Acetylsalicylic acid supplier

Name
Acetylsalicylic acid
EINECS 200-064-1
CAS No. 50-78-2
Article Data154
CAS DataBase
Density 1.35
Solubility water: 3.3 g/L (20 °C)
Melting Point 134-136 °C(lit.)
Formula C₉H₈O₄
Boiling Point 321.4 °C at 760 mmHg
Molecular Weight 180.16
Flash Point 131.1 °C
Transport Information UN 1851
Appearance white solid
Safety 26-36/37/39
Risk Codes 22-36/37/38
Molecular Structure
Hazard Symbols Xn
Synonyms Rhodine(7CI);Salicylic acid acetate (8CI);2-(Acetyloxy)benzoic acid;AC 5230;Acetophen;Acetysal;Acimetten;Acisal;Saletin;Solpyron;Supac;Temperal;Toldex;Trombyl;Yasta;o-(Acetyloxy)benzoic acid;Acetyl Salicylic Acid;Adiro;Asaflow;Asagran;Asatard;Ascoden 30;Ascriptin;Aspalon;Aspirdrops;Aspirin;Aspirin Protect 300;Aspirin-Direkt;Aspro;Aspropharm;Astrix;Benaspir;Bialpirinia;Caprin;Coricidin D;Dolean pH 8;Easprin;Ecotrin;Endosprin;Entericin;Ewin;Extren;Gelprin;
PSA 63.60000
LogP 1.31010

Synthetic route

: 108-24-7
acetic anhydride

: 69-72-7
salicylic acid

: 50-78-2
aspirin

Conditions

Conditions	Yield
In neat (no solvent) Molecular sieve; Microwave irradiation; Green chemistry;	100%
With erbium(III) chloride for 0.2h; Heating;	99%
With SO42-/ZrO2*graphene oxide solid super acid catalyst at 70℃; for 5h; Reagent/catalyst; Green chemistry;	97.1%

: 302353-24-8
methylene-benzo[1,3]dioxin-4-one

: 50-78-2
aspirin

Conditions

Conditions	Yield
With water at 25℃; for 1h; pH=7;	100%

: 64-19-7
acetic acid

: 69-72-7
salicylic acid

: 50-78-2
aspirin

Conditions

Conditions	Yield
at 80 - 90℃;	95%
With sulfuric acid at 70℃; for 5h; Reagent/catalyst;	95.7%

: 2-thioacetoxy-benzoic acid

: 50-78-2
aspirin

Conditions

Conditions	Yield
With thionyl chloride; dihydrogen peroxide In ethanol at 25℃; for 0.0166667h;	95%
With chloro-trimethyl-silane; dihydrogen peroxide In ethanol; water at 25℃; for 0.0666667h; regioselective reaction;	88%
With Oxone for 0.583333h;	58%

: 75-36-5
acetyl chloride

: 69-72-7
salicylic acid

: 50-78-2
aspirin

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃;	86%
With pyridine; sulfuric acid Cooling with ice;	59.23%

: methoxymethyl 2-acetoxybenzoate

: 50-78-2
aspirin

Conditions

Conditions	Yield
With bismuth(III) chloride; water In acetonitrile at 50℃; for 1h;	85%

: 533-18-6
2-methylphenyl acetate

: 50-78-2
aspirin

Conditions

Conditions	Yield
With zinc(II) oxide In N,N-dimethyl-formamide for 0.15h; microwave irradiation;	80%
With potassium permanganate; benzyl(triethyl)ammoniumpermanganate In acetic acid at 30℃; for 72h;	24%
With 2,2'-azobis(isobutyronitrile); oxygen; 1N,3N,5N-trihydroxy-1,3,5-triazin-2,4,6[1H,3H,5H]-trione; cobalt(II) acetate; manganese(II) acetate In acetic acid at 150℃; under 760 Torr; for 14h;	9%

: 85515-88-4
C16H16N2O5S

: 50-78-2
aspirin

Conditions

Conditions	Yield
With copper dichloride In tetrahydrofuran; water for 24h; Ambient temperature;	80%

