Product Name

  • Name

    METHANESULFONYL HYDRAZIDE

  • EINECS -0
  • CAS No. 10393-86-9
  • Article Data16
  • CAS DataBase
  • Density 1.401 g/cm3
  • Solubility
  • Melting Point 46-48 °C
  • Formula CH6N2O2S
  • Boiling Point 229 °C at 760 mmHg
  • Molecular Weight 110.137
  • Flash Point 92.3 °C
  • Transport Information
  • Appearance
  • Safety 15-26-36
  • Risk Codes 36/37/38
  • Molecular Structure Molecular Structure of 10393-86-9 (METHANESULFONYL HYDRAZIDE)
  • Hazard Symbols R36/37/38:Irritating to eyes, respiratory system and skin.;
  • Synonyms Mesyl hydrazide;
  • PSA 80.57000
  • LogP 0.58130

Synthetic route

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

methanesulphonyl hydrazide
10393-86-9

methanesulphonyl hydrazide

Conditions
ConditionsYield
With sodium hydroxide; hydrazine hydrate In water at 8℃;90%
With hydrazine hydrate In tetrahydrofuran at 10 - 15℃; for 0.5h;82%
With hydrazine hydrate In ethanol at 10 - 20℃; for 1h;50%
methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

A

methanesulphonyl hydrazide
10393-86-9

methanesulphonyl hydrazide

B

di-methanesulfonyl hydrazide
18300-37-3

di-methanesulfonyl hydrazide

Conditions
ConditionsYield
With sodium hydroxide; hydrazine hydrate In water cooling;
1-phenyl-3-dimethylaminoprop-2-enone
1201-93-0

1-phenyl-3-dimethylaminoprop-2-enone

methanesulphonyl hydrazide
10393-86-9

methanesulphonyl hydrazide

2-methylsulfonyl-1-phenylethanone
3708-04-1

2-methylsulfonyl-1-phenylethanone

Conditions
ConditionsYield
Stage #1: 1-phenyl-3-dimethylaminoprop-2-enone; methanesulphonyl hydrazide With tert.-butylhydroperoxide In water at 80℃; for 8h;
Stage #2: With copper diacetate In water
96%
N-phthalimidyl-2-aminoacetaldehyde
2913-97-5

N-phthalimidyl-2-aminoacetaldehyde

methanesulphonyl hydrazide
10393-86-9

methanesulphonyl hydrazide

C11H11N3O4S

C11H11N3O4S

Conditions
ConditionsYield
In ethanol at 70℃; for 0.5h; Condensation;95%
styrene
292638-84-7

styrene

methanesulphonyl hydrazide
10393-86-9

methanesulphonyl hydrazide

(E)-methyl styryl sulfone
15436-11-0

(E)-methyl styryl sulfone

Conditions
ConditionsYield
With tert.-butylhydroperoxide; iodine; sodium carbonate In toluene at 90℃; for 3h; Inert atmosphere; stereoselective reaction;95%
With oxygen; copper(l) chloride; lithium bromide In dimethyl sulfoxide at 100℃; under 760.051 Torr; for 12h; Schlenk technique; stereoselective reaction;88%
indole
120-72-9

indole

methanesulphonyl hydrazide
10393-86-9

methanesulphonyl hydrazide

2-(methylsulfonyl)-1H-indole

2-(methylsulfonyl)-1H-indole

Conditions
ConditionsYield
With tert.-butylhydroperoxide; iodine In water; 1,2-dichloro-ethane at 20℃; for 2h; Green chemistry;92%
methanesulphonyl hydrazide
10393-86-9

methanesulphonyl hydrazide

dimethoxyacetaldehyde
51673-84-8

dimethoxyacetaldehyde

A

(E)-N'-(2,2-dimethoxyethylidene)methanesulfonohydrazide
917918-89-9

(E)-N'-(2,2-dimethoxyethylidene)methanesulfonohydrazide

B

C4H10N4O4S2

C4H10N4O4S2

Conditions
ConditionsYield
In tetrahydrofuran at 20℃; for 3.5h;A 91.1%
B n/a
benzophenone
119-61-9

benzophenone

methanesulphonyl hydrazide
10393-86-9

methanesulphonyl hydrazide

N'-(diphenylmethylene)methanesulfonohydrazide
1244620-37-8

N'-(diphenylmethylene)methanesulfonohydrazide

Conditions
ConditionsYield
With hydrogenchloride In methanol; water for 24h; Reflux;90%
With hydrogenchloride In methanol; water for 1h; Reflux;
methanesulphonyl hydrazide
10393-86-9

methanesulphonyl hydrazide

(S)-2-amino-4-phenylbut-3-ene

(S)-2-amino-4-phenylbut-3-ene

C11H14O2S

C11H14O2S

Conditions
ConditionsYield
With palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl In 1,4-dioxane at 20℃; for 24h;90%
methanesulphonyl hydrazide
10393-86-9

methanesulphonyl hydrazide

(3R,3aS,4R,SR,7S,9R,9aR,12R)-3-methoxy-4,7,9,12-tetramethyl-8-oxo-7-vinyldecahydro-4,9a-propanocyclopenta[8]annulen-5-yl carbonochloridate
193536-85-5

