8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
(1-methyl-4-piperidyl)magnesium chloride
8-chloro-6,11-dihydro-11-(1-methyl-4-piperidinyl)-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ol
Conditions | Yield |
---|---|
In tetrahydrofuran Reflux; | 95% |
With (trimethylsilyl)methylmagnesium chloride; lithium chloride; zinc(II) chloride In tetrahydrofuran; diethyl ether at 0℃; for 2h; Inert atmosphere; | 90% |
In tetrahydrofuran at -95 - -15℃; for 2 - 3h; | 71.1% |
4-chloro-1-methylpiperidine
8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
8-chloro-6,11-dihydro-11-(1-methyl-4-piperidinyl)-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ol
Conditions | Yield |
---|---|
Stage #1: 4-chloro-1-methylpiperidine With magnesium; ethylene dibromide In tetrahydrofuran at 20 - 48℃; Stage #2: 8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one In tetrahydrofuran at -80 - -70℃; for 2 - 3h; Product distribution / selectivity; | 73.6% |
8-chloro-6,11-dihydro-11-(1-methyl-4-piperidinyl)-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ol
N-methyldesloratadine
Conditions | Yield |
---|---|
With sulfuric acid at 20℃; for 4.5h; | 85% |
With sulfuric acid at 35 - 45℃; for 2 - 3h; | 80% |
Stage #1: 8-chloro-6,11-dihydro-11-(1-methyl-4-piperidinyl)-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ol With sulfuric acid at 35 - 45℃; for 2 - 3h; Stage #2: In water pH=8 - 9; Product distribution / selectivity; |
8-chloro-6,11-dihydro-11-(1-methyl-4-piperidinyl)-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ol
4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-N-(2-methoxyphenyl)-1-piperidinecarbothioamide
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: sulfuric acid / 4.5 h / 20 °C 2: triethylamine / toluene / 3 h / Reflux 3: potassium hydroxide / ethanol / 6 h / Reflux 4: ethanol / 1 h / 20 °C View Scheme |
8-chloro-6,11-dihydro-11-(1-methyl-4-piperidinyl)-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ol
4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-N-methyl-1-piperidinecarbothioamide
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: sulfuric acid / 4.5 h / 20 °C 2: triethylamine / toluene / 3 h / Reflux 3: potassium hydroxide / ethanol / 6 h / Reflux 4: ethanol / 1 h / 20 °C View Scheme |
8-chloro-6,11-dihydro-11-(1-methyl-4-piperidinyl)-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ol
4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-N-cyclohexyl-1-piperidinecarbothioamide
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: sulfuric acid / 4.5 h / 20 °C 2: triethylamine / toluene / 3 h / Reflux 3: potassium hydroxide / ethanol / 6 h / Reflux 4: ethanol / 1 h / 20 °C View Scheme |
8-chloro-6,11-dihydro-11-(1-methyl-4-piperidinyl)-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ol
4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-N-phenyl-1-piperidinecarbothioamide
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: sulfuric acid / 4.5 h / 20 °C 2: triethylamine / toluene / 3 h / Reflux 3: potassium hydroxide / ethanol / 6 h / Reflux 4: ethanol / 1 h / 20 °C View Scheme |
8-chloro-6,11-dihydro-11-(1-methyl-4-piperidinyl)-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ol
4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-N-(2-methylphenyl)-1-piperidinecarbothioamide
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: sulfuric acid / 4.5 h / 20 °C 2: triethylamine / toluene / 3 h / Reflux 3: potassium hydroxide / ethanol / 6 h / Reflux 4: ethanol / 1 h / 20 °C View Scheme |
8-chloro-6,11-dihydro-11-(1-methyl-4-piperidinyl)-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ol
descarboethoxyloratadine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: sulfuric acid / 4.5 h / 20 °C 2: triethylamine / toluene / 3 h / Reflux 3: potassium hydroxide / ethanol / 6 h / Reflux View Scheme |
8-chloro-6,11-dihydro-11-(1-methyl-4-piperidinyl)-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ol
loratadine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sulfuric acid / 4.5 h / 20 °C 2: triethylamine / toluene / 3 h / Reflux View Scheme |
The cas register number of 8-Chloro-6,11-dihydro-11-(1-methyl-4-piperidinyl)-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ol is 38089-93-9. It also can be called as 5H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-ol,8-chloro-6,11-dihydro-11-(1-methyl-4-piperidinyl)- and the Systematic name about this chemical is 8-chloro-11-(1-methylpiperidin-4-yl)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ol. It belongs to the (intermediate of loratadine).
Physical properties about 8-Chloro-6,11-dihydro-11-(1-methyl-4-piperidinyl)-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ol are: (1)ACD/LogP: 2.08; (2)#H bond acceptors: 3; (3)#H bond donors: 1; (4)#Freely Rotating Bonds: 2; (5)Polar Surface Area: 36.36Å2; (6)Index of Refraction: 1.621; (7)Molar Refractivity: 96.878 cm3; (8)Molar Volume: 275.56 cm3; (9)Polarizability: 38.405x10-24cm3; (10)Surface Tension: 53.655 dyne/cm; (11)Enthalpy of Vaporization: 78.179 kJ/mol.
You can still convert the following datas into molecular structure:
(1)SMILES: Clc1cc3c(cc1)C(O)(c2ncccc2CC3)C4CCN(C)CC4
(2)InChI: InChI=1/C20H23ClN2O/c1-23-11-8-16(9-12-23)20(24)18-7-6-17(21)13-15(18)5-4-14-3-2-10-22-19(14)20/h2-3,6-7,10,13,16,24H,4-5,8-9,11-12H2,1H3
(3)InChIKey: HSLLZISLOQPUNP-UHFFFAOYAN
(4)Std. InChI: InChI=1S/C20H23ClN2O/c1-23-11-8-16(9-12-23)20(24)18-7-6-17(21)13-15(18)5-4-14-3-2-10-22-19(14)20/h2-3,6-7,10,13,16,24H,4-5,8-9,11-12H2,1H3
(5)Std. InChIKey: HSLLZISLOQPUNP-UHFFFAOYSA-N
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