Acetamide supplier | CasNO.60-35-5

Name
Acetamide
EINECS 200-473-5
CAS No. 60-35-5
Article Data547
CAS DataBase
Density 0.947 g/cm³
Solubility 2000 g/L (20 °C) in water
Melting Point 78-80 °C(lit.)
Formula C₂H₅NO
Boiling Point 221.1 °C at 760 mmHg
Molecular Weight 59.0678
Flash Point 90.1 °C
Transport Information UN 3077 9/PG 3
Appearance colourless deliquescent crystals
Safety 36/37
Risk Codes 40
Molecular Structure
Hazard Symbols Xn
Synonyms Aceticacid amide;Acetimidic acid;Ethanamide;Ethanimidic acid;Methanecarboxamide;NSC 25945;
PSA 43.09000
LogP 0.19190

Synthetic route

: 75-05-8
acetonitrile

: 60-35-5
acetamide

Conditions

Conditions	Yield
With manganese(IV) oxide; water In isopropyl alcohol at 70℃; under 5171.62 Torr; for 0.25h;	99%
With C43H42Cl2NRu; water at 20℃; for 4h; Catalytic behavior;	99%
With (PN3P)Ni(OH); water In tetrahydrofuran at 100℃; for 24h; Mechanism; Inert atmosphere; Schlenk technique; Sealed tube;	99%

: α-acetyl-γ-butyrolactone sodium

A: 60-35-5
acetamide

B: 517-23-7
3-acetyl-2-oxo-4,5-dihydrofuran

Conditions

Conditions	Yield
With ethyl hydrazine hydrochloride In methanol at 10 - 20℃; for 2h; Temperature;	A 98.9% B 98.29%

: C4H11NO2

: 60-35-5
acetamide

Conditions

Conditions	Yield
With sodium at 90℃; under 15001.5 Torr; for 6h; Reagent/catalyst; Temperature; Pressure; Time; Autoclave;	98.5%

: 79-20-9
acetic acid methyl ester

: 60-35-5
acetamide

Conditions

Conditions	Yield
With ammonium hydroxide at 36℃; under 525.053 Torr; for 8h; Temperature; Pressure;	98%
With ammonia; water

: 64-19-7
acetic acid

: 60-35-5
acetamide

Conditions

Conditions	Yield
With Candida antarctica lipase B; ammonium carbamate In various solvent(s) at 35℃; for 72h; Substitution;	98%
With ammonia; zirconium(IV) oxide In benzene at 150℃;	97%
With ammonium hydroxide; tin(IV) oxide at 200℃;	3%

: 62-55-5
thioacetamide

: 60-35-5
acetamide

Conditions

Conditions	Yield
With bismuth(III) nitrate In acetonitrile for 0.166667h; Heating;	97%
With tetrabutylammonium periodite In dichloromethane at 20℃; for 0.0333333h;	96%
With Oxone for 0.0833333h;	95%

: 79-07-2
Chloroacetamide

: 60-35-5
acetamide

Conditions

Conditions	Yield
With borohydride exchange resin; nickel diacetate In methanol for 1h; Ambient temperature;	97%

: C8H11NO2

: 60-35-5
acetamide

Conditions

Conditions	Yield
With sodium at 140℃; for 5h; Autoclave;	96.2%

: C9H13NO2

: 60-35-5
acetamide

Conditions

Conditions	Yield
With sodium at 140℃; for 4h; Autoclave;	95.6%

: 120157-98-4
N-(tert-butoxycarbonyl)acetamide

: 60-35-5
acetamide

Conditions

Conditions	Yield
With trifluoroacetic acid In dichloromethane for 1h; Ambient temperature;	95%

: 87986-82-1
tris(2-acetoxyethyl)methane

A: 60-35-5
acetamide

B: 53378-75-9
3-(2-hydroxyethyl)pentane-1,5-diol

Conditions

Conditions	Yield
Stage #1: tris(2-acetoxyethyl)methane With ammonia In methanol at 80℃; for 96h; Stage #2: With ammonia at 80℃; for 24h;	A n/a B 92.1%

