Product Name

  • Name

    amidephrine mesylate

  • EINECS
  • CAS No. 1421-68-7
  • Density g/cm3
  • Solubility
  • Melting Point 207-209°
  • Formula C10H16N2O3S•CH4O3S
  • Boiling Point 430.7°Cat760mmHg
  • Molecular Weight 340.45
  • Flash Point 214.3°C
  • Transport Information
  • Appearance
  • Safety Poison by ingestion, intraperitoneal, intravenous, and intradermal routes. Moderately toxic by subcutaneous route. An eye irritant. When heated to decomposition it emits very toxic fumes of NOx and SOx. A vasoconstrictor and nasal decongestant. See also SULFONATES.
  • Risk Codes
  • Molecular Structure Molecular Structure of 1421-68-7 (amidephrine mesylate)
  • Hazard Symbols
  • Synonyms amidephrine mesylate
  • PSA 149.56000
  • LogP 2.44040

Amidefrine mesylate Chemical Properties

Molecule structure of Amidefrine mesylate (CAS NO.1421-68-7):

IUPAC Name: N-[4-[1-Hydroxy-2-(methylamino)ethyl]phenyl]methanesulfonamide; methanesulfonic acid 
Molecular Weight: 340.4163 g/mol
Molecular Formula: C11H20N2O6S2 
Boiling Point: 430.7 °C at 760 mmHg
Flash Point: 214.3 °C
Enthalpy of Vaporization: 72.34 kJ/mol 
Vapour Pressure: 3.48E-08 mmHg at 25 °C
H-Bond Donor: 4
H-Bond Acceptor: 8
Rotatable Bond Count: 5
Exact Mass: 340.076278
MonoIsotopic Mass: 340.076278
Topological Polar Surface Area: 133
Heavy Atom Count: 21 
Complexity: 384
Canonical SMILES: CNCC(C1=CC=C(C=C1)NS(=O)(=O)C)O.CS(=O)(=O)O
InChI: InChI=1S/C10H16N2O3S.CH4O3S/c1-11-7-10(13)8-3-5-9(6-4-8)12-16(2,14)15;1-5(2,3)4/h3-6,10-13H,7H2,1-2H3;1H3,(H,2,3,4)
InChIKey: VNHHFNWFTCUMGQ-UHFFFAOYSA-N

Amidefrine mesylate Toxicity Data With Reference

1.    

eye-rbt 10 mg MLD

    TXAPA9    Toxicology and Applied Pharmacology. 23 (1972),589.
2.    

orl-rat LD50:13 mg/kg

    TXAPA9    Toxicology and Applied Pharmacology. 23 (1972),589.
3.    

ipr-rat LD50:5 mg/kg

    TXAPA9    Toxicology and Applied Pharmacology. 23 (1972),589.
4.    

orl-mus LD50:2284 mg/kg

    TXAPA9    Toxicology and Applied Pharmacology. 23 (1972),589.
5.    

ipr-mus LD50:780 mg/kg

    TXAPA9    Toxicology and Applied Pharmacology. 23 (1972),589.
6.    

scu-mus LD50:1990 mg/kg

    IJNEAQ    International Journal of Neuropharmacology. 4 (1965),219.
7.    

ivn-mus LD50:190 mg/kg

    IJNEAQ    International Journal of Neuropharmacology. 4 (1965),219.
8.    

ipr-dog LD50:4800 µg/kg

    IJNEAQ    International Journal of Neuropharmacology. 4 (1965),219.
9.    

ivn-dog LD50:1400 µg/kg

    TXAPA9    Toxicology and Applied Pharmacology. 23 (1972),589.
10.    

orl-cat LDLo:2 mg/kg

    TXAPA9    Toxicology and Applied Pharmacology. 23 (1972),589.
11.  

Amidefrine mesylate Safety Profile

Poison by ingestion, intraperitoneal, intravenous, and intradermal routes. Moderately toxic by subcutaneous route. An eye irritant. When heated to decomposition it emits very toxic fumes of NOx and SOx. A vasoconstrictor and nasal decongestant. See also SULFONATES.

Amidefrine mesylate Specification

 Amidefrine mesylate (CAS NO.1421-68-7) is also named as (2-Methylamine-1-hydroxyethyl)methanesulfonanilide methanesulfonate ; 3'-(1-Hydroxy-2-(methylamino)ethyl)methanesulfonanilide methanesulfonate ; 3'-(1-Hydroxy-2-(methylamino)ethyl)methanesulfonanilide monomethanesulfonate (salt) ; 3'-(2-(Methylamino)-l-hydroxyethyl)methanesulfonanilide methanesulfonate ; Amideferini mesilas ; Amideferini mesilas [INN-Latin] ; Amidefrini mesilas ; Amidefrini mesilas [INN-Spanish] ; Amidefrini mesylas ; Amidephrine mesylate ; Amidephrine monomethanesulfonate ; Dricol ; Fentrinol ; MJ 5190 ; Mesilate d'amidefrine ; Mesilate d'amidefrine [INN-French] ; Mesylate d'amideferine ; Methanesulfonamide, N-(3-(1-hydroxy-2-(methylamino)ethyl)phenyl)-, monomethanesulfonate (salt) ; Methanesulfonamide, N-(3-(1-hydroxy-2-(methylamino)ethyl)phenyl)-, monomethanesulfonate salt ; Methanesulfonanilide, 3'-(1-hydroxy-2-(methylamino)ethyl)-, methanesulfonate ; Nalde ; Product 5190 ; UNII-S3IG39T94B . Amidefrine mesylate (CAS NO.1421-68-7) is highly toxic. It is flammable. It will produce toxic nitrogen oxide and sulfur oxide fumes when buring. So the storage environment should be ventilate, low-temperature and dry.

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