5,6-Diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride supplier

Name
5,6-Diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride
EINECS
CAS No. 312753-53-0
Density
Solubility
Melting Point >250 °C
Formula C₁₃H₁₉N^.HCl
Boiling Point 285.2 °C at 760 mmHg
Molecular Weight 225.762
Flash Point 127.6 °C
Transport Information
Appearance
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms 5,6-diethylindan-2-ylamine hydrochloride;5,6-diethylindan-1-one;diethylindanolamine hydrochloride;2-amino-5,6-diethylindane hydrochloride;5,6-Diethyl-2,3-dihydro-1H-inden-2-aminehydrochloride;2-amino-5,6-diethylindan hydrochloride;
PSA 26.02000
LogP 3.73960

Synthetic route

: C15H21NO

: 312753-53-0
5,6-diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In water for 10h; Reflux;	92.6%

: C13H17N3

: 312753-53-0
5,6-diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride

Conditions

Conditions	Yield
Stage #1: C13H17N3 With palladium 10% on activated carbon; hydrogen In methanol under 3800.26 Torr; Autoclave; Stage #2: With hydrogenchloride In ethyl acetate	92%

: 312753-70-1
5,6-diethyl-2,3-dihydro-1H-inden-2-amine

: 312753-53-0
5,6-diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In diethyl ether under 760.051 Torr; Inert atmosphere;	77%
With hydrogenchloride In Isopropyl acetate at 20 - 25℃; for 2.66667h;	70.8 g

: 5,6-diethyl-3-oxime-1H-indene-1,2(3H)-dione

: 312753-53-0
5,6-diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride

Conditions

Conditions	Yield
Stage #1: 5,6-diethyl-3-oxime-1H-indene-1,2(3H)-dione With sulfuric acid; hydrogen; 5%-palladium/activated carbon In acetic acid for 5h; Stage #2: With sodium hydroxide pH=10; Stage #3: With hydrogenchloride In diethyl ether

: 601487-90-5
N-(5,6-diethyl-2,3-dihydro-1H-inden-2-yl)-2,2,2-trifluoroacetamide

: 312753-53-0
5,6-diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In Isopropyl acetate; water

: 193756-44-4
N-(2,3-dihydro-1H-inden-2-yl)-2,2,2-trifluoroacetamide

: 312753-53-0
5,6-diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 1.1: aluminum (III) chloride / neat (no solvent) / 0.25 h / 0 - 5 °C 1.2: 255 / 1 h / 0 - 10 °C 2.1: hydrogen; 5%-palladium/activated carbon / ethanol; water / 25 °C / 2250.23 Torr / Inert atmosphere 3.1: aluminum (III) chloride / dichloromethane / 0.75 h / 0 °C 3.2: 1 h / 0 - 5 °C 4.1: palladium 10% on activated carbon / water; ethyl acetate / 0.17 h / 25 °C / 2828.7 Torr / Inert atmosphere 5.1: sodium hydroxide / ethanol / 1.5 h / 78 °C / Inert atmosphere 6.1: hydrogenchloride / Isopropyl acetate / 2.67 h / 20 - 25 °C View Scheme

Yield

Multi-step reaction with 6 steps
1.1: aluminum (III) chloride / neat (no solvent) / 0.25 h / 0 - 5 °C
1.2: 255 / 1 h / 0 - 10 °C
2.1: hydrogen; 5%-palladium/activated carbon / ethanol; water / 25 °C / 2250.23 Torr / Inert atmosphere
3.1: aluminum (III) chloride / dichloromethane / 0.75 h / 0 °C
3.2: 1 h / 0 - 5 °C
4.1: palladium 10% on activated carbon / water; ethyl acetate / 0.17 h / 25 °C / 2828.7 Torr / Inert atmosphere
5.1: sodium hydroxide / ethanol / 1.5 h / 78 °C / Inert atmosphere
6.1: hydrogenchloride / Isopropyl acetate / 2.67 h / 20 - 25 °C
View Scheme

: 601487-87-0
N-(5-acetyl-2,3-dihydro-1H-inden-2-yl)-2,2,2-trifluoroacetamide

: 312753-53-0
5,6-diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1.1: hydrogen; 5%-palladium/activated carbon / ethanol; water / 25 °C / 2250.23 Torr / Inert atmosphere 2.1: aluminum (III) chloride / dichloromethane / 0.75 h / 0 °C 2.2: 1 h / 0 - 5 °C 3.1: palladium 10% on activated carbon / water; ethyl acetate / 0.17 h / 25 °C / 2828.7 Torr / Inert atmosphere 4.1: sodium hydroxide / ethanol / 1.5 h / 78 °C / Inert atmosphere 5.1: hydrogenchloride / Isopropyl acetate / 2.67 h / 20 - 25 °C View Scheme