: 108-24-7
acetic anhydride

: 15402-17-2
4'-Methoxy-flavyliumchlorid

A: 100-09-4
4-methoxybenzoic acid

B: 50-78-2
aspirin

Conditions

Conditions	Yield
With ruthenium(IV) oxide; sodium periodate 1) 5 h, room temp., pyridine; 2) acetic ester, water, 20 min : decomposition reaction;	A 79% B 52%
With ruthenium(IV) oxide; sodium periodate 1) 5 h, room temp., pyridine; 2) water, acetic ester, 20 min; Yield given. Multistep reaction. Yields of byproduct given;

...Expand

: 925681-78-3
O-acetylsalicylic acid acid 2-oxo-1,2,2-triphenylethyl ester

A: 201-68-3
13-oxa-indeno[1,2-l]phenanthrene

B: 50-78-2
aspirin

Conditions

Conditions	Yield
With air In ethanol; acetonitrile Irradiation;	A n/a B 79%

: 108-24-7
acetic anhydride

: 90-02-8
salicylaldehyde

: 50-78-2
aspirin

Conditions

Conditions	Yield
With oxygen; CoCl2 In 1,2-dichloro-ethane at 25℃; other aldehydes;	71.5%
With oxygen; CoCl2 In 1,2-dichloro-ethane at 25℃;	71.5%
With oxygen; cobalt(II) chloride In 1,2-dichloro-ethane at 25℃; for 20h;	71%

: 52602-01-4
tert-butyl acetylperoxysalicylate

A: 3271-80-5
2-acetoxybiphenyl

B: 122-79-2
Phenyl acetate

C: 69-72-7
salicylic acid

D: 50-78-2
aspirin

Conditions

Conditions	Yield
In benzene at 100℃; for 48h;	A 36% B 10% C 42% D 12%

...Expand

: 580-02-9
methyl acetylsalicylate

: 50-78-2
aspirin

Conditions

Conditions	Yield
With lithium chloride In N,N-dimethyl-formamide for 0.166667h; Microwave irradiation; chemoselective reaction;	34%
Stage #1: methyl acetylsalicylate With sodium hydroxide In methanol; water for 2h; Reflux; Stage #2: With hydrogenchloride

: 129218-88-8
(Z)-1-acetoxy-1-(2-acetoxyphenyl)-1,3-butadiene

A: 129218-93-5
2-methyl-3-(phenylmethyl)chromone

B: 129218-92-4
(E)-1-acetoxy-1-(2-acetoxyphenyl)-1,3-butadiene

C: 50-78-2
aspirin

Conditions

Conditions	Yield
In hexane for 2h; Ambient temperature; Irradiation;	A 7% B 30% C 23%

...Expand

: 108-24-7
acetic anhydride

: 69-72-7
salicylic acid

: 71-43-2
benzene

: 50-78-2
aspirin

...Expand

: 18698-59-4
(2-acetoxy-benzoic acid )-acetic acid-anhydride

: 64-19-7
acetic acid

A: 108-24-7
acetic anhydride

B: 50-78-2
aspirin

...Expand

: 64-19-7
acetic acid

: 94-36-0
dibenzoyl peroxide

A: 65-85-0
benzoic acid

B: 122-79-2
Phenyl acetate

C: 50-78-2
aspirin

D: 71-43-2
benzene

...Expand

: 54-21-7
sodium salicylate

: 75-36-5
acetyl chloride

: 50-78-2
aspirin

: 463-51-4
Ketene

: 67-64-1
acetone

: 69-72-7
salicylic acid

A: 18698-59-4
(2-acetoxy-benzoic acid )-acetic acid-anhydride

B: 50-78-2
aspirin

...Expand

: 463-51-4
Ketene

: 60-29-7
diethyl ether

: 69-72-7
salicylic acid

: 50-78-2
aspirin

...Expand

: 463-51-4
Ketene

: 60-29-7
diethyl ether

: 69-72-7
salicylic acid

A: 18698-59-4
(2-acetoxy-benzoic acid )-acetic acid-anhydride

B: 50-78-2
aspirin

...Expand

: 463-51-4
Ketene

: 69-72-7
salicylic acid

: 50-78-2
aspirin

Conditions

Conditions	Yield
With acetone Behandeln des Reaktionsgemisches mit Wasser;
With acetone Erwaermen des Reaktionsprodukts mit Essigsaeure;
With diethyl ether
With acetone Erwaermen des Reaktionsprodukts mit Essigsaeure;

