• Name

  Calcium phosphorylcholine chloride

• EINECS 225-403-0
• CAS No. 4826-71-5
• Article Data4
• CAS DataBase
• Density 1.613[at 20℃]
• Solubility 203.458g/L at 20℃
• Melting Point
• Formula C5H15 N O4 P . Ca . Cl
• Boiling Point
• Molecular Weight 257.667
• Flash Point
• Transport Information
• Appearance
• Safety
• Risk Codes  Xi:;
  
• Molecular Structure
• Hazard Symbols Xi
• Synonyms Choline,chloride phosphate, Ca salt (6CI); Choline, chloride, dihydrogen phosphate,calcium salt (1:1) (7CI,8CI); Ethanaminium, N,N,N-trimethyl-2-(phosphonooxy)-,chloride, calcium salt (1:1) (9CI); Biocalcose; Calcium phosphorylcholine;Calcium phosphorylcholine chloride; Colifos; Colincalcium; Epafosforil;Fosfocolina; Ipercolin; Isocolin; Mebophos; Merival; Pancholin; Phoscholin;Phosphorylcholine calcium salt; Phosphorylcholine chloride calcium salt
• PSA 82.23000
• LogP -2.31770

Synthetic route

72556-74-2, 137734-45-3

phosphorylcholine chloride calcium salt tetrahydrate

A

4826-71-5

phosphorylcholine chloride, calcium salt

B

H2O

H2O

Conditions

Conditions	Yield
at 25℃; Thermodynamic data; ΔH0;

137753-74-3

phosphorylcholine calcium salt monohydrate

A

4826-71-5

phosphorylcholine chloride, calcium salt

B

H2O

H2O

Conditions

Conditions	Yield
at 25℃; Thermodynamic data; ΔH0, ΔG0, ΔS0;

107-73-3

phosphorylcholine chloride

4826-71-5

phosphorylcholine chloride, calcium salt

Conditions

Conditions	Yield
With calcium hydroxide In water pH=7.8; pH-value;

67-48-1

choline chloride

4826-71-5

phosphorylcholine chloride, calcium salt

Conditions

Conditions	Yield
Stage #1: choline chloride With phosphoric acid at 25 - 120℃; for 6h; Stage #2: With calcium hydroxide In water at 25℃; for 0.166667h;	100 g
Stage #1: choline chloride With phosphoric acid at 25 - 120℃; for 6h; Stage #2: With calcium hydroxide In water at 25℃; for 0.166667h;

4826-71-5

phosphorylcholine chloride, calcium salt

phosphorylcholine chloride potassium salt

Conditions

Conditions	Yield
With potassium hydrogencarbonate In water at 65℃; for 6h; Reagent/catalyst; Temperature;	99.6%

4826-71-5

phosphorylcholine chloride, calcium salt

107-73-3

phosphorylcholine chloride

Conditions

Conditions	Yield
Stage #1: phosphorylcholine chloride, calcium salt With oxalic acid In water at 50℃; for 2h; Stage #2: With ethylenediaminetetraacetic acid In water	95%
With oxalic acid In water Inert atmosphere;	88%
With oxalic acid In water at 45 - 50℃; for 1h;

57090-45-6

(2R)-3-chloro-1,2-propanediol

4826-71-5

phosphorylcholine chloride, calcium salt

34688-34-1

glycerolcholine phosphate

Conditions

Conditions	Yield
Stage #1: phosphorylcholine chloride, calcium salt With potassium oxalate In water at 20℃; for 2h; Stage #2: (2R)-3-chloro-1,2-propanediol With potassium hydroxide In ethanol for 6h;	86%

4826-71-5

phosphorylcholine chloride, calcium salt

76742-17-1

cytidine 5'-monophosphate morpholidate

987-78-0

citicoline

Conditions

Conditions	Yield
With sulfuric acid In methanol at 50℃; for 3h;	85%
at 20 - 60℃; for 10h;

