Product Name

  • Name

    2,8-DICHLORO-QUINOLINE-3-CARBALDEHYDE

  • EINECS 1308068-626-2
  • CAS No. 144918-96-7
  • Article Data6
  • CAS DataBase
  • Density 1.483 g/cm3
  • Solubility
  • Melting Point
  • Formula C10H5Cl2NO
  • Boiling Point 358.1 °C at 760 mmHg
  • Molecular Weight 226.062
  • Flash Point 170.4 °C
  • Transport Information
  • Appearance
  • Safety
  • Risk Codes
  • Molecular Structure Molecular Structure of 144918-96-7 (2,8-DICHLORO-QUINOLINE-3-CARBALDEHYDE)
  • Hazard Symbols
  • Synonyms OTAVA-BB 7020617824;2,8-Dichloroquinoline-3-carbaldehyde;
  • PSA 29.96000
  • LogP 3.35410

Synthetic route

N-(2-chlorophenyl)acetamide
533-17-5

N-(2-chlorophenyl)acetamide

(4,6-dichloro-[1,3,5]triazin-2-yloxymethylene)-dimethyl-ammonium; chloride

(4,6-dichloro-[1,3,5]triazin-2-yloxymethylene)-dimethyl-ammonium; chloride

2,8-dichloroquinoline-3-carbaldehyde
144918-96-7

2,8-dichloroquinoline-3-carbaldehyde

Conditions
ConditionsYield
In dichloromethane for 7h; Reflux;92%
N-(2-chlorophenyl)acetamide
533-17-5

N-(2-chlorophenyl)acetamide

N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

2,8-dichloroquinoline-3-carbaldehyde
144918-96-7

2,8-dichloroquinoline-3-carbaldehyde

Conditions
ConditionsYield
With Triton X-100; trichlorophosphate In acetonitrile for 1.41667h; Vilsmeier-Haack cyclisation; Heating;88%
With trichlorophosphate at 80 - 100℃;
formic acid ethyl ester
109-94-4

formic acid ethyl ester

2,8-dichloroquinoline-3-carbaldehyde
144918-96-7

2,8-dichloroquinoline-3-carbaldehyde

Conditions
ConditionsYield
Stage #1: 2,8-dichloroquinoline With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -78 - 0℃; for 3h;
Stage #2: formic acid ethyl ester In tetrahydrofuran; hexane at -78℃; for 1h;
2,8-dichloroquinoline
4470-83-1

2,8-dichloroquinoline

formic acid ethyl ester
109-94-4

formic acid ethyl ester

2,8-dichloroquinoline-3-carbaldehyde
144918-96-7

2,8-dichloroquinoline-3-carbaldehyde

Conditions
ConditionsYield
Stage #1: 2,8-dichloroquinoline With lithium diisopropyl amide In tetrahydrofuran; cyclohexene at -78℃; for 2h;
Stage #2: formic acid ethyl ester In tetrahydrofuran; cyclohexene at -78℃; for 4h;
2-Chloroaniline
95-51-2

2-Chloroaniline

2,8-dichloroquinoline-3-carbaldehyde
144918-96-7

2,8-dichloroquinoline-3-carbaldehyde

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrogenchloride / water
2: trichlorophosphate / 80 - 100 °C
View Scheme
4-morpholinecarboxaldehyde
4394-85-8

4-morpholinecarboxaldehyde

2,8-dichloroquinoline
4470-83-1

2,8-dichloroquinoline

2,8-dichloroquinoline-3-carbaldehyde
144918-96-7

2,8-dichloroquinoline-3-carbaldehyde

Conditions
ConditionsYield
With 2,2,6,6-tetramethyl-piperidine; n-butyllithium In 2-methyltetrahydrofuran; hexane at -78 - -70℃;
2,8-dichloroquinoline-3-carbaldehyde
144918-96-7

2,8-dichloroquinoline-3-carbaldehyde

(2-pyrazinyl)tributyltin

(2-pyrazinyl)tributyltin

8-chloro-2-(pyrazin-2-yl)quinoline-3-carbaldehyde
1362850-94-9

8-chloro-2-(pyrazin-2-yl)quinoline-3-carbaldehyde

Conditions
ConditionsYield
tetrakis(triphenylphosphine) palladium(0) In 1,4-dioxane at 110℃; for 5h; Inert atmosphere;99%
(R)-2-methylpropane-2-sulfinamide
196929-78-9