: 542-10-9
ethylidene diacetate

: 69-72-7
salicylic acid

: 50-78-2
aspirin

: 869-29-4
1,1-diacetoxy-2-propene

: 69-72-7
salicylic acid

A: 2-vinyl-4H-benzo[d][1,3]dioxin-4-one

B: 50-78-2
aspirin

Conditions

Conditions	Yield
With sulfuric acid; acetic acid at 105℃;

...Expand

: 94-36-0
dibenzoyl peroxide

: 50-78-2
aspirin

Conditions

Conditions	Yield
With acetic acid at 90℃;

: 52602-20-7
2-tert-butoxy-2-methyl-4H-1,3-benzodioxin-4-one

: 50-78-2
aspirin

Conditions

Conditions	Yield
With phosphate buffer In 1,4-dioxane; water at 37℃; Rate constant;

: 52-90-4
L-Cysteine

: 1466-82-6
aspirin anhydride

A: S-(O-acetylsalicyloyl)-2-amino-3-thiopropionic acid

B: 50-78-2
aspirin

Conditions

Conditions	Yield
In 1,4-dioxane; water Rate constant; sodium acetate buffer;;

...Expand

: 616-91-1
N-acetylcystein

: 1466-82-6
aspirin anhydride

A: 2-acetamido-3-(2-acetoxybenzoylthio)propionic acid

B: 50-78-2
aspirin

Conditions

Conditions	Yield
In 1,4-dioxane; water Rate constant; sodium acetate buffer;;

...Expand

: 50785-25-6
2-oxopropyl 2-acetoxybenzoate

A: 2100-38-1
Salicylsaeure-2-oxopropylester

B: 50-78-2
aspirin

Conditions

Conditions	Yield
With buffer pH 8.0 In acetonitrile at 37℃; Kinetics; half-life time of hydrolysis at different pH;

: 50-78-2
aspirin

: 1466-82-6
aspirin anhydride

Conditions

Conditions	Yield
With dicyclohexyl-carbodiimide In dichloromethane at 20℃;	100%
With iodine; triethylamine; triphenylphosphine In dichloromethane at 0 - 20℃;	72%
With triethylamine; trichloroacetonitrile; triphenylphosphine In tetrahydrofuran at 20℃; for 2h;	71%

: 50-78-2
aspirin

: 5538-51-2
O-acetylsalicyloyl chloride

Conditions

Conditions	Yield
Stage #1: aspirin With oxalyl dichloride In dichloromethane at 20℃; for 0.5h; Stage #2: In dichloromethane; N,N-dimethyl-formamide at 20℃; for 6h;	100%
With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 20℃; for 3h;	98.5%
With 2-hydroxypyridin; thionyl chloride In chloroform at 80 - 85℃;	97%

: 50-78-2
aspirin

: 121-45-9
phosphorous acid trimethyl ester

: 62880-92-6
dimethyl 1-(2-acetoxyphenyl)-1-oxomethanephosphonate

Conditions

Conditions	Yield
Stage #1: aspirin With oxalyl dichloride In dichloromethane at 20℃; Stage #2: phosphorous acid trimethyl ester at 5 - 20℃; Further stages.;	100%

: 50-78-2
aspirin

: 100-51-6
benzyl alcohol

: 52602-17-2
2-acetoxybenzoic acid benzyl ester

Conditions

Conditions	Yield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0℃; for 1h; Reagent/catalyst; Solvent; Temperature; Mitsunobu Displacement; Inert atmosphere;	100%

: 41879-37-2
t-butyldimethylsilyl amine

: 50-78-2
aspirin

: 129512-44-3
tert-butyldimethylsilyl 2-acetoxybenzoate

Conditions

Conditions	Yield
In neat (no solvent) at 20℃; for 0.5h; Green chemistry;	100%

: 132539-06-1
zyprexa

: 50-78-2
aspirin

: 929209-00-7
C7H6O3*C17H20N4S

Conditions

Conditions	Yield
In methanol for 24h; Product distribution / selectivity;	99%

: 102-71-6
triethanolamine

: 50-78-2
aspirin

: 2174-16-5
triethanolamine salicylate

Conditions

Conditions	Yield
With methanol for 1h; Reflux;	99%

: 555-75-9
aluminum ethoxide

: 50-78-2
aspirin

: 198878-22-7
Al(OC2H5)(C6H4OCOCH3COO)2

Conditions

Conditions	Yield
In xylene acid heated until dissolved (80-85°C), further heating (90-95°C), alcoholate addn., stirring (90-95°C, 3-4 h); drying in vacuum; elem. anal.;	98.5%

