Product Name

  • Name

    6-Chloro-2-methoxypyridine-3-boronic acid

  • EINECS
  • CAS No. 1072946-50-9
  • Density 1.403 g/cm3
  • Solubility
  • Melting Point
  • Formula C6H7BClNO3
  • Boiling Point 354.461 °C at 760 mmHg
  • Molecular Weight 187.39
  • Flash Point 168.172 °C
  • Transport Information
  • Appearance
  • Safety
  • Risk Codes 22
  • Molecular Structure Molecular Structure of 1072946-50-9 (6-Chloro-2-methoxypyridine-3-boronic acid)
  • Hazard Symbols Xn
  • Synonyms (6-Chloro-2-methoxy-3-pyridyl)boronic acid;
  • PSA 62.58000
  • LogP -0.57660

Synthetic route

2,5-dibromo-3-nitro-pyridine
15862-37-0

2,5-dibromo-3-nitro-pyridine

(6-chloro-2-methoxypyridin-3-yl)boronic acid
1072946-50-9

(6-chloro-2-methoxypyridin-3-yl)boronic acid

5-bromo-6’-chloro-2’-methoxy-3-nitro-2,3’-bipyridine

5-bromo-6’-chloro-2’-methoxy-3-nitro-2,3’-bipyridine

Conditions
ConditionsYield
With potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 In tetrahydrofuran at 80℃; Suzuki Coupling; Inert atmosphere; Sealed tube;78%
(6-chloro-2-methoxypyridin-3-yl)boronic acid
1072946-50-9

(6-chloro-2-methoxypyridin-3-yl)boronic acid

6-chloro-2-methoxypyridine
17228-64-7

6-chloro-2-methoxypyridine

Conditions
ConditionsYield
With [bis(trifluoromethanesulfonyl)imidate](triphenylphosphine)gold(I); water In toluene at 90℃; for 3h; Microwave irradiation; Green chemistry;72%
(6-chloro-2-methoxypyridin-3-yl)boronic acid
1072946-50-9

(6-chloro-2-methoxypyridin-3-yl)boronic acid

6-chloro-N-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)pyridazin-3-amine
1562338-65-1

6-chloro-N-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)pyridazin-3-amine

6-(6-chloro-2-methoxypyridin-3-yl)-N-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)pyridazin-3-amine

6-(6-chloro-2-methoxypyridin-3-yl)-N-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)pyridazin-3-amine

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In 1,4-dioxane; water at 90℃; for 16h;55%
(6-chloro-2-methoxypyridin-3-yl)boronic acid
1072946-50-9

(6-chloro-2-methoxypyridin-3-yl)boronic acid

6-chloro-3-iodo-2-methoxypyridine
1261769-34-9

6-chloro-3-iodo-2-methoxypyridine

Conditions
ConditionsYield
With N-iodo-succinimide at 90℃; for 0.0833333h; Microwave irradiation;51%
(S)-2-(5-bromo-1H-imidazol-2-yl)pyrrolidine-1-carboxylic acid tert-butyl ester
1007882-59-8

(S)-2-(5-bromo-1H-imidazol-2-yl)pyrrolidine-1-carboxylic acid tert-butyl ester

(6-chloro-2-methoxypyridin-3-yl)boronic acid
1072946-50-9

(6-chloro-2-methoxypyridin-3-yl)boronic acid

C18H23ClN4O3
1255936-29-8

C18H23ClN4O3

Conditions
ConditionsYield
Stage #1: (S)-2-(5-bromo-1H-imidazol-2-yl)pyrrolidine-1-carboxylic acid tert-butyl ester; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride In 1,2-dimethoxyethane at 100℃; for 0.0833333h; Inert atmosphere;
Stage #2: (6-chloro-2-methoxypyridin-3-yl)boronic acid With potassium carbonate In 1,2-dimethoxyethane; water for 1.16667h;
Stage #1: (S)-2-(5-bromo-1H-imidazol-2-yl)pyrrolidine-1-carboxylic acid tert-butyl ester; palladium bis[bis(diphenylphosphino)ferrocene] dichloride In 1,2-dimethoxyethane at 100℃; for 0.0833333h; Inert atmosphere;
Stage #2: (6-chloro-2-methoxypyridin-3-yl)boronic acid With potassium acetate In 1,2-dimethoxyethane; water for 1.16667h; Inert atmosphere;
(6-chloro-2-methoxypyridin-3-yl)boronic acid
1072946-50-9