(R)-2-methylpropane-2-sulfinamide

2,8-dichloroquinoline-3-carbaldehyde
144918-96-7

2,8-dichloroquinoline-3-carbaldehyde

(R,E)-N-[(2, 8-dichloroquinolin-3-yl)methylidene]-2-methylpropane-2-sulfinamide
1240186-26-8

(R,E)-N-[(2, 8-dichloroquinolin-3-yl)methylidene]-2-methylpropane-2-sulfinamide

Conditions
ConditionsYield
Stage #1: 2,8-dichloroquinoline-3-carbaldehyde With titanium(IV) isopropylate In tetrahydrofuran at 20℃; for 0.25h;
Stage #2: (R)-2-methylpropane-2-sulfinamide at 20℃; for 17h;		97%
Stage #1: 2,8-dichloroquinoline-3-carbaldehyde With titanium(IV) isopropylate In tetrahydrofuran at 20℃; for 0.25h;
Stage #2: (R)-2-methylpropane-2-sulfinamide In tetrahydrofuran at 20℃; for 17h;		97%
Stage #1: 2,8-dichloroquinoline-3-carbaldehyde With titanium(IV) isopropylate In tetrahydrofuran at 20℃; for 0.25h;
Stage #2: (R)-2-methylpropane-2-sulfinamide In tetrahydrofuran at 20℃; for 17h;		97%
2,8-dichloroquinoline-3-carbaldehyde
144918-96-7

2,8-dichloroquinoline-3-carbaldehyde

phenylboronic acid
98-80-6

phenylboronic acid

8-chloro-2-phenylquinoline-3-carbaldehyde
1362850-80-3

8-chloro-2-phenylquinoline-3-carbaldehyde

Conditions
ConditionsYield
With sodium carbonate; tetrakis(triphenylphosphine) palladium(0) In 1,2-dimethoxyethane; water at 110℃; for 4h; Suzuki Coupling; Inert atmosphere;97%
2,8-dichloroquinoline-3-carbaldehyde
144918-96-7

2,8-dichloroquinoline-3-carbaldehyde

(S)-2-methylpropane-2-sulfinamide
343338-28-3

(S)-2-methylpropane-2-sulfinamide

2-methylpropane-2(S)-sulfinic acid N-(2,8-dichloroquinolin-3-yl)meth-(E)-ylideneamide
1362850-84-7

2-methylpropane-2(S)-sulfinic acid N-(2,8-dichloroquinolin-3-yl)meth-(E)-ylideneamide

Conditions
ConditionsYield
Stage #1: (S)-2-methylpropane-2-sulfinamide With potassium phosphate In water for 0.166667h;
Stage #2: 2,8-dichloroquinoline-3-carbaldehyde In water; isopropyl alcohol for 48h;		95%
3-pyridylboronic acid
1692-25-7

3-pyridylboronic acid

2,8-dichloroquinoline-3-carbaldehyde
144918-96-7

2,8-dichloroquinoline-3-carbaldehyde

8-chloro-2-(pyridin-3-yl)quinoline-3-carbaldehyde
1362850-73-4

8-chloro-2-(pyridin-3-yl)quinoline-3-carbaldehyde

Conditions
ConditionsYield
With sodium carbonate; tetrakis(triphenylphosphine) palladium(0) In 1,2-dimethoxyethane; water at 90℃; for 7h; Suzuki Coupling; Inert atmosphere;91%
With tris-(dibenzylideneacetone)dipalladium(0); triethylamine; tri tert-butylphosphoniumtetrafluoroborate In ethanol; water at 70℃; Inert atmosphere;
(R)-2-methylpropane-2-sulfinamide
196929-78-9

(R)-2-methylpropane-2-sulfinamide

2,8-dichloroquinoline-3-carbaldehyde
144918-96-7

2,8-dichloroquinoline-3-carbaldehyde

N-[(2,8-dichloroquinolin-3-yl)methylene]-2-methylpropane-2(R)-sulfinamide
1256280-05-3

N-[(2,8-dichloroquinolin-3-yl)methylene]-2-methylpropane-2(R)-sulfinamide

Conditions
ConditionsYield
titanium(IV) isopropylate In tetrahydrofuran at 20℃; for 17.25h; Inert atmosphere;89%
4,6-dihydroxy-2-mercaptopyrimidine
504-17-6