: 107-29-9
Acetaldehyde oxime

: 60-35-5
acetamide

Conditions

Conditions	Yield
With [RuCl2(η2-C6H6){P(NMe2)3}]; water at 100℃; for 7h; Inert atmosphere; Sealed tube;	92%
With nickel at 100℃;
bei der Belichtung;
With (ethylenediamine)palladium(II) dinitrate; water at 80℃; Inert atmosphere;

: 86774-75-6
2,4,6-trimethyl-2-(2,4-dimethoxyphenyl)-1,2-dihydro-1,3,5-triazine

A: 60-35-5
acetamide

B: 625-77-4
N-acetylacetamide

C: 829-20-9
2',4'-dimethoxyacetophenone

Conditions

Conditions	Yield
With sodium carbonate In water for 1.5h; Heating;	A 2.5% B 5% C 91%

...Expand

: 2-Acetylamino-2,3-dibromo-propionic acid

A: 60-35-5
acetamide

B: 473-81-4
glyceric acid

Conditions

Conditions	Yield
With sodium hydroxide; sodium tetrahydroborate In water for 4h; Product distribution; pH=10.8-11.0;	A n/a B 90%

: 95-20-5
2-methyl-1H-indole

: 102-96-5
(2-nitroethenyl)benzene

A: 60-35-5
acetamide

B: 38035-81-3
3-phenyl-1H-quinolin-2-one

Conditions

Conditions	Yield
With polyphosphoric acid at 80 - 100℃; for 1.5h;	A n/a B 90%

...Expand

: 67969-82-8
tetrafluoroboric acid diethyl ether

: F6P(1-)*C26H44Fe2NOS2(1+)

: 75-05-8
acetonitrile

A: 60-35-5
acetamide

B: F6P(1-)*C28H46Fe2N2S2(2+)*BF4(1-)

Conditions

Conditions	Yield
In acetone at 20℃; for 2h; Inert atmosphere; Schlenk technique;	A 87% B 90%

...Expand

: 75-05-8
acetonitrile

: 932-90-1
Benzaldoxime

A: 60-35-5
acetamide

B: 100-47-0
benzonitrile

Conditions

Conditions	Yield
With indium(III) nitrate at 100℃; for 18h;	A n/a B 89%

...Expand

: 95-20-5
2-methyl-1H-indole

: 42139-37-7
1-isopropyl-4-(2-nitrovinyl)benzene

A: 60-35-5
acetamide

B: 1459775-45-1
3-(4-isopropylphenyl)quinolin-2(1H)-one

Conditions

Conditions	Yield
With polyphosphoric acid at 80 - 100℃; for 1.5h;	A n/a B 89%

...Expand

: 75-07-0
acetaldehyde

: 60-35-5
acetamide

Conditions

Conditions	Yield
With hydroxylamine hydrochloride; methanesulfonyl chloride In neat (no solvent) at 70℃; for 4h;	88%
With hydroxylamine hydrochloride; C27H27ClIrNO; sodium hydrogencarbonate In dimethyl sulfoxide at 50℃; for 6h;	88%
With [Ru(L1)Cl(CO)(PPh3)2]; hydroxylamine hydrochloride; sodium hydrogencarbonate In toluene for 12h; Catalytic behavior; Inert atmosphere; Reflux;	78%

: 95-20-5
2-methyl-1H-indole

: 858467-52-4
1,2-dimethyl-4-(2-nitrovinyl)benzene

A: 60-35-5
acetamide

B: 1459775-46-2
3-(3,4-dimethylphenyl)quinolin-2(1H)-one

Conditions

Conditions	Yield
With polyphosphoric acid at 80 - 100℃; for 1.5h;	A n/a B 88%

...Expand

: 95-20-5
2-methyl-1H-indole

: 37630-23-2, 18984-16-2
1,2-dichloro-4-(2-nitrovinyl)benzene

A: 60-35-5
acetamide

B: 1459775-51-9
3-(3,4-dichloro-phenyl)quinolin-2(1H)-one

Conditions

Conditions	Yield
With polyphosphoric acid at 80 - 100℃; for 1.5h;	A n/a B 88%

...Expand

: 65562-18-7
N-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-5-(3,4-dimethoxybenzylidene)rhodanine