(6-chloro-2-methoxypyridin-3-yl)boronic acid

2-chloro-6-methoxypyridine-5-d

2-chloro-6-methoxypyridine-5-d

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: [bis(trifluoromethanesulfonyl)imidate](triphenylphosphine)gold(I); water / toluene / 3 h / 90 °C / Microwave irradiation; Green chemistry
2: [bis(trifluoromethanesulfonyl)imidate](triphenylphosphine)gold(I); water-d2 / toluene; tetrahydrofuran / 2 h / 90 °C / Microwave irradiation
View Scheme
(S)-2-(4-bromo-1H-imidazol-2-yl)pyrrolidine-1-carboxylic acid tert-butyl ester
1007882-59-8

(S)-2-(4-bromo-1H-imidazol-2-yl)pyrrolidine-1-carboxylic acid tert-butyl ester

(6-chloro-2-methoxypyridin-3-yl)boronic acid
1072946-50-9

(6-chloro-2-methoxypyridin-3-yl)boronic acid

C18H23ClN4O3
1255936-29-8

C18H23ClN4O3

Conditions
ConditionsYield
Stage #1: (S)-2-(4-bromo-1H-imidazol-2-yl)pyrrolidine-1-carboxylic acid tert-butyl ester With palladium bis[bis(diphenylphosphino)ferrocene] dichloride In 1,2-dimethoxyethane at 100℃; for 0.0833333h; Inert atmosphere;
Stage #2: (6-chloro-2-methoxypyridin-3-yl)boronic acid With potassium carbonate In 1,2-dimethoxyethane; water at 100℃; for 1.16667h;
(6-chloro-2-methoxypyridin-3-yl)boronic acid
1072946-50-9

(6-chloro-2-methoxypyridin-3-yl)boronic acid

1-(2-[{(1H-pyrazol-3-yl)}oxymethyl]-3-methylphenyl)-4-methyl-1,4-dihydrotetrazole-5-one

1-(2-[{(1H-pyrazol-3-yl)}oxymethyl]-3-methylphenyl)-4-methyl-1,4-dihydrotetrazole-5-one

1-(2-{[1-(6-chloro-2-methoxypyridin-3-yl)-1H-pyrazol-3-yl]oxymethyl}-3-methylphenyl)-4-methyl-1,4-dihydrotetrazol-5-one

1-(2-{[1-(6-chloro-2-methoxypyridin-3-yl)-1H-pyrazol-3-yl]oxymethyl}-3-methylphenyl)-4-methyl-1,4-dihydrotetrazol-5-one

Conditions
ConditionsYield
With pyridine; copper diacetate In acetonitrile for 6h; Molecular sieve; Reflux;0.075 g
With pyridine; copper diacetate In acetonitrile for 6h; Molecular sieve; Reflux;0.075 g
(6-chloro-2-methoxypyridin-3-yl)boronic acid
1072946-50-9

(6-chloro-2-methoxypyridin-3-yl)boronic acid

1-(2-[{(1H-pyrazol-3-yl)}oxymethyl]-3-methylphenyl)-4-methyl-1,4-dihydrotetrazole-5-one

1-(2-[{(1H-pyrazol-3-yl)}oxymethyl]-3-methylphenyl)-4-methyl-1,4-dihydrotetrazole-5-one

1-(2-{[1-(6-chloro-2-methoxypyridin-3-yl)-1H-pyrazol-3-yl]oxymethyl}-3-methylphenyl)-4-methyl-1,4-dihydrotetrazole-5-thione

1-(2-{[1-(6-chloro-2-methoxypyridin-3-yl)-1H-pyrazol-3-yl]oxymethyl}-3-methylphenyl)-4-methyl-1,4-dihydrotetrazole-5-thione

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: copper diacetate; pyridine / acetonitrile / 6 h / Molecular sieve; Reflux
2: Lawessons reagent / toluene / 5 h / Reflux
View Scheme
(6-chloro-2-methoxypyridin-3-yl)boronic acid
1072946-50-9

(6-chloro-2-methoxypyridin-3-yl)boronic acid

1-(2-[{(1H-pyrazol-3-yl)}oxymethyl]-3-methylphenyl)-4-methyl-1,4-dihydrotetrazole-5-one

