Acridin-9-amine hydrochloride supplier

Name
Acridin-9-amine hydrochloride
EINECS 205-145-5
CAS No. 134-50-9
Density 1.268g/cm³
Solubility
Melting Point
Formula C13H10 N2 . Cl H
Boiling Point 413.5°Cat760mmHg
Molecular Weight 230.71
Flash Point 233.2°C
Transport Information
Appearance Pale yellow crystals. One of the most highly fluorescent substances.
Safety Poison by ingestion. Mutation data reported. See also AMINES. When heated to decomposition it emits very toxic fumes of HCl and NO_x.
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms 9-Acridinamine,monohydrochloride (9CI); Acridine, 9-amino-, monohydrochloride (8CI);9-Aminoacridine hydrochloride; 9-Aminoacridine monohydrochloride; Acramineyellow; Aminacrine hydrochloride; Monacrin hydrochloride
PSA 38.91000
LogP 4.35340

Synthetic route

: 134-50-9
acridin-9-amine hydrochloride

: 110166-26-2
aminacrine

Conditions

Conditions	Yield
With sodium hydroxide In water; ethyl acetate for 0.25h; Concentration; Reagent/catalyst; Solvent;	100%

: 151-21-3
sodium dodecyl-sulfate

: 134-50-9
acridin-9-amine hydrochloride

: 9-aminoacridinium dodecyl sulfate

Conditions

Conditions	Yield
In ethanol; water for 0.25h; Heating;	99%

: 52824-42-7
N-(7-bromoheptyl)phthalimide

: 134-50-9
acridin-9-amine hydrochloride

: 2-[7-(acridin-9-ylamino)-heptyl]-isoindole-1,3-dione

Conditions

Conditions	Yield
With potassium hydroxide In dimethyl sulfoxide at 20℃; for 12h;	74%

: 108-24-7
acetic anhydride

: 134-50-9
acridin-9-amine hydrochloride

: 23043-52-9
N-(acridin-9-yl)acetamide

Conditions

Conditions	Yield
In pyridine at 70℃; for 24h;	67.8%

: 82484-59-1
4-bis-(β-chloroethyl)aminophenyl isocyanate

: 134-50-9
acridin-9-amine hydrochloride

: 1036724-69-2
1-acridin-9-yl-3-{4-[bis(2-chloroethyl)amino]phenyl}urea

Conditions

Conditions	Yield
With triethylamine In N,N-dimethyl-formamide at 20℃; for 18h;	60%

: 93667-91-5
2-(9-bromononyl)isoindoline-1,3-dione

: 134-50-9
acridin-9-amine hydrochloride

: 2-[9-(acridin-9-ylamino)-nonyl]-isoindole-1,3-dione

Conditions

Conditions	Yield
With potassium hydroxide In dimethyl sulfoxide at 20℃; for 12h;	55.5%

: 25487-66-5
3-Carboxyphenylboronic acid

: 134-50-9
acridin-9-amine hydrochloride

: 1428587-11-4
C20H15BN2O3

Conditions

Conditions	Yield
With 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine In dimethyl sulfoxide at 20 - 40℃; for 49h;	53%
Stage #1: acridin-9-amine hydrochloride With triethylamine In water; dimethyl sulfoxide at 20℃; for 1h; Stage #2: 3-Carboxyphenylboronic acid With 1,8-diazabicyclo[5.4.0]undec-7-ene In water; dimethyl sulfoxide at 40℃; for 48h;	53%

: 17702-83-9
N-8-bromooctylphthalimide

: 134-50-9
acridin-9-amine hydrochloride

: 2-[8-(acridin-9-ylamino)-octyl]-isoindole-1,3-dione

Conditions

Conditions	Yield
With potassium hydroxide In dimethyl sulfoxide at 20℃; for 12h;	18.5%