A: 60-35-5
acetamide

B: 76822-35-0
N-β-D-glucopyranosylthiourea

C: α-mercaptocinnamyl amide

Conditions

Conditions	Yield
With ammonia In methanol Ambient temperature;	A n/a B 87% C n/a

...Expand

: 5-ethoxycarbonyl-6-methyl-1,3-diacetyl-4-phenyl-3,4-dihydropyrimidin-2(1H)-one

A: 60-35-5
acetamide

B: 123043-99-2
5-ethoxycarbonyl-6-methyl-3-acetyl-4-phenyl-3,4-dihydropyrimidin-2(1H)-one

Conditions

Conditions	Yield
With ammonia In tetrahydrofuran at 20℃;	A 78% B 86%

: 70-47-3
L-asparagine

: 60-35-5
acetamide

Conditions

Conditions	Yield
With ammonium bromide In water for 15h; Electrochemical reaction;	86%

: 64-17-5
ethanol

: 60-35-5
acetamide

Conditions

Conditions	Yield
With tert.-butylhydroperoxide; ammonium hydroxide In water at 100℃; for 16h;	85%

: 875-79-6
1,2-dimethylindole

: 102-96-5
(2-nitroethenyl)benzene

A: 60-35-5
acetamide

B: 2859-29-2
1-methyl-3-phenyl-1H-quinolin-2-one

Conditions

Conditions	Yield
With polyphosphoric acid at 130℃;	A n/a B 84%

...Expand

: 3682-01-7
daidzein diacetate

A: 60-35-5
acetamide

B: 531-95-3, 66036-38-2, 94105-90-5
equol

Conditions

Conditions	Yield
With ammonium formate; acetic acid; palladium hydroxide on carbon for 1.4h; Product distribution / selectivity; Heating / reflux;	A n/a B 83.2%

: 114-83-0
1-acetyl-2-phenylhydrazine

A: 60-35-5
acetamide

B: 62-53-3
aniline

Conditions

Conditions	Yield
With hydrogen; palladium on activated charcoal In ethanol; acetic acid under 2585.7 Torr; Product distribution; various phenylhydrazides, hydrogenolytic cleavage;	A 82% B n/a
With hydrogen; palladium In ethanol; acetic acid under 2585.7 Torr;	A 82% B n/a
With titanium tetrachloride; magnesium In diethyl ether; dichloromethane at 20℃; Inert atmosphere;	A 63% B 74%

: 60-35-5
acetamide

: 298-12-4
Glyoxilic acid

: 63327-49-1
N-acetyl-α-hydroxyglycine

Conditions

Conditions	Yield
In water; acetone for 18h; Heating / reflux;	100%
In water
In acetone for 18h; Reflux;

: 60-35-5
acetamide

: 591-50-4
iodobenzene

: 103-84-4
Acetanilid

Conditions

Conditions	Yield
With acetamide; potassium phosphate; CuI In dodecane; ethyl acetate; toluene	100%
With potassium phosphate; copper(l) iodide; L-arginine In 1,4-dioxane at 100℃; for 24h; Goldberg reaction;	99%
With aluminum oxide; potassium fluoride; copper(l) iodide; 1,10-Phenanthroline In toluene at 110℃; for 5h;	97%

: 60-35-5
acetamide

: 53398-55-3
1-bromo-3,5,7-trimethyladamantane

: 15210-64-7
N-acetyl-3,5,7-trimethyl-1-aminoadamantane

Conditions

Conditions	Yield
Heating;	100%

: 60-35-5
acetamide

: 563-96-2
2,2-dihydroxyacetic acid

: 63327-49-1
N-acetyl-α-hydroxyglycine

Conditions

Conditions	Yield
In acetone for 20h; Heating;	100%
In acetone

: 60-35-5
acetamide

: Methanesulfonic acid 2-{(2S,4R)-4-(2-azido-phenyl)-8-[1-(2-azido-phenyl)-meth-(E)-ylidene]-2-ethoxy-3,4,5,6,7,8-hexahydro-2H-chromen-6-yl}-ethyl ester