1-(2-[{(1H-pyrazol-3-yl)}oxymethyl]-3-methylphenyl)-4-methyl-1,4-dihydrotetrazole-5-one

3-[(2-amino-6-methylphenyl)methyloxy]-1-(2-methoxy-6-chloropyridin-3-yl)pyrazole

3-[(2-amino-6-methylphenyl)methyloxy]-1-(2-methoxy-6-chloropyridin-3-yl)pyrazole

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: copper diacetate; pyridine / acetonitrile / 6 h / Molecular sieve; Reflux
2: 5%-palladium/activated carbon; hydrogen / ethyl acetate / 6 h / 20 °C
View Scheme
(6-chloro-2-methoxypyridin-3-yl)boronic acid
1072946-50-9

(6-chloro-2-methoxypyridin-3-yl)boronic acid

11-chloro-8-[(S)-(3-fluoropyridin-2-yl)(oxan-4-yl)methyl]-13-methoxy-5-[4-(2H3)methyl-1-methyl-1H-1,2,3-triazol-5-yl]-3,8,12-triazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaene

11-chloro-8-[(S)-(3-fluoropyridin-2-yl)(oxan-4-yl)methyl]-13-methoxy-5-[4-(2H3)methyl-1-methyl-1H-1,2,3-triazol-5-yl]-3,8,12-triazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaene

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / tetrahydrofuran / 80 °C / Inert atmosphere; Sealed tube
2: 1,2-bis-(diphenylphosphino)ethane / 1,2-dichloro-benzene / 1 h / 150 °C / Inert atmosphere
3: copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); triethylamine / N,N-dimethyl-formamide / 16 h / 100 °C / Inert atmosphere; Sealed tube
4: triphenylphosphine; di-tert-butyl-diazodicarboxylate / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere
View Scheme
(6-chloro-2-methoxypyridin-3-yl)boronic acid
1072946-50-9

(6-chloro-2-methoxypyridin-3-yl)boronic acid

1-{8-[(S)-(3-fluoropyridin-2-yl)(oxan-4-yl)methyl]-13-methoxy-5-[4-(2H3)methyl-1-methyl-1H-1,2,3-triazol-5-yl]-3,8,12-triazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaen-11-yl}ethan-1-one

1-{8-[(S)-(3-fluoropyridin-2-yl)(oxan-4-yl)methyl]-13-methoxy-5-[4-(2H3)methyl-1-methyl-1H-1,2,3-triazol-5-yl]-3,8,12-triazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaen-11-yl}ethan-1-one

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / tetrahydrofuran / 80 °C / Inert atmosphere; Sealed tube
2.1: 1,2-bis-(diphenylphosphino)ethane / 1,2-dichloro-benzene / 1 h / 150 °C / Inert atmosphere
3.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); triethylamine / N,N-dimethyl-formamide / 16 h / 100 °C / Inert atmosphere; Sealed tube
4.1: triphenylphosphine; di-tert-butyl-diazodicarboxylate / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere
5.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane / 100 °C / Inert atmosphere; Sealed tube
5.2: 1.5 h
View Scheme
(6-chloro-2-methoxypyridin-3-yl)boronic acid
1072946-50-9

(6-chloro-2-methoxypyridin-3-yl)boronic acid

2-{8-[(S)-(3-fluoropyridin-2-yl)(oxan-4-yl)methyl]-13-methoxy-5-[4-(2H3)methyl-1-methyl-1H-1,2,3-triazol-5-yl]-3,8,12-triazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaen-11-yl}propan-2-ol

2-{8-[(S)-(3-fluoropyridin-2-yl)(oxan-4-yl)methyl]-13-methoxy-5-[4-(2H3)methyl-1-methyl-1H-1,2,3-triazol-5-yl]-3,8,12-triazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaen-11-yl}propan-2-ol

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / tetrahydrofuran / 80 °C / Inert atmosphere; Sealed tube
2.1: 1,2-bis-(diphenylphosphino)ethane / 1,2-dichloro-benzene / 1 h / 150 °C / Inert atmosphere
3.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); triethylamine / N,N-dimethyl-formamide / 16 h / 100 °C / Inert atmosphere; Sealed tube
4.1: triphenylphosphine; di-tert-butyl-diazodicarboxylate / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere
5.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane / 100 °C / Inert atmosphere; Sealed tube
5.2: 1.5 h
6.1: cerium(III) chloride / tetrahydrofuran / 0.02 h / 20 °C
6.2: 0.17 h
View Scheme
(6-chloro-2-methoxypyridin-3-yl)boronic acid
1072946-50-9

