Aflatoxin-B1: 0 Products found
Name
Aflatoxin-B1
EINECS
214-603-3
CAS No.
1162-65-8
Density
Solubility
Melting Point
268-269 °C
Formula
C17H12O6
Boiling Point
Molecular Weight
312.29
Flash Point
2 °C
Transport Information
UN 3462 6.1/PG 1
Appearance
solid
Safety
53-45-36-26-16-24-7
Risk Codes
45-46-26/27/28-36-20/21/22-11-65-48/23/24/25-36/38-39/23/24/25-23/24/25
Molecular Structure
Hazard Symbols
Synonyms
1-Cyclopentene-1-carboxylicacid, 2-(3a,8a-dihydro-4-hydroxy-6-methoxyfuro[2,3-b]benzofuran-5-yl)-5-oxo-, d-lactone (7CI);Cyclopenta[c]furo[3',2':4,5]furo[2,3-h][1]benzopyran-1,11-dione,2,3,6a,9a-tetrahydro-4-methoxy-, (6aR,9aS)- (9CI);Cyclopenta[c]furo[3',2':4,5]furo[2,3-h][1]benzopyran-1,11-dione,2,3,6a,9a-tetrahydro-4-methoxy-, (6aR-cis)-;Cyclopenta[c]furo[3',2':4,5]furo[2,3-h][1]benzopyran-1,11-dione, 2,3,6aa,9aa-tetrahydro-4-methoxy- (8CI);(-)-Aflatoxin B1;AFB1;NSC 529592;Aflatoxin B1;

History

Formaldehyde was first reported by the Russian chemist Aleksandr Butlerov (1828-1886), but it was conclusively identified by August Wilhelm von Hofmann.

Consensus

IARC Cancer Review: Group 1 IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 (1987),p. 83.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Sufficient Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 10 (1976),p. 51.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 1 (1972),p. 145.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . EPA Genetic Toxicology Program.

Others

The Aflatoxin B1, with the CAS registry number 1162-65-8,is also known as Cyclopenta(c)furo(3',2':4,5)furo(2,3-h)(1)benzopyran-1,11-dione, 2,3,6a,9a-tetrahydro-4-methoxy-. It belongs to the product categories of Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals. Its EINECS number is 214-603-3. This chemical's molecular formula is C17H12O6 and molecular weight is 312.27. What's more,Its systematic name is Aflatoxin B1.It is a potent hepatotoxic and hepatocarcinogenic mycotoxin produced by the Aspergillus flavus group of fungi. It is also mutagenic, teratogenic, and causes immunosuppression in animals. It is found as a contaminant in peanuts, cottonseed meal, corn, and other grains. The mycotoxin requires epoxidation to aflatoxin B1 2,3-oxide for activation. Microsomal monooxygenases biotransform the toxin to the less toxic metabolites aflatoxin M1 and Q1. In addition, Aflatoxin B1 (CAS NO.1162-65-8) is sensitive with air and light. It is not compatible with strong oxidizing agents, acids, alkalies, and you must not take it with dust generation, direct sunlight and incompatible materials and not be exposured to air. And also prevent it to broken down into hazardous decomposition products: carbon dioxide, carbon monoxide.

Physical properties about Aflatoxin B1 are:
(1)ACD/LogP:  2.039; (2)# of Rule of 5 Violations:  0; (3)ACD/LogD (pH 5.5):  2.04; (4)ACD/LogD (pH 7.4):  2.04; (5)ACD/BCF (pH 5.5):  20.87; (6)ACD/BCF (pH 7.4):  20.87; (7)ACD/KOC (pH 5.5):  306.29; (8)ACD/KOC (pH 7.4):  306.29; (9)#H bond acceptors:  6; (10)#H bond donors:  0; (11)#Freely Rotating Bonds:  1; (12)Index of Refraction:  1.687; (13)Molar Refractivity:  76.011 cm3; (14)Molar Volume:  199.584 cm3; (15)Polarizability:  30.133 10-24cm3 ; (16)Surface Tension:  68.7190017700195 dyne/cm; (17)Density:  1.565 g/cm3; (18)Flash Point:  237.669 °C; (19)Enthalpy of Vaporization:  80.29 kJ/mol; (20)Boiling Point:  528.151 °C at 760 mmHg; (21)Vapour Pressure:  0 mmHg at 25°C.

You can still convert the following datas into molecular structure:
(1)SMILES:O=C5C=4C(=O)Oc3c1c(OC2O\C=C/C12)cc(OC)c3C=4CC5;
(2)Std. InChI:InChI=1S/C17H12O6/c1-20-10-6-11-14(8-4-5-21-17(8)22-11)15-13(10)7-2-3-9(18)12(7)16(19)23-15/h4-6,8,17H,2-3H2,1H3;
(3)Std. InChIKey:OQIQSTLJSLGHID-UHFFFAOYSA-N.