: 134-50-9
acridin-9-amine hydrochloride

A: 23045-35-4
2-nitro-9-aminoacridine

B: 157996-62-8
9-amino-2,7-dinitroacridine

Conditions

Conditions	Yield
With sodium nitrate; sulfuric acid at 0℃; for 0.5h;	A 9.6% B 15%
With sodium nitrate; sulfuric acid at 0℃; for 0.5h;	A 9.6% B 15%

: 24566-79-8
2-(6-bromohexyl)isoindole-1,3-dione

: 134-50-9
acridin-9-amine hydrochloride

: 2-[6-(acridin-9-ylamino)-hexyl]-isoindole-1,3-dione

Conditions

Conditions	Yield
With potassium hydroxide In dimethyl sulfoxide at 20℃; for 12h;	15%

: 134-50-9
acridin-9-amine hydrochloride

A: 2-bromo-9-aminoacridine

B: 157996-60-6
9-amino-2,7-dibromoacridine

Conditions

Conditions	Yield
With bromine In chloroform for 2h; Ambient temperature;	A 11.1% B 2.4%

: 1111-97-3
3-chloro-3-methylbut-1-yne

: 134-50-9
acridin-9-amine hydrochloride

A: 133286-71-2
10-(3-Methyl-1,2-butadienyl)-9(10H)-iminoacridin

B: 133286-69-8
9-(3-Methyl-1,2-butadienyl)-9-aminoacridin

C: 133286-70-1
9-(1,1-Dimethyl-2-propinyl)-9-aminoacridin

D: 133286-72-3
10-(1,1-Dimethyl-2-propinyl)-9(10H)-iminoacridin

Conditions

Conditions	Yield
With potassium hydroxide; tetrabutylammomium bromide In toluene for 72h; Heating;	A 370 mg B 1.69 g C 40 mg D 490 mg

...Expand

: 134-50-9
acridin-9-amine hydrochloride

: 9-acetylamino-2-bromoacridine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 67.8 percent / pyridine / 24 h / 70 °C 2: 27.2 percent / Br2 / CHCl3 / 2 h / Ambient temperature View Scheme

: 423768-37-0
1-phenyl-1H-pyrazole-5-carbonyl chloride

: 134-50-9
acridin-9-amine hydrochloride

: 908562-71-0
C23H16N4O

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 18h;

: 806608-18-4
4--phenyl-carbamoylchlorid

: 134-50-9
acridin-9-amine hydrochloride

: 1036724-69-2
1-acridin-9-yl-3-{4-[bis(2-chloroethyl)amino]phenyl}urea

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; for 16h;

: 134-50-9
acridin-9-amine hydrochloride

: 88-99-3
benzene-1,2-dicarboxylic acid

: 1272425-79-2
9-aminoacridiniun ortho-phthalate monohydrate

Conditions

Conditions	Yield
In ethanol; water for 0.0166667h; Reflux;

: 134-50-9
acridin-9-amine hydrochloride

: 65-85-0
benzoic acid

: 1272425-77-0
9-aminoacridiniun benzoate monohydrate

Conditions

Conditions	Yield
In ethanol; water for 0.0166667h; Reflux;

: 134-50-9
acridin-9-amine hydrochloride

: 69-72-7
salicylic acid

: 109653-41-0
9-aminoacridiniun salicylate

Conditions

Conditions	Yield
In ethanol; water for 0.0166667h; Reflux;

: 134-50-9
acridin-9-amine hydrochloride

: 99-06-9
3-Carboxyphenol

: 9-aminoacridinium 3-hydroxybenzoate hydrochloride

Conditions

Conditions	Yield
In ethanol; water for 0.0166667h; Reflux;

: 134-50-9
acridin-9-amine hydrochloride

: 74-11-3
para-chlorobenzoic acid

: 1302149-89-8
9-aminoacridinium 4-chlorobenzoate

Conditions

Conditions	Yield
In ethanol; water for 0.0166667h; Reflux;

: 134-50-9
acridin-9-amine hydrochloride

: 535-80-8
3-chlorobenzoate

: 1302149-88-7
9-aminoacridinium 3-chlorobenzoate

Conditions

Conditions	Yield
In ethanol; water for 0.0166667h; Reflux;

