2,4-Diaminophenol dihydrochloride supplier

Name
2,4-Diaminophenol dihydrochloride
EINECS 205-279-4
CAS No. 137-09-7
Article Data4
CAS DataBase
Density 1.343 g/cm3
Solubility 27.5 g/100 mL (15 °C) in water
Melting Point 222 °C (dec.)(lit.)
Formula C₆H₈N₂O^.2(HCl)
Boiling Point 347.4 °C at 760 mmHg
Molecular Weight 197.064
Flash Point 163.9 °C
Transport Information UN 2811 6.1/PG 3
Appearance Grey white powder
Safety 26-36
Risk Codes 22-36/37/38
Molecular Structure
Hazard Symbols Xn, Xi
Synonyms Amidol(6CI);Phenol, 2,4-diamino-, dihydrochloride (8CI,9CI);2,4-Diaminophenol hydrochloride;Acrol;Diamidophenolhydrochloride;Dianol;
PSA 72.27000
LogP 3.32300

Synthetic route

: 51-28-5
2,4-Dinitrophenol

: 137-09-7
2,4-diaminophenol dihydrochloride

Conditions

Conditions	Yield
With hydrogenchloride	91.5%
With hydrogenchloride; tin faellt aus der filtrieren Fluessigkeit durch konz.Salzsaeure;
With tin In hydrogenchloride Yield given;

: 1878-66-6
4-chlorophenylacetic Acid

: 137-09-7
2,4-diaminophenol dihydrochloride

: 381200-35-7
2-(4-chlorobenzyl)-5-aminobenzoxazole

Conditions

Conditions	Yield
With PPA at 195 - 198℃; for 1.5h;	100%
With polyphosphoric acid at 200℃; for 1.5h;	75%
With PPA Heating;

: 137-09-7
2,4-diaminophenol dihydrochloride

: 65-85-0
benzoic acid

: 41373-37-9
5-amino-2-phenyl-1,3-benzoxazole

Conditions

Conditions	Yield
PPA at 110 - 180℃; for 3h;	97%
With polyphosphoric acid at 110 - 180℃;	97%
With PPA at 110 - 180℃; for 4h;	63%

: 137-09-7
2,4-diaminophenol dihydrochloride

: 98-73-7
4-(1,1-dimethylethyl)benzoic acid

: 293738-21-3
2-(4-tert-butylphenyl)benzo[d]oxazole-5-amine

Conditions

Conditions	Yield
With polyphosphoric acid (PPA) at 180℃;	94%
With polyphosphoric acid (PPA) at 180℃;	94%
In various solvent(s) for 2.5h; Heating;

: 13139-17-8
N-(Benzyloxycarbonyloxy)succinimide

: 137-09-7
2,4-diaminophenol dihydrochloride

: 1360875-58-6
dibenzyl 4-hydroxy-1,3-phenylenedicarbamate

Conditions

Conditions	Yield
With pyridine for 18h;	94%

: 137-09-7
2,4-diaminophenol dihydrochloride

: 99-94-5
p-Toluic acid

: 54995-50-5
2-(4-methylphenyl)-5-aminobenzoxazole

Conditions

Conditions	Yield
With polyphosphoric acid at 170℃; for 1.5h;	92%
With polyphosphoric acid at 170 - 200℃;
With polyphosphoric acid at 160 - 220℃; for 0.1h;
With polyphosphoric acid at 160 - 190℃; for 3h;

: 137-09-7
2,4-diaminophenol dihydrochloride

: 1878-68-8
2-(4-bromophenyl)-acetic acid

: 1016836-17-1
2-(4-bromobenzyl)-5-aminobenzoxazole

Conditions

Conditions	Yield
With polyphosphoric acid at 200℃; for 1.5h;	89%
With PPA Heating;
With polyphosphoric acid at 160 - 220℃; for 0.1h;

: 456-22-4
4-Fluorobenzoic acid

: 137-09-7
2,4-diaminophenol dihydrochloride

: 116248-10-3
2-(4-fluorophenyl)benzo[d]oxazol-5-amine

Conditions

Conditions	Yield
With polyphosphoric acid at 200℃; for 2h;	86%
With PPA for 2.5h; Heating;
In various solvent(s) for 2.5h; Heating;

: 137-09-7
2,4-diaminophenol dihydrochloride

: 535-80-8
3-chlorobenzoate

: 54995-52-7
2-(3-chlorophenyl)benzo[d]oxazol-5-amine

Conditions

Conditions	Yield
With polyphosphoric acid at 120 - 170℃;	86%

: 5,6-bis(2,6-diisopropylphenyloxy)-1,3-diiminoisoindoline

: 137-09-7
2,4-diaminophenol dihydrochloride

: C102H113N7O7

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine at 120℃; for 5.5h;	85%

: 137-09-7
2,4-diaminophenol dihydrochloride

: 1132-21-4
3,5-dimethoxybenzoic acid

: 2-(3,5-dimethoxyphenyl)benzoxazol-5-amine

Conditions

Conditions	Yield
With polyphosphoric acid at 80 - 95℃;	84%

: 137-09-7
2,4-diaminophenol dihydrochloride

: 74-11-3
para-chlorobenzoic acid

: 54995-51-6
2-(4-chlorophenyl)benzo[d]oxazol-5-amine

Conditions

Conditions	Yield
With polyphosphoric acid at 200℃; for 1.5h;	82%
With polyphosphoric acid at 160 - 220℃; for 0.1h;