(6-chloro-2-methoxypyridin-3-yl)boronic acid

8-[(S)-(3-fluoropyridin-2-yl)(oxan-4-yl)methyl]-13-methoxy-N-methyl-5-[4-(2H3)methyl-1-methyl-1H-1,2,3-triazol-5-yl]-N-[2-(methylamino)ethyl]-3,8,12-triazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaen-11-amine

8-[(S)-(3-fluoropyridin-2-yl)(oxan-4-yl)methyl]-13-methoxy-N-methyl-5-[4-(2H3)methyl-1-methyl-1H-1,2,3-triazol-5-yl]-N-[2-(methylamino)ethyl]-3,8,12-triazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaen-11-amine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / tetrahydrofuran / 80 °C / Inert atmosphere; Sealed tube
2: 1,2-bis-(diphenylphosphino)ethane / 1,2-dichloro-benzene / 1 h / 150 °C / Inert atmosphere
3: copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); triethylamine / N,N-dimethyl-formamide / 16 h / 100 °C / Inert atmosphere; Sealed tube
4: triphenylphosphine; di-tert-butyl-diazodicarboxylate / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere
5: triethylamine / 0.5 h / Microwave irradiation
View Scheme
(6-chloro-2-methoxypyridin-3-yl)boronic acid
1072946-50-9

(6-chloro-2-methoxypyridin-3-yl)boronic acid

11-methanesulfonyl-13-methoxy-5-[4-(2H3)methyl-1-methyl-1H-1,2,3-triazol-5-yl]-8-[(S)-oxan-4-yl(phenyl)methyl]-3,8,12-triazatricyclo[7.4.0.02,7]trideca-1(13),2(7),3,5,9,11-hexaene

11-methanesulfonyl-13-methoxy-5-[4-(2H3)methyl-1-methyl-1H-1,2,3-triazol-5-yl]-8-[(S)-oxan-4-yl(phenyl)methyl]-3,8,12-triazatricyclo[7.4.0.02,7]trideca-1(13),2(7),3,5,9,11-hexaene

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / tetrahydrofuran / 80 °C / Inert atmosphere; Sealed tube
2: 1,2-bis-(diphenylphosphino)ethane / 1,2-dichloro-benzene / 1 h / 150 °C / Inert atmosphere
3: triphenylphosphine; triethylamine; di-tert-butyl-diazodicarboxylate / tetrahydrofuran / 0 - 20 °C
4: copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); triethylamine / N,N-dimethyl-formamide / 16 h / 100 °C / Inert atmosphere
5: copper(II) bis(trifluoromethanesulfonate); N,N`-dimethylethylenediamine / dimethyl sulfoxide / 4 h / 100 °C / Inert atmosphere; Sealed tube
View Scheme
(6-chloro-2-methoxypyridin-3-yl)boronic acid
1072946-50-9

(6-chloro-2-methoxypyridin-3-yl)boronic acid

11-(4,4-difluoropiperidin-l-yl)-13-methoxy-5-[4-(2H3)methyl-1-methyl-1H-1,2,3-triazol-5-yl]-8-[(S)-oxan-4-yl(phenyl)methyl]-3,8,12-triazatricyclo[7.4.0.02,7]trideca-1(13),2(7),3,5,9,11-hexaene

11-(4,4-difluoropiperidin-l-yl)-13-methoxy-5-[4-(2H3)methyl-1-methyl-1H-1,2,3-triazol-5-yl]-8-[(S)-oxan-4-yl(phenyl)methyl]-3,8,12-triazatricyclo[7.4.0.02,7]trideca-1(13),2(7),3,5,9,11-hexaene

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / tetrahydrofuran / 80 °C / Inert atmosphere; Sealed tube
2: 1,2-bis-(diphenylphosphino)ethane / 1,2-dichloro-benzene / 1 h / 150 °C / Inert atmosphere
3: triphenylphosphine; triethylamine; di-tert-butyl-diazodicarboxylate / tetrahydrofuran / 0 - 20 °C
4: copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); triethylamine / N,N-dimethyl-formamide / 16 h / 100 °C / Inert atmosphere
5: palladium diacetate; ruphos; sodium t-butanolate / 1,4-dioxane / 16 h / 100 °C / Inert atmosphere; Sealed tube
View Scheme
(6-chloro-2-methoxypyridin-3-yl)boronic acid
1072946-50-9