4,6-dihydroxy-2-mercaptopyrimidine

Chloroacetic anhydride
541-88-8

Chloroacetic anhydride

2,8-dichloroquinoline-3-carbaldehyde
144918-96-7

2,8-dichloroquinoline-3-carbaldehyde

C22H13Cl4N3O8S

C22H13Cl4N3O8S

Conditions
ConditionsYield
With copper In ethanol for 1h; Irradiation;89%
...Expand
2-methyl-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridine
1012084-56-8

2-methyl-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridine

2,8-dichloroquinoline-3-carbaldehyde
144918-96-7

2,8-dichloroquinoline-3-carbaldehyde

8-chloro-2-(2-methylpyridin-3-yl)quinoline-3-carbaldehyde
1065481-93-7

8-chloro-2-(2-methylpyridin-3-yl)quinoline-3-carbaldehyde

Conditions
ConditionsYield
With sodium carbonate; tetrakis(triphenylphosphine) palladium(0) In water; acetonitrile at 100℃; for 3h;86.43%
o-fluorophenylboronic acid
1993-03-9

o-fluorophenylboronic acid

2,8-dichloroquinoline-3-carbaldehyde
144918-96-7

2,8-dichloroquinoline-3-carbaldehyde

8-chloro-2-(2-fluorophenyl)quinoline-3-carbaldehyde
1065481-78-8

8-chloro-2-(2-fluorophenyl)quinoline-3-carbaldehyde

Conditions
ConditionsYield
With sodium carbonate; tetrakis(triphenylphosphine) palladium(0) In water; acetonitrile at 100℃; for 1h;83.1%
4-cyclohexyl-thiosemicarbazide
21198-18-5

4-cyclohexyl-thiosemicarbazide

2,8-dichloroquinoline-3-carbaldehyde
144918-96-7

2,8-dichloroquinoline-3-carbaldehyde

1-((2,8-dichloroquinolin-3-yl)methylene)-4-cyclohexylthiosemicarbazide
1313027-61-0

1-((2,8-dichloroquinolin-3-yl)methylene)-4-cyclohexylthiosemicarbazide

Conditions
ConditionsYield
Stage #1: 4-cyclohexyl-thiosemicarbazide; 2,8-dichloroquinoline-3-carbaldehyde In ethanol
Stage #2: With acetic acid In ethanol at 60℃; for 12h;		81%
thiosemicarbazide
79-19-6

thiosemicarbazide

2,8-dichloroquinoline-3-carbaldehyde
144918-96-7

2,8-dichloroquinoline-3-carbaldehyde

1-((2,8-dichloroquinolin-3-yl)methylene)thiosemicarbazide
1313027-60-9

1-((2,8-dichloroquinolin-3-yl)methylene)thiosemicarbazide

Conditions
ConditionsYield
Stage #1: thiosemicarbazide; 2,8-dichloroquinoline-3-carbaldehyde In ethanol
Stage #2: With acetic acid In ethanol at 60℃; for 12h;		79%
2,8-dichloroquinoline-3-carbaldehyde
144918-96-7

2,8-dichloroquinoline-3-carbaldehyde

4-(4-methylphenyl)-3-thiosemicarbazide
13278-67-6

4-(4-methylphenyl)-3-thiosemicarbazide

1-((2,8-dichloroquinolin-3-yl)methylene)-4-p-tolylthiosemicarbazide
1313027-63-2

1-((2,8-dichloroquinolin-3-yl)methylene)-4-p-tolylthiosemicarbazide

Conditions
ConditionsYield
Stage #1: 2,8-dichloroquinoline-3-carbaldehyde; 4-(4-methylphenyl)-3-thiosemicarbazide In ethanol
Stage #2: With acetic acid In ethanol at 60℃; for 12h;		76%
2,8-dichloroquinoline-3-carbaldehyde
144918-96-7

2,8-dichloroquinoline-3-carbaldehyde

4-cyclopentyl thiosemicarbazide
122813-74-5

4-cyclopentyl thiosemicarbazide

1-((2,8-dichloroquinolin-3-yl)methylene)-4-cyclopentylthiosemicarbazide
1313027-64-3

1-((2,8-dichloroquinolin-3-yl)methylene)-4-cyclopentylthiosemicarbazide

Conditions
ConditionsYield
Stage #1: 2,8-dichloroquinoline-3-carbaldehyde; 4-cyclopentyl thiosemicarbazide In ethanol
Stage #2: With acetic acid In ethanol at 60℃; for 12h;		76%
2,8-dichloroquinoline-3-carbaldehyde
144918-96-7