: 619-64-7
p-ethylbenzoic acid

: 137-09-7
2,4-diaminophenol dihydrochloride

: 116248-09-0
5-amino-2-(4-ethylphenyl)-1,3-benzoxazole

Conditions

Conditions	Yield
With polyphosphoric acid at 180℃; for 2h;	81%
With PPA for 2.5h; Condensation; Cyclization; Heating;
With PPA for 2.5h; Heating;

: 16650-52-5
5-chloro-naphthalene-1-carboxylic acid

: 137-09-7
2,4-diaminophenol dihydrochloride

: 2-(5-chloronaphthalene-1-yl)benzo[d]oxazole-5-amine

Conditions

Conditions	Yield
With polyphosphoric acid (PPA) at 180℃;	79%
With polyphosphoric acid (PPA) at 180℃;	79%

: 86-55-5
1-naphthalenecarboxylic acid

: 137-09-7
2,4-diaminophenol dihydrochloride

: 2-(naphthalene-1-yl)benzo[d]oxazole-5-amine

Conditions

Conditions	Yield
With polyphosphoric acid (PPA) at 180℃;	77%
With polyphosphoric acid (PPA) at 180℃;	77%

: 137-09-7
2,4-diaminophenol dihydrochloride

: 99-05-8
meta-aminobenzoic acid

: 13676-48-7
5-amino-2-(3'-aminophenyl)-benzoxazole

Conditions

Conditions	Yield
With tin(II) chloride dihdyrate at 110 - 195℃; Inert atmosphere;	76.9%
With PPA at 150℃; for 12h;	67%
With PPA

: 137-09-7
2,4-diaminophenol dihydrochloride

: 93-09-4
naphthalene-2-carboxylate

: 95888-12-3
2-(naphthalene-2-yl)-benzo[d]oxazole-5-amine

Conditions

Conditions	Yield
With polyphosphoric acid (PPA) at 180℃;	75%
With polyphosphoric acid (PPA) at 180℃;	75%
at 180℃; for 3h;	63%

: 137-09-7
2,4-diaminophenol dihydrochloride

: 405-50-5
p-Fluorophenylacetic acid

: 959958-63-5
2-(4-fluorobenzyl)-5-aminobenzoxazole

Conditions

Conditions	Yield
With polyphosphoric acid at 200℃; for 1.5h;	72%
With PPA Heating;
With polyphosphoric acid at 160 - 220℃; for 0.1h;

: 24424-99-5
di-tert-butyl dicarbonate

: 137-09-7
2,4-diaminophenol dihydrochloride

: di-tert-butyl (4-hydroxy-1,3-phenylene)dicarbamate

Conditions

Conditions	Yield
With sodium hydrogencarbonate In tetrahydrofuran; water at 20℃; for 48h;	68%

: 103-82-2
phenylacetic acid

: 137-09-7
2,4-diaminophenol dihydrochloride

: 313527-44-5
2-benzyl-5-aminobenzoxazole

Conditions

Conditions	Yield
With PPA at 150 - 160℃; for 2.5h;	66%
With PPA at 210℃; for 2.5h;	65%
With polyphosphoric acid at 180℃; for 1.5h;	61%

: 622-47-9
4-tolylacetic acid

: 137-09-7
2,4-diaminophenol dihydrochloride

: 959958-62-4
2-(4-methylbenzyl)-5-aminobenzoxazole

Conditions

Conditions	Yield
With polyphosphoric acid at 180℃; for 1.5h;	61%
With PPA Heating;
With polyphosphoric acid at 160 - 220℃; for 0.1h;

: 586-76-5
4-Bromobenzoic acid

: 137-09-7
2,4-diaminophenol dihydrochloride

: 54995-56-1
2-(4-bromophenyl)-5-aminobenzoxazole

Conditions

Conditions	Yield
With polyphosphoric acid at 200℃; for 2.5h;	60%
With polyphosphoric acid at 160 - 220℃; for 0.1h;

: 5,6-bis(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)isoindoline-1,3-diimine

: 137-09-7
2,4-diaminophenol dihydrochloride

: C72H101N7O25

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine at 120℃; for 5h;	60%

: 160956-25-2, 160956-26-3, 160956-27-4, 160956-28-5, 160956-29-6
isoindole-1,3-diylidenediamine

