Product Name

  • Name

    Ketorolac

  • EINECS 200-001-2
  • CAS No. 74103-06-3
  • Article Data27
  • CAS DataBase
  • Density 1.398 g/cm3
  • Solubility 183mg/L(32 oC)
  • Melting Point 160-161 ºC
  • Formula C15H13NO3
  • Boiling Point 223.7 ºC at 760 mmHg
  • Molecular Weight 255.273
  • Flash Point 89.1 ºC
  • Transport Information
  • Appearance white crystalline or white powder
  • Safety
  • Risk Codes
  • Molecular Structure Molecular Structure of 74103-06-3 (Ketorolac)
  • Hazard Symbols
  • Synonyms 1H-Pyrrolizine-1-carboxylicacid, 5-benzoyl-2,3-dihydro-, (?à)-;1H-Pyrrolizine-1-carboxylicacid, 5-benzoyl-2,3-dihydro-;(+-)-5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid;(+-)-Ketorolac;
  • PSA 59.30000
  • LogP 2.29100

Synthetic route

Methyl isopropyl 5-benzoyl-1,2-dihydro-3H-pyrrolo<1,2-a>pyrrole-1,1-dicarboxylate
157071-66-4

Methyl isopropyl 5-benzoyl-1,2-dihydro-3H-pyrrolo<1,2-a>pyrrole-1,1-dicarboxylate

Ketorolac
74103-06-3

Ketorolac

Conditions
ConditionsYield
With sodium hydroxide In methanol Ambient temperature;99%
ketorolac tromethamine

ketorolac tromethamine

Ketorolac
74103-06-3

Ketorolac

Conditions
ConditionsYield
With hydrogenchloride In water98%
With hydrogenchloride In water at 0 - 20℃;83.6%
With hydrogenchloride In water
diethyl 5-benzoyl-1,2-dihydro-3H-pyrrolo<1,2-a>pyrrole-1,1-dicarboxylate
140947-23-5

diethyl 5-benzoyl-1,2-dihydro-3H-pyrrolo<1,2-a>pyrrole-1,1-dicarboxylate

Ketorolac
74103-06-3

Ketorolac

Conditions
ConditionsYield
Stage #1: diethyl 5-benzoyl-1,2-dihydro-3H-pyrrolo<1,2-a>pyrrole-1,1-dicarboxylate With sodium hydroxide In diethyl ether; water for 24h; Reflux;
Stage #2: With hydrogenchloride In ethyl acetate at 70℃; for 4h;
80%
With sodium hydroxide In tetrahydrofuran for 9h; Time; Reflux; Green chemistry;47.5%
With hydrogenchloride; sodium hydroxide 1.) ether, reflux, 24 h, 2.) ethyl acetate, 70 deg C, 4 h; Yield given. Multistep reaction;
5-benzoyl-2,3-dihydro-1H-pyrrolizin-1-carboxylic acid-2-propyl ester
66635-74-3

5-benzoyl-2,3-dihydro-1H-pyrrolizin-1-carboxylic acid-2-propyl ester

Ketorolac
74103-06-3

Ketorolac

Conditions
ConditionsYield
With potassium carbonate In methanol; water for 0.5h; Heating;64%
With water In methanol; aq. phosphate buffer at 37℃; pH=8; Kinetics; pH-value;
5-benzoyl-7-bromo-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid
84023-60-9

5-benzoyl-7-bromo-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid

Ketorolac
74103-06-3

Ketorolac

Conditions
ConditionsYield
With hydrogen; magnesium oxide; palladium on activated charcoal In methanol; water under 760 Torr; for 2h; Ambient temperature; Yield given;
2-[2-(2-Benzoyl-5-methanesulfonyl-pyrrol-1-yl)-ethyl]-malonic acid dimethyl ester
80965-05-5

2-[2-(2-Benzoyl-5-methanesulfonyl-pyrrol-1-yl)-ethyl]-malonic acid dimethyl ester