: N-(2-{(2S,4R)-4-(2-Azido-phenyl)-8-[1-(2-azido-phenyl)-meth-(E)-ylidene]-2-ethoxy-3,4,5,6,7,8-hexahydro-2H-chromen-6-yl}-ethyl)-acetamide

Conditions

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide at 0 - 20℃; for 2h;	100%

: 60-35-5
acetamide

: 176441-96-6
3-Hydroxy-2-thiophen-3-ylmethyl-2,3-dihydro-isoindol-1-one

: N-(3-Oxo-2-thiophen-3-ylmethyl-2,3-dihydro-1H-isoindol-1-yl)-acetamide

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In toluene for 48h; Heating;	100%

: 60-35-5
acetamide

: 176441-95-5
3-Hydroxy-2-thiophen-2-ylmethyl-2,3-dihydro-isoindol-1-one

: N-(3-Oxo-2-thiophen-2-ylmethyl-2,3-dihydro-1H-isoindol-1-yl)-acetamide

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In toluene for 48h; Heating;	100%

: 110-89-4
piperidine

: 60-35-5
acetamide

: 50-00-0
formaldehyd

: N-Piperidin-1-ylmethyl-acetamide

Conditions

Conditions	Yield
With aluminum oxide In water for 0.2h; Condensation; microwave irradiation;	100%

...Expand

: 60-35-5
acetamide

: 1435-51-4
1,3-dibromo-5-fluorobenzene

: 807620-95-7
N-(3-bromo-5-fluorophenyl)acetamide

Conditions

Conditions	Yield
With caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium(0) In 1,4-dioxane at 80℃; Inert atmosphere;	100%
With copper(l) iodide; (S,S)-1,2-diaminocyclohexane; potassium carbonate In toluene at 130℃; for 18h;	76%
With caesium carbonate; palladium diacetate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In 1,4-dioxane at 105℃;	44%

: 60-35-5
acetamide

: 79483-05-9
4,5-diethyl-2,5-dihydro-1,2,2,3-tetramethyl-1H-1,2,5-azasilaborole

A: 111869-87-5
ethylbis(dimethyl(2-penten-2-yl)silyloxy)borane

B: 74-89-5
methylamine

Conditions

Conditions	Yield
In 1,2,5-trimethyl-benzene dropwise addn. of acetamide to boron compd. soln., 160°C, 3.5h; heating (reflux), 10h; evapn.; all under Ar; distn.; elem. anal.;	A 100% B 98%

...Expand

: 60-35-5
acetamide

: 4744-50-7
2,3-pyrazinedicarboxylic anhydride

: 135742-53-9
N-acetylpyrazine-2-carboxamide

Conditions

Conditions	Yield
for 4h; Reflux;	100%

: 105-60-2
caprolactam

: 60-35-5
acetamide

: Azepan-2-one; compound with acetamide

Conditions

Conditions	Yield
at 90℃; Inert atmosphere;	100%

: 123-75-1
pyrrolidine

: 60-35-5
acetamide

: 4030-18-6
N-(acetyl)pyrrolidine

Conditions

Conditions	Yield
With Iron(III) nitrate nonahydrate In toluene for 24h; Reflux;	100%

: 60-35-5
acetamide

: (R)-5-chloro-3-(4-(methoxymethyl)-6-(3-methoxytetrahydrofuran-3-yl)pyridin-2-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazolo[3,4-c]pyridine

: (R)-N-(3-(4-(methoxymethyl)-6-(3-methoxytetrahydrofuran-3-yl)pyridin-2-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazolo[3,4-c]pyridin-5-yl)acetamide

