<2-(trimethylsilyloxy)ethyl>urea
(2-hydroxyethyl)urea
Conditions | Yield |
---|---|
With methanol; water for 1h; Heating; | 100% |
N-<2-(trimethylsiloxy)ethyl>-N'-(trimethylsilyl)urea
(2-hydroxyethyl)urea
Conditions | Yield |
---|---|
With methanol; water for 1h; Heating; | 100% |
Conditions | Yield |
---|---|
In ethanol for 48h; | 85% |
Conditions | Yield |
---|---|
Stage #1: potassium cyanate; ethanolamine In water for 0.333333h; Heating; Stage #2: With hydrogenchloride In water at 20℃; for 7h; | 80% |
With hydrogenchloride In water |
Conditions | Yield |
---|---|
With ammonia In formic acid at 115℃; for 3.5h; Temperature; Industrial scale; | 78% |
In N,N-dimethyl-formamide at 105℃; for 24h; |
Conditions | Yield |
---|---|
In water at 85 - 90℃; for 1h; | 68% |
In water |
oxirane
urea
A
dimethylenecyclourethane
B
(2-hydroxyethyl)urea
C
carbamic acid-(2-amino-ethyl ester)
Conditions | Yield |
---|---|
at 136℃; |
oxirane
urea
A
(2-hydroxyethyl)urea
B
carbamic acid-(2-amino-ethyl ester)
Conditions | Yield |
---|---|
at 136℃; |
Conditions | Yield |
---|---|
With sodium tetrahydroborate In ethanol |
Conditions | Yield |
---|---|
mit hilfe eines Ionen-Austauschers; |
(2-hydroxyethyl)urea
bis(tri-n-butyltin)oxide
N-(tributylstannyl)-N'-(2-(tributylstannyloxy)ethyl)urea
Conditions | Yield |
---|---|
In neat (no solvent) byproducts: H2O; at 160-190°C, evacuation down to 2mm for 1 h; elem. anal.; | 95% |
Conditions | Yield |
---|---|
With hydrogenchloride; water In isopropyl alcohol for 0.333333h; Reflux; regioselective reaction; | 93% |
(2-hydroxyethyl)urea
1,3-dimethyl-4,5-dihydroxy-4,5-diphenylimidazolidin-2-one
Conditions | Yield |
---|---|
With hydrogenchloride In methanol; water for 1h; Reflux; | 90% |
(2-hydroxyethyl)urea
4,5-dihydroxy-1,3-diethyl-4,5-diphenylimidazolidine-2-thione
4,6-diethyl-1-(2-hydroxyethyl)-3a,6a-diphenyl-5-thioxooctahydroimidazo[4,5-d]imidazol-2-one
Conditions | Yield |
---|---|
With hydrogenchloride In methanol; water for 2h; Reflux; | 90% |
(2-hydroxyethyl)urea
Conditions | Yield |
---|---|
With hydrogenchloride In water; acetonitrile for 0.333333h; Reflux; regioselective reaction; | 76% |
(2-hydroxyethyl)urea
Conditions | Yield |
---|---|
With hydrogenchloride In water; acetonitrile for 0.333333h; Reflux; regioselective reaction; | 74% |
Conditions | Yield |
---|---|
With ethylene glycol at 160℃; for 1h; | 70% |
(2-hydroxyethyl)urea
4,5-dihydroxy-1,3-dimethyl-4,5-diphenyltetrahydroimidazole-2-thione
1-(2-hydroxyethyl)-4,6-dimethyl-3a,6a-diphenyl-5-thioxooctahydroimidazo[4,5-d]imidazol-2-one
Conditions | Yield |
---|---|
With hydrogenchloride In methanol; water for 2h; Reflux; | 68% |
Conditions | Yield |
---|---|
With hydrogenchloride; water In isopropyl alcohol for 2h; Reflux; regioselective reaction; | 68% |
(2-hydroxyethyl)urea
ethyl 2-cyanoacetate
6-amino-1-β-hydroxyethyluracil
Conditions | Yield |
---|---|
With sodium In ethanol for 10h; Heating; | 67% |
With sodium In ethanol Cooling with ice; Reflux; | 59.4% |
With ethanol; sodium ethanolate |
Conditions | Yield |
---|---|
With hydrogenchloride In water for 1h; pH=1 - 2; Heating; | 55% |
(2-hydroxyethyl)urea
4,5-dihydroxy-2-imidazolidinone
A
2,4-imidazolidinedione
B
2-(2-hydroxyethyl)-2,4,6,8-tetraazabicyclo[3.3.0]octane-3,7-dione
Conditions | Yield |
---|---|
With hydrogenchloride In water at 85℃; for 1h; pH=1 - 2; | A n/a B 55% |
(2-hydroxyethyl)urea