Ketorolac
74103-06-3

Ketorolac

Conditions
ConditionsYield
Yield given. Multistep reaction;
ketorolac acid ethyl ester
108061-03-6

ketorolac acid ethyl ester

Ketorolac
74103-06-3

Ketorolac

Conditions
ConditionsYield
With pooled human serum In water at 37℃; Rate constant; serum metabolism; other reagents and solvent, other temperatures;
ketorolac acid <(N,N-dimethylamino)carbonyl>methyl ester

ketorolac acid <(N,N-dimethylamino)carbonyl>methyl ester

Ketorolac
74103-06-3

Ketorolac

Conditions
ConditionsYield
With pooled human serum In water at 37℃; Rate constant; serum metabolism; other reagents and solvent, other temperatures;
phenyl chloroformate
1885-14-9

phenyl chloroformate

Ketorolac
74103-06-3

Ketorolac

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 1.) oxalyl chloride / 1.) ether, ice-bath cooling, 0.75 h, 2.) CH2Cl2, r.t., 15 h
2: 68 percent / K2CO3, n-Bu4NBr / 44 h / Heating
3: 99 percent / 1 N NaOH / methanol / Ambient temperature
View Scheme
(1H-pyrrol-2-yl)acetic acid isopropyl ester
157071-48-2

(1H-pyrrol-2-yl)acetic acid isopropyl ester

Ketorolac
74103-06-3

Ketorolac

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 96 percent / LDA / tetrahydrofuran / 1.) -75 deg C to -60 deg C, 2.) -70 deg C, 1 h
2: 1.) oxalyl chloride / 1.) ether, ice-bath cooling, 0.75 h, 2.) CH2Cl2, r.t., 15 h
3: 68 percent / K2CO3, n-Bu4NBr / 44 h / Heating
4: 99 percent / 1 N NaOH / methanol / Ambient temperature
View Scheme
Multi-step reaction with 4 steps
1: 1.) oxalyl chloride / 1.) ether, ice-bath cooling, 0.75 h, 2.) CH2Cl2, r.t., 40 h
2: 97 percent / LDA / tetrahydrofuran / 1.) -75 deg C to -60 deg C, 2.) -65 deg C to 0 deg C, ca. 0.5 h
3: 68 percent / K2CO3, n-Bu4NBr / 44 h / Heating
4: 99 percent / 1 N NaOH / methanol / Ambient temperature
View Scheme
Methyl isopropyl 2-pyrrolylmalonate
157071-53-9

Methyl isopropyl 2-pyrrolylmalonate

Ketorolac
74103-06-3

Ketorolac

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 1.) oxalyl chloride / 1.) ether, ice-bath cooling, 0.75 h, 2.) CH2Cl2, r.t., 15 h
2: 68 percent / K2CO3, n-Bu4NBr / 44 h / Heating
3: 99 percent / 1 N NaOH / methanol / Ambient temperature
View Scheme
Isopropyl (5-benzoylpyrrol-2-yl)acetate
157071-65-3

Isopropyl (5-benzoylpyrrol-2-yl)acetate

Ketorolac
74103-06-3

Ketorolac

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 97 percent / LDA / tetrahydrofuran / 1.) -75 deg C to -60 deg C, 2.) -65 deg C to 0 deg C, ca. 0.5 h
2: 68 percent / K2CO3, n-Bu4NBr / 44 h / Heating
3: 99 percent / 1 N NaOH / methanol / Ambient temperature
View Scheme
Methyl isopropyl (5-benzoyl-2-pyrrolyl)malonate
157071-60-8

Methyl isopropyl (5-benzoyl-2-pyrrolyl)malonate

Ketorolac
74103-06-3

Ketorolac

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 68 percent / K2CO3, n-Bu4NBr / 44 h / Heating
2: 99 percent / 1 N NaOH / methanol / Ambient temperature
View Scheme
i-propyl 1,2-dihydro-3H-pyrrolo<1,2-a>pyrrole-1-carboxylate
66635-71-0

i-propyl 1,2-dihydro-3H-pyrrolo<1,2-a>pyrrole-1-carboxylate

Ketorolac
74103-06-3

Ketorolac

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1.) POCl3 / 1.) 1,2-dichloroethane, reflux, 1 h, 2.) 1,2-dichloroethane, reflux, 24 h
2: 64 percent / K2CO3 / methanol; H2O / 0.5 h / Heating
View Scheme
N,N-dimethylbenzamide
611-74-5

