Methyl isopropyl 5-benzoyl-1,2-dihydro-3H-pyrrolo<1,2-a>pyrrole-1,1-dicarboxylate
Ketorolac
Conditions | Yield |
---|---|
With sodium hydroxide In methanol Ambient temperature; | 99% |
Ketorolac
Conditions | Yield |
---|---|
With hydrogenchloride In water | 98% |
With hydrogenchloride In water at 0 - 20℃; | 83.6% |
With hydrogenchloride In water |
diethyl 5-benzoyl-1,2-dihydro-3H-pyrrolo<1,2-a>pyrrole-1,1-dicarboxylate
Ketorolac
Conditions | Yield |
---|---|
Stage #1: diethyl 5-benzoyl-1,2-dihydro-3H-pyrrolo<1,2-a>pyrrole-1,1-dicarboxylate With sodium hydroxide In diethyl ether; water for 24h; Reflux; Stage #2: With hydrogenchloride In ethyl acetate at 70℃; for 4h; | 80% |
With sodium hydroxide In tetrahydrofuran for 9h; Time; Reflux; Green chemistry; | 47.5% |
With hydrogenchloride; sodium hydroxide 1.) ether, reflux, 24 h, 2.) ethyl acetate, 70 deg C, 4 h; Yield given. Multistep reaction; |
5-benzoyl-2,3-dihydro-1H-pyrrolizin-1-carboxylic acid-2-propyl ester
Ketorolac
Conditions | Yield |
---|---|
With potassium carbonate In methanol; water for 0.5h; Heating; | 64% |
With water In methanol; aq. phosphate buffer at 37℃; pH=8; Kinetics; pH-value; |
5-benzoyl-7-bromo-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid
Ketorolac
Conditions | Yield |
---|---|
With hydrogen; magnesium oxide; palladium on activated charcoal In methanol; water under 760 Torr; for 2h; Ambient temperature; Yield given; |
2-[2-(2-Benzoyl-5-methanesulfonyl-pyrrol-1-yl)-ethyl]-malonic acid dimethyl ester
Ketorolac
Conditions | Yield |
---|---|
Yield given. Multistep reaction; |
ketorolac acid ethyl ester
Ketorolac
Conditions | Yield |
---|---|
With pooled human serum In water at 37℃; Rate constant; serum metabolism; other reagents and solvent, other temperatures; |
Ketorolac
Conditions | Yield |
---|---|
With pooled human serum In water at 37℃; Rate constant; serum metabolism; other reagents and solvent, other temperatures; |
phenyl chloroformate
Ketorolac
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 1.) oxalyl chloride / 1.) ether, ice-bath cooling, 0.75 h, 2.) CH2Cl2, r.t., 15 h 2: 68 percent / K2CO3, n-Bu4NBr / 44 h / Heating 3: 99 percent / 1 N NaOH / methanol / Ambient temperature View Scheme |
(1H-pyrrol-2-yl)acetic acid isopropyl ester
Ketorolac
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 96 percent / LDA / tetrahydrofuran / 1.) -75 deg C to -60 deg C, 2.) -70 deg C, 1 h 2: 1.) oxalyl chloride / 1.) ether, ice-bath cooling, 0.75 h, 2.) CH2Cl2, r.t., 15 h 3: 68 percent / K2CO3, n-Bu4NBr / 44 h / Heating 4: 99 percent / 1 N NaOH / methanol / Ambient temperature View Scheme | |
Multi-step reaction with 4 steps 1: 1.) oxalyl chloride / 1.) ether, ice-bath cooling, 0.75 h, 2.) CH2Cl2, r.t., 40 h 2: 97 percent / LDA / tetrahydrofuran / 1.) -75 deg C to -60 deg C, 2.) -65 deg C to 0 deg C, ca. 0.5 h 3: 68 percent / K2CO3, n-Bu4NBr / 44 h / Heating 4: 99 percent / 1 N NaOH / methanol / Ambient temperature View Scheme |
