Conditions | Yield |
---|---|
With sodium anthraquinone-2-sulfonate; trifluoroacetic acid; sodium bromide In water; acetonitrile at 20℃; for 4h; Irradiation; Sealed tube; regioselective reaction; | 93% |
With tribromo-isocyanuric acid In acetonitrile at 25℃; regioselective reaction; | 84% |
With chloroform; bromine | |
With bromine; acetic acid |
Conditions | Yield |
---|---|
With acetic acid In water for 0.5h; | 89% |
With acetic acid In water at 50℃; for 2h; | 78.8% |
In water; acetic acid at 20℃; |
Conditions | Yield |
---|---|
With hydrogenchloride In water for 0.25h; Heating; | 81% |
With hydrogenchloride In water at 20℃; for 12h; Inert atmosphere; | 80% |
With acetic acid In water for 1h; | 76.7% |
Conditions | Yield |
---|---|
With [bis(acetoxy)iodo]benzene; ammonia In methanol at 0 - 20℃; for 2h; Hofmann Rearrangement; Inert atmosphere; | 73% |
4-bromophenylurea
Conditions | Yield |
---|---|
In diethyl ether; water | 50% |
Conditions | Yield |
---|---|
at 140℃; | |
at 140℃; |
C7H6BrN3O2
4-bromophenylurea
Conditions | Yield |
---|---|
chloromethyl formate In methanol; water at 25℃; Rate constant; Thermodynamic data; μ=1.0 mol*l-1; ΔH(excit.), -ΔS(excit.); |
Conditions | Yield |
---|---|
With acetic acid |
Conditions | Yield |
---|---|
With acetic acid |
Conditions | Yield |
---|---|
With acetic acid at 20℃; |
N-trimethylsilyl-N'-phenylurea
4-bromophenylurea
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 64 percent / N-bromosuccinimide / tetrahydrofuran / 4 h / 100 °C 2: 50 percent / H2O; diethyl ether View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: NaOH-solution 2: diluted hydrochloric acid View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: natrium carbonate; chloroform / und Kochen des Produktes mit Wasser 2: glacial acetic acid; bromine View Scheme |
Conditions | Yield |
---|---|
In dichloromethane at 20℃; for 6h; |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: ammonia / hexane / 25 °C / Cooling with ice 2: tribromo-isocyanuric acid / acetonitrile / 25 °C View Scheme |
Conditions | Yield |
---|---|
With acetic acid In water at 20℃; |
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 0.08 h / 0 °C / Inert atmosphere 2: sodium azide; dmap / toluene; N,N-dimethyl-formamide / Inert atmosphere 3: ammonium hydroxide / toluene; N,N-dimethyl-formamide; water / 90 °C / Inert atmosphere View Scheme |
4-bromophenylurea
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium azide; dmap / toluene; N,N-dimethyl-formamide / Inert atmosphere 2: ammonium hydroxide / toluene; N,N-dimethyl-formamide; water / 90 °C / Inert atmosphere View Scheme |
p-bromobenzoyl azide
4-bromophenylurea
Conditions | Yield |
---|---|
With ammonium hydroxide In water; N,N-dimethyl-formamide; toluene at 90℃; Curtius Rearrangement; Inert atmosphere; | 148 mg |
4-bromophenylurea
Conditions | Yield |
---|---|
With Nitrogen dioxide In 1,4-dioxane at 15 - 30℃; for 4h; | 95% |
With tributyl phosphate-NO2 In various solvent(s) at 10 - 15℃; | 86% |
Conditions | Yield |
---|---|
With pyridine at 20℃; Schlenk technique; | 91% |
With pyridine at 25℃; for 1.08333h; Sealed tube; Inert atmosphere; | 44% |
With pyridine |
4-bromophenylurea
diethyl malonate
1-(4-bromophenyl)pyrimidine-2,4,6(1H,3H,5H)-trione
Conditions | Yield |
---|---|
Stage #1: diethyl malonate With methanol; sodium for 0.0833333h; Stage #2: 4-bromophenylurea In methanol for 6h; Reflux; | 89% |
With sodium In ethanol for 35h; Reflux; | 59% |
4-bromophenylurea
ethyl 2-isothiocyanato-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate
Conditions | Yield |
---|---|
In ethanol Heating; | 87% |
Conditions | Yield |
---|---|
With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; sodium hydroxide In tert-Amyl alcohol at 110℃; for 12h; Schlenk technique; Green chemistry; | 82% |
Conditions | Yield |
---|---|
With sodium acetate In ethanol Heating; | 80% |
Conditions | Yield |
---|---|
With sodium acetate In ethanol Heating; | 80% |
Conditions | Yield |
---|---|
With sodium hydroxide; hydrazine hydrate In ethanol for 3h; Heating; | 78% |
With ethanol; hydrazine hydrate | |
With hydrazine hydrate; sodium hydroxide In ethanol Reflux; |
Conditions | Yield |
---|---|