N,N-dimethylbenzamide

Ketorolac
74103-06-3

Ketorolac

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1.) POCl3 / 1.) 1,2-dichloroethane, reflux, 1 h, 2.) 1,2-dichloroethane, reflux, 24 h
2: 64 percent / K2CO3 / methanol; H2O / 0.5 h / Heating
View Scheme
Multi-step reaction with 5 steps
1: 1.) phosphorus oxychloride / 1.) 1,2-dichloroethane, reflux, 0.75 h, 2.) reflux, 1 h
2: 1.) NaH / 1.) DMF, RT, 1 h, 2.) 55 deg C, 5 h
3: 85percent m-chloroperbenzoic acid / CH2Cl2 / 3 h / 0 °C
4: 95 percent / HCl / 0.5 h / Heating
View Scheme
Multi-step reaction with 5 steps
1: 1.) phosphorus oxychloride / 1.) 1,2-dichloroethane, reflux, 0.75 h, 2.) reflux, 1 h
2: 100 percent / 86percent m-chloroperbenzoic acid / CH2Cl2 / 3 h / 5 °C
3: 1.) NaH / 1.) DMF, 2.) 90 deg C, 4 h
4: 95 percent / HCl / 0.5 h / Heating
View Scheme
phenyl(1H-pyrrol-2-yl)methanone
7697-46-3

phenyl(1H-pyrrol-2-yl)methanone

alkaline iodine-potassium iodide

alkaline iodine-potassium iodide

Ketorolac
74103-06-3

Ketorolac

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 75 percent / manganese triacetate trihydrate, NaOAc / 4 h / 70 °C
2: 50 percent / trifluoroacetic acid, triethylsilane / CH2Cl2 / 48 h / 40 °C
3: 67 percent / n-Bu4NBr, K2CO3 / 24 h / Heating
4: 1.) 20percent aq. NaOH, 2.) conc. HCl / 1.) ether, reflux, 24 h, 2.) ethyl acetate, 70 deg C, 4 h
View Scheme
Multi-step reaction with 4 steps
1: 57 percent / manganese triacetate trihydrate, NaOAc / 4 h / 70 °C
2: 50 percent / trifluoroacetic acid, triethylsilane / CH2Cl2 / 48 h / 40 °C
3: 67 percent / n-Bu4NBr, K2CO3 / 24 h / Heating
4: 1.) 20percent aq. NaOH, 2.) conc. HCl / 1.) ether, reflux, 24 h, 2.) ethyl acetate, 70 deg C, 4 h
View Scheme
Multi-step reaction with 3 steps
1: 86 percent / triethylborane, O2 / hexane; benzene / 3 h / Ambient temperature
2: 67 percent / n-Bu4NBr, K2CO3 / 24 h / Heating
3: 1.) 20percent aq. NaOH, 2.) conc. HCl / 1.) ether, reflux, 24 h, 2.) ethyl acetate, 70 deg C, 4 h
View Scheme
triethyl (5-benzoylpyrrol-2-yl)-methanetricarboxylate
136116-84-2

triethyl (5-benzoylpyrrol-2-yl)-methanetricarboxylate

Ketorolac
74103-06-3

Ketorolac

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 83 percent / NaOC2H5 / dimethylformamide / 2 h / Ambient temperature
2: 67 percent / n-Bu4NBr, K2CO3 / 24 h / Heating
3: 1.) 20percent aq. NaOH, 2.) conc. HCl / 1.) ether, reflux, 24 h, 2.) ethyl acetate, 70 deg C, 4 h
View Scheme
Multi-step reaction with 2 steps
1: 80 percent / n-Bu4NBr, K2CO3 / 24 h / Heating
2: 1.) 20percent aq. NaOH, 2.) conc. HCl / 1.) ether, reflux, 24 h, 2.) ethyl acetate, 70 deg C, 4 h
View Scheme
1-(2-chloroethyl)-2-benzoylpyrrole
87549-01-7

