Ahr-376: 0 Products found
Name
Ahr-376
EINECS
CAS No.
13118-10-0
Density
g/cm3
Solubility
Melting Point
Formula
C18H25 N O3 . Cl H
Boiling Point
434.6°Cat760mmHg
Molecular Weight
339.90
Flash Point
216.7°C
Transport Information
Appearance
Safety
Poison by intraperitoneal route. Moderately toxic by ingestion. Human systemic effects by ingestion: hallucinations, distorted perceptions, and toxic psychosis. When heated to decomposition it emits toxic fumes of NOx and HCl.
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms
Benzeneaceticacid, a-cyclopentyl-a-hydroxy-, 1-methyl-3-pyrrolidinylester, hydrochloride (9CI); Mandelic acid, a-cyclopentyl-, 1-methyl-3-pyrrolidinyl ester,hydrochloride (6CI,7CI,8CI); 3-Pyrrolidinol, 1-methyl-, a-cyclopentylmandelate (ester),hydrochloride (8CI); 3-Pyrrolidinol, 1-methyl-, a-cyclopentylmandelate, hydrochloride;1-Methyl-3-pyrrolidyl-a-phenylcyclopentane glycolate hydrochloride; 1-Methyl-3-pyrrolidyl-a-phenylcyclopentylglycolatehydrochloride; AHR 376; NSC 172251

History

Formaldehyde was first reported by the Russian chemist Aleksandr Butlerov (1828-1886), but it was conclusively identified by August Wilhelm von Hofmann.

Chemistry

Molecular Structure of Ahr 376 (CAS NO.13118-10-0):

IUPAC Name: (1-methylpyrrolidin-3-yl) 2-cyclopentyl-2-hydroxy-2-phenylacetate
Empirical Formula: C18H25NO
Molecular Weight: 303.396 
Index of Refraction: 1.577 
Surface Tension: 50.2 dyne/cm
Density: 1.17 g/cm3 
Flash Point: 216.7 °C
Enthalpy of Vaporization: 72.81 kJ/mol 
Boiling Point: 434.6 °C at 760 mmHg
Vapour Pressure: 2.52E-08 mmHg at 25°C 
Synonyms of  Ahr 376 (CAS NO.13118-10-0): 1-Methyl-3-(a-cyclopentylmandeloyloxy)pyrrolidinehydrochloride ; ahr 376 alpha-cyclopentylmandelic acid 1-methyl-3-pyrrolidinyl ester hydrochloride ; mandelic acid, alpha-cyclopentyl-,1-methyl-3-pyrrolidinyl ester, hydrochloride ; 1-Methyl-3-(-cyclopentylmandeloyloxy)pyrrolidine hydrochloride 1-Methyl-3-pyrrolidinyl -cyclopentylmandelate hydrochloride ; mandelic acid, alpha-cyclopentyl-, 1-methyl-3-pyrrolidinyl ester, hydrochloride ; 1-methyl-3-pyrrolidyl alpha-phenylcyclopentaneglycolate hydrochloride

History

 Raw materials:Diethyl ether-->Potassium permanganate-->Magnesium-->Bromoethane-->Styrene-->1,3-Cyclopentadiene-->Benzoylformic acid-->Methyl benzoylformate-->1-Methylpyrrolidine

Toxicity

1.    

orl-hmn TDLo:14 µg/kg/D

    CPAJAK    Canadian Psychiatric Association Journal. 11 (1966),5141.
2.    

orl-mus LD50:500 mg/kg

    JMPCAS    Journal of Medicinal and Pharmaceutical Chemistry. 2 (1960),523.
3.    

ipr-mus LD50:250 mg/kg

    JMPCAS    Journal of Medicinal and Pharmaceutical Chemistry. 2 (1960),523.

Safety

Poison by intraperitoneal route. Moderately toxic by ingestion. Human systemic effects by ingestion: hallucinations, distorted perceptions, and toxic psychosis. When heated to decomposition it emits toxic fumes of NOx and HCl.

Others

 Production methods of Ahr 376 (CAS NO.13118-10-0) is potassium permanganate oxidation of styrene to produce phenyl acid, then with the participation of methanol in sulfuric acid esterification was acetophenone methyl ester, the latter with cyclopentadiene Addition (Grignard reaction, the first metal magnesium, anhydrous ether, ethyl bromide Grignard reagent is made), with α-cyclopentadienyl mandelic acid methyl ester, and thus the activity of nickel-catalyzed hydrogenation under pressure and finally with the N-methyl-pyrrolidine -3 - alcohol ester exchange obtained the goods. Ahr 376 (CAS NO.13118-10-0) can be used as a intermediate product of stomach Changning.

 It is a high-toxic products, with flammable, while burning it would release of toxic nitrogen oxides and hydrogen chloride fumes, and should be stored in ventilated ,low-temperature, drying environment,besides should be kept separate with food and raw materials , dry powder, foam, sand, carbon dioxide, water mist fire-extinguishing agent can be used if emergency.