: 134-50-9
acridin-9-amine hydrochloride

: 934991-54-5
(acridin-9-ylamino)acetic acid ethyl ester

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: sodium hydroxide / water; ethyl acetate / 0.25 h 2: N,N-dimethyl-formamide / 5 h / 80 - 85 °C View Scheme

: 134-50-9
acridin-9-amine hydrochloride

bovine serum albumin: bovine serum albumin

9-aminoacridine hydrochloride binding with bovine serum albumin: 9-aminoacridine hydrochloride binding with bovine serum albumin

Conditions

Conditions	Yield
In aq. phosphate buffer at 24.84℃; pH=7.4; Thermodynamic data; Temperature;

: 134-50-9
acridin-9-amine hydrochloride

: 110166-26-2
aminacrine

Conditions

Conditions	Yield
With sodium hydroxide In water; ethyl acetate for 0.25h; Concentration; Reagent/catalyst; Solvent;	100%

: 151-21-3
sodium dodecyl-sulfate

: 134-50-9
acridin-9-amine hydrochloride

: 9-aminoacridinium dodecyl sulfate

Conditions

Conditions	Yield
In ethanol; water for 0.25h; Heating;	99%

: 52824-42-7
N-(7-bromoheptyl)phthalimide

: 134-50-9
acridin-9-amine hydrochloride

: 2-[7-(acridin-9-ylamino)-heptyl]-isoindole-1,3-dione

Conditions

Conditions	Yield
With potassium hydroxide In dimethyl sulfoxide at 20℃; for 12h;	74%

: 108-24-7
acetic anhydride

: 134-50-9
acridin-9-amine hydrochloride

: 23043-52-9
N-(acridin-9-yl)acetamide

Conditions

Conditions	Yield
In pyridine at 70℃; for 24h;	67.8%

: 82484-59-1
4-bis-(β-chloroethyl)aminophenyl isocyanate

: 134-50-9
acridin-9-amine hydrochloride

: 1036724-69-2
1-acridin-9-yl-3-{4-[bis(2-chloroethyl)amino]phenyl}urea

Conditions

Conditions	Yield
With triethylamine In N,N-dimethyl-formamide at 20℃; for 18h;	60%

: 93667-91-5
2-(9-bromononyl)isoindoline-1,3-dione

: 134-50-9
acridin-9-amine hydrochloride

: 2-[9-(acridin-9-ylamino)-nonyl]-isoindole-1,3-dione

Conditions

Conditions	Yield
With potassium hydroxide In dimethyl sulfoxide at 20℃; for 12h;	55.5%

: 25487-66-5
3-Carboxyphenylboronic acid

: 134-50-9
acridin-9-amine hydrochloride

: 1428587-11-4
C20H15BN2O3

Conditions

Conditions	Yield
With 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine In dimethyl sulfoxide at 20 - 40℃; for 49h;	53%
Stage #1: acridin-9-amine hydrochloride With triethylamine In water; dimethyl sulfoxide at 20℃; for 1h; Stage #2: 3-Carboxyphenylboronic acid With 1,8-diazabicyclo[5.4.0]undec-7-ene In water; dimethyl sulfoxide at 40℃; for 48h;	53%

: 17702-83-9
N-8-bromooctylphthalimide

: 134-50-9
acridin-9-amine hydrochloride

: 2-[8-(acridin-9-ylamino)-octyl]-isoindole-1,3-dione

Conditions

Conditions	Yield
With potassium hydroxide In dimethyl sulfoxide at 20℃; for 12h;	18.5%

: 134-50-9
acridin-9-amine hydrochloride

A: 23045-35-4
2-nitro-9-aminoacridine

B: 157996-62-8
9-amino-2,7-dinitroacridine

Conditions

Conditions	Yield
With sodium nitrate; sulfuric acid at 0℃; for 0.5h;	A 9.6% B 15%
With sodium nitrate; sulfuric acid at 0℃; for 0.5h;	A 9.6% B 15%