1-(2-chloroethyl)-2-benzoylpyrrole

Ketorolac
74103-06-3

Ketorolac

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 80 percent / NaI / acetonitrile / 24 h / Heating
2: 1.) 60percent NaH in mineral oil / 1.) DMF, r.t., 0.5 h, 2.) DMF, r.t., 16 h
3: 1.) 60percent NaH in mineral oil, 2.) N-bromosuccinimide / 1.) THF, r.t., 0.5 h, 2.) 0.5 h, r.t.
4: 75 percent / Et3B, O2 / benzene; hexane / 2 h / Ambient temperature
5: 1.) 20percent aq. NaOH, 2.) conc. HCl / 1.) ether, reflux, 24 h, 2.) ethyl acetate, 70 deg C, 4 h
View Scheme
Multi-step reaction with 4 steps
1: 80 percent / NaI / acetonitrile / 24 h / Heating
2: 1.) 60percent NaH in mineral oil / 1.) DMF, r.t., 0.5 h, 2.) DMF, r.t., 16 h
3: 96 percent / Mn(OAc)3, NaOAc / acetic acid / 6 h / 80 °C
4: 1.) 20percent aq. NaOH, 2.) conc. HCl / 1.) ether, reflux, 24 h, 2.) ethyl acetate, 70 deg C, 4 h
View Scheme
1-(2-iodoethyl)-2-benzoylpyrrole
141031-77-8

1-(2-iodoethyl)-2-benzoylpyrrole

Ketorolac
74103-06-3

Ketorolac

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 1.) 60percent NaH in mineral oil / 1.) DMF, r.t., 0.5 h, 2.) DMF, r.t., 16 h
2: 1.) 60percent NaH in mineral oil, 2.) N-bromosuccinimide / 1.) THF, r.t., 0.5 h, 2.) 0.5 h, r.t.
3: 75 percent / Et3B, O2 / benzene; hexane / 2 h / Ambient temperature
4: 1.) 20percent aq. NaOH, 2.) conc. HCl / 1.) ether, reflux, 24 h, 2.) ethyl acetate, 70 deg C, 4 h
View Scheme
Multi-step reaction with 3 steps
1: 1.) 60percent NaH in mineral oil / 1.) DMF, r.t., 0.5 h, 2.) DMF, r.t., 16 h
2: 96 percent / Mn(OAc)3, NaOAc / acetic acid / 6 h / 80 °C
3: 1.) 20percent aq. NaOH, 2.) conc. HCl / 1.) ether, reflux, 24 h, 2.) ethyl acetate, 70 deg C, 4 h
View Scheme
diethyl 2-(5-benzoyl-1H-pyrrol-2-yl)malonate
144710-35-0

diethyl 2-(5-benzoyl-1H-pyrrol-2-yl)malonate

Ketorolac
74103-06-3

Ketorolac

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 67 percent / n-Bu4NBr, K2CO3 / 24 h / Heating
2: 1.) 20percent aq. NaOH, 2.) conc. HCl / 1.) ether, reflux, 24 h, 2.) ethyl acetate, 70 deg C, 4 h
View Scheme
1-(3,3-diethoxycarbonyl-3-bromopropyl)-2-benzoylpyrrole
141031-81-4

1-(3,3-diethoxycarbonyl-3-bromopropyl)-2-benzoylpyrrole

Ketorolac
74103-06-3

Ketorolac

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 75 percent / Et3B, O2 / benzene; hexane / 2 h / Ambient temperature
2: 1.) 20percent aq. NaOH, 2.) conc. HCl / 1.) ether, reflux, 24 h, 2.) ethyl acetate, 70 deg C, 4 h
View Scheme
1-(3,3-diethoxycarbonylpropyl)-2-benzoylpyrrole
141031-78-9

1-(3,3-diethoxycarbonylpropyl)-2-benzoylpyrrole

Ketorolac
74103-06-3

Ketorolac

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 1.) 60percent NaH in mineral oil, 2.) N-bromosuccinimide / 1.) THF, r.t., 0.5 h, 2.) 0.5 h, r.t.
2: 75 percent / Et3B, O2 / benzene; hexane / 2 h / Ambient temperature
3: 1.) 20percent aq. NaOH, 2.) conc. HCl / 1.) ether, reflux, 24 h, 2.) ethyl acetate, 70 deg C, 4 h
View Scheme
Multi-step reaction with 2 steps
1: 96 percent / Mn(OAc)3, NaOAc / acetic acid / 6 h / 80 °C
2: 1.) 20percent aq. NaOH, 2.) conc. HCl / 1.) ether, reflux, 24 h, 2.) ethyl acetate, 70 deg C, 4 h
View Scheme
diethyl 5-benzoylpyrrol-2-yl-(α-acetoxy)malonate
144710-34-9