Methyl isopropyl 2-pyrrolylmalonate
Ketorolac
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 1.) oxalyl chloride / 1.) ether, ice-bath cooling, 0.75 h, 2.) CH2Cl2, r.t., 15 h 2: 68 percent / K2CO3, n-Bu4NBr / 44 h / Heating 3: 99 percent / 1 N NaOH / methanol / Ambient temperature View Scheme |
Isopropyl (5-benzoylpyrrol-2-yl)acetate
Ketorolac
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 97 percent / LDA / tetrahydrofuran / 1.) -75 deg C to -60 deg C, 2.) -65 deg C to 0 deg C, ca. 0.5 h 2: 68 percent / K2CO3, n-Bu4NBr / 44 h / Heating 3: 99 percent / 1 N NaOH / methanol / Ambient temperature View Scheme |
Methyl isopropyl (5-benzoyl-2-pyrrolyl)malonate
Ketorolac
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 68 percent / K2CO3, n-Bu4NBr / 44 h / Heating 2: 99 percent / 1 N NaOH / methanol / Ambient temperature View Scheme |
i-propyl 1,2-dihydro-3H-pyrrolo<1,2-a>pyrrole-1-carboxylate
Ketorolac
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 1.) POCl3 / 1.) 1,2-dichloroethane, reflux, 1 h, 2.) 1,2-dichloroethane, reflux, 24 h 2: 64 percent / K2CO3 / methanol; H2O / 0.5 h / Heating View Scheme |
N,N-dimethylbenzamide
Ketorolac
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 1.) POCl3 / 1.) 1,2-dichloroethane, reflux, 1 h, 2.) 1,2-dichloroethane, reflux, 24 h 2: 64 percent / K2CO3 / methanol; H2O / 0.5 h / Heating View Scheme | |
Multi-step reaction with 5 steps 1: 1.) phosphorus oxychloride / 1.) 1,2-dichloroethane, reflux, 0.75 h, 2.) reflux, 1 h 2: 1.) NaH / 1.) DMF, RT, 1 h, 2.) 55 deg C, 5 h 3: 85percent m-chloroperbenzoic acid / CH2Cl2 / 3 h / 0 °C 4: 95 percent / HCl / 0.5 h / Heating View Scheme | |
Multi-step reaction with 5 steps 1: 1.) phosphorus oxychloride / 1.) 1,2-dichloroethane, reflux, 0.75 h, 2.) reflux, 1 h 2: 100 percent / 86percent m-chloroperbenzoic acid / CH2Cl2 / 3 h / 5 °C 3: 1.) NaH / 1.) DMF, 2.) 90 deg C, 4 h 4: 95 percent / HCl / 0.5 h / Heating View Scheme |
phenyl(1H-pyrrol-2-yl)methanone
Ketorolac
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 75 percent / manganese triacetate trihydrate, NaOAc / 4 h / 70 °C 2: 50 percent / trifluoroacetic acid, triethylsilane / CH2Cl2 / 48 h / 40 °C 3: 67 percent / n-Bu4NBr, K2CO3 / 24 h / Heating 4: 1.) 20percent aq. NaOH, 2.) conc. HCl / 1.) ether, reflux, 24 h, 2.) ethyl acetate, 70 deg C, 4 h View Scheme | |
Multi-step reaction with 4 steps 1: 57 percent / manganese triacetate trihydrate, NaOAc / 4 h / 70 °C 2: 50 percent / trifluoroacetic acid, triethylsilane / CH2Cl2 / 48 h / 40 °C 3: 67 percent / n-Bu4NBr, K2CO3 / 24 h / Heating 4: 1.) 20percent aq. NaOH, 2.) conc. HCl / 1.) ether, reflux, 24 h, 2.) ethyl acetate, 70 deg C, 4 h View Scheme | |
Multi-step reaction with 3 steps 1: 86 percent / triethylborane, O2 / hexane; benzene / 3 h / Ambient temperature 2: 67 percent / n-Bu4NBr, K2CO3 / 24 h / Heating 3: 1.) 20percent aq. NaOH, 2.) conc. HCl / 1.) ether, reflux, 24 h, 2.) ethyl acetate, 70 deg C, 4 h View Scheme |