Yield

Multi-step reaction with 5 steps
1.1: hydrogen; 5%-palladium/activated carbon / ethanol; water / 25 °C / 2250.23 Torr / Inert atmosphere
2.1: aluminum (III) chloride / dichloromethane / 0.75 h / 0 °C
2.2: 1 h / 0 - 5 °C
3.1: palladium 10% on activated carbon / water; ethyl acetate / 0.17 h / 25 °C / 2828.7 Torr / Inert atmosphere
4.1: sodium hydroxide / ethanol / 1.5 h / 78 °C / Inert atmosphere
5.1: hydrogenchloride / Isopropyl acetate / 2.67 h / 20 - 25 °C
View Scheme

: 601487-88-1
N-(5-ethyl-2,3-dihydro-1H-inden-2-yl)-2,2,2-trifluoroacetamide

: 312753-53-0
5,6-diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1.1: aluminum (III) chloride / dichloromethane / 0.75 h / 0 °C 1.2: 1 h / 0 - 5 °C 2.1: palladium 10% on activated carbon / water; ethyl acetate / 0.17 h / 25 °C / 2828.7 Torr / Inert atmosphere 3.1: sodium hydroxide / ethanol / 1.5 h / 78 °C / Inert atmosphere 4.1: hydrogenchloride / Isopropyl acetate / 2.67 h / 20 - 25 °C View Scheme

: 601487-89-2
N-(5-acetyl-6-ethyl-2,3-dihydro-1H-inden-2-yl)-2,2,2-trifluoroacetamide

: 312753-53-0
5,6-diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: palladium 10% on activated carbon / water; ethyl acetate / 0.17 h / 25 °C / 2828.7 Torr / Inert atmosphere 2: sodium hydroxide / ethanol / 1.5 h / 78 °C / Inert atmosphere 3: hydrogenchloride / Isopropyl acetate / 2.67 h / 20 - 25 °C View Scheme

: 2975-41-9
2,3-dihydro-1H-inden-2-amine

: 312753-53-0
5,6-diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 7 steps 1.1: Isopropyl acetate / 3.17 h / 0 - 25 °C 2.1: aluminum (III) chloride / neat (no solvent) / 0.25 h / 0 - 5 °C 2.2: 255 / 1 h / 0 - 10 °C 3.1: hydrogen; 5%-palladium/activated carbon / ethanol; water / 25 °C / 2250.23 Torr / Inert atmosphere 4.1: aluminum (III) chloride / dichloromethane / 0.75 h / 0 °C 4.2: 1 h / 0 - 5 °C 5.1: palladium 10% on activated carbon / water; ethyl acetate / 0.17 h / 25 °C / 2828.7 Torr / Inert atmosphere 6.1: sodium hydroxide / ethanol / 1.5 h / 78 °C / Inert atmosphere 7.1: hydrogenchloride / Isopropyl acetate / 2.67 h / 20 - 25 °C View Scheme
Multi-step reaction with 6 steps 1.1: triethylamine / dichloromethane / 2 h / 10 - 20 °C 2.1: aluminum (III) chloride / dichloromethane / 0.33 h / 0 - 10 °C 2.2: 1 h / 10 - 20 °C 3.1: 5%-palladium/activated carbon; hydrogen / ethanol / 6 h / 20 °C 4.1: aluminum (III) chloride / dichloromethane / 0.33 h / 0 - 10 °C 4.2: 1 h / 0 - 10 °C 5.1: 5%-palladium/activated carbon; hydrogen / ethanol / 6 h / 20 °C 6.1: hydrogenchloride / water / 10 h / Reflux View Scheme

Yield

Multi-step reaction with 7 steps
1.1: Isopropyl acetate / 3.17 h / 0 - 25 °C
2.1: aluminum (III) chloride / neat (no solvent) / 0.25 h / 0 - 5 °C
2.2: 255 / 1 h / 0 - 10 °C
3.1: hydrogen; 5%-palladium/activated carbon / ethanol; water / 25 °C / 2250.23 Torr / Inert atmosphere
4.1: aluminum (III) chloride / dichloromethane / 0.75 h / 0 °C
4.2: 1 h / 0 - 5 °C
5.1: palladium 10% on activated carbon / water; ethyl acetate / 0.17 h / 25 °C / 2828.7 Torr / Inert atmosphere
6.1: sodium hydroxide / ethanol / 1.5 h / 78 °C / Inert atmosphere
7.1: hydrogenchloride / Isopropyl acetate / 2.67 h / 20 - 25 °C
View Scheme