(3R,3aS,4R,SR,7S,9R,9aR,12R)-3-methoxy-4,7,9,12-tetramethyl-8-oxo-7-vinyldecahydro-4,9a-propanocyclopenta[8]annulen-5-yl carbonochloridate

(3R)-3-deoxo-11-deoxy-3-methoxy-11-oxo-4-epi-mutilin 14-[N-(methanesulphonylamino) carbamate]
193536-97-9

(3R)-3-deoxo-11-deoxy-3-methoxy-11-oxo-4-epi-mutilin 14-[N-(methanesulphonylamino) carbamate]

Conditions
ConditionsYield
In dichloromethane89%
methanesulphonyl hydrazide
10393-86-9

methanesulphonyl hydrazide

methanethiosulfonic acid S-methyl ester
2949-92-0

methanethiosulfonic acid S-methyl ester

Conditions
ConditionsYield
With dipotassium peroxodisulfate; N-iodo-succinimide In tetrahydrofuran at 70℃; for 8h; Schlenk technique; Green chemistry;87%
With copper dichloride In toluene at 90℃; for 15h; Inert atmosphere;68%
With dipotassium peroxodisulfate; tetrabutylammomium bromide In water at 40℃; under 760.051 Torr; for 24h; Schlenk technique;62%
methanesulphonyl hydrazide
10393-86-9

methanesulphonyl hydrazide

C15H16N2O3S

C15H16N2O3S

Conditions
ConditionsYield
With sodium bromate; sodium hydrogensulfite In tetrachloromethane at 60℃;86.6%
methanesulphonyl hydrazide
10393-86-9

methanesulphonyl hydrazide

4-methyl-6-phenylhexa-3,5-dien-2-one
72006-13-4

4-methyl-6-phenylhexa-3,5-dien-2-one

C14H18N2O2S
80457-42-7

C14H18N2O2S

Conditions
ConditionsYield
With hydrogenchloride In ethanol for 2h; Ambient temperature;86%

Methanesulfonic acid,hydrazide Specification

The Methanesulfonic acid,hydrazide, with the CAS registry number of 10393-86-9, is also known as Mesyl hydrazide. Its molecular formula is CH6N2O2S and molecular weight is 110.14. What's more, its IUPAC name is Methanesulfonohydrazide. In addition, it must be stored in airtight containers and placed in a dry, cool place.

Physical properties about the Methanesulfonic acid,hydrazide are: (1)ACD/LogP: -1.47; (2)# of Rule of 5 Violations: 0; (3)#H bond acceptors: 4; (4)#H bond donors: 3; (5)#Freely Rotating Bonds: 1; (6)Polar Surface Area: 49 Å2; (7)Index of Refraction: 1.491; (8)Molar Refractivity: 22.76 cm3; (9)Molar Volume: 78.5 cm3; (10)Surface Tension: 53.1 dyne/cm; (11)Density: 1.401 g/cm3; (12)Flash Point: 92.3 °C; (13)Enthalpy of Vaporization: 46.56 kJ/mol; (14)Boiling Point: 229 °C at 760 mmHg; (15)Vapour Pressure: 0.0711 mmHg at 25 °C.

Preparation: this chemical can be obtained by Methanesulfonyl chloride. The reaction needs reagent Hydrazine hydrate and solvent H2O. The reaction temperature is 8 °C. The yield is about 90 %.

The Methanesulfonic acid,hydrazide can be obtained by Methanesulfonyl chloride

Uses: it is used to produce other chemicals. For example, it is used to produce Phenyl methaneselenesulfonate. This reaction needs solvent CH2Cl2. The reaction time is 30 min. The yield is about 65 %.

The Methanesulfonic acid,hydrazide can react with Benzeneseleninic acid to get Phenyl methaneselenesulfonate

When you are using this chemical, please be cautious about it as the following:
As a chemical, it is irritating to eyes, respiratory system and skin. If contact with eyes accidently, rinse immediately with plenty of water and seek medical advice. In addition, during using it, wear suitable protective clothing.

You can still convert the following datas into molecular structure:
(1) SMILES: O=S(=O)(NN)C
(2) InChI: InChI=1/CH6N2O2S/c1-6(4,5)3-2/h3H,2H2,1H3
(3) InChIKey: VKHZYWVEBNIRLX-UHFFFAOYAS

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