triethyl (5-benzoylpyrrol-2-yl)-methanetricarboxylate
Ketorolac
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 83 percent / NaOC2H5 / dimethylformamide / 2 h / Ambient temperature 2: 67 percent / n-Bu4NBr, K2CO3 / 24 h / Heating 3: 1.) 20percent aq. NaOH, 2.) conc. HCl / 1.) ether, reflux, 24 h, 2.) ethyl acetate, 70 deg C, 4 h View Scheme | |
Multi-step reaction with 2 steps 1: 80 percent / n-Bu4NBr, K2CO3 / 24 h / Heating 2: 1.) 20percent aq. NaOH, 2.) conc. HCl / 1.) ether, reflux, 24 h, 2.) ethyl acetate, 70 deg C, 4 h View Scheme |
1-(2-chloroethyl)-2-benzoylpyrrole
Ketorolac
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 80 percent / NaI / acetonitrile / 24 h / Heating 2: 1.) 60percent NaH in mineral oil / 1.) DMF, r.t., 0.5 h, 2.) DMF, r.t., 16 h 3: 1.) 60percent NaH in mineral oil, 2.) N-bromosuccinimide / 1.) THF, r.t., 0.5 h, 2.) 0.5 h, r.t. 4: 75 percent / Et3B, O2 / benzene; hexane / 2 h / Ambient temperature 5: 1.) 20percent aq. NaOH, 2.) conc. HCl / 1.) ether, reflux, 24 h, 2.) ethyl acetate, 70 deg C, 4 h View Scheme | |
Multi-step reaction with 4 steps 1: 80 percent / NaI / acetonitrile / 24 h / Heating 2: 1.) 60percent NaH in mineral oil / 1.) DMF, r.t., 0.5 h, 2.) DMF, r.t., 16 h 3: 96 percent / Mn(OAc)3, NaOAc / acetic acid / 6 h / 80 °C 4: 1.) 20percent aq. NaOH, 2.) conc. HCl / 1.) ether, reflux, 24 h, 2.) ethyl acetate, 70 deg C, 4 h View Scheme |
1-(2-iodoethyl)-2-benzoylpyrrole
Ketorolac
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 1.) 60percent NaH in mineral oil / 1.) DMF, r.t., 0.5 h, 2.) DMF, r.t., 16 h 2: 1.) 60percent NaH in mineral oil, 2.) N-bromosuccinimide / 1.) THF, r.t., 0.5 h, 2.) 0.5 h, r.t. 3: 75 percent / Et3B, O2 / benzene; hexane / 2 h / Ambient temperature 4: 1.) 20percent aq. NaOH, 2.) conc. HCl / 1.) ether, reflux, 24 h, 2.) ethyl acetate, 70 deg C, 4 h View Scheme | |
Multi-step reaction with 3 steps 1: 1.) 60percent NaH in mineral oil / 1.) DMF, r.t., 0.5 h, 2.) DMF, r.t., 16 h 2: 96 percent / Mn(OAc)3, NaOAc / acetic acid / 6 h / 80 °C 3: 1.) 20percent aq. NaOH, 2.) conc. HCl / 1.) ether, reflux, 24 h, 2.) ethyl acetate, 70 deg C, 4 h View Scheme |
diethyl 2-(5-benzoyl-1H-pyrrol-2-yl)malonate
Ketorolac
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 67 percent / n-Bu4NBr, K2CO3 / 24 h / Heating 2: 1.) 20percent aq. NaOH, 2.) conc. HCl / 1.) ether, reflux, 24 h, 2.) ethyl acetate, 70 deg C, 4 h View Scheme |
1-(3,3-diethoxycarbonyl-3-bromopropyl)-2-benzoylpyrrole
Ketorolac
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 75 percent / Et3B, O2 / benzene; hexane / 2 h / Ambient temperature 2: 1.) 20percent aq. NaOH, 2.) conc. HCl / 1.) ether, reflux, 24 h, 2.) ethyl acetate, 70 deg C, 4 h View Scheme |
1-(3,3-diethoxycarbonylpropyl)-2-benzoylpyrrole
Ketorolac