Multi-step reaction with 6 steps
1.1: triethylamine / dichloromethane / 2 h / 10 - 20 °C
2.1: aluminum (III) chloride / dichloromethane / 0.33 h / 0 - 10 °C
2.2: 1 h / 10 - 20 °C
3.1: 5%-palladium/activated carbon; hydrogen / ethanol / 6 h / 20 °C
4.1: aluminum (III) chloride / dichloromethane / 0.33 h / 0 - 10 °C
4.2: 1 h / 0 - 10 °C
5.1: 5%-palladium/activated carbon; hydrogen / ethanol / 6 h / 20 °C
6.1: hydrogenchloride / water / 10 h / Reflux
View Scheme

: 13935-80-3
N-indan-2-yl-acetamide

: 312753-53-0
5,6-diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1.1: aluminum (III) chloride / dichloromethane / 0.33 h / 0 - 10 °C 1.2: 1 h / 10 - 20 °C 2.1: 5%-palladium/activated carbon; hydrogen / ethanol / 6 h / 20 °C 3.1: aluminum (III) chloride / dichloromethane / 0.33 h / 0 - 10 °C 3.2: 1 h / 0 - 10 °C 4.1: 5%-palladium/activated carbon; hydrogen / ethanol / 6 h / 20 °C 5.1: hydrogenchloride / water / 10 h / Reflux View Scheme

Yield

Multi-step reaction with 5 steps
1.1: aluminum (III) chloride / dichloromethane / 0.33 h / 0 - 10 °C
1.2: 1 h / 10 - 20 °C
2.1: 5%-palladium/activated carbon; hydrogen / ethanol / 6 h / 20 °C
3.1: aluminum (III) chloride / dichloromethane / 0.33 h / 0 - 10 °C
3.2: 1 h / 0 - 10 °C
4.1: 5%-palladium/activated carbon; hydrogen / ethanol / 6 h / 20 °C
5.1: hydrogenchloride / water / 10 h / Reflux
View Scheme

: 114149-10-9
N-(5-acetyl-2,3-dihydro-1H-inden-2-yl)acetamide

: 312753-53-0
5,6-diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1.1: 5%-palladium/activated carbon; hydrogen / ethanol / 6 h / 20 °C 2.1: aluminum (III) chloride / dichloromethane / 0.33 h / 0 - 10 °C 2.2: 1 h / 0 - 10 °C 3.1: 5%-palladium/activated carbon; hydrogen / ethanol / 6 h / 20 °C 4.1: hydrogenchloride / water / 10 h / Reflux View Scheme

: N-(5-ethyl-2,3-dihydro-1H-inden-2-yl)acetamide

: 312753-53-0
5,6-diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: aluminum (III) chloride / dichloromethane / 0.33 h / 0 - 10 °C 1.2: 1 h / 0 - 10 °C 2.1: 5%-palladium/activated carbon; hydrogen / ethanol / 6 h / 20 °C 3.1: hydrogenchloride / water / 10 h / Reflux View Scheme

: 4254-29-9
indan-2-ol

: 312753-53-0
5,6-diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 1: 0 - 20 °C 2: bromine; N-Bromosuccinimide / acetonitrile / 20 °C / Darkness 3: tetrahydrofuran / 20 °C / Inert atmosphere 4: pyridine / dichloromethane / 20 °C 5: sodium azide / N,N-dimethyl-formamide / 20 °C 6: palladium 10% on activated carbon; hydrogen / methanol / 3800.26 Torr / Autoclave View Scheme

: 4254-31-3
2-acetoxyindane

: 312753-53-0
5,6-diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: bromine; N-Bromosuccinimide / acetonitrile / 20 °C / Darkness 2: tetrahydrofuran / 20 °C / Inert atmosphere 3: pyridine / dichloromethane / 20 °C 4: sodium azide / N,N-dimethyl-formamide / 20 °C 5: palladium 10% on activated carbon; hydrogen / methanol / 3800.26 Torr / Autoclave View Scheme

: 862135-55-5
5,6-dibromoindan-2-ol acetate

: 312753-53-0
5,6-diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: tetrahydrofuran / 20 °C / Inert atmosphere 2: pyridine / dichloromethane / 20 °C 3: sodium azide / N,N-dimethyl-formamide / 20 °C 4: palladium 10% on activated carbon; hydrogen / methanol / 3800.26 Torr / Autoclave View Scheme

