Dextromoramide: 0 Products found
Name
Dextromoramide
EINECS
CAS No.
357-56-2
Density
1.121g/cm3
Solubility
Melting Point
Formula
C25H32 N2 O2
Boiling Point
579.6°Cat760mmHg
Molecular Weight
392.59
Flash Point
304.3°C
Transport Information
Appearance
Safety
Poison by subcutaneous and intravenous routes. Human systemic effects by subcutaneous and intramuscular routes: coma, cyanosis, respiratory depression, and nausea or vomiting. Caution: May be habit forming. This is a controlled substance (opiate) listed in the U.S. Code of Federal Regulations, Title 21 Part 1308.11 (1985). When heated to decomposition it emits toxic fumes of NOx.
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms
Pyrrolidine,1-(3-methyl-4-morpholino-2,2-diphenylbutyryl)-, (+)- (8CI);Pyrrolidine,1-[(3S)-3-methyl-4-(4-morpholinyl)-1-oxo-2,2-diphenylbutyl]- (9CI);Pyrrolidine, 1-[3-methyl-4-(4-morpholinyl)-1-oxo-2,2-diphenylbutyl]-, (S)-;(+)-1-(3-Methyl-4-morpholino-2,2-diphenylbutryl)pyrrolidine;(+)-4-[2-Methyl-4-oxo-3,3-diphenyl-4-(1-pyrrolidinyl)butyl]morpholine;Alcoid;Dauran;Dextromoramide;Dimorlin;Jetrium;Jetrium R;Linfadol;MCP 875;Moramide;Narcolo;Palfadonna;Palphium;Pyrrolamidol;Pyrrolamidolum;R 875;SKF 5137;Troxilan;Yetrium;d-2,2-Diphenyl-3-methyl-4-morpholinebutyropyrrolidine;d-2,2-Diphenyl-3-methyl-4-morpholinobutyrylpyrrolidine;d-3-Methyl-2,2-diphenyl-4-morpholinobutyrylpyrrolidine;

History

Formaldehyde was first reported by the Russian chemist Aleksandr Butlerov (1828-1886), but it was conclusively identified by August Wilhelm von Hofmann.

Others

The Dextromoramide, with the CAS registry number 357-56-2,is also known as (+)-1-[(S)-3-Methyl-4-morpholino-2,2-diphenylbutyryl]pyrrolidine;Pyrrolamidol. It belongs to the product categories of Organic matters. This chemical's molecular formula is C25H32N2O2 and molecular weight is 392.533. What's more,Its systematic name is Dextromoramide.It is an opioid analgesic structurally related to METHADONE and used in the treatment of severe pain. It will produce stimulation smoke when buring. So the storage environment should be ventilate, low-temperature and dry. Keep Dextromoramide separate from raw materials of food.

Physical properties about Dextromoramide are:
(1);ACD/LogP:2.526; (2) # of Rule of 5 Violations:0; (3)ACD/LogD (pH 5.5):1.17; (4)ACD/LogD (pH 7.4):2.42; (5)ACD/BCF (pH 5.5):2.15; (6)ACD/BCF (pH 7.4):38.28; (7)ACD/KOC (pH 5.5): 24.76; (8)ACD/KOC (pH 7.4): 440.93; (9)#H bond acceptors:4; (10)#H bond donors:0; (11)#Freely Rotating Bonds:6; (12)Index of Refraction:1.572; (13)Molar Refractivity:115.164 cm3; (14)Molar Volume:350.159 cm3; (15)Polarizability:45.655 10-24cm3; (16)Surface Tension:45.9809989929199 dyne/cm; (17)Density:1.121 g/cm3; (18)Flash Point:304.328 °C; (19) Enthalpy of Vaporization:86.716 kJ/mol; (20)Boiling Point:579.594 °C at 760 mmHg; (21)Vapour Pressure:0 mmHg at 25°C.

You can still convert the following datas into molecular structure:
(1)SMILES:O=C(N1CCCC1)C(c2ccccc2)(c3ccccc3)C(C)CN4CCOCC4;
(2)Std. InChI:InChI=1S/C25H32N2O2/c1-21(20-26-16-18-29-19-17-26)25(22-10-4-2-5-11-22,23-12-6-3-7-13-23)24(28)27-14-8-9-15-27/h2-7,10-13,21H,8-9,14-20H2,1H3;
(3)Std. InChIKey:INUNXTSAACVKJS-UHFFFAOYSA-N.

The toxicity data of Dextromoramide are as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
human TDLo intramuscular 57ug/kg (.057mg/kg) BEHAVIORAL: COMA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
New York State Journal of Medicine. Vol. 61, Pg. 83, 1961.
mouse LD50 intravenous 21mg/kg (21mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Pharmacy and Pharmacology. Vol. 9, Pg. 730, 1957.
mouse LD50 oral 168mg/kg (168mg/kg) LUNGS, THORAX, OR RESPIRATION: CYANOSIS

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Pharmacy and Pharmacology. Vol. 9, Pg. 730, 1957.
mouse LD50 subcutaneous 140mg/kg (140mg/kg)   British Journal of Pharmacology and Chemotherapy. Vol. 17, Pg. 433, 1961.
rat LD50 intravenous 13mg/kg (13mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Pharmacy and Pharmacology. Vol. 9, Pg. 730, 1957.
rat LD50 oral 71800ug/kg (71.8mg/kg)   Drug Development Research. Vol. 1, Pg. 1, 1981.
rat LD50 subcutaneous 50mg/kg (50mg/kg) LUNGS, THORAX, OR RESPIRATION: CYANOSIS

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Pharmacy and Pharmacology. Vol. 9, Pg. 730, 1957.
women TDLo intramuscular 200ug/kg (.2mg/kg) LUNGS, THORAX, OR RESPIRATION: CYANOSIS

GASTROINTESTINAL: NAUSEA OR VOMITING
Practitioner. Vol. 197, Pg. 348, 1966.
women TDLo subcutaneous 150ug/kg (.15mg/kg) BEHAVIORAL: COMA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
British Medical Journal. Vol. 1, Pg. 211, 1959.