Conditions

Conditions	Yield
Stage #1: acetamide; (R)-5-chloro-3-(4-(methoxymethyl)-6-(3-methoxytetrahydrofuran-3-yl)pyridin-2-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazolo[3,4-c]pyridine With caesium carbonate In dimethyl amine for 0.5h; Stage #2: With [(2-di-cyclohexylphosphino-3,6-dimethoxy-2’,4’,6’-triisopropyl-1,1‘-biphenyl)-2-(2‘-amino-1,1’-biphenyl)]palladium(II) methanesulfonate at 120℃; for 0.666667h;	100%

Yield

Stage #1: acetamide; (R)-5-chloro-3-(4-(methoxymethyl)-6-(3-methoxytetrahydrofuran-3-yl)pyridin-2-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazolo[3,4-c]pyridine With caesium carbonate In dimethyl amine for 0.5h;
Stage #2: With [(2-di-cyclohexylphosphino-3,6-dimethoxy-2’,4’,6’-triisopropyl-1,1‘-biphenyl)-2-(2‘-amino-1,1’-biphenyl)]palladium(II) methanesulfonate at 120℃; for 0.666667h;

100%

: 60-35-5
acetamide

: 98-56-6
4-chlorobenzotrifluoride

: 349-97-3
4-(trifluromethyl)acetanilide

Conditions

Conditions	Yield
With C33H37N4P; potassium carbonate; bis(dibenzylideneacetone)-palladium(0) In tert-butyl alcohol at 95℃; for 5h; Inert atmosphere; Sonication;	99.3%
With 5-(di-tert-butylphosphino)-1′, 3′, 5′-triphenyl-1′H-[1,4′]bipyrazole; bis[chloro(1,2,3-trihapto-allylbenzene)palladium(II)]; potassium carbonate In 1,4-dioxane at 90℃; for 18h; Buchwald-Hartwig Coupling; Inert atmosphere; Glovebox;	83%
With potassium phosphate; 2-Phenyl-1,3,2-dioxaborinane In 1,4-dioxane at 115℃; for 30h; Inert atmosphere;	28%
With C33H37N4P; potassium carbonate; bis(dibenzylideneacetone)-palladium(0) In tert-butyl alcohol at 95℃; for 5h; Inert atmosphere; Sonication;

: 60-35-5
acetamide

: 108-90-7
chlorobenzene

: 103-84-4
Acetanilid

Conditions

Conditions	Yield
With C33H37N4P; potassium carbonate; bis(dibenzylideneacetone)-palladium(0) In tert-butyl alcohol at 95℃; for 18h; Catalytic behavior; Solvent; Temperature; Reagent/catalyst; Time; Inert atmosphere; Sonication;	99.1%
With 5-(di-tert-butylphosphino)-1′, 3′, 5′-triphenyl-1′H-[1,4′]bipyrazole; bis[chloro(1,2,3-trihapto-allylbenzene)palladium(II)]; potassium carbonate In 1,4-dioxane at 90℃; for 18h; Buchwald-Hartwig Coupling; Inert atmosphere; Glovebox;	80%
With potassium phosphate; copper(l) iodide In N,N-dimethyl-formamide at 120℃; for 48h; Ullmann condensation;	33%
With copper(l) iodide; potassium carbonate; pipecolic Acid In N,N-dimethyl-formamide at 110℃; for 30h; Goldberg coupling reaction;	24%
With C33H37N4P; potassium carbonate; bis(dibenzylideneacetone)-palladium(0) In tert-butyl alcohol at 95℃; for 18h; Catalytic behavior; Reagent/catalyst; Solvent; Inert atmosphere; Sonication;

: 60-35-5
acetamide

: 104-53-0
3-phenyl-propionaldehyde

: 14473-58-6
N-(1-acetylamino-3-phenylpropyl)acetamide

Conditions

Conditions	Yield
With trifluorormethanesulfonic acid In dichloromethane for 2h; Heating;	99%
With toluene-4-sulfonic acid at 100℃; for 1h; Neat (no solvent);	99%
With toluene-4-sulfonic acid at 100℃; for 0.0166667h; Microwave irradiation; neat (no solvent);	98%