: 137-09-7
2,4-diaminophenol dihydrochloride

: 1301248-13-4
C22H16N6O

Conditions

Conditions	Yield
With triethylamine In ethanol at 0℃; for 24h; Darkness;	53%

: 89-57-6
5-Aminosalicylic Acid

: 137-09-7
2,4-diaminophenol dihydrochloride

: 5-amino-2-(5'-amino-2'-hydroxyphenyl)benzoxazole

Conditions

Conditions	Yield
With PPA for 15h; Heating;	52%
With PPA at 150℃; for 12h;	27%

: 93-85-6
2-aminobenzothiazole-6-carboxylic acid

: 137-09-7
2,4-diaminophenol dihydrochloride

: 2-(2-aminobenzo[d]thiazol-6-yl)benzo[d]oxazol-5-amine

Conditions

Conditions	Yield
With Eaton′s Reagent for 8h; Reflux;	51%

: 3622-35-3
benzothiazole-6-carboxylic acid

: 137-09-7
2,4-diaminophenol dihydrochloride

: 2-(benzo[d]thiazol-6-yl)benzo[d]oxazol-5-amine

Conditions

Conditions	Yield
With Eaton′s Reagent for 8h; Reflux;	49%

: 24424-99-5
di-tert-butyl dicarbonate

: 10401-11-3
3-hydroxy phenylacetylene

: 137-09-7
2,4-diaminophenol dihydrochloride

: 1885-14-9
phenyl chloroformate

: 1135615-11-0
C15H12N2O3

Conditions

Conditions	Yield
Stage #1: di-tert-butyl dicarbonate; 2,4-diaminophenol dihydrochloride With potassium carbonate In water at 20℃; Cooling with ice; Stage #2: phenyl chloroformate With pyridine In 1-methyl-pyrrolidin-2-one at 20℃; Cooling with ice; Stage #3: 3-hydroxy phenylacetylene	45%

...Expand

: 3622-35-3
benzothiazole-6-carboxylic acid

: 137-09-7
2,4-diaminophenol dihydrochloride

: 2-(benzo[d]thiazol-5-yl)benzo[d]oxazole

Conditions

Conditions	Yield
With Eaton′s Reagent for 8h; Reflux;	44%

: 137-09-7
2,4-diaminophenol dihydrochloride

: 100-09-4
4-methoxybenzoic acid

: 2-(4-methoxyphenyl)benzo[d]oxazol-5-amine

Conditions

Conditions	Yield
With polyphosphoric acid at 120 - 180℃; for 2.5h;	42%
With polyphosphoric acid at 120℃; for 2h;	41%

2,4-Diaminophenol dihydrochloride Specification

The CAS register number of Amidol is 137-09-7. It also can be called as Phenol, 2,4-diamino-, dihydrochloride and the IUPAC name about this chemical is 2,4-diaminophenol dihydrochloride. The molecular formula about this chemical is C₆H₈N₂O^.2(HCl) and the molecular weight is 197.06. It belongs to the Industrial/Fine Chemicals. This chemical is stable but it is incompatible with strong oxidizing agents, acids. It is heat sensitive and light sensitive.

Physical properties about Amidol are: (1)ACD/LogP: -1.29; (2)# of Rule of 5 Violations: 1; (3)ACD/LogD (pH 5.5): -1.54; (4)ACD/LogD (pH 7.4): -1.29; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 2.68; (8)ACD/KOC (pH 7.4): 4.68; (9)#H bond acceptors: 3; (10)#H bond donors: 5; (11)#Freely Rotating Bonds: 3; (12)Polar Surface Area: 15.71Å²; (13)Flash Point: 163.9 °C; (14)Enthalpy of Vaporization: 61.51 kJ/mol; (15)Boiling Point: 347.4 °C at 760 mmHg; (16)Vapour Pressure: 2.68E-05 mmHg at 25°C.

The Amidol is a dihydrogen chloride salt and is used as a photographic developer. Prints developed in this chemical are typically a very warm brown-black colour, but overdevelopment can quickly lead to chemical fogging. This chemical can be produced by the reaction of 2,4 - dinitrophenol reduction.

When you are using this chemical, please be cautious about it as the following:
This chemical is harmful if swallowed and it is irritating to eyes, respiratory system and skin. When you are using it, wear suitable protective clothing. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
(1)SMILES: Cl.Cl.Oc1ccc(N)cc1N
(2)InChI: InChI=1/C6H8N2O.2ClH/c7-4-1-2-6(9)5(8)3-4;;/h1-3,9H,7-8H2;2*1H
(3)InChIKey: KQEIJFWAXDQUPR-UHFFFAOYAV
(4)Std. InChI: InChI=1S/C6H8N2O.2ClH/c7-4-1-2-6(9)5(8)3-4;;/h1-3,9H,7-8H2;2*1H
(5)Std. InChIKey: KQEIJFWAXDQUPR-UHFFFAOYSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LDLo	intraperitoneal	50mg/kg (50mg/kg)		Revue Belge de Pathologie et de Medecine Experimentale. Vol. 22, Pg. 1, 1952.
rat	LD50	oral	240mg/kg (240mg/kg)	SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: ATAXIA GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	Journal of the American College of Toxicology. Vol. 13, Pg. 330, 1994.

Product Name

2,4-Diaminophenol dihydrochloride

Synthetic route

2,4-Diaminophenol dihydrochloride Specification

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