2,8-dichloroquinoline-3-carbaldehyde

2-trifluoromethoxyphenylboronic acid
175676-65-0

2-trifluoromethoxyphenylboronic acid

8-chloro-2-(2-(trifluoromethoxy)phenyl)quinoline-3-carbaldehyde
1065481-61-9

8-chloro-2-(2-(trifluoromethoxy)phenyl)quinoline-3-carbaldehyde

Conditions
ConditionsYield
With sodium carbonate; tetrakis(triphenylphosphine) palladium(0) In water; acetonitrile at 100℃; for 15h;70.9%
2,8-dichloroquinoline-3-carbaldehyde
144918-96-7

2,8-dichloroquinoline-3-carbaldehyde

6-chloropyridin-3-ylboronic acid
444120-91-6

6-chloropyridin-3-ylboronic acid

8-chloro-2-(6-chloropyridin-3-yl)quinoline-3-carbaldehyde
1362851-52-2

8-chloro-2-(6-chloropyridin-3-yl)quinoline-3-carbaldehyde

Conditions
ConditionsYield
With sodium carbonate; tetrakis(triphenylphosphine) palladium(0) In 1,4-dioxane; water at 90℃; for 16h; Suzuki Coupling; Inert atmosphere;70%
2,8-dichloroquinoline-3-carbaldehyde
144918-96-7

2,8-dichloroquinoline-3-carbaldehyde

4-(2-methylphenyl)-3-thiosemicarbazide
614-10-8

4-(2-methylphenyl)-3-thiosemicarbazide

1-((2,8-dichloroquinolin-3-yl)methylene)-4-o-tolylthiosemicarbazide
1313027-62-1

1-((2,8-dichloroquinolin-3-yl)methylene)-4-o-tolylthiosemicarbazide

Conditions
ConditionsYield
Stage #1: 2,8-dichloroquinoline-3-carbaldehyde; 4-(2-methylphenyl)-3-thiosemicarbazide In ethanol
Stage #2: With acetic acid In ethanol at 60℃; for 12h;		69%
4-(4-nitrophenyl)-3-thiosemicarbazide
38985-70-5

4-(4-nitrophenyl)-3-thiosemicarbazide

2,8-dichloroquinoline-3-carbaldehyde
144918-96-7

2,8-dichloroquinoline-3-carbaldehyde

1-((2,8-dichloroquinolin-3-yl)methylene)-4-p-nitrophenylthiosemicarbazide
1313027-73-4

1-((2,8-dichloroquinolin-3-yl)methylene)-4-p-nitrophenylthiosemicarbazide

Conditions
ConditionsYield
Stage #1: 4-(4-nitrophenyl)-3-thiosemicarbazide; 2,8-dichloroquinoline-3-carbaldehyde In ethanol
Stage #2: With acetic acid In ethanol at 60℃; for 12h;		67%
2-methoxy-6-(tri-n-butylstannyl)pyrazine
1105511-66-7

2-methoxy-6-(tri-n-butylstannyl)pyrazine

2,8-dichloroquinoline-3-carbaldehyde
144918-96-7

2,8-dichloroquinoline-3-carbaldehyde

8-chloro-2-(6-methoxypyrazin-2-yl)quinoline-3-carbaldehyde
1362850-98-3

8-chloro-2-(6-methoxypyrazin-2-yl)quinoline-3-carbaldehyde

Conditions
ConditionsYield
tetrakis(triphenylphosphine) palladium(0) In 1,4-dioxane at 110℃; Inert atmosphere;63%
2,8-dichloroquinoline-3-carbaldehyde
144918-96-7

2,8-dichloroquinoline-3-carbaldehyde

C8H15NHCSNHNH2
122813-76-7

C8H15NHCSNHNH2

1-((2,8-dichloroquinolin-3-yl)methylene)-4-cyclooctylthiosemicarbazide
1313027-67-6

1-((2,8-dichloroquinolin-3-yl)methylene)-4-cyclooctylthiosemicarbazide

Conditions
ConditionsYield
Stage #1: 2,8-dichloroquinoline-3-carbaldehyde; C8H15NHCSNHNH2 In ethanol
Stage #2: With acetic acid In ethanol at 60℃; for 12h;		62%
(5-fluoro-2-(trifluoromethyl)phenyl)boronic acid
928053-97-8

(5-fluoro-2-(trifluoromethyl)phenyl)boronic acid

2,8-dichloroquinoline-3-carbaldehyde
144918-96-7

2,8-dichloroquinoline-3-carbaldehyde

8-chloro-2-(5-fluoro-2-(trifluoromethyl)phenyl)quinoline-3-carbaldehyde
1065481-66-4