diethyl 5-benzoylpyrrol-2-yl-(α-acetoxy)malonate

Ketorolac
74103-06-3

Ketorolac

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 50 percent / trifluoroacetic acid, triethylsilane / CH2Cl2 / 48 h / 40 °C
2: 67 percent / n-Bu4NBr, K2CO3 / 24 h / Heating
3: 1.) 20percent aq. NaOH, 2.) conc. HCl / 1.) ether, reflux, 24 h, 2.) ethyl acetate, 70 deg C, 4 h
View Scheme
phenyl(1H-pyrrol-2-yl)methanone
7697-46-3

phenyl(1H-pyrrol-2-yl)methanone

Ketorolac
74103-06-3

Ketorolac

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 77 percent / bromine / CH2Cl2 / 0 deg C to RT, 2.5 h
2: 1.) NaH / 1.) DMF, RT, 1 h, 2.) 75-80 deg C, 4 h
3: HCl / 5 h / 0 deg C to RT
5: magnesium oxide, H2 / 5percent Pd/C / H2O; methanol / 2 h / 760 Torr / Ambient temperature
View Scheme
2,3-dibromo-5-benzoylpyrrole
50372-61-7

2,3-dibromo-5-benzoylpyrrole

Ketorolac
74103-06-3

Ketorolac

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 1.) NaH / 1.) DMF, RT, 1 h, 2.) 75-80 deg C, 4 h
2: HCl / 5 h / 0 deg C to RT
4: magnesium oxide, H2 / 5percent Pd/C / H2O; methanol / 2 h / 760 Torr / Ambient temperature
View Scheme
2-(methylthio)-5-benzoylpyrrole
80965-00-0

2-(methylthio)-5-benzoylpyrrole

Ketorolac
74103-06-3

Ketorolac

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 1.) NaH / 1.) DMF, RT, 1 h, 2.) 55 deg C, 5 h
2: 85percent m-chloroperbenzoic acid / CH2Cl2 / 3 h / 0 °C
3: 95 percent / HCl / 0.5 h / Heating
View Scheme
Multi-step reaction with 4 steps
1: 100 percent / 86percent m-chloroperbenzoic acid / CH2Cl2 / 3 h / 5 °C
2: 1.) NaH / 1.) DMF, 2.) 90 deg C, 4 h
3: 95 percent / HCl / 0.5 h / Heating
View Scheme
2-(methylsulfonyl)-5-benzoylpyrrole
80965-03-3

2-(methylsulfonyl)-5-benzoylpyrrole

Ketorolac
74103-06-3

Ketorolac

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 1.) NaH / 1.) DMF, 2.) 90 deg C, 4 h
2: 95 percent / HCl / 0.5 h / Heating
View Scheme
5-[2-(2-Benzoyl-5-methylsulfanyl-pyrrol-1-yl)-ethyl]-2,2-dimethyl-[1,3]dioxane-4,6-dione
83727-08-6

5-[2-(2-Benzoyl-5-methylsulfanyl-pyrrol-1-yl)-ethyl]-2,2-dimethyl-[1,3]dioxane-4,6-dione

Ketorolac
74103-06-3

Ketorolac

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 85percent m-chloroperbenzoic acid / CH2Cl2 / 3 h / 0 °C
2: 95 percent / HCl / 0.5 h / Heating
View Scheme
4-arm-PEG-20K

4-arm-PEG-20K

Ketorolac
74103-06-3

Ketorolac

4-arm-PEG-20K-ketorolac

4-arm-PEG-20K-ketorolac

Conditions
ConditionsYield
With dmap; benzotriazol-1-ol; dicyclohexyl-carbodiimide In dichloromethane at 20℃;95%
4-arm-PEG-40K

4-arm-PEG-40K

Ketorolac
74103-06-3

Ketorolac

4-arm-PEG-40K-ketorolac

4-arm-PEG-40K-ketorolac

Conditions
ConditionsYield
With dmap; benzotriazol-1-ol; dicyclohexyl-carbodiimide In dichloromethane at 20℃;94%
Ketorolac
74103-06-3

