Alloxan: 0 Products found
Name
Alloxan
EINECS
200-062-0
CAS No.
50-71-5
Density
Solubility

History

Formaldehyde was first reported by the Russian chemist Aleksandr Butlerov (1828-1886), but it was conclusively identified by August Wilhelm von Hofmann.

Chemistry


IUPAC Name: 1,3-diazinane-2,4,5,6-tetrone 
Molecular Weight: 142.06968 g/mol
Molecular Formula: C4H2N2O4 
Density: 1.681 g/cm
Melting Point: ~245 °C (dec.)
Boiling Point: 409.5 °C at 760 mmHg 
Flash Point: 201.4 °C
Index of Refraction: 1.519
Molar Refractivity: 25.66 cm3
Molar Volume: 84.5 cm3
Polarizability: 10.17*10-24 cm3
Surface Tension: 62.6 dyne/cm 
Enthalpy of Vaporization: 76.46 kJ/mol
Vapour Pressure: 2.05E-08 mmHg at 25 °C 
XLogP3-AA: -1
H-Bond Donor: 2
H-Bond Acceptor: 4
Tautomer Count: 5
Exact Mass: 142.001457
MonoIsotopic Mass: 142.001457
Topological Polar Surface Area: 92.3
Heavy Atom Count: 10
Complexity: 222
Canonical SMILES: C1(=O)C(=O)NC(=O)NC1=O
InChI: InChI=1S/C4H2N2O4/c7-1-2(8)5-4(10)6-3(1)9/h(H2,5,6,8,9,10)
InChIKey: HIMXGTXNXJYFGB-UHFFFAOYSA-N
EINECS: 200-062-0
Storage temp.: 2-8 °C

History

 Alloxan (CAS NO.50-71-5) was originally isolated in 1818 by Brugnatelli and got its name in 1838 by Friedrich Wöhler and Justus von Liebig. The name "Alloxan" emerged from an amalgamation of the words "Allantoin" and "Oxalsäure" (oxaluric acid).

Production

The original preparation for Alloxan (CAS NO.50-71-5) was by oxidation of uric acid by nitric acid. Alloxan is a strong oxidizing agent and it forms a hemiacetal with its reduced reaction product dialuric acid (in which a carbonyl group is reduced to a hydroxyl group) which is called alloxantin.

Toxicity

1.    

eye-rbt 500 mg/24H MLD

    85JCAE    Prehled Prumyslove Toxikologie; Organicke Latky Marhold, J.,Prague, Czechoslovakia.: Avicenum,1986,862.
2.    

cyt-mus-ipr 50 mg/kg

    JOHEA8    Journal of Heredity. 65 (1974),345.
3.    

ipr-mus TDLo:200 mg/kg (female 8D post):TER

    JEEMAF    Journal of Embryology and Experimental Morphology. 14 (1965),63.
4.    

orl-rat LD50:5210 mg/kg

    28ZOAH    Chemicals in War Prentiss, A.M.,1972,150.
5.    

ivn-rat LD50:300 mg/kg

    CRSBAW    Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. 142 (1948),1335.
6.    

ipr-mus LDLo:300 mg/kg

    PSEBAA    Proceedings of the Society for Experimental Biology and Medicine. 67 (1948),154.
7.    

scu-mus LDLo:400 mg/kg

    PSEBAA    Proceedings of the Society for Experimental Biology and Medicine. 67 (1948),154.
8.    

ivn-mus LDLo:200 mg/kg

    PSEBAA    Proceedings of the Society for Experimental Biology and Medicine. 67 (1948),154.
9.    

ivn-rbt LDLo:300 mg/kg

    AJCPAI    American Journal of Clinical Pathology. 16 (1946),257.
10.    

rec-rbt LDLo:180 mg/kg

  &nbs

Consensus

Reported in EPA TSCA Inventory.

Safety

Poison by intraperitoneal, intravenous, subcutaneous, and rectal routes. Moderately toxic by ingestion. An experimental teratogen. Other experimental reproductive effects. Mutation data reported. Produces diabetes in experimental animals. Decomposes in storage to release CO2. Do not store in sealed container. Explodes when heated above 170°C. When heated to decomposition it emits toxic fumes of NOx.
Hazard Codes: HarmfulXn
Risk Statements: 20/21/22-36/37/38
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed
R36/37/38: Irritating to eyes, respiratory system and skin
Safety Statements: 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36: Wear suitable protective clothing
WGK Germany: 3
F: 8-10-23
Hazardous Substances Data: 50-71-5(Hazardous Substances Data)

Others

 Alloxan (CAS NO.50-71-5) is also called 2,4,5,6(1H,3H)-Pyrimidinetetrone ; Mesoxalylurea ; Mesoxalylcarbamide ; 4,5,6-Pyrimidinetetrone ; 2,4,5,6-Pyrimidintetron ; 2,4,5,6-Tetraoxohexahydropyrimidine . Alloxan (CAS NO.50-71-5) is a kind of pesticides. It's moderate toxic. It will explosive by heating above 170 °C. Alloxan (CAS NO.50-71-5) is also flammable. It will produce toxic nitrogen oxide fumes when buring. And it decomposits of carbon dioxide at room temperature. So the storage environment should be ventilate, low-temperature and dry. Keep Anthramycin (CAS NO.4803-27-4) separate from raw materials of food. Do not store in a sealed tank.