8-chloro-2-(5-fluoro-2-(trifluoromethyl)phenyl)quinoline-3-carbaldehyde

Conditions
ConditionsYield
With sodium carbonate; tetrakis(triphenylphosphine) palladium(0) In water; acetonitrile at 100℃; for 14h;19.4%
2-(trifluoromethyl)phenylboronic acid
1423-27-4

2-(trifluoromethyl)phenylboronic acid

2,8-dichloroquinoline-3-carbaldehyde
144918-96-7

2,8-dichloroquinoline-3-carbaldehyde

8-chloro-2-(2-(trifluoromethyl)phenyl)quinoline-3-carbaldehyde
1064136-74-8

8-chloro-2-(2-(trifluoromethyl)phenyl)quinoline-3-carbaldehyde

Conditions
ConditionsYield
With sodium carbonate; tetrakis(triphenylphosphine) palladium(0) In water; acetonitrile at 100℃;
(5-fluoro-2-methoxyphenyl)boronic acid
179897-94-0

(5-fluoro-2-methoxyphenyl)boronic acid

2,8-dichloroquinoline-3-carbaldehyde
144918-96-7

2,8-dichloroquinoline-3-carbaldehyde

8-chloro-2-(5-fluoro-2-methoxyphenyl)quinoline-3-carbaldehyde
1065481-40-4

8-chloro-2-(5-fluoro-2-methoxyphenyl)quinoline-3-carbaldehyde

Conditions
ConditionsYield
With sodium carbonate; tetrakis(triphenylphosphine) palladium(0) In water; acetonitrile at 100℃; for 4h;
2,8-dichloroquinoline-3-carbaldehyde
144918-96-7

2,8-dichloroquinoline-3-carbaldehyde

(S)-tert-butyl 1-(2,8-dichloroquinolin-3-yl)ethylcarbarnate
1240186-30-4

(S)-tert-butyl 1-(2,8-dichloroquinolin-3-yl)ethylcarbarnate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: titanium(IV) isopropylate / tetrahydrofuran / 0.25 h / 20 °C
1.2: 17 h / 20 °C
2.1: dichloromethane; diethyl ether / -70 - 20 °C / Inert atmosphere
2.2: Cooling with ice
3.1: hydrogenchloride / 1,4-dioxane; methanol / 2 h / 20 °C
4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C
View Scheme
Multi-step reaction with 4 steps
1.1: titanium(IV)isopropoxide / tetrahydrofuran / 0.25 h / 20 °C
1.2: 17 h / 20 °C
2.1: dichloromethane; diethyl ether / -70 - 20 °C / Inert atmosphere
3.1: hydrogenchloride / 1,4-dioxane; methanol / 2 h
4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C
View Scheme
Multi-step reaction with 4 steps
1.1: titanium(IV) isopropylate / tetrahydrofuran / 0.25 h / 20 °C / Inert atmosphere
1.2: 17 h / 20 °C / Inert atmosphere
2.1: dichloromethane; diethyl ether / -70 - 20 °C / Inert atmosphere
2.2: cooling with ice-salt
3.1: hydrogenchloride / 1,4-dioxane; methanol / 2 h / 20 °C / Inert atmosphere
4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C / Inert atmosphere
View Scheme
2,8-dichloroquinoline-3-carbaldehyde
144918-96-7

2,8-dichloroquinoline-3-carbaldehyde

(R)-N-[(S)-1-(2,8-dichloroquinolin-3-yl)ethyl]-2-methylpropane-2-sulfinamide
1240186-28-0

(R)-N-[(S)-1-(2,8-dichloroquinolin-3-yl)ethyl]-2-methylpropane-2-sulfinamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: titanium(IV) isopropylate / tetrahydrofuran / 0.25 h / 20 °C
1.2: 17 h / 20 °C
2.1: dichloromethane; diethyl ether / -70 - 20 °C / Inert atmosphere
2.2: Cooling with ice
View Scheme
Multi-step reaction with 2 steps
1.1: titanium(IV)isopropoxide / tetrahydrofuran / 0.25 h / 20 °C
1.2: 17 h / 20 °C
2.1: dichloromethane; diethyl ether / -70 - 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1.1: titanium(IV) isopropylate / tetrahydrofuran / 0.25 h / 20 °C / Inert atmosphere
1.2: 17 h / 20 °C / Inert atmosphere
2.1: dichloromethane; diethyl ether / -70 - 20 °C / Inert atmosphere
2.2: cooling with ice-salt
View Scheme
2,8-dichloroquinoline-3-carbaldehyde
144918-96-7