Ketorolac

butan-1-ol
71-36-3

butan-1-ol

5-benzoyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid butyl ester
376628-29-4

5-benzoyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid butyl ester

Conditions
ConditionsYield
With toluene-4-sulfonic acid In benzene for 3h; Heating;89%
With toluene-4-sulfonic acid In benzene at 120℃; for 0.333333h;
(L)-phenylalanine ethyl ester hydrochloride
3182-93-2

(L)-phenylalanine ethyl ester hydrochloride

Ketorolac
74103-06-3

Ketorolac

C26H26N2O4
1093407-70-5

C26H26N2O4

Conditions
ConditionsYield
Stage #1: Ketorolac With dicyclohexyl-carbodiimide In dichloromethane for 0.5h;
Stage #2: (L)-phenylalanine ethyl ester hydrochloride With triethylamine In dichloromethane at 0 - 20℃;
88%
(S)-alanine ethyl ester hydrochloride
1115-59-9

(S)-alanine ethyl ester hydrochloride

Ketorolac
74103-06-3

Ketorolac

C20H22N2O4
1093407-68-1

C20H22N2O4

Conditions
ConditionsYield
Stage #1: (S)-alanine ethyl ester hydrochloride; Ketorolac With triethylamine In dichloromethane at 0℃; for 0.5h;
Stage #2: With dicyclohexyl-carbodiimide In dichloromethane for 24h;
83%
chloromethyl n-butyrate
33657-49-7

chloromethyl n-butyrate

Ketorolac
74103-06-3

Ketorolac

5-benzoyl-2,3-dihydro-1H-pyrrolizin-1-carboxylic acid-(butyryloxy)methyl ester

5-benzoyl-2,3-dihydro-1H-pyrrolizin-1-carboxylic acid-(butyryloxy)methyl ester

Conditions
ConditionsYield
With potassium carbonate; potassium iodide In acetone at 20℃;83%
With potassium carbonate; potassium iodide In acetone at 20℃;
n-heptan1ol
111-70-6

n-heptan1ol

Ketorolac
74103-06-3

Ketorolac

ketorolac heptyl ester

ketorolac heptyl ester

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In tetrahydrofuran at 20℃; for 24h; Inert atmosphere;82%
1-bromoethyl acetate
40258-78-4

1-bromoethyl acetate

Ketorolac
74103-06-3

Ketorolac

5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid-1-(acetoxy)ethyl ester

5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid-1-(acetoxy)ethyl ester

Conditions
ConditionsYield
With potassium carbonate In acetone at 20℃;80%
With potassium carbonate In acetone at 20℃;76%
Ketorolac
74103-06-3

Ketorolac

tert-butyl alcohol
75-65-0

tert-butyl alcohol

ketorolac tert-butyl ester

ketorolac tert-butyl ester

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In tetrahydrofuran at 20℃; for 24h; Inert atmosphere;79%
Ketorolac
74103-06-3

Ketorolac

isopropyl alcohol
67-63-0

isopropyl alcohol

5-benzoyl-2,3-dihydro-1H-pyrrolizin-1-carboxylic acid-2-propyl ester
66635-74-3

5-benzoyl-2,3-dihydro-1H-pyrrolizin-1-carboxylic acid-2-propyl ester

Conditions
ConditionsYield
With thionyl chloride at 20℃; Cooling with ice;76%
With thionyl chloride76%
1,7-heptandiol
629-30-1

1,7-heptandiol

Ketorolac
74103-06-3

Ketorolac

diketorolac heptyl diester
1571587-90-0

diketorolac heptyl diester

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In tetrahydrofuran at 20℃; for 24h; Inert atmosphere;75%
Ketorolac
74103-06-3

Ketorolac

5-benzoyl-2,3-dihydro-1H-pyrrolizin-1-one

5-benzoyl-2,3-dihydro-1H-pyrrolizin-1-one

Conditions
ConditionsYield
With iron(III) chloride; oxygen In N,N-dimethyl-formamide at 110℃; for 12h; Catalytic behavior; Mechanism; Temperature; Solvent; Reagent/catalyst;74%
methanol
67-56-1

methanol

Ketorolac
74103-06-3

Ketorolac

5-benzoyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid methyl ester
80965-09-9