: 536-74-3
phenylacetylene

: 50-78-2
aspirin

: (Z)-β-Styryl acetylsalicylate

Conditions

Conditions	Yield
Ru(η3-CH2=C(Me)CH2)2 In toluene at 80℃; for 20h;	98%

: 536-74-3
phenylacetylene

: 50-78-2
aspirin

: 1-phenylvinyl 2-acetoxybenzoate

Conditions

Conditions	Yield
With C58H34F18O6P2Ru; silver trifluoromethanesulfonate In toluene at 70℃; for 2h; Inert atmosphere; Schlenk technique; regioselective reaction;	98%

: 555-31-7
aluminum isopropoxide

: 50-78-2
aspirin

: 198878-23-8
Al(OC3H7)(C6H4OCOCH3COO)2

Conditions

Conditions	Yield
In xylene acid heated until dissolved (80-85°C), further heating (90-95°C), alcoholate addn., stirring (90-95°C, 3-4 h); drying in vacuum; elem. anal.;	97.8%

: vanadocene

: 50-78-2
aspirin

: cyclopentadienylvanadium bisacetylsalicylate

Conditions

Conditions	Yield
In diethyl ether byproducts: C5H6, H2; (vac. or Ar); addn. of acid to V-complex in ether (20°C, 24 h); filtration, washing (ether), drying; elem. anal.;	97%

: 49815-49-8
3-hydroxyimino-olean-12-en-28-oic acid

: 50-78-2
aspirin

: 17,3-(2-acetoxy)benzoyloxyiminoolean-12-en-28-oic acid

Conditions

Conditions	Yield
With dicyclohexyl-carbodiimide In 1,4-dioxane at 20℃;	96.9%
With dicyclohexyl-carbodiimide In chloroform at 0 - 20℃; for 2h;	62%
With dicyclohexyl-carbodiimide In 1,4-dioxane at 20℃;

: 555-31-7
aluminum isopropoxide

: 50-78-2
aspirin

: 29825-08-9
Al(C6H4OCOCH3COO)3

Conditions

Conditions	Yield
In xylene acid heated until dissolved (80-85°C), further heating (90-95°C), alcoholate addn., stirring (90-95°C, 3-4 h); drying in vacuum; elem. anal.;	96.5%

: 555-31-7
aluminum isopropoxide

: 50-78-2
aspirin

: 198878-21-6
Al(OC3H7)2C6H4OCOCH3COO

Conditions

Conditions	Yield
In xylene acid heated until dissolved (80-85°C), further heating (90-95°C), alcoholate addn., stirring (90-95°C, 3-4 h); drying in vacuum; elem. anal.;	96%

: 111-42-2
2,2'-iminobis[ethanol]

: 50-78-2
aspirin

: 109962-24-5
bis(2-hydroxy-ethyl)ammonium 2-hydroxy-benzoate

Conditions

Conditions	Yield
With methanol for 1h; Reflux;	96%

: 100-37-8
2-(Diethylamino)ethanol

: 50-78-2
aspirin

: diethylaminoethylacetylsalicylate acetylsalicylate

Conditions

Conditions	Yield
Stage #1: aspirin With dicyclohexyl-carbodiimide In chloroform at 5 - 20℃; for 2h; Stage #2: 2-(Diethylamino)ethanol at 20℃; for 3h;	96%

: 100-37-8
2-(Diethylamino)ethanol

: 50-78-2
aspirin

: diethylaminoethyl acetylsalicylate acetylsalicylic acid salt

Conditions

Conditions	Yield
Stage #1: aspirin With dicyclohexyl-carbodiimide In chloroform at 5 - 20℃; for 2h; Stage #2: 2-(Diethylamino)ethanol In chloroform at 20℃; for 3h;	96%
Stage #1: aspirin With dicyclohexyl-carbodiimide In chloroform at 5 - 20℃; for 2h; Stage #2: 2-(Diethylamino)ethanol In chloroform at 20℃; for 3h;	96%

