• Name

  8-AMINOGUANINE

• EINECS
• CAS No. 28128-41-8
• Article Data8
• CAS DataBase
• Density 2.53 g/cm³
• Solubility
• Melting Point >330°C (dec.)
• Formula C₅H₆N₆O
• Boiling Point 625.9 °C at 760 mmHg
• Molecular Weight 166.142
• Flash Point 332.3 °C
• Transport Information
• Appearance
• Safety
• Risk Codes
• Molecular Structure
• Hazard Symbols
• Synonyms 6H-Purin-6-one,2,8-diamino-1,7-dihydro- (9CI);Hypoxanthine, 2,8-diamino- (8CI);8-Aminoguanine;NSC 23170;Hydrazinecarboximidamide;
• PSA 126.47000
• LogP -0.02700

Synthetic route

79953-02-9

8-<(4-bromophenyl)azo>guanine

28128-41-8

8-aminoguanine

Conditions

Conditions	Yield
With sodium dithionite In sodium hydroxide at 90℃; for 48h; pH 9;	60%

168701-80-2

8-nitroguanine

28128-41-8

8-aminoguanine

Conditions

Conditions	Yield
With sodium disulfite In water at 20℃; for 0.166667h;
With sodium dithionite Product distribution;

73-40-5

2-amino-1,9-dihydro-6H-purin-6-one

28128-41-8

8-aminoguanine

Conditions

Conditions	Yield
Stage #1: 2-amino-1,9-dihydro-6H-purin-6-one With 4-chlorophenyldiazonium salt Stage #2: With sodium hydrogensulfite
Multi-step reaction with 2 steps 1: peroxynitrite / aq. phosphate buffer / 0.08 h / 20 °C / pH 7 2: sodium dithionite View Scheme
Multi-step reaction with 2 steps 1: aq. HCl; ammonium formate; peroxonitrite / 0.03 h / 20 °C / pH 6.8 - 7.0 2: sodium hydrosulfite / H2O / 0.17 h / 20 °C View Scheme
Multi-step reaction with 2 steps 1: 75 percent / aq. NaOH / 0.25 h / 0 °C / pH 10-11 2: 60 percent / sodium dithionite / aq. NaOH / 48 h / 90 °C / pH 9 View Scheme

3868-32-4

8-aminoguanosine

28128-41-8

8-aminoguanine

Conditions

Conditions	Yield
With hydrogenchloride In water at 70℃; for 1h;

28128-41-8

8-aminoguanine

2,8-diamino-6-chloropurine

Conditions

Conditions	Yield
With N,N-dimethyl-aniline; trichlorophosphate for 0.5h; Heating;	63%

28128-41-8

8-aminoguanine

951-77-9

2'-Deoxycytidine

13389-04-3

8-amino-2'-deoxyguanosine

Conditions

Conditions	Yield
With trans-N-deoxyribosylase from Lactobacillus helveticus In water at 37℃; for 15h; Product distribution; trans-deoxyribosylation; Enzymatic reaction; product analyzed by HPLC;	58 % Chromat.

28128-41-8

8-aminoguanine

4909-78-8

N,N-dimethylformamide dineopentyl acetal

8-amino-2,8-bis(N-dimethylaminomethylene)guanine

Conditions

Conditions	Yield
In N,N-dimethyl-formamide

28128-41-8

8-aminoguanine

[2-(2,8-diamino-6-oxo-1,6-dihydro-purin-9-yl)-ethoxymethyl]-phosphonic acid diisopropyl ester

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: dimethylformamide 2: NaH / dimethylformamide 3: Me3SiBr / acetonitrile View Scheme

28128-41-8

8-aminoguanine

[2-(2,8-diamino-6-oxo-1,6-dihydro-purin-7-yl)-ethoxymethyl]-phosphonic acid diisopropyl ester

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: dimethylformamide 2: NaH / dimethylformamide 3: Me3SiBr / acetonitrile View Scheme

28128-41-8

8-aminoguanine

{2-[2,8-bis-(dimethylamino-methyleneamino)-6-oxo-1,6-dihydro-purin-9-yl]-ethoxymethyl}-phosphonic acid diisopropyl ester

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: dimethylformamide 2: NaH / dimethylformamide View Scheme

28128-41-8

8-aminoguanine

{2-[2,8-bis-(dimethylamino-methyleneamino)-6-oxo-1,6-dihydro-purin-7-yl]-ethoxymethyl}-phosphonic acid diisopropyl ester

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: dimethylformamide 2: NaH / dimethylformamide View Scheme

28128-41-8

8-aminoguanine

2,8-Diamino-9-((S)-2-hydroxy-3-trityloxy-propyl)-1,9-dihydro-purin-6-one

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: dimethylformamide 2: Cs2CO3 / dimethylformamide 3: Me3SiBr / acetonitrile View Scheme

28128-41-8

8-aminoguanine

2,8-Diamino-7-((S)-2-hydroxy-3-trityloxy-propyl)-1,7-dihydro-purin-6-one

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: dimethylformamide 2: Cs2CO3 / dimethylformamide 3: Me3SiBr / acetonitrile View Scheme

28128-41-8

8-aminoguanine

N'-[8-(dimethylamino-methyleneamino)-9-(2-hydroxy-3-trityloxy-propyl)-6-oxo-6,9-dihydro-1H-purin-2-yl]-N,N-dimethyl-formamidine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: dimethylformamide 2: Cs2CO3 / dimethylformamide View Scheme

28128-41-8

8-aminoguanine

N'-[8-(dimethylamino-methyleneamino)-7-(2-hydroxy-3-trityloxy-propyl)-6-oxo-6,7-dihydro-1H-purin-2-yl]-N,N-dimethyl-formamidine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: dimethylformamide 2: Cs2CO3 / dimethylformamide View Scheme

28128-41-8

8-aminoguanine

(2-{2,8-diamino-1-[2-(diisopropoxy-phosphorylmethoxy)-ethyl]-6-oxo-1,6-dihydro-purin-7-yl}-ethoxymethyl)-phosphonic acid diisopropyl ester

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: dimethylformamide 2: NaH / dimethylformamide 3: Me3SiBr / acetonitrile View Scheme

28128-41-8

8-aminoguanine

{2-[1-[2-(diisopropoxy-phosphorylmethoxy)-ethyl]-2,8-bis-(dimethylamino-methyleneamino)-6-oxo-1,6-dihydro-purin-7-yl]-ethoxymethyl}-phosphonic acid diisopropyl ester

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: dimethylformamide 2: NaH / dimethylformamide View Scheme

28128-41-8

8-aminoguanine

2,8-Diamino-1,7-bis-((S)-2-hydroxy-3-trityloxy-propyl)-1,7-dihydro-purin-6-one

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: dimethylformamide 2: Cs2CO3 / dimethylformamide 3: Me3SiBr / acetonitrile View Scheme

28128-41-8

8-aminoguanine

N'-[8-(dimethylamino-methyleneamino)-1,7-bis-(2-hydroxy-3-trityloxy-propyl)-6-oxo-6,7-dihydro-1H-purin-2-yl]-N,N-dimethyl-formamidine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: dimethylformamide 2: Cs2CO3 / dimethylformamide View Scheme

28128-41-8

8-aminoguanine

8-amino-O6-benzylguanine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 63 percent / POCl3, N,N-dimethylaniline / 0.5 h / Heating 2: 21 percent / Na / 5 h / 130 °C View Scheme

6H-Purin-6-one,2,8-diamino-1,9-dihydro- Specification