5-benzoyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid methyl ester

Conditions
ConditionsYield
With thionyl chloride for 14h; Inert atmosphere; Reflux;73%
With sulfuric acid Reflux;
With toluene-4-sulfonic acid In benzene at 120℃; for 0.333333h;
L-leucine ethyl ester hydrochloride
2743-40-0

L-leucine ethyl ester hydrochloride

Ketorolac
74103-06-3

Ketorolac

C23H28N2O4
1093407-72-7

C23H28N2O4

Conditions
ConditionsYield
Stage #1: L-leucine ethyl ester hydrochloride; Ketorolac With triethylamine In dichloromethane at 0℃; for 0.5h;
Stage #2: With dicyclohexyl-carbodiimide In dichloromethane for 24h;
71%
2-(prop-2-yn-1-yl)pent-4-yn-1-yl 3-hydroxybenzoate

2-(prop-2-yn-1-yl)pent-4-yn-1-yl 3-hydroxybenzoate

Ketorolac
74103-06-3

Ketorolac

3-(((2-(prop-2-yn-1-yl)pent-4-yn-1-yl)oxy)carbonyl)phenyl 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylate

3-(((2-(prop-2-yn-1-yl)pent-4-yn-1-yl)oxy)carbonyl)phenyl 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylate

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 17h;71%
L-tryptophan ethyl ester hydrochloride
2899-28-7, 6519-67-1, 61535-49-7, 67557-18-0, 68401-14-9

L-tryptophan ethyl ester hydrochloride

Ketorolac
74103-06-3

Ketorolac

C28H27N3O4
1093407-69-2

C28H27N3O4

Conditions
ConditionsYield
Stage #1: Ketorolac With dicyclohexyl-carbodiimide In dichloromethane for 0.5h;
Stage #2: L-tryptophan ethyl ester hydrochloride With triethylamine In dichloromethane at 0 - 20℃;
70%
Ketorolac
74103-06-3

Ketorolac

benzyl alcohol
100-51-6

benzyl alcohol

ketorolac benzyl ester

ketorolac benzyl ester

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In tetrahydrofuran at 20℃; for 24h; Inert atmosphere;69%
Ketorolac
74103-06-3

Ketorolac

diethyl L-aspartate hydrochloride
16115-68-7

diethyl L-aspartate hydrochloride

C23H26N2O6
1093407-74-9

C23H26N2O6

Conditions
ConditionsYield
Stage #1: Ketorolac; diethyl L-aspartate hydrochloride With triethylamine In dichloromethane at 0℃; for 0.5h;
Stage #2: With dicyclohexyl-carbodiimide In dichloromethane for 24h;
63%
Ketorolac
74103-06-3

Ketorolac

propargyl alcohol
107-19-7

propargyl alcohol

C18H15NO3

C18H15NO3

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0 - 20℃; for 5h;63%
With dmap In 1,2-dichloro-ethane; N,N-dimethyl-formamide at 20℃; for 5h;63%
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0 - 20℃; for 5h;63%
L-Valine ethyl ester hydrochloride
17609-47-1

L-Valine ethyl ester hydrochloride

Ketorolac
74103-06-3

Ketorolac

C22H26N2O4
1093407-71-6

C22H26N2O4

Conditions
ConditionsYield
Stage #1: L-Valine ethyl ester hydrochloride; Ketorolac With triethylamine In dichloromethane at 0℃; for 0.5h;
Stage #2: With dicyclohexyl-carbodiimide In dichloromethane for 24h;
62%
1-deoxy-1-(octylamino)-D-glucitol

1-deoxy-1-(octylamino)-D-glucitol

Ketorolac
74103-06-3

Ketorolac

C15H13NO3*C18H39NO

C15H13NO3*C18H39NO

Conditions
ConditionsYield
In ethanol at 70℃; for 0.5h; Temperature;60%
diethyl-L-glutamate hydrochloride
1118-89-4

diethyl-L-glutamate hydrochloride

Ketorolac
74103-06-3

Ketorolac

C24H28N2O6
1093407-76-1

C24H28N2O6

Conditions
ConditionsYield
Stage #1: Ketorolac With dicyclohexyl-carbodiimide In dichloromethane for 0.5h;
Stage #2: diethyl-L-glutamate hydrochloride With triethylamine In dichloromethane at 0 - 20℃;
59%
Ketorolac
74103-06-3