: 74-55-5
ethambutol

: 50-78-2
aspirin

: C19H30N2O5

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dimethyl sulfoxide at 30℃; Temperature;	96%

: 373-53-5
fluoroiodomethane

: 50-78-2
aspirin

: fluoromethyl 2-acetoxybenzoate

Conditions

Conditions	Yield
With caesium carbonate In acetonitrile at 20℃; for 6h; chemoselective reaction;	96%

: 103150-19-2
exo-7-chloro-endo-7-phenyl-cis-bicyclo<4.2.0>octan-8-one

: 50-78-2
aspirin

: 122898-94-6
exo-1-<(2-acetoxybenzoyl)oxy>-7-phenyl-cis-bicyclo<4.2.0>octane-8-one

Conditions

Conditions	Yield
With triethylamine In acetone at 20℃;	95%

: 50-78-2
aspirin

: 69-72-7
salicylic acid

Conditions

Conditions	Yield
With water; trifluoroacetic acid at 65℃; for 0.5h;	95%
With copper dichloride In methanol; water for 1h; Heating;	90%
With sodium hydroxide In 1,4-dioxane at 56.4℃; Rate constant; pH 12; reaction in the presence of aq. cetyltrimethylammonium bromide (CTBA);

: 771-61-9
2,3,4,5,6-pentafluorophenol

: 50-78-2
aspirin

: 65482-79-3
2-acetoxy-benzoic acid pentafluorophenyl ester

Conditions

Conditions	Yield
With dicyclohexyl-carbodiimide In N,N-dimethyl-formamide at 40℃; for 0.333333h; microwave irradiation;	95%
With dicyclohexyl-carbodiimide In 1,4-dioxane for 4h;	61%

: 106-96-7
propargyl bromide

: 50-78-2
aspirin

: Acetylsalicylic acid propargylic ester

Conditions

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide at 0 - 20℃; for 2h;	95%
With potassium carbonate In N,N-dimethyl-formamide at 20℃;
Stage #1: aspirin With potassium carbonate In N,N-dimethyl-formamide for 0.5h; Stage #2: propargyl bromide In N,N-dimethyl-formamide at 60℃; for 10h;

: 70-54-2, 923-27-3, 6899-06-5, 60103-30-2, 60132-27-6, 56-87-1
2,6-diaminocaproic acid

: 50-78-2
aspirin

: 62952-06-1
lysine Acetylsalicylate

Conditions

Conditions	Yield
In ethanol; water for 0.533333h; Time;	95%
In water; acetone at -15 - 15℃; for 1h; Concentration;	92.4%

: 35137-30-5
3-hydroxyimino-olean-12-en-28-oic acid methyl ester

: 50-78-2
aspirin

: 13,3-(2-acetoxy)benzoyloxyiminoolean-12-en-28-oic acid methyl ester

Conditions

Conditions	Yield
With dicyclohexyl-carbodiimide In 1,4-dioxane at 20℃;	93.9%
With dicyclohexyl-carbodiimide In chloroform at 0 - 20℃; for 2h;	67%
With dicyclohexyl-carbodiimide In 1,4-dioxane at 20℃;

Acetylsalicylic acid Chemical Properties

IUPAC Name: 2-Acetyloxybenzoic acid
Canonical SMILES: CC(=O)OC1=CC=CC=C1C(=O)O
InChI: InChI=1S/C9H8O4/c1-6(10)13-8-5-3-2-4-7(8)9(11)12/h2-5H,1H3,(H,11,12)
Molecular Formula: C₉H₈O₄
Molecular Weight: 180.16 g/mol
EINECS: 200-064-1
Classification Code: Analgesic; Analgesics; Analgesics, Non-Narcotic; Anti-Inflammatory Agents; Anti-inflammatory agents, non-steroidal; Antipyretic; Antirheumatic; Antirheumatic Agents; Cardiovascular Agents; Cyclooxygenase inhibitors; Drug / Therapeutic Agent; Enzyme Inhibitors; Fibrin Modulating Agents; Fibrinolytic agents; Hematologic Agents; Human Data; Mutation data; Peripheral Nervous System Agents; Platelet aggregation inhibitors; Reproductive Effect; Sensory System Agents
Stability: Stable. Keep dry. Incompatible with strong oxidizing agents, strong bases, strong acids, various other compounds such as iodides, iron salts, quinine salts, etc.
storage temp.: Store at RT.
solubility: H₂O: 10 mg/mL at 37 °C
Water Solubility: 3.3 g/L (20 °C)
Melting Point: 134-136 °C(lit.)
Index of Refraction: 1.55
Molar Refractivity: 44.52 cm³
Molar Volume: 139.5 cm³
Surface Tension: 49.8 dyne/cm
Density: 1.29 g/cm³
Flash Point: 131.2 °C
Enthalpy of Vaporization: 59.45 kJ/mol
Boiling Point: 321.4 °C at 760 mmHg
Vapour Pressure of Aspirin (CAS NO.50-78-2): 0.000124 mmHg at 25 °C