: C13H18O

: 312753-53-0
5,6-diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: pyridine / dichloromethane / 20 °C 2: sodium azide / N,N-dimethyl-formamide / 20 °C 3: palladium 10% on activated carbon; hydrogen / methanol / 3800.26 Torr / Autoclave View Scheme

: 312753-53-0
5,6-diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride

: 24424-99-5
di-tert-butyl dicarbonate

: 2-tert-butoxycarbonylamino-(5,6-diethyl)indane

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 5℃; for 4.5h;	96%

: 530084-74-3
(R)-8-(benzyloxy)-5-(2-bromo-1-((tert-butyldimethylsilyl)oxy)ethyl)quinolin-2(1H)-one

: 312753-53-0
5,6-diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride

: (R)-5- [2-(5,6-diethylindan-2-ylamino)-1-hydroxyethyl]-8-benzyloxy-1H-quinolin-2-one hydrochloride

Conditions

Conditions	Yield
Stage #1: (R)-8-(benzyloxy)-5-(2-bromo-1-((tert-butyldimethylsilyl)oxy)ethyl)quinolin-2(1H)-one; 5,6-diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride With sodium hydrogencarbonate In dimethyl sulfoxide at 65 - 125℃; for 6h; Inert atmosphere; Large scale; Stage #2: With hydrogenchloride In ethanol; water at 0 - 72℃; for 27h; Large scale;	71%

: (R)-1-carboxymethyl-3-(2-hydroxy-2,2-diphenylacetoxy)-1-azoniabicyclo[2.2.2]octane trifluoroacetate

: 312753-53-0
5,6-diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride

: (R)-1-[(5,6-diethylindan-2-ylcarbamoyl)methyl]-3-(2-hydroxy-2,2-diphenylacetoxy)-1-azoniabicyclo[2.2.2]octane trifluoroacetate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; HATU In DMF (N,N-dimethyl-formamide) at 20℃;

: 312753-53-0
5,6-diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride

: 1080018-19-4
N,N'-(1,1'-(6-chloro-1,3,5-triazine-2,4-diyl)bis(piperidine-4,1-diyl))bis(azanediyl)bis(iminomethylene)bis(3,5-diamino-6-chloropyrazine-2-carboxamide)

A: 1080018-54-7
N,N'-(1,1'-(6-(dimethylamino)-1,3,5-triazine-2,4-diyl)bis(piperidine-4,1-diyl))bis(azanediyl)bis(aminomethan-1-yl-1-ylidene)bis(3,5-diamino-6-chloropyrazine-2-carboxamide)

B: 1080018-53-6
N,N'-(1,1'-(6-(5,6-diethyl-2,3-dihydro-1H-inden-2-ylamino)-1,3,5-triazine-2,4-diyl)bis(piperidine-4,1-diyl))bis(azanediyl)bis(aminomethan-1-yl-1-ylidene)bis(3,5-diamino-6-chloropyrazine-2-carboxamide)

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 60 - 70℃; for 44.5h; Microwave irradiation;

...Expand

: 312753-53-0
5,6-diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride

: 1585234-56-5
C24H28BrNO4

: C36H44N2O4

Conditions

Conditions	Yield
With sodium carbonate In water at 100℃; for 20h;

: 312753-53-0
5,6-diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride

: C31H34N2O3*BrH

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: sodium hydroxide / water; methanol / 0.5 h 2: butan-1-ol / 3 h / 100 - 110 °C 3: (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole / tetrahydrofuran / 0 - 3 °C / Inert atmosphere View Scheme

: 312753-53-0
5,6-diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride

: indacaterol maleate

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 1: sodium hydroxide / water; methanol / 0.5 h 2: butan-1-ol / 3 h / 100 - 110 °C 3: (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole / tetrahydrofuran / 0 - 3 °C / Inert atmosphere 4: potassium carbonate / water; methanol / 1 h 5: acetic acid; palladium 10% on activated carbon; hydrogen / methanol / 6 h / 0 - 8 °C / 750.08 - 1500.15 Torr / Inert atmosphere 6: methanol / 0.5 h / 60 °C View Scheme

Yield

Multi-step reaction with 6 steps
1: sodium hydroxide / water; methanol / 0.5 h
2: butan-1-ol / 3 h / 100 - 110 °C
3: (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole / tetrahydrofuran / 0 - 3 °C / Inert atmosphere
4: potassium carbonate / water; methanol / 1 h
5: acetic acid; palladium 10% on activated carbon; hydrogen / methanol / 6 h / 0 - 8 °C / 750.08 - 1500.15 Torr / Inert atmosphere
6: methanol / 0.5 h / 60 °C
View Scheme