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 1.) 60percent NaH in mineral oil, 2.) N-bromosuccinimide / 1.) THF, r.t., 0.5 h, 2.) 0.5 h, r.t. 2: 75 percent / Et3B, O2 / benzene; hexane / 2 h / Ambient temperature 3: 1.) 20percent aq. NaOH, 2.) conc. HCl / 1.) ether, reflux, 24 h, 2.) ethyl acetate, 70 deg C, 4 h View Scheme | |
Multi-step reaction with 2 steps 1: 96 percent / Mn(OAc)3, NaOAc / acetic acid / 6 h / 80 °C 2: 1.) 20percent aq. NaOH, 2.) conc. HCl / 1.) ether, reflux, 24 h, 2.) ethyl acetate, 70 deg C, 4 h View Scheme |
diethyl 5-benzoylpyrrol-2-yl-(α-acetoxy)malonate
Ketorolac
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 50 percent / trifluoroacetic acid, triethylsilane / CH2Cl2 / 48 h / 40 °C 2: 67 percent / n-Bu4NBr, K2CO3 / 24 h / Heating 3: 1.) 20percent aq. NaOH, 2.) conc. HCl / 1.) ether, reflux, 24 h, 2.) ethyl acetate, 70 deg C, 4 h View Scheme |
phenyl(1H-pyrrol-2-yl)methanone
Ketorolac
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 77 percent / bromine / CH2Cl2 / 0 deg C to RT, 2.5 h 2: 1.) NaH / 1.) DMF, RT, 1 h, 2.) 75-80 deg C, 4 h 3: HCl / 5 h / 0 deg C to RT 5: magnesium oxide, H2 / 5percent Pd/C / H2O; methanol / 2 h / 760 Torr / Ambient temperature View Scheme |
2,3-dibromo-5-benzoylpyrrole
Ketorolac
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 1.) NaH / 1.) DMF, RT, 1 h, 2.) 75-80 deg C, 4 h 2: HCl / 5 h / 0 deg C to RT 4: magnesium oxide, H2 / 5percent Pd/C / H2O; methanol / 2 h / 760 Torr / Ambient temperature View Scheme |
2-(methylthio)-5-benzoylpyrrole
Ketorolac
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 1.) NaH / 1.) DMF, RT, 1 h, 2.) 55 deg C, 5 h 2: 85percent m-chloroperbenzoic acid / CH2Cl2 / 3 h / 0 °C 3: 95 percent / HCl / 0.5 h / Heating View Scheme | |
Multi-step reaction with 4 steps 1: 100 percent / 86percent m-chloroperbenzoic acid / CH2Cl2 / 3 h / 5 °C 2: 1.) NaH / 1.) DMF, 2.) 90 deg C, 4 h 3: 95 percent / HCl / 0.5 h / Heating View Scheme |
2-(methylsulfonyl)-5-benzoylpyrrole
Ketorolac
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 1.) NaH / 1.) DMF, 2.) 90 deg C, 4 h 2: 95 percent / HCl / 0.5 h / Heating View Scheme |
5-[2-(2-Benzoyl-5-methylsulfanyl-pyrrol-1-yl)-ethyl]-2,2-dimethyl-[1,3]dioxane-4,6-dione
Ketorolac
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 85percent m-chloroperbenzoic acid / CH2Cl2 / 3 h / 0 °C 2: 95 percent / HCl / 0.5 h / Heating View Scheme |
Conditions | Yield |
---|---|
With dmap; benzotriazol-1-ol; dicyclohexyl-carbodiimide In dichloromethane at 20℃; | 95% |
Conditions | Yield |
---|---|
With dmap; benzotriazol-1-ol; dicyclohexyl-carbodiimide In dichloromethane at 20℃; | 94% |
Ketorolac
butan-1-ol
5-benzoyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid butyl ester
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In benzene for 3h; Heating; | 89% |
With toluene-4-sulfonic acid In benzene at 120℃; for 0.333333h; |
Conditions | Yield |
---|---|
Stage #1: Ketorolac With dicyclohexyl-carbodiimide In dichloromethane for 0.5h; Stage #2: (L)-phenylalanine ethyl ester hydrochloride With triethylamine In dichloromethane at 0 - 20℃; | 88% |
