Product Name

  • Name

    Carubicin

  • EINECS
  • CAS No. 39472-31-6
  • Density 1.63g/cm3
  • Solubility
  • Melting Point 191-192°C
  • Formula C26H27NO10
  • Boiling Point 750.6°Cat760mmHg
  • Molecular Weight 513.4933
  • Flash Point 407.7°C
  • Transport Information
  • Appearance
  • Safety Poison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. Human systemic effects by intravenous route: anorexia, hallucinations and distorted perceptions, thrombosis, nausea or vomiting, fatty liver degeneration, impaired liver function, endocrine changes, and leukopenia (reduced white blood cell count). An experimental teratogen. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits acrid smoke and fumes.
  • Risk Codes
  • Molecular Structure Molecular Structure of 39472-31-6 (Carubicin)
  • Hazard Symbols
  • Synonyms Carminomycin;CARMINOMYCIN,CARUBICIN;
  • PSA 196.84000
  • LogP 1.42620

Karminomycin Chemical Properties

IUPAC:  (7S,9S)-9-Acetyl-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-4,6,9,11-tetrahydroxy-8,10-dihydro-7H-tetracene-5,12-dione
 Karminomycin with CAS NO.of  39472-31-6 is also called for Carubicin ; CCRIS 961 ; Carminomycin ; STOCK1N-41435 ; AIDS-166741 ; CID443831 ; NCGC00159344-02 ; C12432  ; O-Demethyldaunomycin  and so on.
Molecular Weight: 513.49
Molecular Formula: C26H27NO10
ACD/LogP: 3.54  
ACD/LogD (pH 5.5): 0.78 
ACD/LogD (pH 7.4): 1.11 
ACD/BCF (pH 5.5): 1 
ACD/BCF (pH 7.4): 1.08 
ACD/KOC (pH 5.5): 3.49 
ACD/KOC (pH 7.4): 7.49 
H bond acceptors: 11 
H bond donors: 7 
Freely Rotating Bonds: 9
Heavy Atom Count: 37
Formal Charge: 0
Complexity: 944
Isotope Atom Count: 0
Defined Atom StereoCenter Count: 6
Undefined Atom StereoCenter Count: 0
Defined Bond StereoCenter Count: 0
Undefined Bond StereoCenter Count: 0
Covalently-Bonded Unit Count: 1 
Index of Refraction: 1.726 
Molar Refractivity: 125.14 cm3 
Molar Volume: 314.6 cm3 
Surface Tension: 99.8 dyne/cm 
Density: 1.63 g/cm3 
Flash Point: 407.7°C
Enthalpy of  Vaporization: 114.8 kJ/mol 
Boiling Point: 750.6°C at 760 mmHg
Vapour Pressure: 1.14E-23 mmHg at 25°C 
The molecular structure of  Karminomycin with CAS NO.of  39472-31-6:

Karminomycin Uses

 Karminomycin (CAS NO.39472-31-6) is used as antineoplastic agent.

Karminomycin Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral 2700ug/kg (2.7mg/kg)   Cancer Treatment Reports. Vol. 63, Pg. 899, 1979.
dog LDLo intravenous 600ug/kg (0.6mg/kg)   Cancer Treatment Reports. Vol. 63, Pg. 899, 1979.
human TDLo intravenous 12mg/kg/5D (12mg/kg) BEHAVIORAL: ANOREXIA (HUMAN

GASTROINTESTINAL: NAUSEA OR VOMITING

BLOOD: LEUKOPENIA		 Cancer Treatment Reports. Vol. 61, Pg. 1705, 1977.
mammal (species unspecified) LD50 intraperitoneal 1300ug/kg (1.3mg/kg)   Antibiotiki. Vol. 29, Pg. 748, 1984.
man TDLo intravenous 1071ug/kg/17D (1.071mg/kg) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

VASCULAR: THROMBOSIS DISTANT FROM INJECTION SITE

GASTROINTESTINAL: NAUSEA OR VOMITING		 Voprosy Onkologii. Problems of Oncology. For English translation, see PONCAU. Vol. 25(2), Pg. 63, 1979.
monkey LD50 oral 288mg/kg (288mg/kg) BEHAVIORAL: FOOD INTAKE (ANIMAL)

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

GASTROINTESTINAL: NAUSEA OR VOMITING		 Drug and Chemical Toxicology. Vol. 4, Pg. 383, 1981.
mouse LD50 intraperitoneal 960ug/kg (0.96mg/kg)   Antibiotiki. Vol. 29, Pg. 437, 1984.
mouse LD50 intravenous 3200ug/kg (3.2mg/kg)   Antibiotiki. Vol. 23, Pg. 1005, 1978.
mouse LD50 oral 7300ug/kg (7.3mg/kg)   Cancer Treatment Reports. Vol. 61, Pg. 1705, 1977.
mouse LD50 subcutaneous 2500ug/kg (2.5mg/kg)   Antibiotiki. Vol. 21, Pg. 1030, 1976.
rat LD50 intraperitoneal 1550ug/kg (1.55mg/kg) LIVER: FATTY LIVER DEGERATION

LIVER: LIVER FUNCTION TESTS IMPAIRED

ENDOCRINE: OTHER CHANGES		 Antibiotiki. Vol. 24, Pg. 218, 1979.
rat LD50 intravenous 1600ug/kg (1.6mg/kg)   Antibiotiki. Vol. 23, Pg. 1005, 1978.
rat LD50 oral 23mg/kg (23mg/kg)   Antibiotiki. Vol. 21, Pg. 904, 1976.
rat LD50 subcutaneous 4366ug/kg (4.366mg/kg)   Drug and Chemical Toxicology. Vol. 4, Pg. 383, 1981.

Karminomycin Safety Profile

Poison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. Human systemic effects by intravenous route: anorexia, hallucinations and distorted perceptions, thrombosis, nausea or vomiting, fatty liver degeneration, impaired liver function, endocrine changes, and leukopenia (reduced white blood cell count). An experimental teratogen. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits acrid smoke and fumes.

Related Products

Hot Products

Post buying leads

About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia

Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog

©2008 LookChem.com,License: ICP

NO.:Zhejiang16009103

complaints:service@lookchem.com Desktop View