Safety Information of Aflatoxin B1:
Risk Statements:(1)Highly flammable; (2)Harmful by inhalation, in contact with skin and if swallowed; (3)Toxic by inhalation, in contact with skin and if swallowed; (4)Very toxic by inhalation, in contact with skin and if swallowed; (5)Irritating to eyes and skin; (6)Danger of very serious irreversible effects; (7)May cause cancer; (8)May cause heritable genetic damage; (9)Harmful: may cause lung damage if swallowed.
Safety Statements:(1)Keep container tightly closed; (2)Keep away from sources of ignition; (3)Avoid contact with skin; (4)In case of contact with eyes, rinse immediately with plenty of water and seek medical advice; (5)Wear suitable protective clothing; (6)In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible; (7)Avoid exposure - obtain special instructions before use

The toxicity data of Aflatoxin B1 are as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LD50 oral 550ug/kg (0.55mg/kg) LIVER: OTHER CHANGES Cancer Research. Vol. 29, Pg. 236, 1969.
cat LD50 unreported 550ug/kg (0.55mg/kg)   Japanese Journal of Toxicology. Vol. 2, Pg. 377, 1989.
chicken LD50 unreported 6300ug/kg (6.3mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 23, Pg. 1327, 1981.
dog LD50 unreported 500ug/kg (0.5mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 23, Pg. 1327, 1981.
dog LDLo intraperitoneal 1mg/kg (1mg/kg)   Pathologia Veterinaria. Vol. 3, Pg. 331, 1966.
domestic animals - goat/sheep LD50 unreported 1mg/kg (1mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 23, Pg. 1327, 1981.
domestic animals - goat/sheep LDLo oral 2mg/kg (2mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Nature. Vol. 225, Pg. 1062, 1970.
duck LD50 oral 335ug/kg (0.335mg/kg)   Proceedings of the Society for Experimental Biology and Medicine. Vol. 123, Pg. 151, 1966.
duck LD50 unreported 335ug/kg (0.335mg/kg)   Japanese Journal of Toxicology. Vol. 2, Pg. 377, 1989.
guinea pig LD50 intraperitoneal 1400ug/kg (1.4mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), ZONAL"
LIVER: OTHER CHANGES
Journal of Pathology and Bacteriology. Vol. 91, Pg. 277, 1966.
guinea pig LD50 oral 2mg/kg (2mg/kg)   Toxicology and Applied Pharmacology. Vol. 19, Pg. 169, 1971.
guinea pig LD50 unreported 1400ug/kg (1.4mg/kg)   Toxicon. Vol. 18, Pg. 121, 1980.
hamster LD50 intraperitoneal 6mg/kg (6mg/kg)   Archives of Pathology. Vol. 83, Pg. 53, 1967.
hamster LD50 oral 10mg/kg (10mg/kg) LIVER: "HEPATITIS, FIBROUS (CIRRHOSIS, POST-NECROTIC SCARRING)"
LIVER: MULTIPLE EFFECTS
Cancer Research. Vol. 29, Pg. 236, 1969.
hamster LD50 unreported 10200ug/kg (10.2mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 23, Pg. 1327, 1981.
monkey LD50 oral 2200ug/kg (2.2mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
LIVER: "JAUNDICE, OTHER OR UNCLASSIFIED"
BEHAVIORAL: FOOD INTAKE (ANIMAL)
Toxicology and Applied Pharmacology. Vol. 19, Pg. 169, 1971.
monkey LD50 unreported 7800ug/kg (7.8mg/kg)   Japanese Journal of Toxicology. Vol. 2, Pg. 377, 1989.
monkey LDLo intraperitoneal 1300ug/kg (1.3mg/kg) LIVER: OTHER CHANGES American Journal of Pathology. Vol. 49, Pg. 1023, 1966.
mouse LD50 intraperitoneal 9500ug/kg (9.5mg/kg)   Life Sciences, Part 1: Physiology and Pharmacology. Vol. 13, Pg. 1143, 1973.
mouse LD50 oral 9mg/kg (9mg/kg)   Annual Review of Phytopathology. Vol. 12, Pg. 303, 1974.
pig LD50 oral 620ug/kg (0.62mg/kg)   Annual Review of Phytopathology. Vol. 12, Pg. 303, 1974.
pig LD50 unreported 6600ug/kg (6.6mg/kg)   Japanese Journal of Toxicology. Vol. 2, Pg. 377, 1989.
rabbit LD50 oral 400ug/kg (0.4mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) American Journal of Veterinary Research. Vol. 43, Pg. 1027, 1982.
rabbit LD50 unreported 300ug/kg (0.3mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 23, Pg. 1327, 1981.
rat LD50 intraperitoneal 6mg/kg (6mg/kg)   Toxicology and Applied Pharmacology. Vol. 25, Pg. 458, 1973.
rat LD50 oral 4800ug/kg (4.8mg/kg)   Cancer Research. Vol. 27, Pg. 2370, 1967.
rat LD50 unreported 6mg/kg (6mg/kg)   Toxicon. Vol. 18, Pg. 121, 1980.