Conditions | Yield |
---|---|
Stage #1: (S)-alanine ethyl ester hydrochloride; Ketorolac With triethylamine In dichloromethane at 0℃; for 0.5h; Stage #2: With dicyclohexyl-carbodiimide In dichloromethane for 24h; | 83% |
chloromethyl n-butyrate
Ketorolac
Conditions | Yield |
---|---|
With potassium carbonate; potassium iodide In acetone at 20℃; | 83% |
With potassium carbonate; potassium iodide In acetone at 20℃; |
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In tetrahydrofuran at 20℃; for 24h; Inert atmosphere; | 82% |
1-bromoethyl acetate
Ketorolac
Conditions | Yield |
---|---|
With potassium carbonate In acetone at 20℃; | 80% |
With potassium carbonate In acetone at 20℃; | 76% |
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In tetrahydrofuran at 20℃; for 24h; Inert atmosphere; | 79% |
Ketorolac
isopropyl alcohol
5-benzoyl-2,3-dihydro-1H-pyrrolizin-1-carboxylic acid-2-propyl ester
Conditions | Yield |
---|---|
With thionyl chloride at 20℃; Cooling with ice; | 76% |
With thionyl chloride | 76% |
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In tetrahydrofuran at 20℃; for 24h; Inert atmosphere; | 75% |
Ketorolac
Conditions | Yield |
---|---|
With iron(III) chloride; oxygen In N,N-dimethyl-formamide at 110℃; for 12h; Catalytic behavior; Mechanism; Temperature; Solvent; Reagent/catalyst; | 74% |
methanol
Ketorolac
5-benzoyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid methyl ester
Conditions | Yield |
---|---|
With thionyl chloride for 14h; Inert atmosphere; Reflux; | 73% |
With sulfuric acid Reflux; | |
With toluene-4-sulfonic acid In benzene at 120℃; for 0.333333h; |
Conditions | Yield |
---|---|
Stage #1: L-leucine ethyl ester hydrochloride; Ketorolac With triethylamine In dichloromethane at 0℃; for 0.5h; Stage #2: With dicyclohexyl-carbodiimide In dichloromethane for 24h; | 71% |
Ketorolac
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 17h; | 71% |
L-tryptophan ethyl ester hydrochloride
Ketorolac
C28H27N3O4
Conditions | Yield |
---|---|
Stage #1: Ketorolac With dicyclohexyl-carbodiimide In dichloromethane for 0.5h; Stage #2: L-tryptophan ethyl ester hydrochloride With triethylamine In dichloromethane at 0 - 20℃; | 70% |
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In tetrahydrofuran at 20℃; for 24h; Inert atmosphere; | 69% |
Conditions | Yield |
---|---|
Stage #1: Ketorolac; diethyl L-aspartate hydrochloride With triethylamine In dichloromethane at 0℃; for 0.5h; Stage #2: With dicyclohexyl-carbodiimide In dichloromethane for 24h; | 63% |
Conditions | Yield |
---|---|
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0 - 20℃; for 5h; | 63% |
With dmap In 1,2-dichloro-ethane; N,N-dimethyl-formamide at 20℃; for 5h; | 63% |
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0 - 20℃; for 5h; | 63% |
Conditions | Yield |
---|---|