(6-chloro-2-methoxypyridin-3-yl)boronic acid

A

(R)-2-{8-[(4,4-difluorocyclohexyl)(phenyl)methyl]-13-methoxy-5-[4-(2H3)methyl-1-methyl-1H-1,2,3-triazol-5-yl]-3,8,12-triazatricyclo[7.4.0.02,7]trideca-1(13),2(7),3,5,9,11-hexaen-11-yl}propan-2-ol

(R)-2-{8-[(4,4-difluorocyclohexyl)(phenyl)methyl]-13-methoxy-5-[4-(2H3)methyl-1-methyl-1H-1,2,3-triazol-5-yl]-3,8,12-triazatricyclo[7.4.0.02,7]trideca-1(13),2(7),3,5,9,11-hexaen-11-yl}propan-2-ol

B

(S)-2-{8-[(4,4-difluorocyclohexyl)(phenyl)methyl]-13-methoxy-5-[4-(2H3)methyl-1-methyl-1H-1,2,3-triazol-5-yl]-3,8,12-triazatricyclo[7.4.0.02,7]trideca-1(13),2(7),3,5,9,11-hexaen-11-yl}propan-2-ol

(S)-2-{8-[(4,4-difluorocyclohexyl)(phenyl)methyl]-13-methoxy-5-[4-(2H3)methyl-1-methyl-1H-1,2,3-triazol-5-yl]-3,8,12-triazatricyclo[7.4.0.02,7]trideca-1(13),2(7),3,5,9,11-hexaen-11-yl}propan-2-ol

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / tetrahydrofuran / 80 °C / Inert atmosphere; Sealed tube
2.1: 1,2-bis-(diphenylphosphino)ethane / 1,2-dichloro-benzene / 1 h / 150 °C / Inert atmosphere
3.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); triethylamine / N,N-dimethyl-formamide / 16 h / 100 °C / Inert atmosphere; Sealed tube
4.1: di-isopropyl azodicarboxylate; triphenylphosphine; triethylamine / dichloromethane / 0 - 20 °C
5.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane / 16 h / 100 °C / Inert atmosphere
5.2: 2 h / 20 °C
6.1: tetrahydrofuran; diethyl ether / 2 h / 0 - 20 °C
View Scheme
(6-chloro-2-methoxypyridin-3-yl)boronic acid
1072946-50-9

(6-chloro-2-methoxypyridin-3-yl)boronic acid

11-chloro-13-methoxy-5-[4-(2H3)methyl-1-methyl-1H-1,2,3-triazol-5-yl]-3,8,12-triazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaene

11-chloro-13-methoxy-5-[4-(2H3)methyl-1-methyl-1H-1,2,3-triazol-5-yl]-3,8,12-triazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaene

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / tetrahydrofuran / 80 °C / Inert atmosphere; Sealed tube
2: 1,2-bis-(diphenylphosphino)ethane / 1,2-dichloro-benzene / 1 h / 150 °C / Inert atmosphere
3: copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); triethylamine / N,N-dimethyl-formamide / 16 h / 100 °C / Inert atmosphere; Sealed tube
View Scheme
(6-chloro-2-methoxypyridin-3-yl)boronic acid
1072946-50-9

(6-chloro-2-methoxypyridin-3-yl)boronic acid

3-bromo-7-chloro-9-methoxy-5H-pyrrolo[3,2-b:4,5-c’]dipyridine

3-bromo-7-chloro-9-methoxy-5H-pyrrolo[3,2-b:4,5-c’]dipyridine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / tetrahydrofuran / 80 °C / Inert atmosphere; Sealed tube
2: 1,2-bis-(diphenylphosphino)ethane / 1,2-dichloro-benzene / 1 h / 150 °C / Inert atmosphere
View Scheme
(6-chloro-2-methoxypyridin-3-yl)boronic acid
1072946-50-9

(6-chloro-2-methoxypyridin-3-yl)boronic acid

(S)-3-bromo-7-chloro-9-methoxy-5-(phenyl(tetrahydro-2H-pyran-4-yl)methyl)-5H-pyrrolo[3,2-b:4,5-c’]dipyridine