: 312753-53-0
5,6-diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride

: 312753-70-1
5,6-diethyl-2,3-dihydro-1H-inden-2-amine

Conditions

Conditions	Yield
With sodium hydroxide In methanol; water for 0.5h;

: 312753-53-0
5,6-diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride

: C31H32N2O3*BrH

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: sodium hydroxide / water; methanol / 0.5 h 2: butan-1-ol / 3 h / 100 - 110 °C View Scheme

: 312753-53-0
5,6-diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride

: 435273-75-9
(R)-8-(benzyloxy)-5-[2-[(5,6-diethyl-2,3-dihydro-1H-indole-2-yl)amino]-1-hydroxyethyl]quinolin-2(1H)-one

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: sodium hydroxide / water; methanol / 0.5 h 2: butan-1-ol / 3 h / 100 - 110 °C 3: (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole / tetrahydrofuran / 0 - 3 °C / Inert atmosphere 4: potassium carbonate / water; methanol / 1 h View Scheme

: 312753-53-0
5,6-diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride

: 312753-06-3
indacaterol

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: sodium hydroxide / water; methanol / 0.5 h 2: butan-1-ol / 3 h / 100 - 110 °C 3: (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole / tetrahydrofuran / 0 - 3 °C / Inert atmosphere 4: potassium carbonate / water; methanol / 1 h 5: acetic acid; palladium 10% on activated carbon; hydrogen / methanol / 6 h / 0 - 8 °C / 750.08 - 1500.15 Torr / Inert atmosphere View Scheme

Yield

Multi-step reaction with 5 steps
1: sodium hydroxide / water; methanol / 0.5 h
2: butan-1-ol / 3 h / 100 - 110 °C
3: (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole / tetrahydrofuran / 0 - 3 °C / Inert atmosphere
4: potassium carbonate / water; methanol / 1 h
5: acetic acid; palladium 10% on activated carbon; hydrogen / methanol / 6 h / 0 - 8 °C / 750.08 - 1500.15 Torr / Inert atmosphere
View Scheme

: 312753-53-0
5,6-diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride

: (R)-5- [2-(5,6-diethylindan-2-ylamino)-1-hydroxyethyl]-8-benzyloxy-1H-quinolin-2-one hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: triethylamine / dichloromethane / 4.5 h / 0 - 5 °C 2.1: potassium tert-butylate / N,N-dimethyl-formamide / 4 h / -5 - 20 °C 2.2: 2 h / 20 °C View Scheme

: 312753-53-0
5,6-diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride

: (R)-5- [2-(5,6-diethylindan-2-ylamino)-1-hydroxyethyl]-8-benzyloxy-1H-quinolin-2-one benzoic acid salt

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: triethylamine / dichloromethane / 4.5 h / 0 - 5 °C 2.1: potassium tert-butylate / N,N-dimethyl-formamide / 4 h / -5 - 20 °C 2.2: 2 h / 20 °C 3.1: potassium carbonate / ethyl acetate / pH 9 / Cooling with ice 3.2: 2 h View Scheme

5,6-Diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride Specification

The 5,6-Diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride, with the CAS registry number 312753-53-0, is also known as 1H-Inden-2-amine, 5,6-diethyl-2,3-dihydro-, hydrochloride (1:1). This chemical's molecular formula is C₁₃H₁₉N^.HCl and formula weight is 225.76. What's more, its systematic name is called 5,6-diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride (1:1).

Physical properties of 5,6-Diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride: (1)ACD/LogP: 3.73; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1; (4)ACD/LogD (pH 7.4): 1; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 2; (7)ACD/KOC (pH 5.5): 2; (8)ACD/KOC (pH 7.4): 14; (9)#H bond acceptors: 1; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 3; (12)Polar Surface Area: 3.24 Å²; (13)Flash Point: 127.6 °C; (14)Enthalpy of Vaporization: 52.42 kJ/mol; (15)Boiling Point: 285.2 °C at 760 mmHg; (16)Vapour Pressure: 0.00285 mmHg at 25°C; (17)Melting Point: >250 °C.

You can still convert the following datas into molecular structure:
(1)SMILES: Cl.c1c(c(cc2c1CC(N)C2)CC)CC
(2)InChI: InChI=1/C13H19N.ClH/c1-3-9-5-11-7-13(14)8-12(11)6-10(9)4-2;/h5-6,13H,3-4,7-8,14H2,1-2H3;1H
(3)InChIKey: ZOVIYWYFBOQKIA-UHFFFAOYAF

Product Name

5,6-Diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride

Synthetic route

5,6-Diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride Specification

Related Products

Hot Products