Ketorolac

silver nitrate

silver nitrate

C15H12AgNO3

C15H12AgNO3

Conditions
ConditionsYield
With ammonia In ethanol; water at 20℃; for 0.25h; pH=8; Darkness;58%
3-(4-sulfamoylphenoxy)propylammonium trifluoroacetate

3-(4-sulfamoylphenoxy)propylammonium trifluoroacetate

Ketorolac
74103-06-3

Ketorolac

5-benzoyl-N-(3-(4-sulfamoylphenoxy)propyl)-2,3-dihydro-1H-pyrrolizine-1-carboxamide

5-benzoyl-N-(3-(4-sulfamoylphenoxy)propyl)-2,3-dihydro-1H-pyrrolizine-1-carboxamide

Conditions
ConditionsYield
Stage #1: Ketorolac With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl acetamide at 20℃; for 0.166667h;
Stage #2: 3-(4-sulfamoylphenoxy)propylammonium trifluoroacetate With N-ethyl-N,N-diisopropylamine In N,N-dimethyl acetamide at 20℃;
58%
Ketorolac
74103-06-3

Ketorolac

[1-{[methyl{(R)-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propyl}-amino]methyl}-2,3-dihydro-1H-pyrrolizin-5-yl](phenyl)methanone
1331729-86-2

[1-{[methyl{(R)-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propyl}-amino]methyl}-2,3-dihydro-1H-pyrrolizin-5-yl](phenyl)methanone

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 20℃; for 18h;56%

Ketorolac Chemical Properties


IUPAC Name: 5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid
Molecular Formula: C15H13NO3
Molecular Weight: 255.27 g/mol
SMILES: n12c([C@@H](C(O)=O)CC2)ccc1C(c1ccccc1)=O
InChI: InChI=1/C15H13NO3/c17-14(10-4-2-1-3-5-10)13-7-6-12-11(15(18)19)8-9-16(12)13/h1-7,11H,8-9H2,(H,18,19)
Classification Code: Analgesics; Analgesics, Non-Narcotic; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Cyclooxygenase Inhibitors; Drug / Therapeutic Agent; Enzyme Inhibitors; Peripheral Nervous System Agents; Sensory System Agents
Product Categories: API's
Index of Refraction: 1.436 
Molar Refractivity: 30.52 cm
Molar Volume: 116.6 cm3 
Polarizability: 12.1×10-24 cm3 
Surface Tension: 28.4 dyne/cm 
Density: 1.398 g/cm3 
Flash Point: 89.1 °C 
Enthalpy of Vaporization: 46.02 kJ/mol 
Boiling Point: 223.7 °C at 760 mmHg 
Melting Point: 160-161 °C
Vapour Pressure of Ketorolac (CAS NO.74103-06-3): 0.0947 mmHg at 25 °C

Ketorolac Uses

 Ketorolac (CAS NO.74103-06-3) is a non-steroidal anti-inflammatory drug, often used as an analgesic, antipyretic (fever reducer), and anti-inflammatory. An ophthalmic (i.e., eye-drop) solution of Ketorolac is available and is used to treat eye pain and to relieve the itchiness and burning of seasonal allergies.

Ketorolac Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 oral 200mg/kg (200mg/kg)   Agents and Actions, A Swiss Journal of Pharmacology. Vol. 12, Pg. 684, 1982.
mouse LDLo intraperitoneal 100mg/kg (100mg/kg)   Agents and Actions, A Swiss Journal of Pharmacology. Vol. 12, Pg. 684, 1982.
 

Ketorolac Safety Profile

RIDADR: 3249
HazardClass: 6.1(a)
PackingGroup of Ketorolac (CAS NO.74103-06-3): II

Ketorolac Specification

 Ketorolac (CAS NO.74103-06-3), its Synonyms are (+-)-5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid ; (+-)-Ketorolac ; Ketorolacum ; 1H-Pyrrolizine-1-carboxylic acid, 2,3-dihydro-5-benzoyl-, (+-)- .

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