(S)-3-bromo-7-chloro-9-methoxy-5-(phenyl(tetrahydro-2H-pyran-4-yl)methyl)-5H-pyrrolo[3,2-b:4,5-c’]dipyridine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / tetrahydrofuran / 80 °C / Inert atmosphere; Sealed tube
2: 1,2-bis-(diphenylphosphino)ethane / 1,2-dichloro-benzene / 1 h / 150 °C / Inert atmosphere
3: triphenylphosphine; triethylamine; di-tert-butyl-diazodicarboxylate / tetrahydrofuran / 0 - 20 °C
View Scheme
(6-chloro-2-methoxypyridin-3-yl)boronic acid
1072946-50-9

(6-chloro-2-methoxypyridin-3-yl)boronic acid

11-chloro-13-methoxy-5-[4-(2H3)methyl-1-methyl-1H-1,2,3-triazol-5-yl]-8-[(S)-oxan-4-yl(phenyl)methyl]-3,8,12-triazatricyclo[7.4.0.02,7]trideca-1(13),2(7),3,5,9,11-hexaene

11-chloro-13-methoxy-5-[4-(2H3)methyl-1-methyl-1H-1,2,3-triazol-5-yl]-8-[(S)-oxan-4-yl(phenyl)methyl]-3,8,12-triazatricyclo[7.4.0.02,7]trideca-1(13),2(7),3,5,9,11-hexaene

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / tetrahydrofuran / 80 °C / Inert atmosphere; Sealed tube
2: 1,2-bis-(diphenylphosphino)ethane / 1,2-dichloro-benzene / 1 h / 150 °C / Inert atmosphere
3: triphenylphosphine; triethylamine; di-tert-butyl-diazodicarboxylate / tetrahydrofuran / 0 - 20 °C
4: copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); triethylamine / N,N-dimethyl-formamide / 16 h / 100 °C / Inert atmosphere
View Scheme
(6-chloro-2-methoxypyridin-3-yl)boronic acid
1072946-50-9

(6-chloro-2-methoxypyridin-3-yl)boronic acid

11-chloro-8-[(4,4-difluorocyclohexyl)(phenyl)methyl]-13-methoxy-5-[4-(2H3)methyl-1-methyl-1H-1,2,3-triazol-5-yl]-3,8,12-triazatricyclo[7.4.0.02,7]trideca-1(13),2(7),3,5,9,11-hexaene

11-chloro-8-[(4,4-difluorocyclohexyl)(phenyl)methyl]-13-methoxy-5-[4-(2H3)methyl-1-methyl-1H-1,2,3-triazol-5-yl]-3,8,12-triazatricyclo[7.4.0.02,7]trideca-1(13),2(7),3,5,9,11-hexaene

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / tetrahydrofuran / 80 °C / Inert atmosphere; Sealed tube
2: 1,2-bis-(diphenylphosphino)ethane / 1,2-dichloro-benzene / 1 h / 150 °C / Inert atmosphere
3: copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); triethylamine / N,N-dimethyl-formamide / 16 h / 100 °C / Inert atmosphere; Sealed tube
4: di-isopropyl azodicarboxylate; triphenylphosphine; triethylamine / dichloromethane / 0 - 20 °C
View Scheme
(6-chloro-2-methoxypyridin-3-yl)boronic acid
1072946-50-9

(6-chloro-2-methoxypyridin-3-yl)boronic acid

C30H27(2)H3F2N6O2

C30H27(2)H3F2N6O2

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / tetrahydrofuran / 80 °C / Inert atmosphere; Sealed tube
2.1: 1,2-bis-(diphenylphosphino)ethane / 1,2-dichloro-benzene / 1 h / 150 °C / Inert atmosphere
3.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); triethylamine / N,N-dimethyl-formamide / 16 h / 100 °C / Inert atmosphere; Sealed tube
4.1: di-isopropyl azodicarboxylate; triphenylphosphine; triethylamine / dichloromethane / 0 - 20 °C
5.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane / 16 h / 100 °C / Inert atmosphere
5.2: 2 h / 20 °C
View Scheme
(6-chloro-2-methoxypyridin-3-yl)boronic acid
1072946-50-9