Acetylsalicylic acid History

Medicines containing derivatives of salicylic acid, structurally similar to aspirin, have been in medical use long long ago. Salicylate-rich willow bark extract became recognized for its specific effects on fever, pain and inflammation in the mid-eighteenth century. By the nineteenth century pharmacists were experimenting with and prescribing a variety of chemicals related to salicylic acid, the active component of willow extract.
French chemist Charles Frederic Gerhardt was the first to prepare acetylsalicylic acid in 1853,he mixed acetyl chloride with a sodium salt of salicylic acid ,during his work on the synthesis and properties of various acid anhydrides.A reaction ensued,the resulting melt solidified quickly.So the compound was called "salicylic-acetic anhydride" by Gerhardt. But he did not pursue it further. In 1859, Von Gilm obtained analytically pure acetylsalicylic acid. In 1897,Bayer began selling aspirin around the world.

Acetylsalicylic acid Uses

Aspirin (CAS NO.50-78-2) is one of the most frequently used drugs in the treatment of mild to moderate pain, including that of migraines and fever.It is often combined with other non-steroidal anti-inflammatory drugs and opioid analgesics in the treatment of moderate to severe pain.In high doses, aspirin and other salicylates are used in the treatment of rheumatic fever, rheumatic arthritis, and other inflammatory joint conditions. In lower doses, aspirin (or its equivalents, e.g., carbasalate calcium) also inhibits platelet aggregation, and has been shown to reduce the incidence of transient ischemic attacks and unstable angina in men, and can be used prophylactically. It is also used in the treatment of pericarditis, coronary artery disease, and acute myocardial infarction.Low doses of aspirin are also recommended for the prevention of stroke, and myocardial infarction in patients with diagnosed cardiovascular disease. It is of no value in people without proven heart disease.