25542-62-5

6-bromo-hexanoic acid ethyl ester

4826-71-5

phosphorylcholine chloride, calcium salt

134046-84-7

Ethyl 6-(O-phosphorylcholine)hydroxyhexanoate

Conditions

Conditions	Yield
18-crown-6 ether In formamide at 110 - 120℃; for 3h;	74%
Stage #1: phosphorylcholine chloride, calcium salt With oxalic acid neutralization; Stage #2: With potassium hydroxide pH=9; neutralization; Stage #3: 6-bromo-hexanoic acid ethyl ester With dibenzo-18-crown-6 In formamide at 110 - 120℃; for 3h; Substitution;

C12H15N5O7P(1-)

15715-58-9

triethylamine carbonate

4826-71-5

phosphorylcholine chloride, calcium salt

triethylammonium cytidine 5’-diphosphate choline

Conditions

Conditions	Yield
Stage #1: C12H15N5O7P(1-); phosphorylcholine chloride, calcium salt In acetonitrile for 4h; Stage #2: triethylamine carbonate pH=7.5;	34%

...Expand

C13H13N4O9P

4826-71-5

phosphorylcholine chloride, calcium salt

33818-15-4

cytidine 5'-diphosphocholine sodium salt

Conditions

Conditions	Yield
In acetonitrile for 2h;	30%

186581-53-3, 908094-01-9

diazomethane

4826-71-5

phosphorylcholine chloride, calcium salt

2375-06-6

methylphosphorylcholine

Conditions

Conditions	Yield
(i) oxalic acid, H2O, (ii) /BRN= 102415/, Et2O, MeOH; Multistep reaction;

4826-71-5

phosphorylcholine chloride, calcium salt

645-84-1

choline phosphate

Conditions

Conditions	Yield
With IR-120 (H+-form) In water

2052-49-5

tetra(n-butyl)ammonium hydroxide

4826-71-5

phosphorylcholine chloride, calcium salt

Phosphorylcholine tetra-n-butylammonium salt

Conditions

Conditions	Yield
Stage #1: phosphorylcholine chloride, calcium salt With oxalic acid Substitution; Stage #2: tetra(n-butyl)ammonium hydroxide In water pH=9; neutralization;
Stage #1: phosphorylcholine chloride, calcium salt With oxalic acid In water Stage #2: tetra(n-butyl)ammonium hydroxide In water pH=9;

4224-70-8

6-bromohexanoic acid

4826-71-5

phosphorylcholine chloride, calcium salt

73839-24-4

6-(O-phosphorylcholine)hydroxyhexanoic acid

Conditions

Conditions	Yield
18-crown-6 ether In formamide at 110 - 120℃; for 3h; Product distribution / selectivity;

63-37-6

cytidine monophosphate

4826-71-5

phosphorylcholine chloride, calcium salt

33818-15-4

cytidine 5'-diphosphocholine sodium salt

Conditions

Conditions	Yield
Stage #1: phosphorylcholine chloride, calcium salt With oxalic acid In water at 45 - 50℃; Stage #2: cytidine monophosphate With morpholine; hydrogenchloride; dicyclohexyl-carbodiimide In methanol; water at 50 - 55℃; pH=3.5; Stage #3: With sodium hydroxide In water Reagent/catalyst; Temperature;
Stage #1: phosphorylcholine chloride, calcium salt In benzene at 120℃; for 0.5h; Stage #2: With sodium carbonate In benzene for 2h; Stage #3: cytidine monophosphate Temperature; Further stages;

4826-71-5

phosphorylcholine chloride, calcium salt

57044-25-4

(R)-oxiranemethanol

28319-77-9

L-glycero-3-phosphorylcholine

Conditions

Conditions	Yield
Stage #1: phosphorylcholine chloride, calcium salt With sodium carbonate In water at 20℃; for 1h; Stage #2: (R)-oxiranemethanol Reagent/catalyst; Concentration; Reflux;	289 g

4826-71-5

phosphorylcholine chloride, calcium salt

C5H13NO4P(1-)*Cl(1-)*2Na(1+)

Conditions

Conditions	Yield
With sodium carbonate In water
With sodium carbonate In water

Calcium phosphorylcholine chloride Chemical Properties

Calcium phosphorylcholine chloride Safety Profile