1-benzyl-3,5-dichloro-6-methylpyrazin-2(1H)-one
Conditions | Yield |
---|---|
With palladium diacetate; caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In 1,2-dimethoxyethane at 80 - 100℃; Microwave irradiation; | 50% |
(2-hydroxyethyl)urea
2,2-dimethylpenta-3,4-dienal oxime
benzaldehyde
N-[2-({3,3-dimethyl-1-oxido-5-[(E)-2-(phenyl)vinyl]-3,4-dihydro-2H-pyrrol-2-yl}oxy)ethyl]urea
Conditions | Yield |
---|---|
With potassium tert-butylate In tert-butyl alcohol at 80℃; for 2.5h; Inert atmosphere; | 46% |
(2-hydroxyethyl)urea
3-Nitrosooxazolidin-2-one
Conditions | Yield |
---|---|
With nitrosylchloride In chloroform | 42% |
With nitrosylchloride In chloroform at 0℃; Product distribution; other reagents; | 42% |
(2-hydroxyethyl)urea
1,1,1,3,3,3-hexamethyl-disilazane
A
trimethylsilyl isocyanate
B
N-<2-(trimethylsiloxy)ethyl>-N'-(trimethylsilyl)urea
Conditions | Yield |
---|---|
With sulfuric acid at 120 - 152℃; for 6h; | A 39% B 36% |
Conditions | Yield |
---|---|
With hydrogenchloride; water for 2h; Reflux; diastereoselective reaction; | A 38% B 14% |
The Urea,N-(2-hydroxyethyl)- with CAS registry number 2078-71-9 belongs to the classes of Carbonyl Compounds; Organic Building Blocks; Ureas. The IUPAC name is 1-(2-hydroxyethyl)urea. In addition, the molecular formula is C3H8N2O2 and the molecular weight is 104.108.
Physical properties about this chemical are: (1)ACD/LogP: -1.86; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -1.86; (4)ACD/LogD (pH 7.4): -1.86; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 2.33; (8)ACD/KOC (pH 7.4): 2.33; (9)#H bond acceptors: 4; (10)#H bond donors: 4; (11)#Freely Rotating Bonds: 3; (12)Polar Surface Area: 32.78 Å2; (13)Index of Refraction: 1.49; (14)Molar Refractivity: 24.64 cm3; (15)Molar Volume: 85.1 cm3; (16)Polarizability: 9.76×10-24cm3; (17)Surface Tension: 53.4 dyne/cm; (18)Density: 1.222 g/cm3; (19)Flash Point: 107.6 °C; (20)Enthalpy of Vaporization: 57.13 kJ/mol; (21)Boiling Point: 254.3 °C at 760 mmHg; (22)Vapour Pressure: 0.00266 mmHg at 25°C.
Preparation of Urea,N-(2-hydroxyethyl)-: it can be prepared by Ethanolamine and Carbamide. You can add the diethanolamine into the reaction pot at first, then add the ureawith with stirring. You should heat the mixture to 110-115 °C for 4 hours, cool the product at last.
Uses of Urea,N-(2-hydroxyethyl)-: it can be used for the intermediate of Furazolidone. And it can be used to produce 3-nitroso-oxazolidin-2-one. This reaction will need reagent NOCl and solvent CHCl3. The yield is about 42% at reaction temperature of 0 °C.
When you are using this chemical, please be cautious about it as the following:
It irritates to eyes, respiratory system and skin. When use it, you should wear suitable protective clothing, gloves and eye/face protection. If contact with eyes, rinse immediately with plenty of water and seek medical advice.
You can still convert the following datas into molecular structure:
(1)SMILES: O=C(N)NCCO
(2)InChI: InChI=1/C3H8N2O2/c4-3(7)5-1-2-6/h6H,1-2H2,(H3,4,5,7)
(3)InChIKey: CLAHOZSYMRNIPY-UHFFFAOYAJ
The toxicity data is as follows:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LDLo | intraperitoneal | 7280mg/kg (7280mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Journal of Pharmacology and Experimental Therapeutics. Vol. 54, Pg. 188, 1935 |
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