Acetylsalicylic acid Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
child	LDLo	oral	104mg/kg (104mg/kg)	LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA GASTROINTESTINAL: NAUSEA OR VOMITING BLOOD: HEMORRHAGE	Lancet. Vol. 2, Pg. 809, 1952.
child	TDLo	oral	10mg/kg/1D-I (10mg/kg)	LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED	Clinical Toxicology. Vol. 18, Pg. 247, 1981.
child	TDLo	oral	39mg/kg/13D-I (39mg/kg)	LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), DIFFUSE"	American Journal of Diseases of Children. Vol. 139, Pg. 453, 1985.
dog	LD50	intravenous	681mg/kg (681mg/kg)	BEHAVIORAL: ANALGESIA	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 149, Pg. 571, 1964.
dog	LD50	oral	700mg/kg (700mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 719, 1971.
guinea pig	LD50	oral	1075mg/kg (1075mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: TREMOR BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 47, Pg. 479, 1958.
hamster	LD50	oral	3500mg/kg (3500mg/kg)		Archives of Toxicology, Supplement. Vol. 7, Pg. 365, 1984.
human	TDLo	oral	480mg/kg/7D-I (480mg/kg)	SENSE ORGANS AND SPECIAL SENSES: TINNITUS: EAR BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: OTHER CHANGES	Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 281, 1975.
human	TDLo	oral	669mg/kg/11D (669mg/kg)	LIVER: LIVER FUNCTION TESTS IMPAIRED	American Journal of Hospital Pharmacy. Vol. 35, Pg. 330, 1978.
human	TDLo	oral	1050mg/kg/14D (1050mg/kg)	VASCULAR: OTHER CHANGES	Clinical Pharmacology and Therapeutics Vol. 67, Pg. 530, 2000.
human	TDLo	oral	2880mg/kg/8W (2880mg/kg)	SENSE ORGANS AND SPECIAL SENSES: TINNITUS: EAR GASTROINTESTINAL: NAUSEA OR VOMITING GASTROINTESTINAL: DECREASED MOTILITY OR CONSTIPATION	Arzneimittel-Forschung. Drug Research. Vol. 33, Pg. 631, 1983.
infant	TDLo	oral	120mg/kg (120mg/kg)	LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION KIDNEY, URETER, AND BLADDER: HEMATURIA	British Medical Journal. Vol. 1, Pg. 1081, 1979.
mammal (species unspecified)	LD50	oral	1750mg/kg (1750mg/kg)		Indian Journal of Medical Research. Vol. 81, Pg. 621, 1985.
man	LDLo	unreported	294mg/kg (294mg/kg)		"Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970.
man	TDLo	oral	857mg/kg (857mg/kg)	BEHAVIORAL: COMA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION	Human Toxicology. Vol. 7, Pg. 161, 1988.
man	TDLo	oral	1625mg/kg (1625mg/kg)	BEHAVIORAL: COMA	Clinical Pediatrics Vol. 24, Pg. 678, 1985.
man	TDLo	oral	13036mg/kg/5Y (13036mg/kg)	GASTROINTESTINAL: OTHER CHANGES MUSCULOSKELETAL: JOINTS SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"	Annals of Internal Medicine. Vol. 126, Pg. 665, 1997.
mouse	LD50	intraperitoneal	167mg/kg (167mg/kg)		United States Patent Document. Vol. #4376771,
mouse	LD50	oral	250mg/kg (250mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 5, Pg. 572, 1955.
mouse	LD50	subcutaneous	1020mg/kg (1020mg/kg)		Chemical and Pharmaceutical Bulletin. Vol. 28, Pg. 1237, 1980.
mouse	LD50	unreported	1350mg/kg (1350mg/kg)		United States Patent Document. Vol. #5240918,
rabbit	LD50	oral	1010mg/kg (1010mg/kg)	BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)	Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 24(3), Pg. 43, 1980.
rat	LD50	intraperitoneal	340mg/kg (340mg/kg)		Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 62, Pg. 11, 1966.
rat	LD50	oral	200mg/kg (200mg/kg)		"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 67, 1969.
rat	LD50	rectal	790mg/kg (790mg/kg)		"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 67, 1969.
women	TDLo	oral	480mg/kg/5D-I (480mg/kg)	KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"	New England Journal of Medicine. Vol. 296, Pg. 418, 1977.
women	TDLo	oral	525mg/kg/5D-I (525mg/kg)	LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), DIFFUSE"	Annals of Internal Medicine. Vol. 80, Pg. 74, 1974.
women	TDLo	oral	800mg/kg (800mg/kg)	KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" MUSCULOSKELETAL: OTHER CHANGES	American Journal of Emergency Medicine. Vol. 7, Pg. 409, 1989.
women	TDLo	rectal	4550mg/kg (4550mg/kg)	BRAIN AND COVERINGS: ENCEPHALITIS BEHAVIORAL: COMA CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)	Annals of Pharmacotherpy. Vol. 28, Pg. 467, 1994.

Acetylsalicylic acid Safety Profile

Hazard Codes: Harmful Xn
Risk Statements: 22-36/37/38
R22: Harmful if swallowed.
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36/37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
RIDADR: UN 1851
WGK Germany: 1
RTECS: VO0700000
PackingGroup: III

Acetylsalicylic acid Specification

Aspirin (CAS NO.50-78-2), its Synonyms are Acetylsalicylic acid ; 2-(Acetyloxy)benzoic acid ; 2-Acetoxybenzoic acid ; 2-Carboxyphenyl acetate ; Acesal ; Aceticyl ; Acetilsalicilico ; Acetilum acidulatum ; Benzoic acid, 2-(acetyloxy)- ; O-Acetylsalicylic acid ; Salicylic acid, acetate . It is odorless white crystals or crystalline powder with a slightly bitter taste.

Product Name

Acetylsalicylic acid

Synthetic route

Acetylsalicylic acid Chemical Properties

Acetylsalicylic acid History

Acetylsalicylic acid Uses

Acetylsalicylic acid Toxicity Data With Reference

Acetylsalicylic acid Safety Profile

Acetylsalicylic acid Specification

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