: 60-35-5
acetamide

: 123-72-8
butyraldehyde

: 7070-34-0
1,1-bis-acetylamino-butane

Conditions

Conditions	Yield
With trifluorormethanesulfonic acid In dichloromethane for 4h; Heating;	99%
With acetic acid
With benzene Entfernen des entstehenden Wassers;
at 80 - 100℃;
With carbon monoxide; hydrogen; dicobalt octacarbonyl In ethyl acetate at 90 - 100℃;

: 60-35-5
acetamide

: 100-46-9
benzylamine

: 588-46-5
N-(phenylmethyl)acetamide

Conditions

Conditions	Yield
With nanosized zeolite beta In neat (no solvent) at 100℃; for 24h;	99%
With [Ru-NHC] In toluene at 110℃; for 8h; Inert atmosphere; Schlenk technique; Sealed tube;	98%
With H-β-zeolite In neat (no solvent) at 130℃; for 24h; Reagent/catalyst; Green chemistry;	97%

: 60-35-5
acetamide

: 201230-82-2
carbon monoxide

: 590-86-3
isovaleraldehyde

: 99-15-0
N-acetylleucine

Conditions

Conditions	Yield
With sulfuric acid; lithium bromide; bis(triphenylphosphine)palladium dibromide In various solvent(s) at 120℃; under 45003.6 Torr; for 12h;	99%
With 1-methyl-pyrrolidin-2-one; sulfuric acid; lithium bromide; palladium on activated charcoal at 100℃; under 45003.6 Torr; for 12h;	75%
With sulfuric acid; triphenylphosphine; lithium bromide; palladium on activated charcoal In 1-methyl-pyrrolidin-2-one; toluene at 90℃; under 45003.6 Torr; for 16h;	64.4%
With 3-ethyl-1-methyl-1H-imidazol-3-ium bromide; triphenylphosphine; palladium(II) bromide at 100℃; under 45004.5 Torr; for 15h;	63%
With hydrogenchloride; potassium tetrachloroplatinate; triphenylphosphine In 1,4-dioxane at 120℃; under 45600 Torr; for 15h;	44%

...Expand

: 60-35-5
acetamide

: 924-44-7
glyoxylic acid ethyl ester

: acetylaminohydroxyacetic acid ethyl ester

Conditions

Conditions	Yield
In tetrahydrofuran; toluene at 80℃; Inert atmosphere;	99%
In toluene at 60 - 80℃; for 62h; Solvent; Temperature;	87%
With acetic acid In n-heptane; Isopropyl acetate; toluene at 55 - 60℃; for 1h;	85%

: 60-35-5
acetamide

: 18306-29-1
bis(trimethylsilyl)sulphate

A: 107-46-0
Hexamethyldisiloxane

B: N-(trimethylsilyl) acetimidate

C: 75-05-8
acetonitrile

D: acetamide sulfate

Conditions

Conditions	Yield
Dehydration; sulfation; silylation; Heating;	A 69% B 5% C 94% D 99%

...Expand

: 60-35-5
acetamide

: 615-37-2
ortho-methylphenyl iodide

: 120-66-1
N-(2-methylphenyl)acetamide

Conditions

Conditions	Yield
With aluminum oxide; potassium fluoride; copper(l) iodide; 1,10-Phenanthroline In toluene at 110℃; for 8h;	99%
With potassium phosphate; copper(l) iodide; N,N`-dimethylethylenediamine In N,N-dimethyl-formamide at 80℃; for 23h;	95%
With aluminum oxide; potassium fluoride; copper(l) iodide; N,N'-Dibenzylethylenediamine In toluene at 110℃; for 3h; Ullmann reaction; Inert atmosphere;	90%