Stage #1: L-Valine ethyl ester hydrochloride; Ketorolac With triethylamine In dichloromethane at 0℃; for 0.5h; Stage #2: With dicyclohexyl-carbodiimide In dichloromethane for 24h; | 62% |
Conditions | Yield |
---|---|
In ethanol at 70℃; for 0.5h; Temperature; | 60% |
Conditions | Yield |
---|---|
Stage #1: Ketorolac With dicyclohexyl-carbodiimide In dichloromethane for 0.5h; Stage #2: diethyl-L-glutamate hydrochloride With triethylamine In dichloromethane at 0 - 20℃; | 59% |
Conditions | Yield |
---|---|
With ammonia In ethanol; water at 20℃; for 0.25h; pH=8; Darkness; | 58% |
Ketorolac
Conditions | Yield |
---|---|
Stage #1: Ketorolac With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl acetamide at 20℃; for 0.166667h; Stage #2: 3-(4-sulfamoylphenoxy)propylammonium trifluoroacetate With N-ethyl-N,N-diisopropylamine In N,N-dimethyl acetamide at 20℃; | 58% |
Ketorolac
(R)-fluoxetine
[1-{[methyl{(R)-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propyl}-amino]methyl}-2,3-dihydro-1H-pyrrolizin-5-yl](phenyl)methanone
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 20℃; for 18h; | 56% |
IUPAC Name: 5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid
Molecular Formula: C15H13NO3
Molecular Weight: 255.27 g/mol
SMILES: n12c([C@@H](C(O)=O)CC2)ccc1C(c1ccccc1)=O
InChI: InChI=1/C15H13NO3/c17-14(10-4-2-1-3-5-10)13-7-6-12-11(15(18)19)8-9-16(12)13/h1-7,11H,8-9H2,(H,18,19)
Classification Code: Analgesics; Analgesics, Non-Narcotic; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Cyclooxygenase Inhibitors; Drug / Therapeutic Agent; Enzyme Inhibitors; Peripheral Nervous System Agents; Sensory System Agents
Product Categories: API's
Index of Refraction: 1.436
Molar Refractivity: 30.52 cm3
Molar Volume: 116.6 cm3
Polarizability: 12.1×10-24 cm3
Surface Tension: 28.4 dyne/cm
Density: 1.398 g/cm3
Flash Point: 89.1 °C
Enthalpy of Vaporization: 46.02 kJ/mol
Boiling Point: 223.7 °C at 760 mmHg
Melting Point: 160-161 °C
Vapour Pressure of Ketorolac (CAS NO.74103-06-3): 0.0947 mmHg at 25 °C
Ketorolac (CAS NO.74103-06-3) is a non-steroidal anti-inflammatory drug, often used as an analgesic, antipyretic (fever reducer), and anti-inflammatory. An ophthalmic (i.e., eye-drop) solution of Ketorolac is available and is used to treat eye pain and to relieve the itchiness and burning of seasonal allergies.
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | oral | 200mg/kg (200mg/kg) | Agents and Actions, A Swiss Journal of Pharmacology. Vol. 12, Pg. 684, 1982. | |
mouse | LDLo | intraperitoneal | 100mg/kg (100mg/kg) | Agents and Actions, A Swiss Journal of Pharmacology. Vol. 12, Pg. 684, 1982. |
RIDADR: 3249
HazardClass: 6.1(a)
PackingGroup of Ketorolac (CAS NO.74103-06-3): II
Ketorolac (CAS NO.74103-06-3), its Synonyms are (+-)-5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid ; (+-)-Ketorolac ; Ketorolacum ; 1H-Pyrrolizine-1-carboxylic acid, 2,3-dihydro-5-benzoyl-, (+-)- .
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