Stage #1: ethyl 2-diazo-3-oxobutanoate; 4-bromophenylurea With rhodium (II) octanoate dimer In 1,2-dichloro-ethane; toluene at 80℃; for 1.5h; Stage #2: With trifluoroacetic acid In 1,2-dichloro-ethane; toluene at 20℃; for 0.5h; | 75.2% |
Conditions | Yield |
---|---|
With potassium hydroxide at 135℃; for 24h; Sealed tube; Schlenk technique; Green chemistry; | 75% |
Conditions | Yield |
---|---|
With potassium hydroxide at 135℃; for 24h; Schlenk technique; | 65% |
ethyl 2-(4-chloro-6-(2-oxo-2H-chromen-4-yloxy)-1,3,5-triazin-2-ylamino)acetate
4-bromophenylurea
ethyl 2-(4-(2-oxo-2H-chromen-4-yloxy)-6-(3-(4-bromophenyl)ureido)-1,3,5-triazin-2-ylamino)acetate
Conditions | Yield |
---|---|
In 1,4-dioxane for 4h; Reflux; | 63% |
Conditions | Yield |
---|---|
With potassium hydroxide at 135℃; for 24h; Schlenk technique; | 63% |
4-bromophenylglyoxal
4-bromophenylurea
1,5-bis-(4-bromo-phenyl)-imidazolidine-2,4-dione
Conditions | Yield |
---|---|
With hydrogenchloride; acetic acid for 4h; Heating; | 62% |
phenylglyoxal hydrate
4-bromophenylurea
1-(4-bromo-phenyl)-5-phenyl-imidazolidine-2,4-dione
Conditions | Yield |
---|---|
With hydrogenchloride; acetic acid for 4h; Heating; | 60% |
Conditions | Yield |
---|---|
With sodium ethanolate In ethanol for 12h; Heating; | 58% |
Conditions | Yield |
---|---|
Stage #1: 4-bromophenylurea; (4-CF3C6H4)COC(N2)COO-JandaJel hydroxypentyl resin With rhodium (II) octanoate dimer In 1,2-dichloro-ethane; toluene at 80℃; for 0.5h; Stage #2: With trifluoroacetic acid at 20℃; for 0.5h; Stage #3: sodium methylate In tetrahydrofuran; methanol at 50℃; for 1h; | 57% |
4-(4-chloro-6-(3,4-dimethoxyphenethylamino)-1,3,5-triazin-2-yloxy)-2H-chromen-2-one
4-bromophenylurea
1-(4-bromophenyl)-3-(4-(3,4-dimethoxyphenethylamino)-6-(2-oxo-2H-chromen-4-yloxy)-1,3,5-triazin-2-yl)urea
Conditions | Yield |
---|---|
In 1,4-dioxane for 4h; Reflux; | 56% |
4-bromophenylurea
1-benzyl-3,5-dichloro-6-methylpyrazin-2(1H)-one
Conditions | Yield |
---|---|
With palladium diacetate; caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In 1,2-dimethoxyethane at 80 - 100℃; Microwave irradiation; | 56% |
Conditions | Yield |
---|---|
With potassium hydroxide In dimethyl sulfoxide microwave irradiation; | 50% |
4-bromophenylurea
4,4'-dibromobenzil
Conditions | Yield |
---|---|
With potassium hydroxide In dimethyl sulfoxide microwave irradiation; | 48% |
With potassium hydroxide In dimethyl sulfoxide microwave irradiation; |
Conditions | Yield |
---|---|
With potassium hydroxide In dimethyl sulfoxide microwave irradiation; | 47% |
With potassium hydroxide In dimethyl sulfoxide microwave irradiation; |
The Urea,N-(4-bromophenyl)-, with the CAS registry number 1967-25-5, is also known as 1-(4-Bromophenyl)urea. This chemical's molecular formula is C7H7BrN2O and molecular weight is 215.05. What's more, its IUPAC name is called (4-Bromophenyl)urea.
Physical properties about Urea,N-(4-bromophenyl)- are: (1) ACD/LogP: 1.98; (2) # of Rule of 5 Violations: 0; (3) ACD/LogD (pH 5.5): 1.98; (4) ACD/LogD (pH 7.4): 1.98; (5) ACD/BCF (pH 5.5): 18.83; (6) ACD/BCF (pH 7.4): 18.83; (7) ACD/KOC (pH 5.5): 284.52; (8) ACD/KOC (pH 7.4): 284.52; (9) #H bond acceptors: 3; (10) #H bond donors: 3; (11) #Freely Rotating Bonds: 1; (12) Polar Surface Area: 23.55 Å2; (13) Index of Refraction: 1.671; (14) Molar Refractivity: 47.11 cm3; (15) Molar Volume: 125.8 cm3; (16) Surface Tension: 60.3 dyne/cm; (17) Density: 1.708 g/cm3; (18) Flash Point: 129.7 °C; (19) Enthalpy of Vaporization: 53.02 kJ/mol; (20) Boiling Point: 290.9 °C at 760 mmHg; (21) Vapour Pressure: 0.00202 mmHg at 25 °C; (22) Melting Point: 225-227 °C.
Uses of Urea,N-(4-bromophenyl)-: it is used to produce other chemicals. For example, it is used to produce 4-(4-Bromo-phenyl)-semicarbazide. The reaction occurs with reagent NH2NH2·H2O, NaOH, solvent Ethanol and other condition of heating for 3 hours. The yield is 78 %.
When you are dealing with this chemical, you should be very careful. The gas of this chemical can not be breathed. In addition, you should avoid contacting with skin and eyes.
You can still convert the following datas into molecular structure:
(1) SMILES: Brc1ccc(NC(=O)N)cc1
(2) InChI: InChI=1/C7H7BrN2O/c8-5-1-3-6(4-2-5)10-7(9)11/h1-4H,(H3,9,10,11)
(3) InChIKey: PFQUUCXMPUNRLA-UHFFFAOYAM
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