: 24566-79-8
2-(6-bromohexyl)isoindole-1,3-dione

: 134-50-9
acridin-9-amine hydrochloride

: 2-[6-(acridin-9-ylamino)-hexyl]-isoindole-1,3-dione

Conditions

Conditions	Yield
With potassium hydroxide In dimethyl sulfoxide at 20℃; for 12h;	15%

: 134-50-9
acridin-9-amine hydrochloride

A: 2-bromo-9-aminoacridine

B: 157996-60-6
9-amino-2,7-dibromoacridine

Conditions

Conditions	Yield
With bromine In chloroform for 2h; Ambient temperature;	A 11.1% B 2.4%

: 1111-97-3
3-chloro-3-methylbut-1-yne

: 134-50-9
acridin-9-amine hydrochloride

A: 133286-71-2
10-(3-Methyl-1,2-butadienyl)-9(10H)-iminoacridin

B: 133286-69-8
9-(3-Methyl-1,2-butadienyl)-9-aminoacridin

C: 133286-70-1
9-(1,1-Dimethyl-2-propinyl)-9-aminoacridin

D: 133286-72-3
10-(1,1-Dimethyl-2-propinyl)-9(10H)-iminoacridin

Conditions

Conditions	Yield
With potassium hydroxide; tetrabutylammomium bromide In toluene for 72h; Heating;	A 370 mg B 1.69 g C 40 mg D 490 mg

...Expand

: 134-50-9
acridin-9-amine hydrochloride

: 9-acetylamino-2-bromoacridine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 67.8 percent / pyridine / 24 h / 70 °C 2: 27.2 percent / Br2 / CHCl3 / 2 h / Ambient temperature View Scheme

: 423768-37-0
1-phenyl-1H-pyrazole-5-carbonyl chloride

: 134-50-9
acridin-9-amine hydrochloride

: 908562-71-0
C23H16N4O

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 18h;

: 806608-18-4
4--phenyl-carbamoylchlorid

: 134-50-9
acridin-9-amine hydrochloride

: 1036724-69-2
1-acridin-9-yl-3-{4-[bis(2-chloroethyl)amino]phenyl}urea

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; for 16h;

: 134-50-9
acridin-9-amine hydrochloride

: 88-99-3
benzene-1,2-dicarboxylic acid

: 1272425-79-2
9-aminoacridiniun ortho-phthalate monohydrate

Conditions

Conditions	Yield
In ethanol; water for 0.0166667h; Reflux;

: 134-50-9
acridin-9-amine hydrochloride

: 65-85-0
benzoic acid

: 1272425-77-0
9-aminoacridiniun benzoate monohydrate

Conditions

Conditions	Yield
In ethanol; water for 0.0166667h; Reflux;

: 134-50-9
acridin-9-amine hydrochloride

: 69-72-7
salicylic acid

: 109653-41-0
9-aminoacridiniun salicylate

Conditions

Conditions	Yield
In ethanol; water for 0.0166667h; Reflux;

: 134-50-9
acridin-9-amine hydrochloride

: 99-06-9
3-Carboxyphenol

: 9-aminoacridinium 3-hydroxybenzoate hydrochloride

Conditions

Conditions	Yield
In ethanol; water for 0.0166667h; Reflux;

: 134-50-9
acridin-9-amine hydrochloride

: 74-11-3
para-chlorobenzoic acid

: 1302149-89-8
9-aminoacridinium 4-chlorobenzoate

Conditions

Conditions	Yield
In ethanol; water for 0.0166667h; Reflux;

: 134-50-9
acridin-9-amine hydrochloride

: 535-80-8
3-chlorobenzoate

: 1302149-88-7
9-aminoacridinium 3-chlorobenzoate

Conditions

Conditions	Yield
In ethanol; water for 0.0166667h; Reflux;

: 134-50-9
acridin-9-amine hydrochloride

: 934991-54-5
(acridin-9-ylamino)acetic acid ethyl ester

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: sodium hydroxide / water; ethyl acetate / 0.25 h 2: N,N-dimethyl-formamide / 5 h / 80 - 85 °C View Scheme