(6-chloro-2-methoxypyridin-3-yl)boronic acid

6-[2-methoxy-6-(1H-pyrazol-4-yl)pyridin-3-yl]-N-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)pyridazin-3-amine hydrochloride

6-[2-methoxy-6-(1H-pyrazol-4-yl)pyridin-3-yl]-N-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)pyridazin-3-amine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / 1,4-dioxane; water / 16 h / 90 °C
2: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / 1,4-dioxane; water / 16 h / 90 °C
3: hydrogenchloride / 1,4-dioxane / 0.33 h / 20 °C
View Scheme
(6-chloro-2-methoxypyridin-3-yl)boronic acid
1072946-50-9

(6-chloro-2-methoxypyridin-3-yl)boronic acid

6-(2-methoxy-6-(1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl)pyridin-3-yl)-N-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)pyridazin-3-amine

6-(2-methoxy-6-(1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl)pyridin-3-yl)-N-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)pyridazin-3-amine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / 1,4-dioxane; water / 16 h / 90 °C
2: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / 1,4-dioxane; water / 16 h / 90 °C
View Scheme
(6-chloro-2-methoxypyridin-3-yl)boronic acid
1072946-50-9

(6-chloro-2-methoxypyridin-3-yl)boronic acid

3-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)-6-(1H-pyrazol-4-yl)pyridin-2-ol hydrochloride

3-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)-6-(1H-pyrazol-4-yl)pyridin-2-ol hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / 1,4-dioxane; water / 16 h / 90 °C
2: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / 1,4-dioxane; water / 16 h / 90 °C
3: hydrogenchloride / 1,4-dioxane / 2 h / 60 °C
View Scheme
(6-chloro-2-methoxypyridin-3-yl)boronic acid
1072946-50-9

(6-chloro-2-methoxypyridin-3-yl)boronic acid

(S)-tert-butyl 4-bromo-2-(1-((tert-butoxycarbonyl)amino)-7-(oxazol-2-yl)-7-oxoheptyl)-1H-imidazole-1-carboxylate

(S)-tert-butyl 4-bromo-2-(1-((tert-butoxycarbonyl)amino)-7-(oxazol-2-yl)-7-oxoheptyl)-1H-imidazole-1-carboxylate

(S)-tert-butyl 2-(1-((tert-butoxycarbonyl)amino)-7-(oxazol-2-yl)-7-oxoheptyl)-4-(6-chloro-2-methoxypyridin-3-yl)-l H-imidazole-1-carboxylate

(S)-tert-butyl 2-(1-((tert-butoxycarbonyl)amino)-7-(oxazol-2-yl)-7-oxoheptyl)-4-(6-chloro-2-methoxypyridin-3-yl)-l H-imidazole-1-carboxylate

Conditions
ConditionsYield
With potassium phosphate; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II) In tetrahydrofuran; water at 20 - 60℃; for 2h;

6-Chloro-2-methoxypyridine-3-boronic acid Specification

The CAS registry number of 6-Chloro-2-methoxypyridine-3-boronic acid is 1072946-50-9. Its molecular formula is C6H7BClNO3 and molecular weight is 187.38868. Its systematic name is called (6-Chloro-2-methoxy-3-pyridyl)boronic acid.

Physical properties about 6-Chloro-2-methoxypyridine-3-boronic acid are: (1)ACD/LogP: 1.44; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1.282; (4)ACD/BCF (pH 5.5): 5.082; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 100.438; (7)ACD/KOC (pH 7.4): 4.024; (8)#H bond acceptors: 4; (9)#H bond donors: 2; (10)#Freely Rotating Bonds: 4; (11)Index of Refraction: 1.546; (12)Molar Refractivity: 42.279 cm3; (13)Molar Volume: 133.589 cm3; (14)Surface Tension: 54.525 dyne/cm; (15)Density: 1.403 g/cm3; (16)Flash Point: 168.172 °C; (17)Enthalpy of Vaporization: 63.261 kJ/mol; (18)Boiling Point: 354.461 °C at 760 mmHg.

You can still convert the following datas into molecular structure:
(1)SMILES: B(c1ccc(nc1OC)Cl)(O)O
(2)InChI: InChI=1/C6H7BClNO3/c1-12-6-4(7(10)11)2-3-5(8)9-6/h2-3,10-11H,1H3
(3)InChIKey: QMTFZVCHSRMZJW-UHFFFAOYAH

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