2,8-dichloroquinoline-3-carbaldehyde

(S)-1-(2,8-dichloroquinolin-3-yl)ethanamine
1240186-29-1

(S)-1-(2,8-dichloroquinolin-3-yl)ethanamine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: titanium(IV) isopropylate / tetrahydrofuran / 0.25 h / 20 °C
1.2: 17 h / 20 °C
2.1: dichloromethane; diethyl ether / -70 - 20 °C / Inert atmosphere
2.2: Cooling with ice
3.1: hydrogenchloride / 1,4-dioxane; methanol / 2 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: titanium(IV)isopropoxide / tetrahydrofuran / 0.25 h / 20 °C
1.2: 17 h / 20 °C
2.1: dichloromethane; diethyl ether / -70 - 20 °C / Inert atmosphere
3.1: hydrogenchloride / 1,4-dioxane; methanol / 2 h
View Scheme
Multi-step reaction with 3 steps
1.1: titanium(IV) isopropylate / tetrahydrofuran / 0.25 h / 20 °C / Inert atmosphere
1.2: 17 h / 20 °C / Inert atmosphere
2.1: dichloromethane; diethyl ether / -70 - 20 °C / Inert atmosphere
2.2: cooling with ice-salt
3.1: hydrogenchloride / 1,4-dioxane; methanol / 2 h / 20 °C / Inert atmosphere
View Scheme
2,8-dichloroquinoline-3-carbaldehyde
144918-96-7

2,8-dichloroquinoline-3-carbaldehyde

C23H32ClN5O3
1242181-15-2

C23H32ClN5O3

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: titanium(IV) isopropylate / tetrahydrofuran / 0.25 h / 20 °C
1.2: 17 h / 20 °C
2.1: dichloromethane; diethyl ether / -70 - 20 °C / Inert atmosphere
2.2: Cooling with ice
3.1: hydrogenchloride / 1,4-dioxane; methanol / 2 h / 20 °C
4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C
5.1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 2 h / 130 °C / microwave irradiation
View Scheme

2,8-Dichloroquinoline-3-carboxaldehyde Specification

The 2,8-Dichloroquinoline-3-carboxaldehyde has the CAS registry number 144918-96-7. This chemical's molecular formula is C10H5Cl2NO and molecular weight is 226.06. What's more, its systematic name is 2,8-dichloroquinoline-3-carbaldehyde.

Physical properties of 2,8-Dichloroquinoline-3-carboxaldehyde are: (1)ACD/LogP: 3.07; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 3.07; (4)ACD/LogD (pH 7.4): 3.07; (5)ACD/BCF (pH 5.5): 127.31; (6)ACD/BCF (pH 7.4): 127.31; (7)ACD/KOC (pH 5.5): 1117.57; (8)ACD/KOC (pH 7.4): 1117.57; (9)#H bond acceptors: 2; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 1; (12)Polar Surface Area: 29.96 Å2; (13)Index of Refraction: 1.697 ; (14)Molar Refractivity: 58.72 cm3; (15)Molar Volume: 152.3 cm3; (16)Polarizability: 23.28×10-24cm3; (17)Surface Tension: 58.9 dyne/cm; (18)Density: 1.483 g/cm3; (19)Flash Point: 170.4 °C; (20)Enthalpy of Vaporization: 60.35 kJ/mol; (21)Boiling Point: 358.1 °C at 760 mmHg; (22)Vapour Pressure: 2.61E-05 mmHg at 25°C.

Preparation of 2,8-Dichloroquinoline-3-carboxaldehyde: this chemical can be prepared by N,N-dimethyl-formamide and acetic acid-(2-chloro-anilide) by heating. This reaction will need reagents POCl3, Triton X-100 and solvent acetonitrile with the reaction time of 85 min. The yield is about 88%.

2,8-Dichloroquinoline-3-carboxaldehyde　can be prepared by N,N-dimethyl-formamide and acetic acid-(2-chloro-anilide) by heating

You can still convert the following datas into molecular structure:
(1)SMILES: Clc1cccc2cc(C=O)c(Cl)nc12
(2)InChI: InChI=1S/C10H5Cl2NO/c11-8-3-1-2-6-4-7(5-14)10(12)13-9(6)8/h1-5H
(3)InChIKey: LPMXEZKNTOGEMM-UHFFFAOYSA-N

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