: 60-35-5
acetamide

: (5-bromo-1-methyl-1H-indol-2-yl)-(4-fluoro-phenyl)-methanone

: N-[2-(4-Fluoro-benzoyl)-1-methyl-1H-indol-5-yl]-acetamide

Conditions

Conditions	Yield
Stage #1: acetamide; (5-bromo-1-methyl-1H-indol-2-yl)-(4-fluoro-phenyl)-methanone With copper(l) iodide; phosphate potassium salt In 1,4-dioxane for 0.333333h; Argon atmosphere; Stage #2: With N,N`-dimethylethylenediamine In 1,4-dioxane at 110℃;	99%

: 626-60-8
3-Chloropyridine

: 60-35-5
acetamide

: 5867-45-8
N-(pyridin-3-yl)acetamide

Conditions

Conditions	Yield
With potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0) In tert-butyl alcohol at 110℃; for 4h;	99%
With 5-(di-tert-butylphosphino)-1′, 3′, 5′-triphenyl-1′H-[1,4′]bipyrazole; bis[chloro(1,2,3-trihapto-allylbenzene)palladium(II)]; potassium carbonate In 1,4-dioxane at 90℃; for 18h; Buchwald-Hartwig Coupling; Inert atmosphere; Glovebox;	82%

: 60-35-5
acetamide

: 623-12-1
4-chloromethoxybenzene

: 51-66-1
4-methoxyacetanilide

Conditions

Conditions	Yield
With potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0) In tert-butyl alcohol at 110℃; for 24h;	99%
With 5-(di-tert-butylphosphino)-1′, 3′, 5′-triphenyl-1′H-[1,4′]bipyrazole; bis[chloro(1,2,3-trihapto-allylbenzene)palladium(II)]; potassium carbonate In 1,4-dioxane at 90℃; for 18h; Buchwald-Hartwig Coupling; Inert atmosphere; Glovebox;	92%
With 2-di-tertbutylphosphino-3,4,5,6-tetramethyl-2',4',6'-triisopropyl-1,1'-biphenyl; potassium phosphate; water; palladium diacetate In tert-butyl alcohol at 110℃; for 3h; Inert atmosphere;	84%
With copper(I) oxide; potassium phosphate; N1,N2-bis(thiophen-2-ylmethyl)oxalamide In dimethyl sulfoxide at 120℃; for 24h; Inert atmosphere; Schlenk technique;	50%

: 60-35-5
acetamide

: 106-43-4
para-chlorotoluene

: 103-89-9
4-Methylacetanilide

Conditions

Conditions	Yield
With potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0) In tert-butyl alcohol at 110℃; for 12h;	99%
With copper(I) oxide; potassium phosphate; N1,N2-bis(thiophen-2-ylmethyl)oxalamide In tert-butyl alcohol at 130℃; for 24h; Schlenk technique;	81%
Stage #1: acetamide; para-chlorotoluene With copper(l) iodide; potassium carbonate; trans-N,N'-dimethylcyclohexane-1,2-diamine In acetonitrile for 0.00277778h; Inert atmosphere; Glovebox; Stage #2: In acetonitrile at 200℃; for 1h; Microwave irradiation;	74%

: 60-35-5
acetamide

: 766-51-8
2-Chloroanisole

: 93-26-5
2-methoxyacetanilide

Conditions

Conditions	Yield
With potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0) In tert-butyl alcohol at 110℃; for 7h;	99%
With potassium phosphate; t-BuBrettPhos; water; palladium diacetate In tert-butyl alcohol at 110℃; for 3h; Inert atmosphere;	91%

Acetamide Specification

The IUPAC name of this chemical is acetamide. With the CAS registry number 60-35-5 and EINECS 200-473-5, it is also named as Acetic acid amide. The product's categories are Pharmaceutical Intermediates; Acetamide. It is colourless deliquescent crystals which is soluble in liquid ammonia, aliphatic amines, water, alcohol, pyridine, chloroform, glycerol, hot benzene, methyl ethyl ketone, butanol, benzyl alcohol, cyclohexanone, isoamyl alcohol, slightly soluble in benzene, insoluble in ether. It will produce toxic nitrogen oxide fumes when buring. So the storage environment should be well-ventilated, low-temperature and dry.

