: (E)-(E)-3-(3,5-dimethyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl)acrylic pivalic anhydride In tetrahydrofuran at -78℃; for 1.5h;	48.92%

2(1H)-Pyridinone,5,6-dihydro- Specification

The 2(1H)-Pyridinone,5,6-dihydro-, also known as 5,6-Dihydro-2(1H)-pyridone, is an organic compound with the formula C₅H₇NO. With the CAS registry number 6052-73-9, its systematic name is 5,6-dihydropyridin-2(1H)-one.

Physical properties of 2(1H)-Pyridinone,5,6-dihydro-: (1)ACD/LogP: -0.65; (2)ACD/LogD (pH 5.5): -0.65; (3)ACD/LogD (pH 7.4): -0.65; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 10.57; (7)ACD/KOC (pH 7.4): 10.57; (8)#H bond acceptors: 2; (9)#H bond donors: 1; (10)Index of Refraction: 1.478; (11)Molar Refractivity: 26.14 cm³; (12)Molar Volume: 92.2 cm³; (13)Surface Tension: 33.2 dyne/cm; (14)Density: 1.052 g/cm³; (15)Flash Point: 158 °C; (16)Enthalpy of Vaporization: 52.61 kJ/mol; (17)Boiling Point: 287 °C at 760 mmHg; (18)Vapour Pressure: 0.00256 mmHg at 25°C.

You can still convert the following datas into molecular structure:
(1)SMILES: O=C1\C=C/CCN1
(2)InChI: InChI=1/C5H7NO/c7-5-3-1-2-4-6-5/h1,3H,2,4H2,(H,6,7)
(3)InChIKey: OXRRHYRRQWIHIV-UHFFFAOYAD

Product Name

5,6-dihydro-1H-pyridin-2-one

Synthetic route

2(1H)-Pyridinone,5,6-dihydro- Specification

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