: 134-50-9
acridin-9-amine hydrochloride

bovine serum albumin: bovine serum albumin

9-aminoacridine hydrochloride binding with bovine serum albumin: 9-aminoacridine hydrochloride binding with bovine serum albumin

Conditions

Conditions	Yield
In aq. phosphate buffer at 24.84℃; pH=7.4; Thermodynamic data; Temperature;

: 134-50-9
acridin-9-amine hydrochloride

human serum albumin: human serum albumin

9-aminoacridine hydrochloride binding with human serum albumin: 9-aminoacridine hydrochloride binding with human serum albumin

Conditions

Conditions	Yield
In aq. phosphate buffer at 24.84℃; pH=7.4; Thermodynamic data; Temperature;

Acridin-9-amine hydrochloride Chemical Properties

IUPAC Name: Acridin-9-amine hydrochloride
The MF of Acridin-9-amine hydrochloride (CAS NO.134-50-9) is C₁₃H₁₁ClN₂.

The MW of Acridin-9-amine hydrochloride (CAS NO.134-50-9) is 230.69.
Synonyms of Acridin-9-amine hydrochloride (CAS NO.134-50-9): 9-Aminoacridine hydrochloride ; Acridin-9-amine hydrochloride ; 5-Aminoacridine hydrochloride
Apperance: Pale yellow crystals.One of the most highly fluorescent substances
Flash Point: 233.2 °C
Boiling Point: 413.5 °C
EINECS: 205-145-5

Acridin-9-amine hydrochloride Uses

Acridin-9-amine hydrochloride (CAS NO.134-50-9) is used experimentally as a probe for biological membranes and dna.

Acridin-9-amine hydrochloride Production

Acridin-9-amine hydrochloride forms from treatment of 9-aminoacridine with hydrogen chloride. It is amphoteric (reacts both as a weak acid and as a weak base).

Acridin-9-amine hydrochloride Toxicity Data With Reference

1.	mmo-sat 10 µg/plate	KSRNAM Kiso to Rinsho. Clinical Report. 16 (1982),6240.
2.	mma-sat 50 µg/plate	KSRNAM Kiso to Rinsho. Clinical Report. 17 (1983),70.
3.	dnr-esc 20 µL/disc	MUREAV Mutation Research. 97 (1982),1.
4.	dnr-bcs 20 µL/disc	MUREAV Mutation Research. 97 (1982),1.
5.	cyt-ham:lng 600 µg/L	GMCRDC Gann Monograph on Cancer Research. 27 (1981),95.
6.	dnd-man:lym 10 pph	BIPMAA Biopolymers. 11 (1972),2537.
7.	orl-mus LD50:78 mg/kg	29ZVAB Handbook of Analytical Toxicology ,Sunshine, I., ed., Cleveland, OH.: Chemical Rubber Co.,1969,7

Acridin-9-amine hydrochloride Consensus Reports

Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.

Acridin-9-amine hydrochloride Safety Profile

Poison by ingestion. Mutation data reported. See also AMINES. When heated to decomposition it emits very toxic fumes of HCl and NO_x.Safety information of Acridin-9-amine hydrochloride (CAS NO.134-50-9):
Safety Statements
22 Do not breathe dust
24/25 Avoid contact with skin and eyes
WGK Germany 3

Acridin-9-amine hydrochloride Specification

Flash point data for Acridin-9-amine hydrochloride is not available, but Acridin-9-amine hydrochloride is probably combustible.

Product Name

Acridin-9-amine hydrochloride

Synthetic route

Acridin-9-amine hydrochloride Chemical Properties

Acridin-9-amine hydrochloride Uses

Acridin-9-amine hydrochloride Production

Acridin-9-amine hydrochloride Toxicity Data With Reference

Acridin-9-amine hydrochloride Consensus Reports

Acridin-9-amine hydrochloride Safety Profile

Acridin-9-amine hydrochloride Specification

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