The other characteristics of this product can be summarized as: (1)ACD/LogP: -1.23; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -1.23; (4)ACD/LogD (pH 7.4): -1.23; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 5.08; (8)ACD/KOC (pH 7.4): 5.08; (9)#H bond acceptors: 2; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 0; (12)Polar Surface Area: 20.31 Å²; (13)Index of Refraction: 1.392; (14)Molar Refractivity: 14.87 cm³; (15)Molar Volume: 62.3 cm³; (16)Surface Tension: 29.9 dyne/cm; (17)Enthalpy of Vaporization: 45.76 kJ/mol; (18)Vapour Pressure: 0.109 mmHg at 25°C; (19)Tautomer Count: 2; (20)Exact Mass: 59.037114; (21)MonoIsotopic Mass: 59.037114; (22)Topological Polar Surface Area: 43.1; (23)Heavy Atom Count: 4; (24)Complexity: 33.

Preparation of Acetamide: In laboratory, it can be obtained by dehydration of ammonium acetate: CH₃COONH₄ → CH₃CONH₂ + H₂O. It is also typically produced by hydrolysis of acetonitrile in industry: CH₃CN + H₂O → CH₃C(O)NH₂.

Uses of Acetamide: It is used as plasticizer, stabilizing agent, analytical reagent and industrial solvent. It is also used in organic synthesis, pharmacy industry and dye preparation. Besides, it can react with propionyl chloride to get acetyl-propionyl-amine. This reaction needs reagent pyridine by heating. The reaction time is 1 hours. The yield is 72%.

When you are using this chemical, please be cautious about it as the following:
It has limited evidence of a carcinogenic effect. If you want to contact this product, you must wear suitable protective clothing and gloves.

People can use the following data to convert to the molecule structure.
1. SMILES:O=C(N)C
2. InChI:InChI=1/C2H5NO/c1-2(3)4/h1H3,(H2,3,4)
3. InChIKey:DLFVBJFMPXGRIB-UHFFFAOYAC

The following are the toxicity data which has been tested.

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
chicken	LDLo	intravenous	33410mg/kg (33410mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 1242, 1970.
mouse	LD50	intraperitoneal	1gm/kg (1000mg/kg)		JNCI, Journal of the National Cancer Institute. Vol. 62, Pg. 911, 1979.
mouse	LD50	intravenous	10gm/kg (10000mg/kg)	PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE	Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 64(1), Pg. 42S, 1968.
mouse	LD50	oral	12900mg/kg (12900mg/kg)	PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE	Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 64(1), Pg. 42S, 1968.
mouse	LD50	subcutaneous	8300mg/kg (8300mg/kg)	PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) CARDIAC: CHANGE IN RATE AUTONOMIC NERVOUS SYSTEM: "SMOOTH MUSCLE RELAXANT (MECHANISM UNDEFINED, SPASMOLYTIC)"	Oyo Yakuri. Pharmacometrics. Vol. 4, Pg. 451, 1970.
rabbit	LD50	intravenous	7500mg/kg (7500mg/kg)	PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE	Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 64(1), Pg. 42S, 1968.
rat	LD50	intraperitoneal	10300mg/kg (10300mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: MUSCLE WEAKNESS LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 1242, 1970.
rat	LD50	intravenous	12500mg/kg (12500mg/kg)	PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE	Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 64(1), Pg. 42S, 1968.
rat	LD50	oral	7gm/kg (7000mg/kg)		Journal of Reproduction and Fertility. Vol. 4, Pg. 219, 1962.
rat	LD50	subcutaneous	10gm/kg (10000mg/kg)	PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) AUTONOMIC NERVOUS SYSTEM: "SMOOTH MUSCLE RELAXANT (MECHANISM UNDEFINED, SPASMOLYTIC)" CARDIAC: CHANGE IN RATE	Oyo Yakuri. Pharmacometrics. Vol. 4, Pg. 451, 1970.
rat	LD50	unreported	2300mg/kg (2300mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 18, Pg. 645, 1968.

Product Name

Acetamide

Synthetic route

Acetamide Specification

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